From aea40d137667873b17a3385dbee8b882765beafc Mon Sep 17 00:00:00 2001 From: Vinh Nguyen Date: Mon, 7 Oct 2024 14:33:24 -0400 Subject: [PATCH 1/6] #123 - Initial commit for RS oncology CA 125 test data --- data-raw/rs_supprs_onco_ca125.R | 170 ++++++++++++++++++++++++++++++++ data/rs_onco_ca125.rda | Bin 0 -> 1065 bytes data/supprs_onco_ca125.rda | Bin 0 -> 817 bytes 3 files changed, 170 insertions(+) create mode 100644 data-raw/rs_supprs_onco_ca125.R create mode 100644 data/rs_onco_ca125.rda create mode 100644 data/supprs_onco_ca125.rda diff --git a/data-raw/rs_supprs_onco_ca125.R b/data-raw/rs_supprs_onco_ca125.R new file mode 100644 index 00000000..e549e907 --- /dev/null +++ b/data-raw/rs_supprs_onco_ca125.R @@ -0,0 +1,170 @@ +# Datasets: rs_onco_ca125, supprs_onco_ca125 +# Description: RS Oncology and SUPPRS dataset using IMWG criteria + +# Load libraries ----- +library(dplyr) +library(usethis) + +# Create rs_onco_ca125 ---- +rs_onco_ca124 <- tibble::tribble( + ~DOMAIN, ~STUDYID, ~USUBJID, ~VISITNUM, ~VISIT, ~RSCAT, ~RSTESTCD, ~RSTEST, ~RSORRES, ~RSSTRESC, ~RSEVAL, ~RSEVALID, ~RSACPTFL, ~RSDTC, ~RSSEQ, + "RS", "CDISCPILOT01", "01-701-1015", 2L, "WEEK 3", "CA125", "OVRLRESP", "Overall Response", "Non-Response/ Non-PD", "SD", "INVESTIGATOR", NA, NA, "2014-01-23", 3L, + "RS", "CDISCPILOT01", "01-701-1015", 3L, "WEEK 6", "CA125", "OVRLRESP", "Overall Response", "Not Evaluable", "NE", "INVESTIGATOR", NA, NA, "2014-02", 6L, + "RS", "CDISCPILOT01", "01-701-1015", 4L, "WEEK 9", "CA125", "OVRLRESP", "Overall Response", "Response But Not Within Normal Range", "PR", "INVESTIGATOR", NA, NA, "2014-03-06", 9L, + "RS", "CDISCPILOT01", "01-701-1028", 2L, "WEEK 3", "CA125", "OVRLRESP", "Overall Response", "Progressive Disease", "PD", "INVESTIGATOR", NA, NA, "2013-08-09", 3L, + "RS", "CDISCPILOT01", "01-701-1028", 3L, "WEEK 6", "CA125", "OVRLRESP", "Overall Response", "Progressive Disease", "PD", "INVESTIGATOR", NA, NA, "2013-08-30", 6L, + "RS", "CDISCPILOT01", "01-701-1028", 4L, "WEEK 9", "CA125", "OVRLRESP", "Overall Response", "Progressive Disease", "PD", "INVESTIGATOR", NA, NA, "2013-09-30", 9L, + "RS", "CDISCPILOT01", "01-701-1034", 2L, "WEEK 3", "CA125", "OVRLRESP", "Overall Response", "Response Within Normal Range", "CR", "INVESTIGATOR", NA, NA, "2014-07-22", 3L, + "RS", "CDISCPILOT01", "01-701-1034", 3L, "WEEK 6", "CA125", "OVRLRESP", "Overall Response", "Response Within Normal Range", "CR", "INVESTIGATOR", NA, NA, "2014-08-20", 6L, + "RS", "CDISCPILOT01", "01-701-1097", 2L, "WEEK 3", "CA125", "OVRLRESP", "Overall Response", "Non-Response/ Non-PD", "SD", "INVESTIGATOR", NA, NA, "2014-01-22", 3L, + "RS", "CDISCPILOT01", "01-701-1115", 2L, "WEEK 3", "CA125", "OVRLRESP", "Overall Response", "Response But Not Within Normal Range", "PR", "INVESTIGATOR", NA, NA, "2012-12-21", 3L, + "RS", "CDISCPILOT01", "01-701-1115", 3L, "WEEK 6", "CA125", "OVRLRESP", "Overall Response", "Response But Not Within Normal Range", "PR", "INVESTIGATOR", NA, NA, "2013-01-11", 6L, + "RS", "CDISCPILOT01", "01-701-1115", 4L, "WEEK 9", "CA125", "OVRLRESP", "Overall Response", "Response Within Normal Range", "CR", "INVESTIGATOR", NA, NA, "2013-02-01", 9L, + "RS", "CDISCPILOT01", "01-701-1118", 2L, "WEEK 3", "CA125", "OVRLRESP", "Overall Response", "Non-Response/ Non-PD", "SD", "INVESTIGATOR", NA, NA, "2014-04-02", 3L, + "RS", "CDISCPILOT01", "01-701-1118", 3L, "WEEK 6", "CA125", "OVRLRESP", "Overall Response", "Response Within Normal Range", "CR", "INVESTIGATOR", NA, NA, "2014-04-23", 6L, + "RS", "CDISCPILOT01", "01-701-1118", 4L, "WEEK 9", "CA125", "OVRLRESP", "Overall Response", "Not Evaluable", "NE", "INVESTIGATOR", NA, NA, "2014-05-14", 9L, + "RS", "CDISCPILOT01", "01-701-1118", 5L, "WEEK 12", "CA125", "OVRLRESP", "Overall Response", "Response Within Normal Range", "CR", "INVESTIGATOR", NA, NA, "2014-06-04", 12L, + "RS", "CDISCPILOT01", "01-701-1130", 2L, "WEEK 3", "CA125", "OVRLRESP", "Overall Response", "Non-Response/ Non-PD", "SD", "INVESTIGATOR", NA, NA, "2014-03-08", 3L, + "RS", "CDISCPILOT01", "01-701-1130", 3L, "WEEK 6", "CA125", "OVRLRESP", "Overall Response", "Progressive Disease", "PD", "INVESTIGATOR", NA, NA, "2014-03-29", 6L, + "RS", "CDISCPILOT01", "01-701-1130", 4L, "WEEK 9", "CA125", "OVRLRESP", "Overall Response", "Progressive Disease", "PD", "INVESTIGATOR", NA, NA, "2014-04-19", 9L, + "RS", "CDISCPILOT01", "01-701-1133", 2L, "WEEK 3", "CA125", "OVRLRESP", "Overall Response", "Response But Not Within Normal Range", "PR", "INVESTIGATOR", NA, NA, "2012-11-18", 3L, + "RS", "CDISCPILOT01", "01-701-1133", 3L, "WEEK 6", "CA125", "OVRLRESP", "Overall Response", "Progressive Disease", "PD", "INVESTIGATOR", NA, NA, "2012-12-09", 6L, + "RS", "CDISCPILOT01", "01-701-1133", 4L, "WEEK 9", "CA125", "OVRLRESP", "Overall Response", "Progressive Disease", "PD", "INVESTIGATOR", NA, NA, "2012-12-30", 9L, + "RS", "CDISCPILOT01", "01-701-1015", 2L, "WEEK 3", "RECIST 1.1", "OVRLRESP", "Overall Response", "SD", "SD", "INVESTIGATOR", NA, NA, "2014-01-23", 12L, + "RS", "CDISCPILOT01", "01-701-1015", 3L, "WEEK 6", "RECIST 1.1", "OVRLRESP", "Overall Response", "NE", "NE", "INVESTIGATOR", NA, NA, "2014-02", 15L, + "RS", "CDISCPILOT01", "01-701-1015", 4L, "WEEK 9", "RECIST 1.1", "OVRLRESP", "Overall Response", "PR", "PR", "INVESTIGATOR", NA, NA, "2014-03-06", 18L, + "RS", "CDISCPILOT01", "01-701-1028", 2L, "WEEK 3", "RECIST 1.1", "OVRLRESP", "Overall Response", "PR", "PR", "INVESTIGATOR", NA, NA, "2013-08-09", 12L, + "RS", "CDISCPILOT01", "01-701-1028", 3L, "WEEK 6", "RECIST 1.1", "OVRLRESP", "Overall Response", "PD", "PD", "INVESTIGATOR", NA, NA, "2013-08-30", 15L, + "RS", "CDISCPILOT01", "01-701-1028", 4L, "WEEK 9", "RECIST 1.1", "OVRLRESP", "Overall Response", "PD", "PD", "INVESTIGATOR", NA, NA, "2013-09-30", 18L, + "RS", "CDISCPILOT01", "01-701-1034", 2L, "WEEK 3", "RECIST 1.1", "OVRLRESP", "Overall Response", "NON-CR/NON-PD", "NON-CR/NON-PD", "INVESTIGATOR", NA, NA, "2014-07-22", 12L, + "RS", "CDISCPILOT01", "01-701-1034", 3L, "WEEK 6", "RECIST 1.1", "OVRLRESP", "Overall Response", "CR", "CR", "INVESTIGATOR", NA, NA, "2014-08-20", 15L, + "RS", "CDISCPILOT01", "01-701-1097", 2L, "WEEK 3", "RECIST 1.1", "OVRLRESP", "Overall Response", "SD", "SD", "INVESTIGATOR", NA, NA, "2014-01-22", 12L, + "RS", "CDISCPILOT01", "01-701-1115", 2L, "WEEK 3", "RECIST 1.1", "OVRLRESP", "Overall Response", "SD", "SD", "INVESTIGATOR", NA, NA, "2012-12-21", 12L, + "RS", "CDISCPILOT01", "01-701-1115", 3L, "WEEK 6", "RECIST 1.1", "OVRLRESP", "Overall Response", "PR", "PR", "INVESTIGATOR", NA, NA, "2013-01-11", 15L, + "RS", "CDISCPILOT01", "01-701-1115", 4L, "WEEK 9", "RECIST 1.1", "OVRLRESP", "Overall Response", "CR", "CR", "INVESTIGATOR", NA, NA, "2013-02-01", 18L, + "RS", "CDISCPILOT01", "01-701-1118", 2L, "WEEK 3", "RECIST 1.1", "OVRLRESP", "Overall Response", "SD", "SD", "INVESTIGATOR", NA, NA, "2014-04-02", 12L, + "RS", "CDISCPILOT01", "01-701-1118", 3L, "WEEK 6", "RECIST 1.1", "OVRLRESP", "Overall Response", "CR", "CR", "INVESTIGATOR", NA, NA, "2014-04-23", 15L, + "RS", "CDISCPILOT01", "01-701-1118", 4L, "WEEK 9", "RECIST 1.1", "OVRLRESP", "Overall Response", "NE", "NE", "INVESTIGATOR", NA, NA, "2014-05-14", 18L, + "RS", "CDISCPILOT01", "01-701-1118", 5L, "WEEK 12", "RECIST 1.1", "OVRLRESP", "Overall Response", "CR", "CR", "INVESTIGATOR", NA, NA, "2014-06-04", 21L, + "RS", "CDISCPILOT01", "01-701-1130", 2L, "WEEK 3", "RECIST 1.1", "OVRLRESP", "Overall Response", "SD", "SD", "INVESTIGATOR", NA, NA, "2014-03-08", 12L, + "RS", "CDISCPILOT01", "01-701-1130", 3L, "WEEK 6", "RECIST 1.1", "OVRLRESP", "Overall Response", "PD", "PD", "INVESTIGATOR", NA, NA, "2014-03-29", 15L, + "RS", "CDISCPILOT01", "01-701-1130", 4L, "WEEK 9", "RECIST 1.1", "OVRLRESP", "Overall Response", "PD", "PD", "INVESTIGATOR", NA, NA, "2014-04-19", 18L, + "RS", "CDISCPILOT01", "01-701-1133", 2L, "WEEK 3", "RECIST 1.1", "OVRLRESP", "Overall Response", "PR", "PR", "INVESTIGATOR", NA, NA, "2012-11-18", 12L, + "RS", "CDISCPILOT01", "01-701-1133", 3L, "WEEK 6", "RECIST 1.1", "OVRLRESP", "Overall Response", "PR", "PR", "INVESTIGATOR", NA, NA, "2012-12-09", 15L, + "RS", "CDISCPILOT01", "01-701-1133", 