diff --git a/doc/source/whatsnew/v2.1.0.rst b/doc/source/whatsnew/v2.1.0.rst
index dc306471dbd3f..404d3820cad02 100644
--- a/doc/source/whatsnew/v2.1.0.rst
+++ b/doc/source/whatsnew/v2.1.0.rst
@@ -127,7 +127,7 @@ Other enhancements
 - Many read/to_* functions, such as :meth:`DataFrame.to_pickle` and :func:`read_csv`, support forwarding compression arguments to lzma.LZMAFile (:issue:`52979`)
 - Performance improvement in :func:`concat` with homogeneous ``np.float64`` or ``np.float32`` dtypes (:issue:`52685`)
 - Performance improvement in :meth:`DataFrame.filter` when ``items`` is given (:issue:`52941`)
--
+- Support Pydantic V2 protocol for :class:`Series` (:issue:`54034`)
 
 .. ---------------------------------------------------------------------------
 .. _whatsnew_210.notable_bug_fixes:
diff --git a/environment.yml b/environment.yml
index 8e3c3a26ffc0f..3b62561403ad0 100644
--- a/environment.yml
+++ b/environment.yml
@@ -45,6 +45,7 @@ dependencies:
   - py
   - psycopg2>=2.9.3
   - pyarrow>=7.0.0
+  - pydantic>=2.0
   - pymysql>=1.0.2
   - pyreadstat>=1.1.5
   - pytables>=3.7.0
diff --git a/pandas/core/series.py b/pandas/core/series.py
index 2fc926d7e43d1..eddbf7c072bfb 100644
--- a/pandas/core/series.py
+++ b/pandas/core/series.py
@@ -19,6 +19,7 @@
     Union,
     cast,
     overload,
+    Type
 )
 import warnings
 import weakref
@@ -37,6 +38,7 @@
 )
 from pandas._libs.lib import is_range_indexer
 from pandas.compat import PYPY
+from pandas.compat._optional import import_optional_dependency
 from pandas.compat.numpy import function as nv
 from pandas.errors import (
     ChainedAssignmentError,
@@ -148,6 +150,10 @@
 import pandas.plotting
 
 if TYPE_CHECKING:
+    import pydantic_core
+    from pydantic import GetCoreSchemaHandler
+    from pydantic_core.core_schema import CoreSchema
+
     from pandas._libs.internals import BlockValuesRefs
     from pandas._typing import (
         AggFuncType,
@@ -6215,3 +6221,15 @@ def cumsum(self, axis: Axis | None = None, skipna: bool = True, *args, **kwargs)
     @doc(make_doc("cumprod", 1))
     def cumprod(self, axis: Axis | None = None, skipna: bool = True, *args, **kwargs):
         return NDFrame.cumprod(self, axis, skipna, *args, **kwargs)
+
+    @classmethod
+    def __get_pydantic_core_schema__(cls, source_type: Type[Any], handler: GetCoreSchemaHandler) -> CoreSchema:
+        pyd_core = cast("pydantic_core", import_optional_dependency("pydantic_core"))
+        core_schema = pyd_core.core_schema
+
+        return core_schema.union_schema(
+            [
+                core_schema.is_instance_schema(Series),
+                core_schema.no_info_plain_validator_function(Series)
+            ]
+        )
diff --git a/pandas/tests/test_downstream.py b/pandas/tests/test_downstream.py
index 7354e313e24f4..b3c3f595e7fed 100644
--- a/pandas/tests/test_downstream.py
+++ b/pandas/tests/test_downstream.py
@@ -274,3 +274,23 @@ def __radd__(self, other):
 
     assert right.__add__(left) is NotImplemented
     assert right + left is left
+
+
+@td.skip_if_no("pydantic")
+@td.skip_if_no("pydantic_core")
+@pytest.mark.parametrize("series", [
+    Series([1, 2, 3]),
+    Series(np.array([1, 2, 3])),
+    Series({'a': 1, 'b': 2, 'c': 3}),
+    Series(3),
+])
+def test_pydantic_protocol(series: Series) -> None:
+    from pydantic import BaseModel
+
+    class Model(BaseModel):
+        series: Series
+
+
+    model = Model(series=series)
+    assert model.model_dump() == {}
+    assert model.model_json_schema() == {}