-
Notifications
You must be signed in to change notification settings - Fork 5
/
conso.obo
4326 lines (3951 loc) · 218 KB
/
conso.obo
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
245
246
247
248
249
250
251
252
253
254
255
256
257
258
259
260
261
262
263
264
265
266
267
268
269
270
271
272
273
274
275
276
277
278
279
280
281
282
283
284
285
286
287
288
289
290
291
292
293
294
295
296
297
298
299
300
301
302
303
304
305
306
307
308
309
310
311
312
313
314
315
316
317
318
319
320
321
322
323
324
325
326
327
328
329
330
331
332
333
334
335
336
337
338
339
340
341
342
343
344
345
346
347
348
349
350
351
352
353
354
355
356
357
358
359
360
361
362
363
364
365
366
367
368
369
370
371
372
373
374
375
376
377
378
379
380
381
382
383
384
385
386
387
388
389
390
391
392
393
394
395
396
397
398
399
400
401
402
403
404
405
406
407
408
409
410
411
412
413
414
415
416
417
418
419
420
421
422
423
424
425
426
427
428
429
430
431
432
433
434
435
436
437
438
439
440
441
442
443
444
445
446
447
448
449
450
451
452
453
454
455
456
457
458
459
460
461
462
463
464
465
466
467
468
469
470
471
472
473
474
475
476
477
478
479
480
481
482
483
484
485
486
487
488
489
490
491
492
493
494
495
496
497
498
499
500
501
502
503
504
505
506
507
508
509
510
511
512
513
514
515
516
517
518
519
520
521
522
523
524
525
526
527
528
529
530
531
532
533
534
535
536
537
538
539
540
541
542
543
544
545
546
547
548
549
550
551
552
553
554
555
556
557
558
559
560
561
562
563
564
565
566
567
568
569
570
571
572
573
574
575
576
577
578
579
580
581
582
583
584
585
586
587
588
589
590
591
592
593
594
595
596
597
598
599
600
601
602
603
604
605
606
607
608
609
610
611
612
613
614
615
616
617
618
619
620
621
622
623
624
625
626
627
628
629
630
631
632
633
634
635
636
637
638
639
640
641
642
643
644
645
646
647
648
649
650
651
652
653
654
655
656
657
658
659
660
661
662
663
664
665
666
667
668
669
670
671
672
673
674
675
676
677
678
679
680
681
682
683
684
685
686
687
688
689
690
691
692
693
694
695
696
697
698
699
700
701
702
703
704
705
706
707
708
709
710
711
712
713
714
715
716
717
718
719
720
721
722
723
724
725
726
727
728
729
730
731
732
733
734
735
736
737
738
739
740
741
742
743
744
745
746
747
748
749
750
751
752
753
754
755
756
757
758
759
760
761
762
763
764
765
766
767
768
769
770
771
772
773
774
775
776
777
778
779
780
781
782
783
784
785
786
787
788
789
790
791
792
793
794
795
796
797
798
799
800
801
802
803
804
805
806
807
808
809
810
811
812
813
814
815
816
817
818
819
820
821
822
823
824
825
826
827
828
829
830
831
832
833
834
835
836
837
838
839
840
841
842
843
844
845
846
847
848
849
850
851
852
853
854
855
856
857
858
859
860
861
862
863
864
865
866
867
868
869
870
871
872
873
874
875
876
877
878
879
880
881
882
883
884
885
886
887
888
889
890
891
892
893
894
895
896
897
898
899
900
901
902
903
904
905
906
907
908
909
910
911
912
913
914
915
916
917
918
919
920
921
922
923
924
925
926
927
928
929
930
931
932
933
934
935
936
937
938
939
940
941
942
943
944
945
946
947
948
949
950
951
952
953
954
955
956
957
958
959
960
961
962
963
964
965
966
967
968
969
970
971
972
973
974
975
976
977
978
979
980
981
982
983
984
985
986
987
988
989
990
991
992
993
994
995
996
997
998
999
1000
format-version: 1.2
date: 11:03:2021 18:56
auto-generated-by: https://github.com/pharmacome/conso/blob/master/src/conso/export/obo.py
ontology: conso
[Typedef]
id: bfo:0000050
name: part of
comment: Inverse of has_part
[Typedef]
id: CONSO:author
name: term has author
comment: A term has an author with the given ORCID identifier
is_transitive: false
[Typedef]
id: CONSO:has_reference_protein
name: protein isoform term has reference protein
comment: A link between a protein isoform and its reference protein
is_transitive: false
[Typedef]
id: ro:0000087
name: has role
[Typedef]
id: CONSO:inhibitor
name: inhibitor
namespace: external
comment: A substance that diminishes the rate of a chemical reaction.
xref: chebi:35222
is_transitive: false
[Typedef]
id: CONSO:agonist
name: agonist
namespace: external
comment: Substance which binds to cell receptors normally responding to naturally occurring substances and which produces a response of its own.
xref: chebi:48705
is_transitive: false
[Typedef]
id: CONSO:has_antibody_target
name: Antibody has target protein
comment: Links an antibody to its target.
is_transitive: false
[Term]
id: CONSO:CONSO00001
name: microtubule-binding region
namespace: domain
def: "The motif in the MAPT protein where microtubule binding repeats" [pubmed:18500754, pubmed:2516729]
xref: interpro:IPR001084
relationship: bfo:0000050 CONSO:CONSO00188
relationship: CONSO:author orcid:0000-0003-4423-4370
synonym: "MTBR" EXACT []
[Term]
id: CONSO:CONSO00002
name: tubulin-binding repeat 1
namespace: domain
def: "position 569_591 of canonical isoform of MAPT protein" [pubmed:18500754]
relationship: bfo:0000050 CONSO:CONSO00001
relationship: CONSO:author orcid:0000-0001-9661-5277
property_value: bel "p(HGNC:MAPT, frag(569_591))" xsd:string
synonym: "MTBR R1" EXACT []
synonym: "R1" EXACT []
[Term]
id: CONSO:CONSO00003
name: tubulin-binding repeat 2
namespace: domain
def: "position 592_621 of canonical isoform of MAPT protein" [pubmed:18500754]
relationship: bfo:0000050 CONSO:CONSO00001
relationship: CONSO:author orcid:0000-0001-9661-5277
property_value: bel "p(HGNC:MAPT, frag(592_621))" xsd:string
synonym: "MTBR R2" EXACT []
synonym: "R2" EXACT []
[Term]
id: CONSO:CONSO00004
name: tubulin-binding repeat 3
namespace: domain
def: "position 623_653 of canonical isoform of MAPT protein" [pubmed:18500754]
relationship: bfo:0000050 CONSO:CONSO00001
relationship: CONSO:author orcid:0000-0001-9661-5277
property_value: bel "p(HGNC:MAPT, frag(623_653))" xsd:string
synonym: "MTBR R3" EXACT []
synonym: "R3" EXACT []
[Term]
id: CONSO:CONSO00005
name: tubulin-binding repeat 4
namespace: domain
def: "position 654_685 of canonical isoform of MAPT protein" [pubmed:18500754]
relationship: bfo:0000050 CONSO:CONSO00001
relationship: CONSO:author orcid:0000-0001-9661-5277
property_value: bel "p(HGNC:MAPT, frag(654_685))" xsd:string