4L, "WEEK 9", "RECIST 1.1", "OVRLRESP", "Overall Response", "PR", "PR", "INVESTIGATOR", NA, NA, "2012-12-30", 18L, + "RS", "CDISCPILOT01", "01-701-1015", 2L, "WEEK 3", "RECIST 1.1 - CA125", "OVRLRESP", "Overall Response", "Stable Disease", "SD", "INVESTIGATOR", NA, NA, "2014-01-23", 21L, + "RS", "CDISCPILOT01", "01-701-1015", 3L, "WEEK 6", "RECIST 1.1 - CA125", "OVRLRESP", "Overall Response", "Not Evaluable", "NE", "INVESTIGATOR", NA, NA, "2014-02", 24L, + "RS", "CDISCPILOT01", "01-701-1015", 4L, "WEEK 9", "RECIST 1.1 - CA125", "OVRLRESP", "Overall Response", "Partial Response", "PR", "INVESTIGATOR", NA, NA, "2014-03-06", 27L, + "RS", "CDISCPILOT01", "01-701-1028", 2L, "WEEK 3", "RECIST 1.1 - CA125", "OVRLRESP", "Overall Response", "Progressive Disease", "PD", "INVESTIGATOR", NA, NA, "2013-08-09", 21L, + "RS", "CDISCPILOT01", "01-701-1028", 3L, "WEEK 6", "RECIST 1.1 - CA125", "OVRLRESP", "Overall Response", "Progressive Disease", "PD", "INVESTIGATOR", NA, NA, "2013-08-30", 24L, + "RS", "CDISCPILOT01", "01-701-1028", 4L, "WEEK 9", "RECIST 1.1 - CA125", "OVRLRESP", "Overall Response", "Progressive Disease", "PD", "INVESTIGATOR", NA, NA, "2013-09-30", 27L, + "RS", "CDISCPILOT01", "01-701-1034", 2L, "WEEK 3", "RECIST 1.1 - CA125", "OVRLRESP", "Overall Response", "Complete Response", "CR", "INVESTIGATOR", NA, NA, "2014-07-22", 21L, + "RS", "CDISCPILOT01", "01-701-1034", 3L, "WEEK 6", "RECIST 1.1 - CA125", "OVRLRESP", "Overall Response", "Complete Response", "CR", "INVESTIGATOR", NA, NA, "2014-08-20", 24L, + "RS", "CDISCPILOT01", "01-701-1097", 2L, "WEEK 3", "RECIST 1.1 - CA125", "OVRLRESP", "Overall Response", "Stable Disease", "SD", "INVESTIGATOR", NA, NA, "2014-01-22", 21L, + "RS", "CDISCPILOT01", "01-701-1115", 2L, "WEEK 3", "RECIST 1.1 - CA125", "OVRLRESP", "Overall Response", "Partial Response", "PR", "INVESTIGATOR", NA, NA, "2012-12-21", 21L, + "RS", "CDISCPILOT01", "01-701-1115", 3L, "WEEK 6", "RECIST 1.1 - CA125", "OVRLRESP", "Overall Response", "Partial Response", "PR", "INVESTIGATOR", NA, NA, "2013-01-11", 24L, + "RS", "CDISCPILOT01", "01-701-1115", 4L, "WEEK 9", "RECIST 1.1 - CA125", "OVRLRESP", "Overall Response", "Complete Response", "CR", "INVESTIGATOR", NA, NA, "2013-02-01", 27L, + "RS", "CDISCPILOT01", "01-701-1118", 2L, "WEEK 3", "RECIST 1.1 - CA125", "OVRLRESP", "Overall Response", "Stable Disease", "SD", "INVESTIGATOR", NA, NA, "2014-04-02", 21L, + "RS", "CDISCPILOT01", "01-701-1118", 3L, "WEEK 6", "RECIST 1.1 - CA125", "OVRLRESP", "Overall Response", "Complete Response", "CR", "INVESTIGATOR", NA, NA, "2014-04-23", 24L, + "RS", "CDISCPILOT01", "01-701-1118", 4L, "WEEK 9", "RECIST 1.1 - CA125", "OVRLRESP", "Overall Response", "Not Evaluable", "NE", "INVESTIGATOR", NA, NA, "2014-05-14", 27L, + "RS", "CDISCPILOT01", "01-701-1118", 5L, "WEEK 12", "RECIST 1.1 - CA125", "OVRLRESP", "Overall Response", "Complete Response", "CR", "INVESTIGATOR", NA, NA, "2014-06-04", 30L, + "RS", "CDISCPILOT01", "01-701-1130", 2L, "WEEK 3", "RECIST 1.1 - CA125", "OVRLRESP", "Overall Response", "Stable Disease", "SD", "INVESTIGATOR", NA, NA, "2014-03-08", 21L, + "RS", "CDISCPILOT01", "01-701-1130", 3L, "WEEK 6", "RECIST 1.1 - CA125", "OVRLRESP", "Overall Response", "Progressive Disease", "PD", "INVESTIGATOR", NA, NA, "2014-03-29", 24L, + "RS", "CDISCPILOT01", "01-701-1130", 4L, "WEEK 9", "RECIST 1.1 - CA125", "OVRLRESP", "Overall Response", "Progressive Disease", "PD", "INVESTIGATOR", NA, NA, "2014-04-19", 27L, + "RS", "CDISCPILOT01", "01-701-1133", 2L, "WEEK 3", "RECIST 1.1 - CA125", "OVRLRESP", "Overall Response", "Partial Response", "PR", "INVESTIGATOR", NA, NA, "2012-11-18", 21L, + "RS", "CDISCPILOT01", "01-701-1133", 3L, "WEEK 6", "RECIST 1.1 - CA125", "OVRLRESP", "Overall Response", "Progressive Disease", "PD", "INVESTIGATOR", NA, NA, "2012-12-09", 24L, + "RS", "CDISCPILOT01", "01-701-1133", 4L, "WEEK 9", "RECIST 1.1 - CA125", "OVRLRESP", "Overall Response", "Progressive Disease", "PD", "INVESTIGATOR", NA, NA, "2012-12-30", 27L +) %>% + mutate( + STUDYID = "CDISCPILOT01", + DOMAIN = "RS", + # RSCAT = "IMWG", + RSEVAL = "INVESTIGATOR" + ) %>% + relocate( + STUDYID, DOMAIN, USUBJID, RSSEQ, RSTESTCD, RSTEST, RSCAT, RSORRES, + RSSTRESC, RSEVAL, VISITNUM, VISIT, RSDTC + ) + +attr(rs_onco_ca125, "label") <- "Disease Response (CA125)" + +usethis::use_data(rs_onco_ca125, overwrite = TRUE) + +# Create supprs_onco_imwg ---- +supprs_onco_ca125 <- tibble::tribble( + ~STUDYID, ~RDOMAIN, ~USUBJID, ~IDVAR, ~IDVARVAL, ~QNAM, ~QLABEL, ~QVAL, + "CDISCPILOT01", "RS", "01-701-1133", "RSSEQ", 3L, "CA125EFL", "CA-125 response evaluable", "Y", + "CDISCPILOT01", "RS", "01-701-1133", "RSSEQ", 6L, "CA125EFL", "CA-125 response evaluable", "Y", + "CDISCPILOT01", "RS", "01-701-1133", "RSSEQ", 9L, "CA125EFL", "CA-125 response evaluable", "Y", + "CDISCPILOT01", "RS", "01-701-1133", "RSSEQ", 3L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", + "CDISCPILOT01", "RS", "01-701-1133", "RSSEQ", 6L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", + "CDISCPILOT01", "RS", "01-701-1133", "RSSEQ", 9L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", + "CDISCPILOT01", "RS", "01-701-1133", "RSSEQ", 6L, "CANORM2X", "CA125 normal, lab increased >=2x ULRR", "Y", + "CDISCPILOT01", "RS", "01-701-1133", "RSSEQ", 9L, "CANORM2X", "CA125 normal, lab increased >=2x ULRR", "Y", + "CDISCPILOT01", "RS", "01-701-1130", "RSSEQ", 3L, "CA125EFL", "CA-125 response evaluable", "Y", + "CDISCPILOT01", "RS", "01-701-1130", "RSSEQ", 6L, "CA125EFL", "CA-125 response evaluable", "Y", + "CDISCPILOT01", "RS", "01-701-1130", "RSSEQ", 9L, "CA125EFL", "CA-125 response evaluable", "Y", + "CDISCPILOT01", "RS", "01-701-1130", "RSSEQ", 3L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", + "CDISCPILOT01", "RS", "01-701-1130", "RSSEQ", 6L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", + "CDISCPILOT01", "RS", "01-701-1130", "RSSEQ", 9L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", + "CDISCPILOT01", "RS", "01-701-1130", "RSSEQ", 6L, "CNOTNORM", "CA125 not norm, lab increased >=2x nadir", "Y", + "CDISCPILOT01", "RS", "01-701-1130", "RSSEQ", 9L, "CNOTNORM", "CA125 not norm, lab increased >=2x nadir", "Y", + "CDISCPILOT01", "RS", "01-701-1028", "RSSEQ", 3L, "CA125EFL", "CA-125 response evaluable", "Y", + "CDISCPILOT01", "RS", "01-701-1028", "RSSEQ", 6L, "CA125EFL", "CA-125 response evaluable", "Y", + "CDISCPILOT01", "RS", "01-701-1028", "RSSEQ", 9L, "CA125EFL", "CA-125 response evaluable", "Y", + "CDISCPILOT01", "RS", "01-701-1028", "RSSEQ", 6L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "N", + "CDISCPILOT01", "RS", "01-701-1028", "RSSEQ", 6L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "N", + "CDISCPILOT01", "RS", "01-701-1028", "RSSEQ", 9L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "N", + "CDISCPILOT01", "RS", "01-701-1028", "RSSEQ", 6L, "CNOTNORM", "CA125 not norm, lab increased >=2x nadir", "Y", + "CDISCPILOT01", "RS", "01-701-1028", "RSSEQ", 9L, "CNOTNORM", "CA125 not norm, lab increased >=2x nadir", "Y", + "CDISCPILOT01", "RS", "01-701-1034", "RSSEQ", 3L, "CA125EFL", "CA-125 response evaluable", "Y", + "CDISCPILOT01", "RS", "01-701-1034", "RSSEQ", 6L, "CA125EFL", "CA-125 response evaluable", "Y", + "CDISCPILOT01", "RS", "01-701-1034", "RSSEQ", 3L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", + "CDISCPILOT01", "RS", "01-701-1034", "RSSEQ", 6L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", + "CDISCPILOT01", "RS", "01-701-1034", "RSSEQ", 3L, "CA50RED", ">50% reduction from baseline", "Y", + "CDISCPILOT01", "RS", "01-701-1034", "RSSEQ", 6L, "CA50RED", ">50% reduction from baseline", "Y", + "CDISCPILOT01", "RS", "01-701-1097", "RSSEQ", 3L, "CA125EFL", "CA-125 response evaluable", "Y", + "CDISCPILOT01", "RS", "01-701-1097", "RSSEQ", 3L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", + "CDISCPILOT01", "RS", "01-701-1015", "RSSEQ", 3L, "CA125EFL", "CA-125 response evaluable", "Y", + "CDISCPILOT01", "RS", "01-701-1015", "RSSEQ", 6L, "CA125EFL", "CA-125 response evaluable", "Y", + "CDISCPILOT01", "RS", "01-701-1015", "RSSEQ", 9L, "CA125EFL", "CA-125 response evaluable", "Y", + "CDISCPILOT01", "RS", "01-701-1015", "RSSEQ", 