diff --git a/src/course-home/data/__snapshots__/redux.test.js.snap b/src/course-home/data/__snapshots__/redux.test.js.snap
index 9df06d19e6..a08587b0d1 100644
--- a/src/course-home/data/__snapshots__/redux.test.js.snap
+++ b/src/course-home/data/__snapshots__/redux.test.js.snap
@@ -518,6 +518,7 @@ Object {
               "hideFromTOC": undefined,
               "icon": null,
               "id": "block-v1:edX+DemoX+Demo_Course+type@sequential+block@bcdabcdabcdabcdabcdabcdabcdabcd1",
+              "navigationDisabled": undefined,
               "sectionId": "block-v1:edX+DemoX+Demo_Course+type@chapter+block@bcdabcdabcdabcdabcdabcdabcdabcd2",
               "showLink": true,
               "title": "Title of Sequence",
diff --git a/src/course-home/data/api.js b/src/course-home/data/api.js
index 7ce2525ffe..f963f715c8 100644
--- a/src/course-home/data/api.js
+++ b/src/course-home/data/api.js
@@ -154,6 +154,7 @@ export function normalizeOutlineBlocks(courseId, blocks) {
           showLink: !!block.lms_web_url,
           title: block.display_name,
           hideFromTOC: block.hide_from_toc,
+          navigationDisabled: block.navigation_disabled,
         };
         break;
 
diff --git a/src/courseware/course/Course.jsx b/src/courseware/course/Course.jsx
index a00a45b333..74fc267b62 100644
--- a/src/courseware/course/Course.jsx
+++ b/src/courseware/course/Course.jsx
@@ -37,6 +37,7 @@ const Course = ({
   const sequence = useModel('sequences', sequenceId);
   const section = useModel('sections', sequence ? sequence.sectionId : null);
   const enableNewSidebar = getConfig().ENABLE_NEW_SIDEBAR;
+  const navigationDisabled = sequence?.navigationDisabled ?? false;
 
   const pageTitleBreadCrumbs = [
     sequence,
@@ -76,13 +77,17 @@ const Course = ({
         <title>{`${pageTitleBreadCrumbs.join(' | ')} | ${getConfig().SITE_NAME}`}</title>
       </Helmet>
       <div className="position-relative d-flex align-items-center mb-4 mt-1">
-        <CourseBreadcrumbs
-          courseId={courseId}
-          sectionId={section ? section.id : null}
-          sequenceId={sequenceId}
-          isStaff={isStaff}
-          unitId={unitId}
-        />
+        {navigationDisabled || (
+        <>
+          <CourseBreadcrumbs
+            courseId={courseId}
+            sectionId={section ? section.id : null}
+            sequenceId={sequenceId}
+            isStaff={isStaff}
+            unitId={unitId}
+          />
+        </>
+        )}
         {shouldDisplayChat && (
           <>
             <Chat
diff --git a/src/courseware/course/Course.test.jsx b/src/courseware/course/Course.test.jsx
index a2b101ae2e..de8a057874 100644
--- a/src/courseware/course/Course.test.jsx
+++ b/src/courseware/course/Course.test.jsx
@@ -78,6 +78,27 @@ describe('Course', () => {
     );
   });
 