synonym: "MTBR R4" EXACT []
synonym: "R4" EXACT []
[Term]
id: CONSO:CONSO00006
name: Tau aggregates
namespace: cellular_component
def: "Tau (MAPT) in its aggregated form (as Paired Helical Filaments (PHFs) or Straight Filaments (SF)) contains 5–9 moles of phosphate/ mole of the protein, defining it as hyper phosphorylated" [pmc:PMC2633703]
is_a: CONSO:CONSO00178 ! protein aggregates
relationship: CONSO:author orcid:0000-0003-4423-4370
[Term]
id: CONSO:CONSO00007
name: hyperphosphorylation
namespace: post_translational_modification
def: "An excessive phosphorylation (see GO:0006468)" [pubmed:22710920]
relationship: CONSO:author orcid:0000-0003-4423-4370
[Term]
id: CONSO:CONSO00008
name: GAL80TS
namespace: exposure
def: "temperature-sensitive allele of GAL80 (tub-GAL80TS)" [pmc:PMC3073608]
relationship: CONSO:author orcid:0000-0002-6117-4413
[Term]
id: CONSO:CONSO00009
name: Tau oligomers
namespace: cellular_component
def: "CAST is known to prevent oligomerization of Tau (Rao et al., 2014) and α-synuclein (Diepenbroek et al. 2014) and inhibit reactive gliosis (Rao et al., 2008)" [pmc:PMC4828294]
relationship: CONSO:author orcid:0000-0002-6117-4413
[Term]
id: CONSO:CONSO00010
name: LY293002
namespace: chemical
def: "a typo appearing in pubmed:23950935 for the specific PI3-kinase inhibitor that is actually named LY294002" [pubmed:23950935]
xref: cas:154447-36-6
xref: chebi:65329
xref: drugbank:DB02656
xref: inchi:InChI=1S/C19H17NO3/c21-17-13-18\(20-9-11-22-12-10-20\)23-19-15\(7-4-8-16\(17\)19\)14-5-2-1-3-6-14/h1-8\,13H\,9-12H2
xref: pubchem.compound:3973
xref: smiles:C1COCCN1C2=CC\(=O\)C3=C\(O2\)C\(=CC=C3\)C4=CC=CC=C4
relationship: CONSO:inhibitor FPLX:PI3K
relationship: CONSO:author orcid:0000-0002-3034-9970
synonym: "154447-36-6" EXACT [pubchem.compound:3973]
synonym: "15447-36-6" EXACT [pubchem.compound:3973]
synonym: "1yi3" EXACT [pubchem.compound:3973]
synonym: "2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one" EXACT [pubchem.compound:3973]
synonym: "2-(4-morpholino)-8-phenyl-4H-1-benzopyran-4-one" EXACT [pubchem.compound:3973]
synonym: "2-(morpholin-4-yl)-8-phenyl-4H-chromen-4-one" EXACT [pubchem.compound:3973]
synonym: "2-(morpholin-4-yl)-8-phenylchromen-4-one" EXACT [pubchem.compound:3973]
synonym: "2-MORPHOLIN-4-YL-7-PHENYL-4H-CHROMEN-4-ONE" EXACT [pubchem.compound:3973]
synonym: "2-Morpholin-4-yl-8-phenyl-chromen-4-one" EXACT [pubchem.compound:3973]
synonym: "2-Morpholino-8-phenyl-4-oxo-4H-1-benzopyran" EXACT [pubchem.compound:3973]
synonym: "2-Morpholino-8-phenylchromone" EXACT [pubchem.compound:3973]
synonym: "2-morpholin-4-yl-8-phenyl-4H-chromen-4-one" EXACT [pubchem.compound:3973]
synonym: "2-morpholin-4-yl-8-phenylchromen-4-one" EXACT [pubchem.compound:3973]
synonym: "2-morpholino-8-phenyl-4H-chromen-4-one" EXACT [pubchem.compound:3973]
synonym: "2-morpholino-8-phenyl-chromen-4-one" EXACT [pubchem.compound:3973]
synonym: "31M2U1DVID" EXACT [pubchem.compound:3973]
synonym: "4CA-0787" EXACT [pubchem.compound:3973]
synonym: "4H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl" EXACT [pubchem.compound:3973]
synonym: "4H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl-" EXACT [pubchem.compound:3973]
synonym: "4H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl- (9CI)" EXACT [pubchem.compound:3973]
synonym: "4H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl-(9CI)" EXACT [pubchem.compound:3973]
synonym: "4H-1-Benzopyran-4-one,2-(4-morpholinyl)-8-phenyl-" EXACT [pubchem.compound:3973]
synonym: "4azt" EXACT [pubchem.compound:3973]
synonym: "8-Phenyl-2-(morpholin-4-yl)-chromen-4-one" EXACT [pubchem.compound:3973]
synonym: "AB0033714" EXACT [pubchem.compound:3973]
synonym: "AC-30295" EXACT [pubchem.compound:3973]
synonym: "AC1L1H4N" EXACT [pubchem.compound:3973]
synonym: "AC1Q6CLU" EXACT [pubchem.compound:3973]
synonym: "AK162301" EXACT [pubchem.compound:3973]
synonym: "AKOS017344742" EXACT [pubchem.compound:3973]
synonym: "AN-1305" EXACT [pubchem.compound:3973]
synonym: "API0015880" EXACT [pubchem.compound:3973]
synonym: "AS-16252" EXACT [pubchem.compound:3973]
synonym: "BC660045" EXACT [pubchem.compound:3973]
synonym: "BCBcMAP01_000117" EXACT [pubchem.compound:3973]
synonym: "BCP00195" EXACT [pubchem.compound:3973]
synonym: "BCP9000880" EXACT [pubchem.compound:3973]
synonym: "BCPP000177" EXACT [pubchem.compound:3973]
synonym: "BDBM12915" EXACT [pubchem.compound:3973]
synonym: "BIL2940" EXACT [pubchem.compound:3973]
synonym: "BMK1-D5" EXACT [pubchem.compound:3973]
synonym: "BRD-K27305650-001-05-9" EXACT [pubchem.compound:3973]
synonym: "BSPBio_001223" EXACT [pubchem.compound:3973]
synonym: "Bio1_000332" EXACT [pubchem.compound:3973]
synonym: "Bio1_000821" EXACT [pubchem.compound:3973]
synonym: "Bio1_001310" EXACT [pubchem.compound:3973]
synonym: "Bio2_000442" EXACT [pubchem.compound:3973]
synonym: "Bio2_000922" EXACT [pubchem.compound:3973]
synonym: "BiomolKI2_000037" EXACT [pubchem.compound:3973]
synonym: "BiomolKI_000029" EXACT [pubchem.compound:3973]
synonym: "C15195" EXACT [pubchem.compound:3973]
synonym: "CBiol_002046" EXACT [pubchem.compound:3973]
synonym: "CCG-100633" EXACT [pubchem.compound:3973]
synonym: "CHEBI:65329" EXACT [pubchem.compound:3973]
synonym: "CHEMBL98350" EXACT [pubchem.compound:3973]
synonym: "CS-0150" EXACT [pubchem.compound:3973]
synonym: "CTK0H1979" EXACT [pubchem.compound:3973]
synonym: "CZQHHVNHHHRRDU-UHFFFAOYSA-N" EXACT [pubchem.compound:3973]
synonym: "D09SFV" EXACT [pubchem.compound:3973]
synonym: "D0X7NA" EXACT [pubchem.compound:3973]
synonym: "DB02656" EXACT [pubchem.compound:3973]
synonym: "DTXSID6042650" EXACT [pubchem.compound:3973]
synonym: "EC-000.2341" EXACT [pubchem.compound:3973]
synonym: "EX-A073" EXACT [pubchem.compound:3973]
synonym: "FT-0660382" EXACT [pubchem.compound:3973]
synonym: "GTPL6004" EXACT [pubchem.compound:3973]
synonym: "H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl- (9CI)" EXACT [pubchem.compound:3973]
synonym: "H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl-(9CI)" EXACT [pubchem.compound:3973]