3L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", + "CDISCPILOT01", "RS", "01-701-1015", "RSSEQ", 6L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", + "CDISCPILOT01", "RS", "01-701-1015", "RSSEQ", 9L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", + "CDISCPILOT01", "RS", "01-701-1015", "RSSEQ", 9L, "CA50RED", ">50% reduction from baseline", "Y", + "CDISCPILOT01", "RS", "01-701-1015", "RSSEQ", 6L, "MOUSEANT", "Received mouse antibodies", "Y", + "CDISCPILOT01", "RS", "01-701-1115", "RSSEQ", 3L, "CA125EFL", "CA-125 response evaluable", "Y", + "CDISCPILOT01", "RS", "01-701-1115", "RSSEQ", 6L, "CA125EFL", "CA-125 response evaluable", "Y", + "CDISCPILOT01", "RS", "01-701-1115", "RSSEQ", 9L, "CA125EFL", "CA-125 response evaluable", "Y", + "CDISCPILOT01", "RS", "01-701-1115", "RSSEQ", 3L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", + "CDISCPILOT01", "RS", "01-701-1115", "RSSEQ", 6L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", + "CDISCPILOT01", "RS", "01-701-1115", "RSSEQ", 9L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", + "CDISCPILOT01", "RS", "01-701-1115", "RSSEQ", 3L, "CA50RED", ">50% reduction from baseline", "Y", + "CDISCPILOT01", "RS", "01-701-1115", "RSSEQ", 6L, "CA50RED", ">50% reduction from baseline", "Y", + "CDISCPILOT01", "RS", "01-701-1115", "RSSEQ", 9L, "CA50RED", ">50% reduction from baseline", "Y", + "CDISCPILOT01", "RS", "01-701-1118", "RSSEQ", 3L, "CA125EFL", "CA-125 response evaluable", "Y", + "CDISCPILOT01", "RS", "01-701-1118", "RSSEQ", 6L, "CA125EFL", "CA-125 response evaluable", "Y", + "CDISCPILOT01", "RS", "01-701-1118", "RSSEQ", 9L, "CA125EFL", "CA-125 response evaluable", "Y", + "CDISCPILOT01", "RS", "01-701-1118", "RSSEQ", 12L, "CA125EFL", "CA-125 response evaluable", "Y", + "CDISCPILOT01", "RS", "01-701-1118", "RSSEQ", 3L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", + "CDISCPILOT01", "RS", "01-701-1118", "RSSEQ", 6L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", + "CDISCPILOT01", "RS", "01-701-1118", "RSSEQ", 9L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", + "CDISCPILOT01", "RS", "01-701-1118", "RSSEQ", 12L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", + "CDISCPILOT01", "RS", "01-701-1118", "RSSEQ", 3L, "CA50RED", ">50% reduction from baseline", "Y", + "CDISCPILOT01", "RS", "01-701-1118", "RSSEQ", 9L, "CA50RED", ">50% reduction from baseline", "Y", + "CDISCPILOT01", "RS", "01-701-1118", "RSSEQ", 12L, "CA50RED", ">50% reduction from baseline", "Y" + ) %>% + mutate( + STUDYID = "CDISCPILOT01", + RDOMAIN = "RS", + IDVAR = "RSSEQ", + QORIG = "CRF", + IDVARVAL = as.character(IDVARVAL) + ) %>% + relocate( + STUDYID, RDOMAIN, USUBJID, IDVAR, IDVARVAL, QNAM, QLABEL, QVAL, QORIG + ) + +attr(supprs_onco_ca125, "label") <- "Supplemental Qualifiers for RS_ONCO_CA125" + +usethis::use_data(supprs_onco_ca125, overwrite = TRUE) diff --git a/data/rs_onco_ca125.rda b/data/rs_onco_ca125.rda new file mode 100644 index 0000000000000000000000000000000000000000..607d08e87812524a35488420fec28dff2517cdb5 GIT binary patch literal 1065 zcmV+^1lIdPT4*^jL0KkKS*;UMIRF+||H%LU{!K(<|KLBr|KPvp-+({>00962&;_1) zBme~fBm{Aj1klK2WMt6L27@CA27^YK3`0N;GGLk+42+DL8UWB_VF1u*(;nMy7^CO*9OR4@sla8e>ocC#d@yPQAC>7r%!ig_=4zbP77SUHnGQPF}5?`L!I@ zrE0Q>?=1Uy6nHyYLG7ty}H(>ucAt-Eg;WvE;X)`$rL? zo}X7y<#QaiE5qAl4w_oBqZjN!y$3XH85tO|Q!i_4Rj@%d2TOUj!a|6>6=OH%6|WVR9`E>w3t`d}$htwpkjnRxQHP zF-=?K#o1-S2K!d{(P}rNR*aYp#8T$2B3MKN(vB)ZB^i>wDFjS2P5V%OQkx*~{q%az zntn@pj51-BjAJZ+H&$%4gVDRq*To+v-5ZL1NI0PHY(uT#L9>wCp$F6H__rYHLD|}a z;X%&u6z{$+C_b)7N)DtQo}IAnAGz?l_n_@QlOuVDUyR^`tF;HvgV2Ly9sAj37Ar4bT4FKd&rzPsd0LPtH)T}t=_GLqxEXAy|EVYd_txheOnKKtO+E>}K z4h}I+rFW-KqoO-i&oBEPDnCqgtFw<}chF(3&mM=WZcyrsx+jh>b#iNTWK)xZz6s_Y zK4_+)yTdreIH3PM%IA+FzQ51J?{a50-Pp+t%wr~FGGxq;1sm1ADZ3TQdnOxuhxYdP jPDtiEkBs+C%J&d+{HO%x$NEGFf5qI9P81|7MAS||tOWq< literal 0 HcmV?d00001 diff --git a/data/supprs_onco_ca125.rda b/data/supprs_onco_ca125.rda new file mode 100644 index 0000000000000000000000000000000000000000..199afe8f1d5bba584b839243fd15e6538e55656d GIT binary patch literal 817 zcmV-11J3+HT4*^jL0KkKS!>&o?Enri|HS|PXe2^sf9F59|6so--@rfs1ONa5&;z{i zBr2i`9B9drgkk}N&|nimpk&FTCPN4eaibfQNKoj8gromO8>}M zJp(ncoG=3OApuM%RJ9a_09T|GfGegcW{*G^A;1;T74m|*z-)# zECFy4Q`&+dKt1BZonDwBBLhJVz-j>0G#v_{K?k)BXi!r0PZ6{gzQ92&A*}Bqta{M6 zJwPM9r(yE6b;Pd8g)xd}_Zb5iDUAqzK&%YBz^_Ov#p;P8ycPPYP1n&50-0h8#1*zF zE^p6WGUo+#dBIvFo*0EXwt~BbOKczK9u4}f;tfV&GVkB)j)1HUH6pcwxq2_dV(6tX z0rh0uLU2~<)GBa-v;wowvp_3+6~pTVVhYt6EWJnoN@3v?xC3f$HVtFqW|BcqN(&{r zKm544yQ01Voq=z_uW+Yr#(shALuaOg8<`H z-XQbPch@l;c~>(GLkp~N)6Qq(qF zgbc8+61Eb8m#SZmI3cMHO`@B*1k{$*(M?jJNX!*Y5le%pDJrgz=^>iEQwU;Xkf!x) vDLbkufL5Mfnr=eEor0XgogC Date: Mon, 7 Oct 2024 14:39:21 -0400 Subject: [PATCH 2/6] #123 - Updated object name --- data-raw/rs_supprs_onco_ca125.R | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/data-raw/rs_supprs_onco_ca125.R b/data-raw/rs_supprs_onco_ca125.R index e549e907..ccce6249 100644 --- a/data-raw/rs_supprs_onco_ca125.R +++ b/data-raw/rs_supprs_onco_ca125.R @@ -6,7 +6,7 @@ library(dplyr) library(usethis) # Create rs_onco_ca125 ---- -rs_onco_ca124 <- tibble::tribble( +rs_onco_ca125 <- tibble::tribble( ~DOMAIN, ~STUDYID, ~USUBJID, ~VISITNUM, ~VISIT, ~RSCAT, ~RSTESTCD, ~RSTEST, ~RSORRES, ~RSSTRESC, ~RSEVAL, ~RSEVALID, ~RSACPTFL, ~RSDTC, ~RSSEQ, "RS", "CDISCPILOT01", "01-701-1015", 2L, "WEEK 3", "CA125", "OVRLRESP", "Overall Response", "Non-Response/ Non-PD", "SD", "INVESTIGATOR", NA, NA, "2014-01-23", 3L, "RS", "CDISCPILOT01", "01-701-1015", 3L, "WEEK 6", "CA125", "OVRLRESP", "Overall Response", "Not Evaluable", "NE", "INVESTIGATOR", NA, NA, "2014-02", 6L, From a1127a3b1c4ebcbb4dd513670744d2852b87f5ff Mon Sep 17 00:00:00 2001 From: Vinh Nguyen Date: Wed, 16 Oct 2024 12:09:32 -0400 Subject: [PATCH 3/6] #123 - updated supp data for 1028 --- data-raw/rs_supprs_onco_ca125.R | 9 +++++---- 1 file changed, 5 insertions(+), 4 deletions(-) diff --git a/data-raw/rs_supprs_onco_ca125.R b/data-raw/rs_supprs_onco_ca125.R index ccce6249..580a24ee 100644 --- a/data-raw/rs_supprs_onco_ca125.R +++ b/data-raw/rs_supprs_onco_ca125.R @@ -109,12 +109,13 @@ supprs_onco_ca125 <- tibble::tribble( "CDISCPILOT01", "RS", "01-701-1130", "RSSEQ", 9L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", "CDISCPILOT01", "RS", "01-701-1130", "RSSEQ", 6L, "CNOTNORM", "CA125 not norm, lab increased >=2x nadir", "Y", "CDISCPILOT01", "RS", "01-701-1130", "RSSEQ", 9L, "CNOTNORM", "CA125 not norm, lab increased >=2x nadir", "Y", - "CDISCPILOT01", "RS", "01-701-1028", "RSSEQ", 3L, "CA125EFL", "CA-125 response evaluable", "Y", - "CDISCPILOT01", "RS", "01-701-1028", "RSSEQ", 6L, "CA125EFL", "CA-125 response evaluable", "Y", - "CDISCPILOT01", "RS", "01-701-1028", "RSSEQ", 9L, "CA125EFL", "CA-125 response evaluable", "Y", - "CDISCPILOT01", "RS", "01-701-1028", "RSSEQ", 6L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "N", + "CDISCPILOT01", "RS", "01-701-1028", "RSSEQ", 3L, "CA125EFL", "CA-125 response evaluable", "N", + "CDISCPILOT01", "RS", "01-701-1028", "RSSEQ", 6L, "CA125EFL", "CA-125 response evaluable", "N", + "CDISCPILOT01", "RS", "01-701-1028", "RSSEQ", 9L, "CA125EFL", "CA-125 response evaluable", "N", + "CDISCPILOT01", "RS", "01-701-1028", "RSSEQ", 3L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "N", "CDISCPILOT01", "RS", "01-701-1028", "RSSEQ", 6L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "N", "CDISCPILOT01", "RS", "01-701-1028", "RSSEQ", 9L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "N", + "CDISCPILOT01", "RS", "01-701-1028", "RSSEQ", 3L, "CNOTNORM", "CA125 not norm, lab increased >=2x nadir", "Y", "CDISCPILOT01", "RS", "01-701-1028", "RSSEQ", 6L, "CNOTNORM", "CA125 not norm, lab increased >=2x nadir", "Y", "CDISCPILOT01", "RS", "01-701-1028", "RSSEQ", 9L, "CNOTNORM", "CA125 not norm, lab increased >=2x nadir", "Y", "CDISCPILOT01", "RS", "01-701-1034", "RSSEQ", 3L, "CA125EFL", "CA-125 response evaluable", "Y", From 16bfd5c03674ee33b4abf46a8a1b03e7ca87f6d5 Mon Sep 17 00:00:00 2001 From: Vinh Nguyen Date: Wed, 13 Nov 2024 09:43:37 -0500 Subject: [PATCH 4/6] #123 - Updated per comments --- data-raw/rs_supprs_onco_ca125.R | 9 +++++---- data/rs_onco_ca125.rda | Bin 1065 -> 1048 bytes data/supprs_onco_ca125.rda | Bin 817 -> 833 bytes 3 files changed, 5 insertions(+), 4 deletions(-) diff --git a/data-raw/rs_supprs_onco_ca125.R b/data-raw/rs_supprs_onco_ca125.R index 580a24ee..f7110fed 100644 --- a/data-raw/rs_supprs_onco_ca125.R +++ b/data-raw/rs_supprs_onco_ca125.R @@ -36,7 +36,7 @@ rs_onco_ca125 <- tibble::tribble( "RS", "CDISCPILOT01", "01-701-1028", 2L, "WEEK 3", "RECIST 1.1", "OVRLRESP", "Overall Response", "PR", "PR", "INVESTIGATOR", NA, NA, "2013-08-09", 12L, "RS", "CDISCPILOT01", "01-701-1028", 3L, "WEEK 6", "RECIST 1.1", "OVRLRESP", "Overall Response", "PD", "PD", "INVESTIGATOR", NA, NA, "2013-08-30", 15L, "RS", "CDISCPILOT01", "01-701-1028", 4L, "WEEK 9", "RECIST 1.1", "OVRLRESP", "Overall Response", "PD", "PD", "INVESTIGATOR", NA, NA, "2013-09-30", 18L, - "RS", "CDISCPILOT01", "01-701-1034", 2L, "WEEK 3", "RECIST 1.1", "OVRLRESP", "Overall Response", "NON-CR/NON-PD", "NON-CR/NON-PD", "INVESTIGATOR", NA, NA, "2014-07-22", 12L, + "RS", "CDISCPILOT01", "01-701-1034", 2L, "WEEK 3", "RECIST 1.1", "OVRLRESP", "Overall Response", "CR", "CR", "INVESTIGATOR", NA, NA, "2014-07-22", 12L, "RS", "CDISCPILOT01", "01-701-1034", 3L, "WEEK 6", "RECIST 1.1", "OVRLRESP", "Overall Response", "CR", "CR", "INVESTIGATOR", NA, NA, "2014-08-20", 15L, "RS", "CDISCPILOT01", "01-701-1097", 2L, "WEEK 3", "RECIST 1.1", "OVRLRESP", "Overall Response", "SD", "SD", "INVESTIGATOR", NA, NA, "2014-01-22", 12L, "RS", "CDISCPILOT01", "01-701-1115", 2L, "WEEK 3", "RECIST 1.1", "OVRLRESP", "Overall Response", "SD", "SD", "INVESTIGATOR", NA, NA, "2012-12-21", 12L, @@ -115,9 +115,9 @@ supprs_onco_ca125 <- tibble::tribble( "CDISCPILOT01", "RS", "01-701-1028", "RSSEQ", 3L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "N", "CDISCPILOT01", "RS", "01-701-1028", "RSSEQ", 6L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "N", "CDISCPILOT01", "RS", "01-701-1028", "RSSEQ", 9L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "N", - "CDISCPILOT01", "RS", "01-701-1028", "RSSEQ", 3L, "CNOTNORM", "CA125 not norm, lab increased >=2x nadir", "Y", - "CDISCPILOT01", "RS", "01-701-1028", "RSSEQ", 6L, "CNOTNORM", "CA125 not norm, lab increased >=2x nadir", "Y", - "CDISCPILOT01", "RS", "01-701-1028", "RSSEQ", 9L, "CNOTNORM", "CA125 not norm, lab increased >=2x nadir", "Y", + "CDISCPILOT01", "RS", "01-701-1028", "RSSEQ", 3L, "CANORM2X", "CA125 normal, lab increased >=2x ULRR", "Y", + "CDISCPILOT01", "RS", "01-701-1028", "RSSEQ", 6L, "CANORM2X", "CA125 normal, lab increased >=2x ULRR", "Y", + "CDISCPILOT01", "RS", "01-701-1028", "RSSEQ", 9L, "CANORM2X", "CA125 normal, lab increased >=2x ULRR", "Y", "CDISCPILOT01", "RS", "01-701-1034", "RSSEQ", 3L, "CA125EFL", "CA-125 response evaluable", "Y", "CDISCPILOT01", "RS", "01-701-1034", "RSSEQ", 6L, "CA125EFL", "CA-125 response evaluable", "Y", "CDISCPILOT01", "RS", "01-701-1034", "RSSEQ", 3L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", @@ -134,6 +134,7 @@ supprs_onco_ca125 <- tibble::tribble( "CDISCPILOT01", "RS", "01-701-1015", "RSSEQ", 9L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", "CDISCPILOT01", "RS", "01-701-1015", "RSSEQ", 9L, "CA50RED", ">50% reduction from baseline", "Y", "CDISCPILOT01", "RS", "01-701-1015", "RSSEQ", 6L, "MOUSEANT", "Received mouse antibodies", "Y", + "CDISCPILOT01", "RS", "01-701-1015", "RSSEQ", 24L, "MOUSEANT", "Received mouse antibodies", "Y", "CDISCPILOT01", "RS", "01-701-1115", "RSSEQ", 3L, "CA125EFL", "CA-125 response evaluable", "Y", "CDISCPILOT01", "RS", "01-701-1115", "RSSEQ", 6L, "CA125EFL", "CA-125 response evaluable", "Y", 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zaB1T@6Z@qFK42D?_&@%=yFcoI;3?W$^h)m(-EqQgUC3eXsHbAwgy0~jfzffzhzw{| z4L4^n7DD!EjbvCb4B$DG9x{uZsvIW`kiCIZG$D9XIHwJ1;SkV!t}t0*7DA?1gD}LG zJ@krnS0o@)aSPUqMJk}cR)iN@P2d$FK%|uiGVM)HCn2OV{riN53DcUK-Da*!&_9>SNXDHxB@qf99BmOSr Lig2MIS1}QMiOOaq literal 817 zcmV-11J3+HT4*^jL0KkKS!>&o?Enri|HS|PXe2^sf9F59|6so--@rfs1ONa5&;z{i zBr2i`9B9drgkk}N&|nimpk&FTCPN4eaibfQNKoj8gromO8>}M zJp(ncoG=3OApuM%RJ9a_09T|GfGegcW{*G^A;1;T74m|*z-)# zECFy4Q`&+dKt1BZonDwBBLhJVz-j>0G#v_{K?k)BXi!r0PZ6{gzQ92&A*}Bqta{M6 zJwPM9r(yE6b;Pd8g)xd}_Zb5iDUAqzK&%YBz^_Ov#p;P8ycPPYP1n&50-0h8#1*zF zE^p6WGUo+#dBIvFo*0EXwt~BbOKczK9u4}f;tfV&GVkB)j)1HUH6pcwxq2_dV(6tX z0rh0uLU2~<)GBa-v;wowvp_3+6~pTVVhYt6EWJnoN@3v?xC3f$HVtFqW|BcqN(&{r zKm544yQ01Voq=z_uW+Yr#(shALuaOg8<`H z-XQbPch@l;c~>(GLkp~N)6Qq(qF zgbc8+61Eb8m#SZmI3cMHO`@B*1k{$*(M?jJNX!*Y5le%pDJrgz=^>iEQwU;Xkf!x) vDLbkufL5Mfnr=eEor0XgogC Date: Fri, 22 Nov 2024 13:55:41 -0500 Subject: [PATCH 5/6] 123 - updated per comment --- data-raw/rs_supprs_onco_ca125.R | 266 ++++++++++++++++---------------- data/rs_onco_ca125.rda | Bin 1048 -> 1017 bytes data/supprs_onco_ca125.rda | Bin 833 -> 852 bytes 3 files changed, 133 insertions(+), 133 deletions(-) diff --git a/data-raw/rs_supprs_onco_ca125.R b/data-raw/rs_supprs_onco_ca125.R index f7110fed..8dffa908 100644 --- a/data-raw/rs_supprs_onco_ca125.R +++ b/data-raw/rs_supprs_onco_ca125.R @@ -6,75 +6,75 @@ library(dplyr) library(usethis) # Create rs_onco_ca125 ---- -rs_onco_ca125 <- tibble::tribble( - ~DOMAIN, ~STUDYID, ~USUBJID, ~VISITNUM, ~VISIT, ~RSCAT, ~RSTESTCD, ~RSTEST, ~RSORRES, ~RSSTRESC, ~RSEVAL, ~RSEVALID, ~RSACPTFL, ~RSDTC, ~RSSEQ, - "RS", "CDISCPILOT01", "01-701-1015", 2L, "WEEK 3", "CA125", "OVRLRESP", "Overall Response", "Non-Response/ Non-PD", "SD", "INVESTIGATOR", NA, NA, "2014-01-23", 3L, - "RS", "CDISCPILOT01", "01-701-1015", 3L, "WEEK 6", "CA125", "OVRLRESP", "Overall Response", "Not Evaluable", "NE", "INVESTIGATOR", NA, NA, "2014-02", 6L, - "RS", "CDISCPILOT01", "01-701-1015", 4L, "WEEK 9", "CA125", "OVRLRESP", "Overall Response", "Response But Not Within Normal Range", "PR", "INVESTIGATOR", NA, NA, "2014-03-06", 9L, - "RS", "CDISCPILOT01", "01-701-1028", 2L, "WEEK 3", "CA125", "OVRLRESP", "Overall Response", "Progressive Disease", "PD", "INVESTIGATOR", NA, NA, "2013-08-09", 3L, - "RS", "CDISCPILOT01", "01-701-1028", 3L, "WEEK 6", "CA125", "OVRLRESP", "Overall Response", "Progressive Disease", "PD", "INVESTIGATOR", NA, NA, "2013-08-30", 6L, - "RS", "CDISCPILOT01", "01-701-1028", 4L, "WEEK 9", "CA125", "OVRLRESP", "Overall Response", "Progressive Disease", "PD", "INVESTIGATOR", NA, NA, "2013-09-30", 9L, - "RS", "CDISCPILOT01", "01-701-1034", 2L, "WEEK 3", "CA125", "OVRLRESP", "Overall Response", "Response Within Normal Range", "CR", "INVESTIGATOR", NA, NA, "2014-07-22", 3L, - "RS", "CDISCPILOT01", "01-701-1034", 3L, "WEEK 6", "CA125", "OVRLRESP", "Overall Response", "Response Within Normal Range", "CR", "INVESTIGATOR", NA, NA, "2014-08-20", 6L, - "RS", "CDISCPILOT01", "01-701-1097", 2L, "WEEK 3", "CA125", "OVRLRESP", "Overall Response", "Non-Response/ Non-PD", "SD", "INVESTIGATOR", NA, NA, "2014-01-22", 3L, - "RS", "CDISCPILOT01", "01-701-1115", 2L, "WEEK 3", "CA125", "OVRLRESP", "Overall Response", "Response But Not Within Normal Range", "PR", "INVESTIGATOR", NA, NA, "2012-12-21", 3L, - "RS", "CDISCPILOT01", "01-701-1115", 3L, "WEEK 6", "CA125", "OVRLRESP", "Overall Response", "Response But Not Within Normal Range", "PR", "INVESTIGATOR", NA, NA, "2013-01-11", 6L, - "RS", "CDISCPILOT01", "01-701-1115", 4L, "WEEK 9", "CA125", "OVRLRESP", "Overall Response", "Response Within Normal Range", "CR", "INVESTIGATOR", NA, NA, "2013-02-01", 9L, - "RS", "CDISCPILOT01", "01-701-1118", 2L, "WEEK 3", "CA125", "OVRLRESP", "Overall Response", "Non-Response/ Non-PD", "SD", "INVESTIGATOR", NA, NA, "2014-04-02", 3L, - "RS", "CDISCPILOT01", "01-701-1118", 3L, "WEEK 6", "CA125", "OVRLRESP", "Overall Response", "Response Within Normal Range", "CR", "INVESTIGATOR", NA, NA, "2014-04-23", 6L, - "RS", "CDISCPILOT01", "01-701-1118", 4L, "WEEK 9", "CA125", "OVRLRESP", "Overall Response", "Not Evaluable", "NE", "INVESTIGATOR", NA, NA, "2014-05-14", 9L, - "RS", "CDISCPILOT01", "01-701-1118", 5L, "WEEK 12", "CA125", "OVRLRESP", "Overall Response", "Response Within Normal Range", "CR", "INVESTIGATOR", NA, NA, "2014-06-04", 12L, - "RS", "CDISCPILOT01", "01-701-1130", 2L, "WEEK 3", "CA125", "OVRLRESP", "Overall Response", "Non-Response/ Non-PD", "SD", "INVESTIGATOR", NA, NA, "2014-03-08", 