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Improve full-repertoire reconstruction on large samples #165

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psathyrella opened this issue Feb 14, 2016 · 2 comments
Open

Improve full-repertoire reconstruction on large samples #165

psathyrella opened this issue Feb 14, 2016 · 2 comments
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@psathyrella
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Most notably, by seeing about varying naive hfrac and logprob thresholds with sample size.

@matsen matsen self-assigned this Mar 17, 2016
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matsen commented Mar 17, 2016

This the issue that has been much debated concerning "false positive" control under multiple testing.

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matsen commented Mar 25, 2016

Here's an idea, if we want to be quite conservative: calculate probability of near collision using the inferred parameters. Then somehow adjust our level of clustering to target a given false-positive rate.

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