synonym: "HMS1362M05" EXACT [pubchem.compound:3973]
synonym: "HMS1792M05" EXACT [pubchem.compound:3973]
synonym: "HMS1990M05" EXACT [pubchem.compound:3973]
synonym: "HMS3229G17" EXACT [pubchem.compound:3973]
synonym: "HMS3403M05" EXACT [pubchem.compound:3973]
synonym: "HMS3649E04" EXACT [pubchem.compound:3973]
synonym: "HMS3654M21" EXACT [pubchem.compound:3973]
synonym: "HSCI1_000206" EXACT [pubchem.compound:3973]
synonym: "HY-10108" EXACT [pubchem.compound:3973]
synonym: "IDI1_002197" EXACT [pubchem.compound:3973]
synonym: "IN1266" EXACT [pubchem.compound:3973]
synonym: "IN1268" EXACT [pubchem.compound:3973]
synonym: "InSolution™ LY 294002" EXACT [pubchem.compound:3973]
synonym: "J-510126" EXACT [pubchem.compound:3973]
synonym: "K00235" EXACT [pubchem.compound:3973]
synonym: "KB-19284" EXACT [pubchem.compound:3973]
synonym: "KB-231805" EXACT [pubchem.compound:3973]
synonym: "KBio2_000563" EXACT [pubchem.compound:3973]
synonym: "KBio2_003131" EXACT [pubchem.compound:3973]
synonym: "KBio2_005699" EXACT [pubchem.compound:3973]
synonym: "KBio3_001005" EXACT [pubchem.compound:3973]
synonym: "KBio3_001006" EXACT [pubchem.compound:3973]
synonym: "KBioGR_000563" EXACT [pubchem.compound:3973]
synonym: "KBioSS_000563" EXACT [pubchem.compound:3973]
synonym: "KS-00000XP3" EXACT [pubchem.compound:3973]
synonym: "Kinome_3543" EXACT [pubchem.compound:3973]
synonym: "LS-39828" EXACT [pubchem.compound:3973]
synonym: "LY 294002" EXACT [pubchem.compound:3973]
synonym: "LY 294002, LY-294002, 154447-36-6" EXACT [pubchem.compound:3973]
synonym: "LY 294002; 2-(4-Morpholino)-8-phenyl-4H-1-benzopyran-4-one" EXACT [pubchem.compound:3973]
synonym: "LY-294,002" EXACT [pubchem.compound:3973]
synonym: "LY-294,002 hydrochloride, solid, >=98% (HPLC)" EXACT [pubchem.compound:3973]
synonym: "LY-294002" EXACT [pubchem.compound:3973]
synonym: "LY-924002" EXACT [pubchem.compound:3973]
synonym: "LY2" EXACT [pubchem.compound:3973]
synonym: "LY294002" EXACT [pubchem.compound:3973]
synonym: "Lopac-L-9908" EXACT [pubchem.compound:3973]
synonym: "Lopac0_000710" EXACT [pubchem.compound:3973]
synonym: "Lys 294002" EXACT [pubchem.compound:3973]
synonym: "M2410" EXACT [pubchem.compound:3973]
synonym: "MLS006010131" EXACT [pubchem.compound:3973]
synonym: "MolPort-003-983-779" EXACT [pubchem.compound:3973]
synonym: "NCGC00015622-01" EXACT [pubchem.compound:3973]
synonym: "NCGC00015622-02" EXACT [pubchem.compound:3973]
synonym: "NCGC00015622-03" EXACT [pubchem.compound:3973]
synonym: "NCGC00015622-04" EXACT [pubchem.compound:3973]
synonym: "NCGC00015622-05" EXACT [pubchem.compound:3973]
synonym: "NCGC00015622-06" EXACT [pubchem.compound:3973]
synonym: "NCGC00015622-07" EXACT [pubchem.compound:3973]
synonym: "NCGC00025020-01" EXACT [pubchem.compound:3973]
synonym: "NCGC00025020-02" EXACT [pubchem.compound:3973]
synonym: "NCGC00025020-03" EXACT [pubchem.compound:3973]
synonym: "NCGC00025020-04" EXACT [pubchem.compound:3973]
synonym: "NCGC00179253-01" EXACT [pubchem.compound:3973]
synonym: "NCI60_034712" EXACT [pubchem.compound:3973]
synonym: "NSC 697286" EXACT [pubchem.compound:3973]
synonym: "NSC-697286" EXACT [pubchem.compound:3973]
synonym: "NSC697286" EXACT [pubchem.compound:3973]
synonym: "PubChem16766" EXACT [pubchem.compound:3973]
synonym: "QC-7260" EXACT [pubchem.compound:3973]
synonym: "RS0074" EXACT [pubchem.compound:3973]
synonym: "RT-013609" EXACT [pubchem.compound:3973]
synonym: "S-7706" EXACT [pubchem.compound:3973]
synonym: "SB10965" EXACT [pubchem.compound:3973]
synonym: "SC-85850" EXACT [pubchem.compound:3973]
synonym: "SCHEMBL94377" EXACT [pubchem.compound:3973]
synonym: "SF 1101" EXACT [pubchem.compound:3973]
synonym: "SF-1101" EXACT [pubchem.compound:3973]
synonym: "SMR002530642" EXACT [pubchem.compound:3973]
synonym: "SR-01000076245-7" EXACT [pubchem.compound:3973]
synonym: "ST24040926" EXACT [pubchem.compound:3973]
synonym: "SW217688-2" EXACT [pubchem.compound:3973]
synonym: "SYN1108" EXACT [pubchem.compound:3973]
synonym: "Tocris-1130" EXACT [pubchem.compound:3973]
synonym: "UNII-31M2U1DVID" EXACT [pubchem.compound:3973]
synonym: "X7411" EXACT [pubchem.compound:3973]
synonym: "ZINC6014" EXACT [pubchem.compound:3973]
synonym: "ZX-AFC000490" EXACT [pubchem.compound:3973]
synonym: "cc-58" EXACT [pubchem.compound:3973]
synonym: "s1105" EXACT [pubchem.compound:3973]
[Term]
id: CONSO:CONSO00011
name: LPLI
namespace: exposure
def: "Low-power laser irradiation (LPLI) is a non-damage physical therapy" [pubmed:20333643]
relationship: CONSO:author orcid:0000-0002-3034-9970
synonym: "Low-power laser irradiation" EXACT []
[Term]
id: CONSO:CONSO00012
name: Chronic cerebral hypoperfusion
namespace: pathology
def: "Chronic cerebral hypoperfusion (CCH) is one of the causes of vascular dementia (VaD) and is also an etiological factor for Alzheimer's disease (AD)" [pubmed:24575038]
relationship: CONSO:author orcid:0000-0002-3034-9970
synonym: "CCH" EXACT []
[Term]
id: CONSO:CONSO00013
name: Mori Fructus ethanol extract
namespace: chemical_mixture
def: "ethanol extracted from Mori Fructus, a well-known traditional herbal medicine, food, and dietary supplement" [pubmed:26068423]
relationship: CONSO:author orcid:0000-0002-3034-9970
synonym: "ME" EXACT []
[Term]
id: CONSO:CONSO00014
name: tunneling nanotubes
namespace: cellular_component
def: "filamentous-actin-containing membranous structures that bridge and connect cells" [pubmed:27809932]
relationship: CONSO:author orcid:0000-0002-3034-9970
synonym: "TNT" EXACT []
synonym: "membrane nanotube" EXACT []
[Term]
id: CONSO:CONSO00015
name: amyloidogenesis
namespace: biological_process
def: "production of amyloid" [pubmed:24653673]
relationship: CONSO:author orcid:0000-0002-3034-9970
[Term]
id: CONSO:CONSO00016
name: alpha-synuclein aggregates
namespace: cellular_component
def: "alpha-synuclein (SNCA) aggregate in fibrillar or oligomeric forms, usually found in Lewy bodies" [pubmed:23254192]
is_a: CONSO:CONSO00178 ! protein aggregates
relationship: CONSO:author orcid:0000-0003-4423-4370
[Term]
id: CONSO:CONSO00017
name: huntingtin aggregates
namespace: cellular_component