3L, - "RS", "CDISCPILOT01", "01-701-1130", 3L, "WEEK 6", "CA125", "OVRLRESP", "Overall Response", "Progressive Disease", "PD", "INVESTIGATOR", NA, NA, "2014-03-29", 6L, - "RS", "CDISCPILOT01", "01-701-1130", 4L, "WEEK 9", "CA125", "OVRLRESP", "Overall Response", "Progressive Disease", "PD", "INVESTIGATOR", NA, NA, "2014-04-19", 9L, - "RS", "CDISCPILOT01", "01-701-1133", 2L, "WEEK 3", "CA125", "OVRLRESP", "Overall Response", "Response But Not Within Normal Range", "PR", "INVESTIGATOR", NA, NA, "2012-11-18", 3L, - "RS", "CDISCPILOT01", "01-701-1133", 3L, "WEEK 6", "CA125", "OVRLRESP", "Overall Response", "Progressive Disease", "PD", "INVESTIGATOR", NA, NA, "2012-12-09", 6L, - "RS", "CDISCPILOT01", "01-701-1133", 4L, "WEEK 9", "CA125", "OVRLRESP", "Overall Response", "Progressive Disease", "PD", "INVESTIGATOR", NA, NA, "2012-12-30", 9L, - "RS", "CDISCPILOT01", "01-701-1015", 2L, "WEEK 3", "RECIST 1.1", "OVRLRESP", "Overall Response", "SD", "SD", "INVESTIGATOR", NA, NA, "2014-01-23", 12L, - "RS", "CDISCPILOT01", "01-701-1015", 3L, "WEEK 6", "RECIST 1.1", "OVRLRESP", "Overall Response", "NE", "NE", "INVESTIGATOR", NA, NA, "2014-02", 15L, - "RS", "CDISCPILOT01", "01-701-1015", 4L, "WEEK 9", "RECIST 1.1", "OVRLRESP", "Overall Response", "PR", "PR", "INVESTIGATOR", NA, NA, "2014-03-06", 18L, - "RS", "CDISCPILOT01", "01-701-1028", 2L, "WEEK 3", "RECIST 1.1", "OVRLRESP", "Overall Response", "PR", "PR", "INVESTIGATOR", NA, NA, "2013-08-09", 12L, - "RS", "CDISCPILOT01", "01-701-1028", 3L, "WEEK 6", "RECIST 1.1", "OVRLRESP", "Overall Response", "PD", "PD", "INVESTIGATOR", NA, NA, "2013-08-30", 15L, - "RS", "CDISCPILOT01", "01-701-1028", 4L, "WEEK 9", "RECIST 1.1", "OVRLRESP", "Overall Response", "PD", "PD", "INVESTIGATOR", NA, NA, "2013-09-30", 18L, - "RS", "CDISCPILOT01", "01-701-1034", 2L, "WEEK 3", "RECIST 1.1", "OVRLRESP", "Overall Response", "CR", "CR", "INVESTIGATOR", NA, NA, "2014-07-22", 12L, - "RS", "CDISCPILOT01", "01-701-1034", 3L, "WEEK 6", "RECIST 1.1", "OVRLRESP", "Overall Response", "CR", "CR", "INVESTIGATOR", NA, NA, "2014-08-20", 15L, - "RS", "CDISCPILOT01", "01-701-1097", 2L, "WEEK 3", "RECIST 1.1", "OVRLRESP", "Overall Response", "SD", "SD", "INVESTIGATOR", NA, NA, "2014-01-22", 12L, - "RS", "CDISCPILOT01", "01-701-1115", 2L, "WEEK 3", "RECIST 1.1", "OVRLRESP", "Overall Response", "SD", "SD", "INVESTIGATOR", NA, NA, "2012-12-21", 12L, - "RS", "CDISCPILOT01", "01-701-1115", 3L, "WEEK 6", "RECIST 1.1", "OVRLRESP", "Overall Response", "PR", "PR", "INVESTIGATOR", NA, NA, "2013-01-11", 15L, - "RS", "CDISCPILOT01", "01-701-1115", 4L, "WEEK 9", "RECIST 1.1", "OVRLRESP", "Overall Response", "CR", "CR", "INVESTIGATOR", NA, NA, "2013-02-01", 18L, - "RS", "CDISCPILOT01", "01-701-1118", 2L, "WEEK 3", "RECIST 1.1", "OVRLRESP", "Overall Response", "SD", "SD", "INVESTIGATOR", NA, NA, "2014-04-02", 12L, - "RS", "CDISCPILOT01", "01-701-1118", 3L, "WEEK 6", "RECIST 1.1", "OVRLRESP", "Overall Response", "CR", "CR", "INVESTIGATOR", NA, NA, "2014-04-23", 15L, - "RS", "CDISCPILOT01", "01-701-1118", 4L, "WEEK 9", "RECIST 1.1", "OVRLRESP", "Overall Response", "NE", "NE", "INVESTIGATOR", NA, NA, "2014-05-14", 18L, - "RS", "CDISCPILOT01", "01-701-1118", 5L, "WEEK 12", "RECIST 1.1", "OVRLRESP", "Overall Response", "CR", "CR", "INVESTIGATOR", NA, NA, "2014-06-04", 21L, - "RS", "CDISCPILOT01", "01-701-1130", 2L, "WEEK 3", "RECIST 1.1", "OVRLRESP", "Overall Response", "SD", "SD", "INVESTIGATOR", NA, NA, "2014-03-08", 12L, - "RS", "CDISCPILOT01", "01-701-1130", 3L, "WEEK 6", "RECIST 1.1", "OVRLRESP", "Overall Response", "PD", "PD", "INVESTIGATOR", NA, NA, "2014-03-29", 15L, - "RS", "CDISCPILOT01", "01-701-1130", 4L, "WEEK 9", "RECIST 1.1", "OVRLRESP", "Overall Response", "PD", "PD", "INVESTIGATOR", NA, NA, "2014-04-19", 18L, - "RS", "CDISCPILOT01", "01-701-1133", 2L, "WEEK 3", "RECIST 1.1", "OVRLRESP", "Overall Response", "PR", "PR", "INVESTIGATOR", NA, NA, "2012-11-18", 12L, - "RS", "CDISCPILOT01", "01-701-1133", 3L, "WEEK 6", "RECIST 1.1", "OVRLRESP", "Overall Response", "PR", "PR", "INVESTIGATOR", NA, NA, "2012-12-09", 15L, - "RS", "CDISCPILOT01", "01-701-1133", 4L, "WEEK 9", "RECIST 1.1", "OVRLRESP", "Overall Response", "PR", "PR", "INVESTIGATOR", NA, NA, "2012-12-30", 18L, - "RS", "CDISCPILOT01", "01-701-1015", 2L, "WEEK 3", "RECIST 1.1 - CA125", "OVRLRESP", "Overall Response", "Stable Disease", "SD", "INVESTIGATOR", NA, NA, "2014-01-23", 21L, - "RS", "CDISCPILOT01", "01-701-1015", 3L, "WEEK 6", "RECIST 1.1 - CA125", "OVRLRESP", "Overall Response", "Not Evaluable", "NE", "INVESTIGATOR", NA, NA, "2014-02", 24L, - "RS", "CDISCPILOT01", "01-701-1015", 4L, "WEEK 9", "RECIST 1.1 - CA125", "OVRLRESP", "Overall Response", "Partial Response", "PR", "INVESTIGATOR", NA, NA, "2014-03-06", 27L, - "RS", "CDISCPILOT01", "01-701-1028", 2L, "WEEK 3", "RECIST 1.1 - CA125", "OVRLRESP", "Overall Response", "Progressive Disease", "PD", "INVESTIGATOR", NA, NA, "2013-08-09", 21L, - "RS", "CDISCPILOT01", "01-701-1028", 3L, "WEEK 6", "RECIST 1.1 - CA125", "OVRLRESP", "Overall Response", "Progressive Disease", "PD", "INVESTIGATOR", NA, NA, "2013-08-30", 24L, - "RS", "CDISCPILOT01", "01-701-1028", 4L, "WEEK 9", "RECIST 1.1 - CA125", "OVRLRESP", "Overall Response", "Progressive Disease", "PD", "INVESTIGATOR", NA, NA, "2013-09-30", 27L, - "RS", "CDISCPILOT01", "01-701-1034", 2L, "WEEK 3", "RECIST 1.1 - CA125", "OVRLRESP", "Overall Response", "Complete Response", "CR", "INVESTIGATOR", NA, NA, "2014-07-22", 21L, - "RS", "CDISCPILOT01", "01-701-1034", 3L, "WEEK 6", "RECIST 1.1 - CA125", "OVRLRESP", "Overall Response", "Complete Response", "CR", "INVESTIGATOR", NA, NA, "2014-08-20", 24L, - "RS", "CDISCPILOT01", "01-701-1097", 2L, "WEEK 3", "RECIST 1.1 - CA125", "OVRLRESP", "Overall Response", "Stable Disease", "SD", "INVESTIGATOR", NA, NA, "2014-01-22", 21L, - "RS", "CDISCPILOT01", "01-701-1115", 2L, "WEEK 3", "RECIST 1.1 - CA125", "OVRLRESP", "Overall Response", "Partial Response", "PR", "INVESTIGATOR", NA, NA, "2012-12-21", 21L, - "RS", "CDISCPILOT01", "01-701-1115", 3L, "WEEK 6", "RECIST 1.1 - CA125", "OVRLRESP", "Overall Response", "Partial Response", "PR", "INVESTIGATOR", NA, NA, "2013-01-11", 24L, - "RS", "CDISCPILOT01", "01-701-1115", 4L, "WEEK 9", "RECIST 1.1 - CA125", "OVRLRESP", "Overall Response", "Complete Response", "CR", "INVESTIGATOR", NA, NA, "2013-02-01", 27L, - "RS", "CDISCPILOT01", "01-701-1118", 2L, "WEEK 3", "RECIST 1.1 - CA125", "OVRLRESP", "Overall Response", "Stable Disease", "SD", "INVESTIGATOR", NA, NA, "2014-04-02", 21L, - "RS", "CDISCPILOT01", "01-701-1118", 3L, "WEEK 6", "RECIST 1.1 - CA125", "OVRLRESP", "Overall Response", "Complete Response", "CR", "INVESTIGATOR", NA, NA, "2014-04-23", 24L, - "RS", "CDISCPILOT01", "01-701-1118", 4L, "WEEK 9", "RECIST 1.1 - CA125", "OVRLRESP", "Overall Response", "Not Evaluable", "NE", "INVESTIGATOR", NA, NA, "2014-05-14", 27L, - "RS", "CDISCPILOT01", "01-701-1118", 5L, "WEEK 12", "RECIST 1.1 - CA125", "OVRLRESP", "Overall Response", "Complete Response", "CR", "INVESTIGATOR", NA, NA, "2014-06-04", 30L, - "RS", "CDISCPILOT01", "01-701-1130", 2L, "WEEK 3", "RECIST 1.1 - CA125", "OVRLRESP", "Overall Response", "Stable Disease", "SD", "INVESTIGATOR", NA, NA, "2014-03-08", 21L, - "RS", "CDISCPILOT01", "01-701-1130", 3L, "WEEK 6", "RECIST 1.1 - CA125", "OVRLRESP", "Overall Response", "Progressive Disease", "PD", "INVESTIGATOR", NA, NA, "2014-03-29", 24L, - "RS", "CDISCPILOT01", "01-701-1130", 4L, "WEEK 9", "RECIST 1.1 - CA125", "OVRLRESP", "Overall Response", "Progressive Disease", "PD", "INVESTIGATOR", NA, NA, "2014-04-19", 27L, - "RS", "CDISCPILOT01", "01-701-1133", 2L, "WEEK 3", "RECIST 1.1 - CA125", "OVRLRESP", "Overall Response", "Partial Response", "PR", "INVESTIGATOR", NA, NA, "2012-11-18", 21L, - "RS", "CDISCPILOT01", "01-701-1133", 3L, "WEEK 6", "RECIST 1.1 - CA125", "OVRLRESP", "Overall Response", "Progressive Disease", "PD", "INVESTIGATOR", NA, NA, "2012-12-09", 24L, - "RS", "CDISCPILOT01", "01-701-1133", 4L, "WEEK 9", "RECIST 1.1 - CA125", "OVRLRESP", "Overall Response", "Progressive Disease", "PD", "INVESTIGATOR", NA, NA, "2012-12-30", 27L -) %>% +rs_onco_ca125 <-tibble::tribble( + ~USUBJID, ~RSSEQ, ~RSTESTCD, ~RSTEST, ~RSCAT, ~RSORRES, ~RSSTRESC, ~RSEVAL, ~VISITNUM, ~VISIT, ~RSDTC, + "01-701-1015", 3L, "OVRLRESP", "Overall Response", "CA125", "Non-Response/ Non-PD", "SD", "INVESTIGATOR", 2L, "WEEK 3", "2014-01-23", + "01-701-1015", 6L, "OVRLRESP", "Overall Response", "CA125", "Not Evaluable", "NE", "INVESTIGATOR", 3L, "WEEK 6", "2014-02", + "01-701-1015", 9L, "OVRLRESP", "Overall Response", "CA125", "Response But Not Within Normal Range", "PR", "INVESTIGATOR", 4L, "WEEK 9", "2014-03-06", + "01-701-1028", 3L, "OVRLRESP", "Overall Response", "CA125", "Progressive Disease", "PD", "INVESTIGATOR", 2L, "WEEK 3", "2013-08-09", + "01-701-1028", 6L, "OVRLRESP", "Overall Response", "CA125", "Progressive Disease", "PD", "INVESTIGATOR", 3L, "WEEK 6", "2013-08-30", + "01-701-1028", 9L, "OVRLRESP", "Overall Response", "CA125", "Progressive Disease", "PD", "INVESTIGATOR", 4L, "WEEK 9", "2013-09-30", + "01-701-1034", 3L, "OVRLRESP", "Overall Response", "CA125", "Response Within Normal Range", "CR", "INVESTIGATOR", 2L, "WEEK 3", "2014-07-22", + "01-701-1034", 6L, "OVRLRESP", "Overall Response", "CA125", "Response Within Normal Range", "CR", "INVESTIGATOR", 3L, "WEEK 6", "2014-08-20", + "01-701-1097", 3L, "OVRLRESP", "Overall Response", "CA125", "Non-Response/ Non-PD", "SD", "INVESTIGATOR", 2L, "WEEK 3", "2014-01-22", + "01-701-1115", 3L, "OVRLRESP", "Overall Response", "CA125", "Response But Not Within Normal Range", "PR", "INVESTIGATOR", 2L, "WEEK 3", "2012-12-21", + "01-701-1115", 6L, "OVRLRESP", "Overall Response", "CA125", "Response But Not Within Normal Range", "PR", "INVESTIGATOR", 3L, "WEEK 6", "2013-01-11", + "01-701-1115", 9L, "OVRLRESP", "Overall Response", "CA125", "Response Within Normal Range", "CR", "INVESTIGATOR", 4L, "WEEK 9", "2013-02-01", + "01-701-1118", 3L, "OVRLRESP", "Overall Response", "CA125", "Non-Response/ Non-PD", "SD", "INVESTIGATOR", 2L, "WEEK 3", "2014-04-02", + "01-701-1118", 6L, "OVRLRESP", "Overall Response", "CA125", "Response Within Normal Range", "CR", "INVESTIGATOR", 3L, "WEEK 6", "2014-04-23", + "01-701-1118", 9L, "OVRLRESP", "Overall Response", "CA125", "Not Evaluable", "NE", "INVESTIGATOR", 4L, "WEEK 9", "2014-05-14", + "01-701-1118", 12L, "OVRLRESP", "Overall Response", "CA125", "Response Within Normal Range", "CR", "INVESTIGATOR", 5L, "WEEK 12", "2014-06-04", + "01-701-1130", 3L, "OVRLRESP", "Overall Response", "CA125", "Non-Response/ Non-PD", "SD", "INVESTIGATOR", 2L, "WEEK 3", "2014-03-08", + "01-701-1130", 6L, "OVRLRESP", "Overall Response", "CA125", "Progressive Disease", "PD", "INVESTIGATOR", 3L, "WEEK 6", "2014-03-29", + "01-701-1130", 9L, "OVRLRESP", "Overall Response", "CA125", "Progressive Disease", "PD", "INVESTIGATOR", 4L, "WEEK 9", "2014-04-19", + "01-701-1133", 3L, "OVRLRESP", "Overall Response", "CA125", "Response But Not Within Normal Range", "PR", "INVESTIGATOR", 2L, "WEEK 3", "2012-11-18", + "01-701-1133", 6L, "OVRLRESP", "Overall Response", "CA125", "Progressive Disease", "PD", "INVESTIGATOR", 3L, "WEEK 6", "2012-12-09", + "01-701-1133", 9L, "OVRLRESP", "Overall Response", "CA125", "Progressive Disease", "PD", "INVESTIGATOR", 4L, "WEEK 9", "2012-12-30", + "01-701-1015", 12L, "OVRLRESP", "Overall Response", "RECIST 1.1", "SD", "SD", "INVESTIGATOR", 2L, "WEEK 3", "2014-01-23", + "01-701-1015", 15L, "OVRLRESP", "Overall Response", "RECIST 1.1", "NE", "NE", "INVESTIGATOR", 3L, "WEEK 6", "2014-02", + "01-701-1015", 18L, "OVRLRESP", "Overall Response", "RECIST 1.1", "PR", "PR", "INVESTIGATOR", 4L, "WEEK 9", "2014-03-06", + "01-701-1028", 12L, "OVRLRESP", "Overall Response", "RECIST 1.1", "PR", "PR", "INVESTIGATOR", 2L, "WEEK 3", "2013-08-09", + "01-701-1028", 15L, "OVRLRESP", "Overall Response", "RECIST 1.1", "PD", "PD", "INVESTIGATOR", 3L, "WEEK 6", "2013-08-30", + "01-701-1028", 18L, "OVRLRESP", "Overall Response", "RECIST 1.1", "PD", "PD", "INVESTIGATOR", 4L, "WEEK 9", "2013-09-30", + "01-701-1034", 12L, "OVRLRESP", "Overall Response", "RECIST 1.1", "CR", "CR", "INVESTIGATOR", 2L, "WEEK 3", "2014-07-22", + "01-701-1034", 15L, "OVRLRESP", "Overall Response", "RECIST 1.1", "CR", "CR", "INVESTIGATOR", 3L, "WEEK 6", "2014-08-20", + "01-701-1097", 12L, "OVRLRESP", "Overall Response", "RECIST 1.1", "SD", "SD", "INVESTIGATOR", 2L, "WEEK 3", "2014-01-22", + "01-701-1115", 12L, "OVRLRESP", "Overall Response", "RECIST 1.1", "SD", "SD", "INVESTIGATOR", 2L, "WEEK 3", "2012-12-21", + "01-701-1115", 15L, "OVRLRESP", "Overall Response", "RECIST 1.1", "PR", "PR", "INVESTIGATOR", 3L, "WEEK 6", "2013-01-11", + "01-701-1115", 18L, "OVRLRESP", "Overall Response", "RECIST 1.1", "CR", "CR", "INVESTIGATOR", 4L, "WEEK 9", "2013-02-01", + "01-701-1118", 12L, "OVRLRESP", "Overall Response", "RECIST 1.1", "SD", "SD", "INVESTIGATOR", 2L, "WEEK 3", "2014-04-02", + "01-701-1118", 15L, "OVRLRESP", "Overall Response", "RECIST 1.1", "CR", "CR", "INVESTIGATOR", 3L, "WEEK 6", "2014-04-23", + "01-701-1118", 18L, "OVRLRESP", "Overall Response", "RECIST 1.1", "NE", "NE", "INVESTIGATOR", 4L, "WEEK 9", "2014-05-14", + "01-701-1118", 21L, "OVRLRESP", "Overall Response", "RECIST 1.1", "CR", "CR", "INVESTIGATOR", 5L, "WEEK 12", "2014-06-04", + "01-701-1130", 12L, "OVRLRESP", "Overall Response", "RECIST 1.1", "SD", "SD", "INVESTIGATOR", 2L, "WEEK 3", "2014-03-08", + "01-701-1130", 15L, "OVRLRESP", "Overall Response", "RECIST 1.1", "PD", "PD", "INVESTIGATOR", 3L, "WEEK 6", "2014-03-29", + "01-701-1130", 18L, "OVRLRESP", "Overall Response", "RECIST 1.1", "PD", "PD", "INVESTIGATOR", 4L, "WEEK 9", "2014-04-19", + "01-701-1133", 12L, "OVRLRESP", "Overall Response", "RECIST 1.1", "PR", "PR", "INVESTIGATOR", 2L, "WEEK 3", "2012-11-18", + "01-701-1133", 15L, "OVRLRESP", "Overall Response", "RECIST 1.1", "PR", "PR", "INVESTIGATOR", 3L, "WEEK 6", "2012-12-09", + "01-701-1133", 18L, "OVRLRESP", "Overall Response", "RECIST 1.1", "PR", "PR", "INVESTIGATOR", 4L, "WEEK 9", "2012-12-30", + "01-701-1015", 21L, "OVRLRESP", "Overall Response", "RECIST 1.1 - CA125", "Stable Disease", "SD", "INVESTIGATOR", 2L, "WEEK 3", "2014-01-23", + "01-701-1015", 24L, "OVRLRESP", "Overall Response", "RECIST 1.1 - CA125", "Not Evaluable", "NE", "INVESTIGATOR", 3L, "WEEK 6", "2014-02", + "01-701-1015", 27L, "OVRLRESP", "Overall Response", "RECIST 1.1 - CA125", "Partial Response", "PR", "INVESTIGATOR", 4L, "WEEK 9", "2014-03-06", + "01-701-1028", 21L, "OVRLRESP", "Overall Response", "RECIST 1.1 - CA125", "Progressive Disease", "PD", "INVESTIGATOR", 2L, "WEEK 3", "2013-08-09", + "01-701-1028", 24L, "OVRLRESP", "Overall Response", "RECIST 1.1 - CA125", "Progressive Disease", "PD", "INVESTIGATOR", 3L, "WEEK 6", "2013-08-30", + "01-701-1028", 27L, "OVRLRESP", "Overall Response", "RECIST 1.1 - CA125", "Progressive Disease", "PD", "INVESTIGATOR", 4L, "WEEK 9", "2013-09-30", + "01-701-1034", 21L, "OVRLRESP", "Overall Response", "RECIST 1.1 - CA125", "Complete Response", "CR", "INVESTIGATOR", 2L, "WEEK 3", "2014-07-22", + "01-701-1034", 24L, "OVRLRESP", "Overall Response", "RECIST 1.1 - CA125", "Complete Response", "CR", "INVESTIGATOR", 3L, "WEEK 6", "2014-08-20", + "01-701-1097", 21L, "OVRLRESP", "Overall Response", "RECIST 1.1 - CA125", "Stable Disease", "SD", "INVESTIGATOR", 2L, "WEEK 3", "2014-01-22", + "01-701-1115", 21L, "OVRLRESP", "Overall Response", "RECIST 1.1 - CA125", "Partial Response", "PR", "INVESTIGATOR", 2L, "WEEK 3", "2012-12-21", + "01-701-1115", 24L, "OVRLRESP", "Overall Response", "RECIST 1.1 - CA125", "Partial Response", "PR", "INVESTIGATOR", 3L, "WEEK 6", "2013-01-11", + "01-701-1115", 27L, "OVRLRESP", "Overall Response", "RECIST 1.1 - CA125", "Complete Response", "CR", "INVESTIGATOR", 4L, "WEEK 9", "2013-02-01", + "01-701-1118", 21L, "OVRLRESP", "Overall Response", "RECIST 1.1 - CA125", "Stable Disease", "SD", "INVESTIGATOR", 2L, "WEEK 3", "2014-04-02", + "01-701-1118", 24L, "OVRLRESP", "Overall Response", "RECIST 1.1 - CA125", "Complete Response", "CR", "INVESTIGATOR", 3L, "WEEK 6", "2014-04-23", + "01-701-1118", 27L, "OVRLRESP", "Overall Response", "RECIST 1.1 - CA125", "Not Evaluable", "NE", "INVESTIGATOR", 4L, "WEEK 9", "2014-05-14", + "01-701-1118", 30L, "OVRLRESP", "Overall