+  it('removes breadcrumbs when navigation is disabled', async () => {
+    const sequenceBlocks = [Factory.build(
+      'block',
+      { type: 'sequential', children: [] },
+      { courseId: mockData.courseId },
+    )];
+    const sequenceMetadata = [Factory.build(
+      'sequenceMetadata',
+      { navigation_disabled: true },
+      { courseId: mockData.courseId, sequenceBlock: sequenceBlocks[0] },
+    )];
+    const testStore = await initializeTestStore({ sequenceBlocks, sequenceMetadata }, false);
+    const testData = {
+      ...mockData,
+      sequenceId: sequenceBlocks[0].id,
+      onNavigate: jest.fn(),
+    };
+    render(<Course {...testData} />, { store: testStore, wrapWithRouter: true });
+    expect(screen.queryByRole('navigation', { name: 'breadcrumb' })).not.toBeInTheDocument();
+  });
+
   it('displays first section celebration modal', async () => {
     const courseHomeMetadata = Factory.build('courseHomeMetadata', { celebrations: { firstSection: true } });
     const testStore = await initializeTestStore({ courseHomeMetadata }, false);
diff --git a/src/courseware/course/sequence/sequence-navigation/SequenceNavigation.jsx b/src/courseware/course/sequence/sequence-navigation/SequenceNavigation.jsx
index f52e585892..37b03a4038 100644
--- a/src/courseware/course/sequence/sequence-navigation/SequenceNavigation.jsx
+++ b/src/courseware/course/sequence/sequence-navigation/SequenceNavigation.jsx
@@ -32,7 +32,12 @@ const SequenceNavigation = ({
 }) => {
   const sequence = useModel('sequences', sequenceId);
   const {
-    isFirstUnit, isLastUnit, nextLink, previousLink,
+    isFirstUnit,
+    isLastUnit,
+    nextLink,
+    previousLink,
+    navigationDisabledPrevSequence,
+    navigationDisabledNextSequence,
   } = useSequenceNavigationMetadata(sequenceId, unitId);
   const {
     courseId,
@@ -68,8 +73,7 @@ const SequenceNavigation = ({
   const renderPreviousButton = () => {
     const disabled = isFirstUnit;
     const prevArrow = isRtl(getLocale()) ? ChevronRight : ChevronLeft;
-
-    return (
+    return navigationDisabledPrevSequence || (
       <Button
         variant="link"
         className="previous-btn"
@@ -90,7 +94,7 @@ const SequenceNavigation = ({
     const disabled = isLastUnit && !exitActive;
     const nextArrow = isRtl(getLocale()) ? ChevronLeft : ChevronRight;
 
-    return (
+    return navigationDisabledNextSequence || (
       <Button
         variant="link"
         className="next-btn"
diff --git a/src/courseware/course/sequence/sequence-navigation/SequenceNavigation.test.jsx b/src/courseware/course/sequence/sequence-navigation/SequenceNavigation.test.jsx
index aa0b157e2d..9558a41a5f 100644
--- a/src/courseware/course/sequence/sequence-navigation/SequenceNavigation.test.jsx
+++ b/src/courseware/course/sequence/sequence-navigation/SequenceNavigation.test.jsx
@@ -161,4 +161,52 @@ describe('Sequence Navigation', () => {
     fireEvent.click(screen.getByRole('link', { name: /next/i }));
     expect(nextHandler).toHaveBeenCalledTimes(1);
   });
+
+  it('removes "Previous" for first unit in sequence when navigation is disabled', async () => {
+    const sequenceBlocks = [Factory.build(
+      'block',
+      { type: 'sequential', children: unitBlocks.map(block => block.id) },
+      { courseId: courseMetadata.id },
+    )];
+    const sequenceMetadata = [Factory.build(
+      'sequenceMetadata',
+      { navigation_disabled: true },
+      { courseId: courseMetadata.id, unitBlocks, sequenceBlock: sequenceBlocks[0] },
+    )];
+    const testStore = await initializeTestStore({ unitBlocks, sequenceBlocks, sequenceMetadata }, false);
+    const testData = {
+      ...mockData,
+      sequenceId: sequenceBlocks[0].id,
+      onNavigate: jest.fn(),
+    };
+    render(<SequenceNavigation {...testData} unitId={unitBlocks[0].id} />, { store: testStore, wrapWithRouter: true });
+    expect(screen.queryByRole('link', { name: /previous/i })).not.toBeInTheDocument();
+  });
+
+  it('removes "Next" for last unit in sequence when navigation is disabled', async () => {
+    const sequenceBlocks = [Factory.build(
+      'block',
+      { type: 'sequential', children: unitBlocks.map(block => block.id) },
+      { courseId: courseMetadata.id },
+    )];
+    const sequenceMetadata = [Factory.build(
+      'sequenceMetadata',
+      { navigation_disabled: true },
+      { courseId: courseMetadata.id, unitBlocks, sequenceBlock: sequenceBlocks[0] },
+    )];
+    const testStore = await initializeTestStore({ unitBlocks, sequenceBlocks, sequenceMetadata }, false);
+    const testData = {
+      ...mockData,
+      sequenceId: sequenceBlocks[0].id,
+      onNavigate: jest.fn(),
+    };
+    render(
+      <SequenceNavigation
+        {...testData}
+        unitId={unitBlocks[unitBlocks.length - 1].id}
+      />,
+      { store: testStore, wrapWithRouter: true },
+    );
+    expect(screen.queryByRole('link', { name: /next/i })).not.toBeInTheDocument();
+  });
 });
diff --git a/src/courseware/course/sequence/sequence-navigation/hooks.js b/src/courseware/course/sequence/sequence-navigation/hooks.js
index 8b714a247f..20c4e6bb2d 100644
--- a/src/courseware/course/sequence/sequence-navigation/hooks.js
+++ b/src/courseware/course/sequence/sequence-navigation/hooks.js
@@ -13,7 +13,12 @@ export function useSequenceNavigationMetadata(currentSequenceId, currentUnitId)
 