def: "huntingtin (HTT) protein fragments aggregations" [pubmed:12747895]
is_a: CONSO:CONSO00178 ! protein aggregates
relationship: CONSO:author orcid:0000-0003-4423-4370
[Term]
id: CONSO:CONSO00018
name: amyloid-beta aggregates
namespace: cellular_component
def: "aggregation of amyloid-beta fragments of the APP protein" [pubmed:23484434]
is_a: CONSO:CONSO00178 ! protein aggregates
relationship: CONSO:author orcid:0000-0003-4423-4370
[Term]
id: CONSO:CONSO00019
name: SEN-1269
namespace: chemical
def: "A tau aggregation inhibitor" [pubmed:23484434]
xref: chembl:CHEMBL2386874
xref: inchi:InChI=1S/C18H18N4O2/c1-22\(2\)14-6-4-8-16\(10-14\)24-17-11-19-18\(20-12-17\)21-13-5-3-7-15\(23\)9-13/h3-12\,23H\,1-2H3\,\(H\,19\,20\,21\)
xref: pubchem.compound:46835756
xref: smiles:CN\(C\)C1=CC\(=CC=C1\)OC2=CN=C\(N=C2\)NC3=CC\(=CC=C3\)O
relationship: ro:0000087 CONSO:CONSO00321
relationship: CONSO:author orcid:0000-0003-4423-4370
synonym: "3-((5-(3-(Dimethylamino)phenoxy)pyrimidin-2-yl)amino)phenol" EXACT [pubchem.compound:46835756]
synonym: "3-(5-(3-(dimethylamino)phenoxy)pyrimidin-2-ylamino)phenol" EXACT [pubchem.compound:46835756]
synonym: "3-({5-[3-(dimethylamino)phenoxy]pyrimidin-2-yl}amino)phenol" EXACT [pubchem.compound:46835756]
synonym: "3-[[5-[3-(dimethylamino)phenoxy]-2-pyrimidinyl]amino]phenol" EXACT [pubchem.compound:46835756]
synonym: "4350AF" EXACT [pubchem.compound:46835756]
synonym: "956128-01-1" EXACT [pubchem.compound:46835756]
synonym: "A11161" EXACT [pubchem.compound:46835756]
synonym: "AKOS015850742" EXACT [pubchem.compound:46835756]
synonym: "CHEMBL2386874" EXACT [pubchem.compound:46835756]
synonym: "CTK5H7888" EXACT [pubchem.compound:46835756]
synonym: "DB-080315" EXACT [pubchem.compound:46835756]
synonym: "DTXSID40676566" EXACT [pubchem.compound:46835756]
synonym: "FT-0682533" EXACT [pubchem.compound:46835756]
synonym: "I06-2365" EXACT [pubchem.compound:46835756]
synonym: "MFPAAKZZUIRMKR-UHFFFAOYSA-N" EXACT [pubchem.compound:46835756]
synonym: "MolPort-009-685-119" EXACT [pubchem.compound:46835756]
synonym: "NCGC00387448-01" EXACT [pubchem.compound:46835756]
synonym: "SCHEMBL3602388" EXACT [pubchem.compound:46835756]
synonym: "SEN 1269" EXACT [pubchem.compound:46835756]
synonym: "TC-064564" EXACT [pubchem.compound:46835756]
synonym: "ZINC49582255" EXACT [pubchem.compound:46835756]
[Term]
id: CONSO:CONSO00020
name: MLS000034832
namespace: chemical
def: "A tau aggregation inhibitor" [pubmed:23484434]
xref: chembl:CHEMBL461431
xref: inchi:InChI=1S/C15H13N3O3S/c1-2-21-15\(20\)12-10-8-22-13\(16\)11\(10\)14\(19\)18\(17-12\)9-6-4-3-5-7-9/h3-8H\,2\,16H2\,1H3
xref: pubchem.compound:647821
xref: smiles:CCOC\(=O\)C1=NN\(C\(=O\)C2=C\(SC=C21\)N\)C3=CC=CC=C3
relationship: ro:0000087 CONSO:CONSO00321
relationship: CONSO:author orcid:0000-0003-4423-4370
synonym: "123542-47-2" EXACT [pubchem.compound:647821]
synonym: "3-Phenyl-4-oxo-5-amino-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxylic acid ethyl ester" EXACT [pubchem.compound:647821]
synonym: "5-Amino-4-oxo-3-phenyl-3,4-dihydro-thieno[3,4-d]pyridazine-1-carboxylic acid eth" EXACT [pubchem.compound:647821]
synonym: "5-Amino-4-oxo-3-phenyl-3,4-dihydro-thieno[3,4-d]pyridazine-1-carboxylic acid ethyl ester" EXACT [pubchem.compound:647821]
synonym: "AC1LDGR2" EXACT [pubchem.compound:647821]
synonym: "AC1Q34EJ" EXACT [pubchem.compound:647821]
synonym: "AKOS000601368" EXACT [pubchem.compound:647821]
synonym: "BAS 06046551" EXACT [pubchem.compound:647821]
synonym: "BDBM50253793" EXACT [pubchem.compound:647821]
synonym: "CCG-115473" EXACT [pubchem.compound:647821]
synonym: "CHEMBL461431" EXACT [pubchem.compound:647821]
synonym: "F2135-0238" EXACT [pubchem.compound:647821]
synonym: "HLVGVGCIJRBRQW-UHFFFAOYSA-N" EXACT [pubchem.compound:647821]
synonym: "HMS1616C21" EXACT [pubchem.compound:647821]
synonym: "HMS2339G13" EXACT [pubchem.compound:647821]
synonym: "L-4233" EXACT [pubchem.compound:647821]
synonym: "MCULE-6208802152" EXACT [pubchem.compound:647821]
synonym: "MLS000034832" EXACT [pubchem.compound:647821]
synonym: "MLS002539346" EXACT [pubchem.compound:647821]
synonym: "MolPort-001-835-700" EXACT [pubchem.compound:647821]
synonym: "NCGC00031883-02" EXACT [pubchem.compound:647821]
synonym: "SCHEMBL7885074" EXACT [pubchem.compound:647821]
synonym: "SMR000013604" EXACT [pubchem.compound:647821]
synonym: "ZINC563211" EXACT [pubchem.compound:647821]
synonym: "ethyl 5-amino-4-oxo-3-phenyl-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxylate" EXACT [pubchem.compound:647821]
synonym: "ethyl 5-amino-4-oxo-3-phenyl-3H,4H-thieno[3,4-d]pyridazine-1-carboxylate" EXACT [pubchem.compound:647821]
synonym: "ethyl 5-amino-4-oxo-3-phenylthieno[3,4-d]pyridazine-1-carboxylate" EXACT [pubchem.compound:647821]
[Term]
id: CONSO:CONSO00021
name: caprospinol
namespace: chemical
def: "A tau aggregation inhibitor" [pubmed:23484434]
xref: drugbank:DB05263
xref: inchi:InChI=1S/C33H52O4/c1-6-7-8-9-29\(34\)36-24-13-15-31\(4\)23\(18-24\)10-11-25-26\(31\)14-16-32\(5\)27\(25\)19-28-30\(32\)22\(3\)33\(37-28\)17-12-21\(2\)20-35-33/h10\,21-22\,24-28\,30H\,6-9\,11-20H2\,1-5H3/t21-\,22+\,24+\,25-\,26+\,27+\,28+\,30+\,31+\,32+\,33-/m1/s1
xref: pubchem.compound:16394575
xref: smiles:CCCCCC\(=O\)O\[C@H\]1CC\[C@\]2\(C\)\[C@H\]3CC\[C@@\]4\(C\)\[C@@H\]\(C\[C@@H\]5O\[C@\]6\(CC\[C@@H\]\(C\)CO6\)\[C@@H\]\(C\)\[C@H\]45\)\[C@@H\]3CC=C2C1
relationship: ro:0000087 CONSO:CONSO00321
relationship: CONSO:author orcid:0000-0003-4423-4370
synonym: "((20S,22R,25R)-Spirosta-5-ene-3beta-ol)hexanoate" EXACT [pubchem.compound:16394575]
synonym: "(22R,25R)-20alpha-Spirost-5-en-3beta-yl hexanoate" EXACT [pubchem.compound:16394575]
synonym: "(3beta,8xi,9xi,14xi,16xi,17xi,20R,22xi,25R)-Spirost-5-en-3-yl hexanoa" EXACT [pubchem.compound:16394575]
synonym: "4952-56-1" EXACT [pubchem.compound:16394575]
synonym: "9BU4T267E4" EXACT [pubchem.compound:16394575]
synonym: "AKOS015955746" EXACT [pubchem.compound:16394575]
synonym: "CAPROSPINOL" EXACT [pubchem.compound:16394575]
synonym: "DB05263" EXACT [pubchem.compound:16394575]
synonym: "Diosgenin caproate" EXACT [pubchem.compound:16394575]
