diff --git a/doc/source/whatsnew/v3.0.0.rst b/doc/source/whatsnew/v3.0.0.rst
index 89bc942cb7250..84893b011f76b 100644
--- a/doc/source/whatsnew/v3.0.0.rst
+++ b/doc/source/whatsnew/v3.0.0.rst
@@ -702,6 +702,7 @@ I/O
 - Bug in :meth:`read_stata` raising ``KeyError`` when input file is stored in big-endian format and contains strL data. (:issue:`58638`)
 - Bug in :meth:`read_stata` where extreme value integers were incorrectly interpreted as missing for format versions 111 and prior (:issue:`58130`)
 - Bug in :meth:`read_stata` where the missing code for double was not recognised for format versions 105 and prior (:issue:`58149`)
+- Bug in :meth:`set_option` where setting the pandas option ``display.html.use_mathjax`` to ``False`` has no effect (:issue:`59884`)
 
 Period
 ^^^^^^
diff --git a/pandas/io/formats/html.py b/pandas/io/formats/html.py
index fdea1831d5596..c4884ef4ce4a9 100644
--- a/pandas/io/formats/html.py
+++ b/pandas/io/formats/html.py
@@ -241,6 +241,7 @@ def _write_table(self, indent: int = 0) -> None:
         use_mathjax = get_option("display.html.use_mathjax")
         if not use_mathjax:
             _classes.append("tex2jax_ignore")
+            _classes.append("mathjax_ignore")
         if self.classes is not None:
             if isinstance(self.classes, str):
                 self.classes = self.classes.split()
diff --git a/pandas/io/formats/style_render.py b/pandas/io/formats/style_render.py
index 08d9fd938c873..84503944378f1 100644
--- a/pandas/io/formats/style_render.py
+++ b/pandas/io/formats/style_render.py
@@ -366,9 +366,11 @@ def _translate(
         if not get_option("styler.html.mathjax"):
             table_attr = table_attr or ""
             if 'class="' in table_attr:
-                table_attr = table_attr.replace('class="', 'class="tex2jax_ignore ')
+                table_attr = table_attr.replace(
+                    'class="', ' class="tex2jax_ignore mathjax_ignore '
+                )
             else:
-                table_attr += ' class="tex2jax_ignore"'
+                table_attr += ' class="tex2jax_ignore mathjax_ignore"'
         d.update({"table_attributes": table_attr})
 
         if self.tooltips:
diff --git a/pandas/tests/io/formats/style/test_style.py b/pandas/tests/io/formats/style/test_style.py
index e9fc2b2d27afd..ff8a1b9f570ab 100644
--- a/pandas/tests/io/formats/style/test_style.py
+++ b/pandas/tests/io/formats/style/test_style.py
@@ -488,9 +488,11 @@ def test_repr_html_ok(self, styler):
     def test_repr_html_mathjax(self, styler):
         # gh-19824 / 41395
         assert "tex2jax_ignore" not in styler._repr_html_()
+        assert "mathjax_ignore" not in styler._repr_html_()
 
         with option_context("styler.html.mathjax", False):
             assert "tex2jax_ignore" in styler._repr_html_()
+            assert "mathjax_ignore" in styler._repr_html_()
 
     def test_update_ctx(self, styler):
         styler._update_ctx(DataFrame({"A": ["color: red", "color: blue"]}))
diff --git a/pandas/tests/io/formats/test_to_html.py b/pandas/tests/io/formats/test_to_html.py
index 8031f67cd0567..b1a437bfdbd8a 100644
--- a/pandas/tests/io/formats/test_to_html.py
+++ b/pandas/tests/io/formats/test_to_html.py
@@ -934,9 +934,11 @@ def test_repr_html(self, float_frame):
     def test_repr_html_mathjax(self):
         df = DataFrame([[1, 2], [3, 4]])
         assert "tex2jax_ignore" not in df._repr_html_()
+        assert "mathjax_ignore" not in df._repr_html_()
 
         with option_context("display.html.use_mathjax", False):
             assert "tex2jax_ignore" in df._repr_html_()
+            assert "mathjax_ignore" in df._repr_html_()
 
     def test_repr_html_wide(self):
         max_cols = 20