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[gget_alphafold] - Feature Request - Add an option to submit a MSA instead of a protein sequence #52

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kchennen opened this issue Jan 9, 2023 · 1 comment
Open

[gget_alphafold] - Feature Request - Add an option to submit a MSA instead of a protein sequence #52

kchennen opened this issue Jan 9, 2023 · 1 comment
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enhancement New feature or request

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@kchennen
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kchennen commented Jan 9, 2023

Hi Laura,
It would be great if there was an option to be able to submit a MSA instead of a protein sequence as input for gget alphafold. The use case here is to submit (manually) curated MSA, instead of "all" sequences holomologs that come usually with sequence errors (prediction errors, isoforms, fragments... etc; PMID: 33172385), inorder to improve the folding predictions.
@lauraluebbert lauraluebbert added the enhancement New feature or request label Jan 10, 2023
@anhchi172
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Can you provide an example of the manually curated MSA so we can determine the structure of the input better?

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@kchennen @anhchi172 @lauraluebbert