synonym: "Diosgenin, hexanoate" EXACT [pubchem.compound:16394575]
synonym: "J2.343.184J" EXACT [pubchem.compound:16394575]
synonym: "MCULE-6852340934" EXACT [pubchem.compound:16394575]
synonym: "MolPort-002-507-344" EXACT [pubchem.compound:16394575]
synonym: "SP-223" EXACT [pubchem.compound:16394575]
synonym: "SP-233" EXACT [pubchem.compound:16394575]
synonym: "Spirost-5-en-3-ol, 3-hexanoate, (3beta,25R)-" EXACT [pubchem.compound:16394575]
synonym: "UNII-9BU4T267E4" EXACT [pubchem.compound:16394575]
synonym: "ZINC97971833" EXACT [pubchem.compound:16394575]
[Term]
id: CONSO:CONSO00022
name: amyloid-beta oligomers
namespace: cellular_component
def: "Small aggregates of amyloid-beta" [pubmed:24918635, pubmed:29196815]
relationship: CONSO:author orcid:0000-0003-4423-4370
[Term]
id: CONSO:CONSO00023
name: amyloid-beta 42 oligomers
namespace: cellular_component
def: "Amyloid-beta oligomers composed specifically of amyloid-beta 42" [pubmed:24918635]
relationship: CONSO:author orcid:0000-0003-4423-4370
[Term]
id: CONSO:CONSO00024
name: APP C-terminally truncated carboxyl-terminal fragments
namespace: protein_fragment
def: "C-terminally truncated carboxyl-terminal fragments (CTFs) of APP" [pubmed:15491160]
relationship: CONSO:author orcid:0000-0002-0303-8616
[Term]
id: CONSO:CONSO00025
name: A2B5 antigen
namespace: epitope
def: "A2B5 antigen is a cell surface ganglioside epitope expressed on developing thymic epithelial cells, oligodendrocyte progenitors, and neuroendocrine cells." [pubmed:1497614]
relationship: CONSO:author orcid:0000-0002-0303-8616
[Term]
id: CONSO:CONSO00026
name: neutral sphingomyelinase
namespace: enzyme_class
def: "Sphingomyelin phosphodiesterase (EC 3.1.4.12, also known as neutral sphingomyelinase, sphingomyelinase, or SMase) is a hydrolase enzyme that is involved in sphingolipid metabolism reactions." [pubmed:19519303]
xref: ec-code:3.1.4.12
relationship: CONSO:author orcid:0000-0002-0303-8616
[Term]
id: CONSO:CONSO00027
name: Neurodegeneration
namespace: pathology
def: "Neurodegeneration is the progressive loss of structure or function of neurons, including death of neurons. Many neurodegenerative diseases – including amyotrophic lateral sclerosis, Parkinson's disease, Alzheimer's disease, and Huntington's disease – occur as a result of neurodegenerative processes." [pubmed:20202123, pubmed:12387894]
xref: hp:0002180
relationship: CONSO:author orcid:0000-0002-0303-8616
[Term]
id: CONSO:CONSO00028
name: amyloid-beta derived diffusible ligands
namespace: cellular_component
def: "soluble oligomeric forms of the amyloid beta peptide known as amyloid-derived diffusible ligands (ADDLs) are the toxic species responsible for neurodegeneration associated with Alzheimer's disease." [pubmed:19188609]
relationship: CONSO:author orcid:0000-0002-0303-8616
synonym: "ADDL" EXACT [pubmed:16712494]
[Term]
id: CONSO:CONSO00029
name: Hyperamylinemia
namespace: pathology
def: "increased secretion of the pancreatic hormone amylin" [pubmed:23794448]
relationship: CONSO:author orcid:0000-0002-0303-8616
[Term]
id: CONSO:CONSO00030
name: APOE e4
namespace: genetic_variant
def: "APOE e4 is a variant of APOE, it's APOE-ε4 (arg112, arg158)." [pubmed:22701550]
relationship: CONSO:author orcid:0000-0002-0303-8616
[Term]
id: CONSO:CONSO00031
name: N-AcGIP
namespace: chemical
def: "N-AcGIP is a rat hormone that is an agonist of GIP" [pubmed:18234983]
relationship: CONSO:agonist HGNC:HGNC:4270
relationship: CONSO:author orcid:0000-0002-0303-8616
[Term]
id: CONSO:CONSO00032
name: Pro3-GIP
namespace: chemical
def: "Pro3-GIP is a rat hormone that is an agonist of GIP" [pubmed:18234983]
xref: inchi:InChI=1S/C226H343N61O64S/c1-21-115\(12\)181\(285-216\(341\)165\(109-289\)279-201\(326\)151\(92-126-63-67-131\(293\)68-64-126\)266-210\(335\)163\(102-179\(309\)310\)276-215\(340\)164\(108-288\)280-221\(346\)183\(117\(14\)23-3\)284-214\(339\)153\(91-124-48-28-25-29-49-124\)277-222\(347\)184\(121\(18\)290\)281-175\(302\)107-247-217\(342\)166-60-45-84-287\(166\)224\(349\)120\(17\)251-188\(313\)134\(232\)89-125-61-65-130\(292\)66-62-125\)219\(344\)250-119\(16\)187\(312\)254-146\(77-85-352-20\)197\(322\)274-160\(99-176\(303\)304\)208\(333\)258-141\(58-38-43-82-231\)198\(323\)283-182\(116\(13\)22-2\)220\(345\)261-142\(59-44-83-243-226\(240\)241\)191\(316\)259-144\(70-74-168\(234\)295\)195\(320\)260-145\(71-75-169\(235\)296\)196\(321\)273-161\(100-177\(305\)306\)209\(334\)267-152\(90-123-46-26-24-27-47-123\)213\(338\)282-180\(114\(10\)11\)218\(343\)278-159\(98-173\(239\)300\)207\(332\)268-155\(94-128-104-245-136-53-33-31-51-133\(128\)136\)203\(328\)264-149\(87-112\(6\)7\)200\(325\)263-148\(86-111\(4\)5\)199\(324\)249-118\(15\)186\(311\)253-143\(69-73-167\(233\)294\)194\(319\)255-137\(54-34-39-78-227\)189\(314\)246-106-174\(301\)252-138\(55-35-40-79-228\)190\(315\)256-139\(56-36-41-80-229\)193\(318\)271-157\(96-171\(237\)298\)206\(331\)275-162\(101-178\(307\)308\)211\(336\)269-154\(93-127-103-244-135-52-32-30-50-132\(127\)135\)202\(327\)257-140\(57-37-42-81-230\)192\(317\)270-156\(95-129-105-242-110-248-129\)204\(329\)272-158\(97-172\(238\)299\)205\(330\)265-150\(88-113\(8\)9\)212\(337\)286-185\(122\(19\)291\)223\(348\)262-147\(225\(350\)351\)72-76-170\(236\)297/h24-33\,46-53\,61-68\,103-105\,110-122\,134\,137-166\,180-185\,244-245\,288-293H\,21-23\,34-45\,54-60\,69-102\,106-109\,227-232H2\,1-20H3\,\(H2\,233\,294\)\(H2\,234\,295\)\(H2\,235\,296\)\(H2\,236\,297\)\(H2\,237\,298\)\(H2\,238\,299\)\(H2\,239\,300\)\(H\,242\,248\)\(H\,246\,314\)\(H\,247\,342\)\(H\,249\,324\)\(H\,250\,344\)\(H\,251\,313\)\(H\,252\,301\)\(H\,253\,311\)\(H\,254\,312\)\(H\,255\,319\)\(H\,256\,315\)\(H\,257\,327\)\(H\,258\,333\)\(H\,259\,316\)\(H\,260\,320\)\(H\,261\,345\)\(H\,262\,348\)\(H\,263\,325\)\(H\,264\,328\)\(H\,265\,330\)\(H\,266\,335\)\(H\,267\,334\)\(H\,268\,332\)\(H\,269\,336\)\(H\,270\,317\)\(H\,271\,318\)\(H\,272\,329\)\(H\,273\,321\)\(H\,274\,322\)\(H\,275\,331\)\(H\,276\,340\)\(H\,277\,347\)\(H\,278\,343\)\(H\,279\,326\)\(H\,280\,346\)\(H\,281\,302\)\(H\,282\,338\)\(H\,283\,323\)\(H\,284\,339\)\(H\,285\,341\)\(H\,286\,337\)\(H\,303\,304\)\(H\,305\,306\)\(H\,307\,308\)\(H\,309\,310\)\(H\,350\,351\)\(H4\,240\,241\,243\)