Response", "RECIST 1.1 - CA125", "Complete Response", "CR", "INVESTIGATOR", 5L, "WEEK 12", "2014-06-04", + "01-701-1130", 21L, "OVRLRESP", "Overall Response", "RECIST 1.1 - CA125", "Stable Disease", "SD", "INVESTIGATOR", 2L, "WEEK 3", "2014-03-08", + "01-701-1130", 24L, "OVRLRESP", "Overall Response", "RECIST 1.1 - CA125", "Progressive Disease", "PD", "INVESTIGATOR", 3L, "WEEK 6", "2014-03-29", + "01-701-1130", 27L, "OVRLRESP", "Overall Response", "RECIST 1.1 - CA125", "Progressive Disease", "PD", "INVESTIGATOR", 4L, "WEEK 9", "2014-04-19", + "01-701-1133", 21L, "OVRLRESP", "Overall Response", "RECIST 1.1 - CA125", "Partial Response", "PR", "INVESTIGATOR", 2L, "WEEK 3", "2012-11-18", + "01-701-1133", 24L, "OVRLRESP", "Overall Response", "RECIST 1.1 - CA125", "Progressive Disease", "PD", "INVESTIGATOR", 3L, "WEEK 6", "2012-12-09", + "01-701-1133", 27L, "OVRLRESP", "Overall Response", "RECIST 1.1 - CA125", "Progressive Disease", "PD", "INVESTIGATOR", 4L, "WEEK 9", "2012-12-30" + ) %>% mutate( STUDYID = "CDISCPILOT01", DOMAIN = "RS", @@ -92,70 +92,70 @@ usethis::use_data(rs_onco_ca125, overwrite = TRUE) # Create supprs_onco_imwg ---- supprs_onco_ca125 <- tibble::tribble( - ~STUDYID, ~RDOMAIN, ~USUBJID, ~IDVAR, ~IDVARVAL, ~QNAM, ~QLABEL, ~QVAL, - "CDISCPILOT01", "RS", "01-701-1133", "RSSEQ", 3L, "CA125EFL", "CA-125 response evaluable", "Y", - "CDISCPILOT01", "RS", "01-701-1133", "RSSEQ", 6L, "CA125EFL", "CA-125 response evaluable", "Y", - "CDISCPILOT01", "RS", "01-701-1133", "RSSEQ", 9L, "CA125EFL", "CA-125 response evaluable", "Y", - "CDISCPILOT01", "RS", "01-701-1133", "RSSEQ", 3L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", - "CDISCPILOT01", "RS", "01-701-1133", "RSSEQ", 6L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", - "CDISCPILOT01", "RS", "01-701-1133", "RSSEQ", 9L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", - "CDISCPILOT01", "RS", "01-701-1133", "RSSEQ", 6L, "CANORM2X", "CA125 normal, lab increased >=2x ULRR", "Y", - "CDISCPILOT01", "RS", "01-701-1133", "RSSEQ", 9L, "CANORM2X", "CA125 normal, lab increased >=2x ULRR", "Y", - "CDISCPILOT01", "RS", "01-701-1130", "RSSEQ", 3L, "CA125EFL", "CA-125 response evaluable", "Y", - "CDISCPILOT01", "RS", "01-701-1130", "RSSEQ", 6L, "CA125EFL", "CA-125 response evaluable", "Y", - "CDISCPILOT01", "RS", "01-701-1130", "RSSEQ", 9L, "CA125EFL", "CA-125 response evaluable", "Y", - "CDISCPILOT01", "RS", "01-701-1130", "RSSEQ", 3L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", - "CDISCPILOT01", "RS", "01-701-1130", "RSSEQ", 6L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", - "CDISCPILOT01", "RS", "01-701-1130", "RSSEQ", 9L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", - "CDISCPILOT01", "RS", "01-701-1130", "RSSEQ", 6L, "CNOTNORM", "CA125 not norm, lab increased >=2x nadir", "Y", - "CDISCPILOT01", "RS", "01-701-1130", "RSSEQ", 9L, "CNOTNORM", "CA125 not norm, lab increased >=2x nadir", "Y", - "CDISCPILOT01", "RS", "01-701-1028", "RSSEQ", 3L, "CA125EFL", "CA-125 response evaluable", "N", - "CDISCPILOT01", "RS", "01-701-1028", "RSSEQ", 6L, "CA125EFL", "CA-125 response evaluable", "N", - "CDISCPILOT01", "RS", "01-701-1028", "RSSEQ", 9L, "CA125EFL", "CA-125 response evaluable", "N", - "CDISCPILOT01", "RS", "01-701-1028", "RSSEQ", 3L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "N", - "CDISCPILOT01", "RS", "01-701-1028", "RSSEQ", 6L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "N", - "CDISCPILOT01", "RS", "01-701-1028", "RSSEQ", 9L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "N", - "CDISCPILOT01", "RS", "01-701-1028", "RSSEQ", 3L, "CANORM2X", "CA125 normal, lab increased >=2x ULRR", "Y", - "CDISCPILOT01", "RS", "01-701-1028", "RSSEQ", 6L, "CANORM2X", "CA125 normal, lab increased >=2x ULRR", "Y", - "CDISCPILOT01", "RS", "01-701-1028", "RSSEQ", 9L, "CANORM2X", "CA125 normal, lab increased >=2x ULRR", "Y", - "CDISCPILOT01", "RS", "01-701-1034", "RSSEQ", 3L, "CA125EFL", "CA-125 response evaluable", "Y", - "CDISCPILOT01", "RS", "01-701-1034", "RSSEQ", 6L, "CA125EFL", "CA-125 response evaluable", "Y", - "CDISCPILOT01", "RS", "01-701-1034", "RSSEQ", 3L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", - "CDISCPILOT01", "RS", "01-701-1034", "RSSEQ", 6L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", - "CDISCPILOT01", "RS", "01-701-1034", "RSSEQ", 3L, "CA50RED", ">50% reduction from baseline", "Y", - "CDISCPILOT01", "RS", "01-701-1034", "RSSEQ", 6L, "CA50RED", ">50% reduction from baseline", "Y", - "CDISCPILOT01", "RS", "01-701-1097", "RSSEQ", 3L, "CA125EFL", "CA-125 response evaluable", "Y", - "CDISCPILOT01", "RS", "01-701-1097", "RSSEQ", 3L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", - "CDISCPILOT01", "RS", "01-701-1015", "RSSEQ", 3L, "CA125EFL", "CA-125 response evaluable", "Y", - "CDISCPILOT01", "RS", "01-701-1015", "RSSEQ", 6L, "CA125EFL", "CA-125 response evaluable", "Y", - "CDISCPILOT01", "RS", "01-701-1015", "RSSEQ", 9L, "CA125EFL", "CA-125 response evaluable", "Y", - "CDISCPILOT01", "RS", "01-701-1015", "RSSEQ", 3L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", - "CDISCPILOT01", "RS", "01-701-1015", "RSSEQ", 6L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", - "CDISCPILOT01", "RS", "01-701-1015", "RSSEQ", 9L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", - "CDISCPILOT01", "RS", "01-701-1015", "RSSEQ", 9L, "CA50RED", ">50% reduction from baseline", "Y", - "CDISCPILOT01", "RS", "01-701-1015", "RSSEQ", 6L, "MOUSEANT", "Received mouse antibodies", "Y", - "CDISCPILOT01", "RS", "01-701-1015", "RSSEQ", 24L, "MOUSEANT", "Received mouse antibodies", "Y", - "CDISCPILOT01", "RS", "01-701-1115", "RSSEQ", 3L, "CA125EFL", "CA-125 response evaluable", "Y", - "CDISCPILOT01", "RS", "01-701-1115", "RSSEQ", 6L, "CA125EFL", "CA-125 response evaluable", "Y", - "CDISCPILOT01", "RS", "01-701-1115", "RSSEQ", 9L, "CA125EFL", "CA-125 response evaluable", "Y", - "CDISCPILOT01", "RS", "01-701-1115", "RSSEQ", 3L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", - "CDISCPILOT01", "RS", "01-701-1115", "RSSEQ", 6L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", - "CDISCPILOT01", "RS", "01-701-1115", "RSSEQ", 9L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", - "CDISCPILOT01", "RS", "01-701-1115", "RSSEQ", 3L, "CA50RED", ">50% reduction from baseline", "Y", - "CDISCPILOT01", "RS", "01-701-1115", "RSSEQ", 6L, "CA50RED", ">50% reduction from baseline", "Y", - "CDISCPILOT01", "RS", "01-701-1115", "RSSEQ", 9L, "CA50RED", ">50% reduction from baseline", "Y", - "CDISCPILOT01", "RS", "01-701-1118", "RSSEQ", 3L, "CA125EFL", "CA-125 response evaluable", "Y", - "CDISCPILOT01", "RS", "01-701-1118", "RSSEQ", 6L, "CA125EFL", "CA-125 response evaluable", "Y", - "CDISCPILOT01", "RS", "01-701-1118", "RSSEQ", 9L, "CA125EFL", "CA-125 response evaluable", "Y", - "CDISCPILOT01", "RS", "01-701-1118", "RSSEQ", 12L, "CA125EFL", "CA-125 response evaluable", "Y", - "CDISCPILOT01", "RS", "01-701-1118", "RSSEQ", 3L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", - "CDISCPILOT01", "RS", "01-701-1118", "RSSEQ", 6L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", - "CDISCPILOT01", "RS", "01-701-1118", "RSSEQ", 9L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", - "CDISCPILOT01", "RS", "01-701-1118", "RSSEQ", 12L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", - "CDISCPILOT01", "RS", "01-701-1118", "RSSEQ", 3L, "CA50RED", ">50% reduction from baseline", "Y", - "CDISCPILOT01", "RS", "01-701-1118", "RSSEQ", 9L, "CA50RED", ">50% reduction from baseline", "Y", - "CDISCPILOT01", "RS", "01-701-1118", "RSSEQ", 12L, "CA50RED", ">50% reduction from baseline", "Y" - ) %>% + ~USUBJID, ~IDVARVAL, ~QNAM, ~QLABEL, ~QVAL, + "01-701-1133", 3L, "CA125EFL", "CA-125 response evaluable", "Y", + "01-701-1133", 6L, "CA125EFL", "CA-125 response evaluable", "Y", + "01-701-1133", 9L, "CA125EFL", "CA-125 response evaluable", "Y", + "01-701-1133", 3L, "CAELEPRE", "Elevated pre-treatment CA-125", "Y", + "01-701-1133", 6L, "CAELEPRE", "Elevated pre-treatment CA-125", "Y", + "01-701-1133", 9L, "CAELEPRE", "Elevated pre-treatment CA-125", "Y", + "01-701-1133", 6L, "CANORM2X", "CA125 normal, lab increased >=2x ULRR", "Y", + "01-701-1133", 9L, "CANORM2X", "CA125 normal, lab increased >=2x ULRR", "Y", + "01-701-1130", 3L, "CA125EFL", "CA-125 response evaluable", "Y", + "01-701-1130", 6L, "CA125EFL", "CA-125 response evaluable", "Y", + "01-701-1130", 9L, "CA125EFL", "CA-125 response evaluable", "Y", + "01-701-1130", 3L, "CAELEPRE", "Elevated pre-treatment CA-125", "Y", + "01-701-1130", 6L, "CAELEPRE", "Elevated pre-treatment CA-125", "Y", + "01-701-1130", 9L, "CAELEPRE", "Elevated pre-treatment CA-125", "Y", + "01-701-1130", 6L, "CNOTNORM", "CA125 not norm, lab increased >=2x nadir", "Y", + "01-701-1130", 9L, "CNOTNORM", "CA125 not norm, lab increased >=2x nadir", "Y", + "01-701-1028", 3L, "CA125EFL", "CA-125 response evaluable", "N", + "01-701-1028", 6L, "CA125EFL", "CA-125 response evaluable", "N", + "01-701-1028", 9L, "CA125EFL", "CA-125 response evaluable", "N", + "01-701-1028", 3L, "CAELEPRE", "Elevated pre-treatment CA-125", "N", + "01-701-1028", 6L, "CAELEPRE", "Elevated pre-treatment CA-125", "N", + "01-701-1028", 9L, "CAELEPRE", "Elevated pre-treatment CA-125", "N", + "01-701-1028", 3L, "CANORM2X", "CA125 normal, lab increased >=2x ULRR", "Y", + "01-701-1028", 6L, "CANORM2X", "CA125 normal, lab increased >=2x ULRR", "Y", + "01-701-1028", 9L, "CANORM2X", "CA125 normal, lab increased >=2x ULRR", "Y", + "01-701-1034", 3L, "CA125EFL", "CA-125 response evaluable", "Y", + "01-701-1034", 6L, "CA125EFL", "CA-125 response evaluable", "Y", + "01-701-1034", 3L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", + "01-701-1034", 6L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", + "01-701-1034", 3L, "CA50RED", ">=50% reduction from baseline", "Y", + "01-701-1034", 6L, "CA50RED", ">=50% reduction from baseline", "Y", + "01-701-1097", 3L, "CA125EFL", "CA-125 response evaluable", "Y", + "01-701-1097", 3L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", + "01-701-1015", 3L, "CA125EFL", "CA-125 response evaluable", "Y", + "01-701-1015", 6L, "CA125EFL", "CA-125 response evaluable", "Y", + "01-701-1015", 9L, "CA125EFL", "CA-125 response evaluable", "Y", + "01-701-1015", 3L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", + "01-701-1015", 6L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", + "01-701-1015", 9L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", + "01-701-1015", 9L, "CA50RED", ">=50% reduction from baseline", "Y", + "01-701-1015", 6L, "MOUSEANT", "Received mouse antibodies", "Y", + "01-701-1015", 24L, "MOUSEANT", "Received mouse antibodies", "Y", + "01-701-1115", 3L, "CA125EFL", "CA-125 response evaluable", "Y", + "01-701-1115", 6L, "CA125EFL", "CA-125 response evaluable", "Y", + "01-701-1115", 9L, "CA125EFL", "CA-125 response evaluable", "Y", + "01-701-1115", 3L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", + "01-701-1115", 6L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", + "01-701-1115", 9L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", + "01-701-1115", 3L, "CA50RED", ">=50% reduction from baseline", "Y", + "01-701-1115", 6L, "CA50RED", ">=50% reduction from baseline", "Y", + "01-701-1115", 9L, "CA50RED", ">=50% reduction from baseline", "Y", + "01-701-1118", 3L, "CA125EFL", "CA-125 response evaluable", "Y", + "01-701-1118", 6L, "CA125EFL", "CA-125 response evaluable", "Y", + "01-701-1118", 9L, "CA125EFL", "CA-125 response evaluable", "Y", + "01-701-1118", 12L, "CA125EFL", "CA-125 response evaluable", "Y", + "01-701-1118", 3L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", + "01-701-1118", 6L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", + "01-701-1118", 9L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", + "01-701-1118", 12L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", + "01-701-1118", 3L, "CA50RED", ">=50% reduction from baseline", "Y", + "01-701-1118", 9L, "CA50RED", ">=50% reduction from baseline", "Y", + "01-701-1118", 12L, "CA50RED", ">=50% reduction from baseline", "Y" + ) %>% mutate( STUDYID = "CDISCPILOT01", RDOMAIN = "RS", diff --git a/data/rs_onco_ca125.rda b/data/rs_onco_ca125.rda index 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z%KG$F?j(eqIc)tYiw@`RS~ZJsNJv5K8WKyTFjoFft{^(O5aCKnA!w3|ungR&ti#4+ z=BK*aGAT$FNg&2TF~T+yN=o^>qM&)e0Am1QRI!0pCL}V?DkPfuEKvi7Dn9gftV3P? zA{kEvAf|tEI_t|?np&QzGmj)>r*1gM9N6tDx{6^{wNAdy@YNmlS2C-iRlt^r*p)h! zS(Dkgwdjni6fmZM-i%c5Z{H{*bIIE0RzWS*%J`xM>0^_?}kIC`|kg*%q0 zOUNnlKFf|_qgBXY!l|MVsHTxhA*z=A zVi=9L6{5r_g{Efw<0`uH+9~7Cg>WGSH&D#BUMWiqMahRAy!M8O$xZs3?k*;%(;T}L za!UDP=ARezwIz!hFw$x1J29iM~$jL}(*pRCzRHC-5$gOx$So?6ABXt$4 zvhie*%0z^oOqAPfSa5e08_{kF2?#K1Ni7T4V%OEk2UfH=($dIONoC>#Cn_s2`Em17 z-|dQvXcUBGNeLoFD=z2MDhJj807w83RT%(QBt!~UiU^6LT@*mwg-7%$t#i+zM&oJ_ zDU0%l;ds{pe8g!**n||~Lm(Lw8KhPHK}ag)6z|{21|&6#x`ke`R{)KW#v-RMt4JqZ z!#G-jNEE07v>{WiDilJfeF<=Ovlj;f3*Aru~DFd;!pz@D=ht9r;m zEFpltx=`AOiGO4f^X2b4ET6$sH+~UK!kc&#QO*i;p$YUAV7uNb`Gs5c!bCX5Uri)p zkwO|pHPR~5D%dG4oS$2zv{li>MJ|OM?OoI@6>@=k1LPHED%)>pn5&#s>K%brqOMBQzd?)uFC1MWo+TR? zaB1T@6Z@qFK42D?_&@%=yFcoI;3?W$^h)m(-EqQgUC3eXsHbAwgy0~jfzffzhzw{| z4L4^n7DD!EjbvCb4B$DG9x{uZsvIW`kiCIZG$D9XIHwJ1;SkV!t}t0*7DA?1gD}LG zJ@krnS0o@)aSPUqMJk}cR)iN@P2d$FK%|uiGVM)HCn2OV{riN53DcUK-Da*!&_9>SNXDHxB@qf99BmOSr Lig2MIS1}QMiOOaq From d09fc4650c036c1c3698b33a90d2df910d3c4bb4 Mon Sep 17 00:00:00 2001 From: Vinh Nguyen Date: Fri, 20 Dec 2024 10:06:53 -0500 Subject: [PATCH 6/6] #123 - Removed CA2XULRR from the supprs --- data-raw/rs_supprs_onco_ca125.R | 13 ------------- data/ca125_rs.rda | Bin 0 -> 8974 bytes data/supprs_onco_ca125.rda | Bin 852 -> 812 bytes 3 files changed, 13 deletions(-) create mode 100644 data/ca125_rs.rda diff --git a/data-raw/rs_supprs_onco_ca125.R b/data-raw/rs_supprs_onco_ca125.R index 8dffa908..152a938c 100644 --- a/data-raw/rs_supprs_onco_ca125.R +++ b/data-raw/rs_supprs_onco_ca125.R @@ -120,27 +120,18 @@ supprs_onco_ca125 <- tibble::tribble( "01-701-1028", 9L, "CANORM2X", "CA125 normal, lab increased >=2x ULRR", "Y", "01-701-1034", 3L, "CA125EFL", "CA-125 response evaluable", "Y", "01-701-1034", 6L, "CA125EFL", "CA-125 response evaluable", "Y", - "01-701-1034", 3L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", - "01-701-1034", 6L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", "01-701-1034", 3L, "CA50RED", ">=50% reduction from baseline", "Y", "01-701-1034", 6L, "CA50RED", ">=50% reduction from baseline", "Y", "01-701-1097", 3L, "CA125EFL", "CA-125 response evaluable", "Y", - "01-701-1097", 3L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", "01-701-1015", 3L, "CA125EFL", "CA-125 response evaluable", "Y", "01-701-1015", 6L, "CA125EFL", "CA-125 response evaluable", "Y", "01-701-1015", 9L, "CA125EFL", "CA-125 response evaluable", "Y", - "01-701-1015", 3L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", - "01-701-1015", 6L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", - "01-701-1015", 9L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", "01-701-1015", 9L, "CA50RED", ">=50% reduction from baseline", "Y", "01-701-1015", 6L, "MOUSEANT", "Received mouse antibodies", "Y", "01-701-1015", 24L, "MOUSEANT", "Received mouse antibodies", "Y", "01-701-1115", 3L, "CA125EFL", "CA-125 response evaluable", "Y", "01-701-1115", 6L, "CA125EFL", "CA-125 response evaluable", "Y", "01-701-1115", 9L, "CA125EFL", "CA-125 response evaluable", "Y", - "01-701-1115", 3L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", - "01-701-1115", 6L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", - "01-701-1115", 9L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", "01-701-1115", 3L, "CA50RED", ">=50% reduction from baseline", "Y", "01-701-1115", 6L, "CA50RED", ">=50% reduction from baseline", "Y", "01-701-1115", 9L, "CA50RED", ">=50% reduction from baseline", "Y", @@ -148,10 +139,6 @@ supprs_onco_ca125 <- tibble::tribble( "01-701-1118", 6L, "CA125EFL", "CA-125 response evaluable", "Y", "01-701-1118", 9L, "CA125EFL", "CA-125 response evaluable", "Y", "01-701-1118", 12L, "CA125EFL", "CA-125 response evaluable", "Y", - "01-701-1118", 3L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", - "01-701-1118", 6L, "CA2XULRR", "CA-125 pre-treatment 2x ULRR", "Y", - 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