   // If we don't know the sequence and unit yet, then assume no.
   if (courseStatus !== 'loaded' || sequenceStatus !== 'loaded' || !currentSequenceId || !currentUnitId) {
-    return { isFirstUnit: false, isLastUnit: false };
+    return {
+      isFirstUnit: false,
+      isLastUnit: false,
+      navigationDisabledNextSequence: false,
+      navigationDisabledPrevSequence: false,
+    };
   }
 
   const sequenceIndex = sequenceIds.indexOf(currentSequenceId);
@@ -25,6 +30,9 @@ export function useSequenceNavigationMetadata(currentSequenceId, currentUnitId)
   const isLastSequence = sequenceIndex === sequenceIds.length - 1;
   const isLastUnitInSequence = unitIndex === sequence.unitIds.length - 1;
   const isLastUnit = isLastSequence && isLastUnitInSequence;
+  const sequenceNavigationDisabled = sequence.navigationDisabled;
+  const navigationDisabledPrevSequence = sequenceNavigationDisabled && isFirstUnitInSequence;
+  const navigationDisabledNextSequence = sequenceNavigationDisabled && isLastUnitInSequence;
 
   const nextSequenceId = sequenceIndex < sequenceIds.length - 1 ? sequenceIds[sequenceIndex + 1] : null;
   const previousSequenceId = sequenceIndex > 0 ? sequenceIds[sequenceIndex - 1] : null;
@@ -52,6 +60,11 @@ export function useSequenceNavigationMetadata(currentSequenceId, currentUnitId)
   }
 
   return {
-    isFirstUnit, isLastUnit, nextLink, previousLink,
+    isFirstUnit,
+    isLastUnit,
+    nextLink,
+    previousLink,
+    navigationDisabledNextSequence,
+    navigationDisabledPrevSequence,
   };
 }
diff --git a/src/courseware/data/api.js b/src/courseware/data/api.js
index f3a82a5e2b..95b3b49401 100644
--- a/src/courseware/data/api.js
+++ b/src/courseware/data/api.js
@@ -160,6 +160,7 @@ function normalizeSequenceMetadata(sequence) {
       saveUnitPosition: sequence.save_position,
       showCompletion: sequence.show_completion,
       allowProctoringOptOut: sequence.allow_proctoring_opt_out,
+      navigationDisabled: sequence.navigation_disabled,
     },
     units: sequence.items.map(unit => ({
       id: unit.id,