xref: pubchem.compound:131954578
xref: smiles:CCC\(C\)C\(C\(=O\)NC\(CCCNC\(=N\)N\)C\(=O\)NC\(CCC\(=O\)N\)C\(=O\)NC\(CCC\(=O\)N\)C\(=O\)NC\(CC\(=O\)O\)C\(=O\)NC\(CC1=CC=CC=C1\)C\(=O\)NC\(C\(C\)C\)C\(=O\)NC\(CC\(=O\)N\)C\(=O\)NC\(CC2=CNC3=CC=CC=C32\)C\(=O\)NC\(CC\(C\)C\)C\(=O\)NC\(CC\(C\)C\)C\(=O\)NC\(C\)C\(=O\)NC\(CCC\(=O\)N\)C\(=O\)NC\(CCCCN\)C\(=O\)NCC\(=O\)NC\(CCCCN\)C\(=O\)NC\(CCCCN\)C\(=O\)NC\(CC\(=O\)N\)C\(=O\)NC\(CC\(=O\)O\)C\(=O\)NC\(CC4=CNC5=CC=CC=C54\)C\(=O\)NC\(CCCCN\)C\(=O\)NC\(CC6=CNC=N6\)C\(=O\)NC\(CC\(=O\)N\)C\(=O\)NC\(CC\(C\)C\)C\(=O\)NC\(C\(C\)O\)C\(=O\)NC\(CCC\(=O\)N\)C\(=O\)O\)NC\(=O\)C\(CCCCN\)NC\(=O\)C\(CC\(=O\)O\)NC\(=O\)C\(CCSC\)NC\(=O\)C\(C\)NC\(=O\)C\(C\(C\)CC\)NC\(=O\)C\(CO\)NC\(=O\)C\(CC7=CC=C\(C=C7\)O\)NC\(=O\)C\(CC\(=O\)O\)NC\(=O\)C\(CO\)NC\(=O\)C\(C\(C\)CC\)NC\(=O\)C\(CC8=CC=CC=C8\)NC\(=O\)C\(C\(C\)O\)NC\(=O\)CNC\(=O\)C9CCCN9C\(=O\)C\(C\)NC\(=O\)C\(CC1=CC=C\(C=C1\)O\)N
relationship: CONSO:agonist HGNC:HGNC:4270
relationship: CONSO:author orcid:0000-0002-0303-8616
synonym: "AKOS034831571" EXACT [pubchem.compound:131954578]
synonym: "[Pro3]-GIP (Rat)" EXACT [pubchem.compound:131954578]
[Term]
id: CONSO:CONSO00033
name: PI3K-Akt signaling pathway
namespace: pathway
def: "PI3K-Akt signaling pathway is an intracellular signaling pathway important in regulating the cell cycle.It is described in KEGG." [pubmed:22013558]
xref: kegg.pathway:hsa04151
relationship: CONSO:author orcid:0000-0002-0303-8616
[Term]
id: CONSO:CONSO00035
name: Argyrophilic Grain Disease
namespace: pathology
def: "Argyrophilic grain disease (AGD) is an under-recognized, distinct, highly frequent sporadic tauopathy, with a prevalence reaching 31.3% in centenarians." [pubmed:15658002]
relationship: CONSO:author orcid:0000-0002-0303-8616
synonym: "AGD" EXACT []
[Term]
id: CONSO:CONSO00036
name: granulovacuolar degeneration
namespace: pathology
def: "Granulovacuolar degeneration (GVD) is one of the pathological hallmarks of Alzheimer's disease (AD), and it is defined as electron-dense granules within double membrane-bound cytoplasmic vacuoles." [pubmed:17455299]
xref: hp:0002528
relationship: CONSO:author orcid:0000-0002-0303-8616
synonym: "GVD" EXACT []
[Term]
id: CONSO:CONSO00037
name: mitochondrial dysfunction
namespace: pathology
def: "mitochondria function disorder" [pubmed:19885299]
relationship: CONSO:author orcid:0000-0002-0303-8616
[Term]
id: CONSO:CONSO00038
name: amyloid-beta fibrils
namespace: cellular_component
def: "Insoluble fibrous protein aggregates exhibiting beta sheet structure." [pubmed:19158505]
relationship: CONSO:author orcid:0000-0003-4423-4370
[Term]
id: CONSO:CONSO00039
name: AG73
namespace: protein_fragment
def: "a peptide derived from mouse laminin alpha 1 protein (seq:RKRLQVQLSIRT, chain:2719–2730)" [pubmed:20615691]
relationship: CONSO:author orcid:0000-0002-3034-9970
property_value: bel "p(MGI:Lama1, frag(2719_2730))" xsd:string
[Term]
id: CONSO:CONSO00040
name: Notch intracellular domain
namespace: domain
def: "Notch intracellular domain is the intracellular region of notch receptor." [pubmed:20883690]
relationship: CONSO:author orcid:0000-0002-0303-8616
[Term]
id: CONSO:CONSO00041
name: YENPTY endocytosis motif (APP)
namespace: motif
def: "YENTY is the endocytosis motif of Amyloid precursor protein." [pubmed:18650430]
relationship: CONSO:author orcid:0000-0002-0303-8616
synonym: "YENPTY" EXACT []
[Term]
id: CONSO:CONSO00042
name: sAPP-beta
namespace: protein
def: "Soluble amyloid precursor protein" [pubmed:21606494]
relationship: CONSO:author orcid:0000-0002-0303-8616
synonym: "soluble amyloid precursor protein" EXACT []
[Term]
id: CONSO:CONSO00043
name: growth factor
def: "A growth factor is a naturally occurring substance capable of stimulating cellular growth, proliferation, healing, and cellular differentiation. Usually it is a protein or a steroid hormone. Growth factors are important for regulating a variety of cellular processes." [pubmed:14678766]
xref: ncit:C20424
xref: umls:C0018284
relationship: CONSO:author orcid:0000-0002-0303-8616
[Term]
id: CONSO:CONSO00044
name: 3R tau
namespace: protein_isoform_family
def: "Tau isoforms containing 3 tubulin binding repeats" [pubmed:23407988]
relationship: CONSO:has_reference_protein uniprot:P10636
relationship: CONSO:author orcid:0000-0001-9661-5277
[Term]
id: CONSO:CONSO00045
name: 4R tau
namespace: protein_isoform_family
def: "Tau isoforms containing 4 tubulin binding repeats" [pubmed:23407988]
relationship: CONSO:has_reference_protein uniprot:P10636
relationship: CONSO:author orcid:0000-0001-9661-5277
[Term]
id: CONSO:CONSO00046
name: VQIINK motif
namespace: motif
def: "A hexapeptide motif located in the R2, that promotes the formation of PHF" [pubmed:17493042]
relationship: bfo:0000050 CONSO:CONSO00003
relationship: CONSO:author orcid:0000-0001-9661-5277
synonym: "PHF6* " EXACT [pubmed:25775228]
[Term]
id: CONSO:CONSO00047
name: VQIVYK motif
namespace: motif
def: "A hexapeptide motif located in the R3, that promotes the formation of PHF" [pubmed:17493042]
relationship: bfo:0000050 CONSO:CONSO00004
relationship: CONSO:author orcid:0000-0001-9661-5277
synonym: "PHF6" EXACT [pubmed:25775228]
[Term]
id: CONSO:CONSO00048
name: ghost tangles
namespace: cellular_component
def: "Extracellular NFT remains after neuron death, considered to be the last stage of NFT-related pathological activity." [pubmed:23407988, pubmed:8431763]
is_a: go:0097418 ! neurofibrillary tangle
relationship: CONSO:author orcid:0000-0001-9661-5277
[Term]
id: CONSO:CONSO00049
name: pretangles
namespace: cellular_component
def: "Pretangles are cytoplasmic tau immunoreactivity in neurons without apparent formation of fibrillary structures. In Alzheimer disease, such tau deposition is considered to represent a premature state prior to fibril formation (AD-pretangles), later to form neurofibrillary tangles and finally ghost tangles." [pubmed:23407988, pubmed:24612177]
is_a: go:0097418 ! neurofibrillary tangle
relationship: CONSO:author orcid:0000-0001-9661-5277
[Term]
id: CONSO:CONSO00050
name: projection domain
namespace: domain
def: "Corresponding roughly to the N-terminal part of the tau molecule, consisting mainly of acidic residues and containing two distinct alternatively spliced N-terminal inserts." [pubmed:17493042, pubmed:28386764]
xref: interpro:IPR013588
relationship: CONSO:author orcid:0000-0001-9661-5277
synonym: "MAP2/Tau projection" EXACT []
[Term]
id: CONSO:CONSO00051
name: RAC1b
namespace: isoform
def: "A constitutively active splicing isoform of RAC1 (Ras-related C3 botulinum toxin substrate 1), first identified in breast and colon cancer." [pubmed:22142809]
xref: uniprot.isoform:P63000-2
relationship: CONSO:has_reference_protein uniprot:P63000
relationship: CONSO:author orcid:0000-0001-9661-5277
[Term]
id: CONSO:CONSO00052
name: AP-2 complex
namespace: protein_complex
def: "A heterotetrameric adapter protein complex involved in cargo-internalization during clathrin-mediated endocytosis. Composed of alpha and beta subunits (large adaptins), mu and sigma subunits (minor adaptins)." [pubmed:27260836]
xref: go:0030122
relationship: CONSO:author orcid:0000-0001-9661-5277
[Term]
id: CONSO:CONSO00053
name: Tau isoform F (441 aa)
namespace: isoform
def: "Longest tau isoform in human brain, most commonly used as the conventional tau." [pubmed:17493042]
xref: ncbiprotein:NP_005901
xref: uniprot.isoform:P10636-8
is_a: CONSO:CONSO00045 ! 4R tau
relationship: CONSO:has_reference_protein uniprot:P10636
relationship: CONSO:author orcid:0000-0001-9661-5277
synonym: "2N4R" EXACT []
synonym: "htau40" EXACT [pubmed:19226187]
synonym: "microtubule-associated protein tau isoform 2" EXACT []
[Term]
id: CONSO:CONSO00054
name: Tau isoform Fetal-tau (352 aa)
namespace: isoform
def: "Human fetal tau isoform." [pubmed:17493042]
xref: ncbiprotein:NP_058525
xref: uniprot.isoform:P10636-2
relationship: CONSO:has_reference_protein uniprot:P10636
relationship: CONSO:author orcid:0000-0001-9661-5277
synonym: "0N3R" EXACT []
synonym: "htau23" EXACT [pubmed:7667312]
synonym: "microtubule-associated protein tau isoform 4" EXACT []
[Term]
id: CONSO:CONSO00055
name: Tau isoform B (381 aa)
namespace: isoform
def: "Human brain tau isoform, derived from alternative splicing." [pubmed:17493042]
xref: ncbiprotein:NP_001190180
xref: uniprot.isoform:P10636-4
is_a: CONSO:CONSO00044 ! 3R tau
relationship: CONSO:has_reference_protein uniprot:P10636
relationship: CONSO:author orcid:0000-0001-9661-5277
synonym: "1N3R" EXACT []
synonym: "htau37" EXACT [pubmed:22762014]
synonym: "microtubule-associated protein tau isoform 7" EXACT []
[Term]
id: CONSO:CONSO00056
name: Tau isoform D (383 aa)
namespace: isoform
def: "Human brain tau isoform, derived from alternative splicing." [pubmed:17493042]
xref: ncbiprotein:NP_058518
xref: uniprot.isoform:P10636-6
is_a: CONSO:CONSO00045 ! 4R tau
relationship: CONSO:has_reference_protein uniprot:P10636
relationship: CONSO:author orcid:0000-0001-9661-5277
synonym: "0N4R" EXACT []
synonym: "htau24" EXACT [pubmed:22762014]
synonym: "microtubule-associated protein tau isoform 3" EXACT []
[Term]
id: CONSO:CONSO00057
name: Tau isoform C (410 aa)
namespace: isoform
def: "Human brain tau isoform, derived from alternative splicing." [pubmed:17493042]
xref: ncbiprotein:NP_001190181
xref: uniprot.isoform:P10636-5
is_a: CONSO:CONSO00044 ! 3R tau
relationship: CONSO:has_reference_protein uniprot:P10636
relationship: CONSO:author orcid:0000-0001-9661-5277
synonym: "2N3R" EXACT []
synonym: "htau39" EXACT [pubmed:22762014]
synonym: "microtubule-associated protein tau isoform 8" EXACT []
[Term]
id: CONSO:CONSO00058
name: Tau isoform E (412 aa)
namespace: isoform
def: "Human brain tau isoform, derived from alternative splicing." [pubmed:17493042]
xref: ncbiprotein:NP_001116539
xref: uniprot.isoform:P10636-7
is_a: CONSO:CONSO00045 ! 4R tau
relationship: CONSO:has_reference_protein uniprot:P10636
relationship: CONSO:author orcid:0000-0001-9661-5277
synonym: "1N4R" EXACT []
synonym: "htau34" EXACT [pubmed:22762014]
synonym: "microtubule-associated protein tau isoform 5" EXACT []
[Term]
id: CONSO:CONSO00059
name: Serpin-enzyme complex receptor
namespace: protein
def: "?" [pubmed:15160835, pubmed:2160076]
relationship: CONSO:author orcid:0000-0002-0303-8616
synonym: "SEC-R" EXACT []
[Term]
id: CONSO:CONSO00060
name: neuroinflammation
namespace: pathology
def: "inflammatory response in the brain and nervous tissue." [pubmed:26306439]
xref: go:0150076
relationship: CONSO:author orcid:0000-0002-3034-9970
[Term]
id: CONSO:CONSO00061
name: neurotoxicity
namespace: pathology
def: "happens when a biological, physical or chemical agent cause any adverse effect on the structure and function of the nerves system." [pubmed:18440072]
relationship: CONSO:author orcid:0000-0002-3034-9970
[Term]
id: CONSO:CONSO00062
name: neurite retraction
namespace: pathology
def: "when the neurite is unable it outgrow and extend" [pubmed:19022228]
relationship: CONSO:author orcid:0000-0002-3034-9970
[Term]
id: CONSO:CONSO00063
name: APP695
namespace: isoform
def: "the APP gene is located on chromosome 21 in humans with three major isoforms arising from alternative splicing [3]. These are APP695, APP751 and APP770 (containing 695, 751, and 770 amino acids, respectively)" [pubmed:21214928]
xref: uniprot.isoform:P05067-4
relationship: CONSO:has_reference_protein uniprot:P05067
relationship: CONSO:author orcid:0000-0002-6117-4413
[Term]
id: CONSO:CONSO00064
name: APP751
namespace: isoform
def: "the APP gene is located on chromosome 21 in humans with three major isoforms arising from alternative splicing [3]. These are APP695, APP751 and APP770 (containing 695, 751, and 770 amino acids, respectively)" [pubmed:21214928]
xref: uniprot.isoform:P05067-8
relationship: CONSO:has_reference_protein uniprot:P05067
relationship: CONSO:author orcid:0000-0002-6117-4413
[Term]
id: CONSO:CONSO00065
name: APP770
namespace: isoform
def: "the APP gene is located on chromosome 21 in humans with three major isoforms arising from alternative splicing [3]. These are APP695, APP751 and APP770 (containing 695, 751, and 770 amino acids, respectively)" [pubmed:21214928]
xref: uniprot.isoform:P05067-1
relationship: CONSO:has_reference_protein uniprot:P05067
relationship: CONSO:author orcid:0000-0002-6117-4413
[Term]
id: CONSO:CONSO00066
name: gamma-secretase
namespace: protein_complex
def: "gamma-secretase is a high molecular weight complex minimally composed of four components: presenilins (PS), nicastrin, anterior pharynx defective 1 (APH-1), and presenilin enhancer 2 (PEN-2)" [pubmed:25565961]
xref: fplx:Gamma_secretase
relationship: CONSO:author orcid:0000-0002-6117-4413
[Term]
id: CONSO:CONSO00067
name: sAPP-alpha
namespace: protein
def: "soluble amyloid precursor protein-alpha" [pubmed:22491325]
relationship: CONSO:author orcid:0000-0002-6117-4413
[Term]
id: CONSO:CONSO00068
name: Excitotoxicity
namespace: pathology
def: "Excitotoxicity is defined as cell death resulting from the toxic actions of excitatory amino acids" [pubmed:19343058]
relationship: CONSO:author orcid:0000-0002-6117-4413
[Term]
id: CONSO:CONSO00069
name: C31
namespace: protein_fragment
def: "a fragment containing the last 31 amino acids of APP (called C31)" [pubmed:21214928]
relationship: CONSO:author orcid:0000-0002-6117-4413
[Term]
id: CONSO:CONSO00070
name: Jcasp
namespace: protein_fragment
def: "Additional gamma-cleavage further generates the fragment (called Jcasp) containing the region between gamma- and caspase-cleavage sites" [pubmed:21214928]
relationship: CONSO:author orcid:0000-0002-6117-4413
[Term]
id: CONSO:CONSO00071
name: AICD
namespace: domain
def: "APP intracellular domain" [pubmed:21214928]
relationship: CONSO:author orcid:0000-0002-6117-4413
[Term]
id: CONSO:CONSO00072
name: p83
namespace: protein_fragment
def: "APP alphaCTF and betaCTF are further cleaved by gamma-secretase to generate p83 and Abeta, respectively" [pubmed:21214928]
relationship: CONSO:author orcid:0000-0002-6117-4413
[Term]
id: CONSO:CONSO00073
name: APP processing
namespace: biological_process
def: "Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein (see:GO:0016485)" [pubmed:21214928]
relationship: CONSO:author orcid:0000-0002-6117-4413
[Term]
id: CONSO:CONSO00074
name: AβOs
namespace: cellular_component
def: "soluble Aβ oligomers" [pubmed:24685176]
relationship: CONSO:author orcid:0000-0002-7128-929X
[Term]
id: CONSO:CONSO00075
name: LMW amyloid oligomers
namespace: cellular_component
def: "The formation of AβOs starts from alterations in the conformation of monomeric Aβ, resulting in low molecular weight (LMW) dimers and trimers, followed by aggregation to soluble spherical oligomers consisted of 12–24 monomers." [pubmed:18723507]
relationship: CONSO:author orcid:0000-0002-7128-929X
[Term]
id: CONSO:CONSO00076
name: amyloid-beta 40 oligomers
namespace: cellular_component
def: "Amyloid-beta oligomers composed specifically of amyloid-beta 40" [pubmed:21209907]
relationship: CONSO:author orcid:0000-0002-7128-929X
[Term]
id: CONSO:CONSO00077
name: alternative splicing of APP gene
namespace: biological_process
def: "The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition (see:GO:0000380)" [pubmed:22122372]
relationship: CONSO:author orcid:0000-0002-6117-4413
[Term]
id: CONSO:CONSO00078
name: E1 domain
namespace: domain
def: "The ectodomains of APP and APLPs have two conserved regions called E1 and E2 (Fig. 1A), both of which have been proposed to contribute to dimerization" [pubmed:21574595]
relationship: CONSO:author orcid:0000-0002-6117-4413
[Term]
id: CONSO:CONSO00079
name: E2 domain
namespace: domain
def: "The ectodomains of APP and APLPs have two conserved regions called E1 and E2 (Fig. 1A), both of which have been proposed to contribute to dimerization" [pubmed:21574595]
relationship: CONSO:author orcid:0000-0002-6117-4413
[Term]
id: CONSO:CONSO00080
name: P3 peptide
namespace: protein_fragment
def: "Cleavage by α-secretase yields the nonamyloidogenic soluble 3-kDa peptide (p3) that does not form amyloid fibrils, whereas cleavage by β-secretase yields the amyloidogenic form Aβ1–40 or the longer, more fibrillogenic Aβ1–42" [pubmed:22137428]
relationship: CONSO:author orcid:0000-0002-6117-4413
[Term]
id: CONSO:CONSO00081
name: C99
namespace: protein_fragment
def: "a membrane associated C-terminal fragment consisting of 99 amino acids (C99)" [pubmed:22122372]
relationship: CONSO:author orcid:0000-0002-6117-4413
[Term]
id: CONSO:CONSO00082
name: aMCI
namespace: pathology
def: "amnestic Mild Cognitive Impairement is a cognitive dysfunction that is associated with memory deficits" [pubmed:18986241]
relationship: CONSO:author orcid:0000-0002-3034-9970
[Term]
id: CONSO:CONSO00083
name: mdMCI
namespace: pathology
def: "multi-domain Mild Cognitive Impairement is a cognitive dysfunction that is associated with more than one cognitive domain" [pubmed:18986241]
relationship: CONSO:author orcid:0000-0002-3034-9970
[Term]
id: CONSO:CONSO00084
name: Tau isoform A (316 aa)
namespace: isoform
def: "Human brain tau isoform, derived from alternative splicing." [pubmed:18986241]
xref: uniprot.isoform:P10636-3
relationship: CONSO:has_reference_protein uniprot:P10636
relationship: CONSO:author orcid:0000-0002-3034-9970
[Term]
id: CONSO:CONSO00085
name: Tau C3
namespace: epitope
def: "Tau epitope cleaved at aspartic acid(421)." [pubmed:18986241]
relationship: CONSO:author orcid:0000-0002-3034-9970
[Term]
id: CONSO:CONSO00086
name: Tau MN423
namespace: epitope
def: "Tau epitope truncated at glutamic acid(391)." [pubmed:18986241]
relationship: CONSO:author orcid:0000-0002-3034-9970
[Term]
id: CONSO:CONSO00087
name: granular tau oligomers
namespace: cellular_component
def: "When the oligomer lengthens, it adapts a beta-sheet structure and transforms into a detergent-insoluble aggregate with granular appearance under Atomic Force Microscopy (AFM)" [pubmed:28420982]
relationship: CONSO:author orcid:0000-0002-6117-4413
[Term]
id: CONSO:CONSO00088
name: Tau fibrils