diff --git a/.pre-commit-config.yaml b/.pre-commit-config.yaml
index a8c7696df62..80c5c578743 100644
--- a/.pre-commit-config.yaml
+++ b/.pre-commit-config.yaml
@@ -1,9 +1,9 @@
 repos:
-  - repo: https://github.com/asottile/pyupgrade
-    rev: v3.13.0
+  - repo: https://github.com/astral-sh/ruff-pre-commit
+    rev: v0.1.3
     hooks:
-      - id: pyupgrade
-        args: [--py38-plus]
+      - id: ruff
+        args: [--fix, --exit-non-zero-on-fix]
 
   - repo: https://github.com/psf/black-pre-commit-mirror
     rev: 23.9.1
@@ -11,11 +11,6 @@ repos:
       - id: black
         args: [--target-version=py38]
 
-  - repo: https://github.com/PyCQA/isort
-    rev: 5.12.0
-    hooks:
-      - id: isort
-
   - repo: https://github.com/PyCQA/bandit
     rev: 1.7.5
     hooks:
@@ -23,28 +18,15 @@ repos:
       args: [--severity-level=high]
       files: ^src/
 
-  - repo: https://github.com/asottile/yesqa
-    rev: v1.5.0
-    hooks:
-      - id: yesqa
-
   - repo: https://github.com/Lucas-C/pre-commit-hooks
     rev: v1.5.4
     hooks:
       - id: remove-tabs
         exclude: (Makefile$|\.bat$|\.cmake$|\.eps$|\.fits$|\.gd$|\.opt$)
 
-  - repo: https://github.com/PyCQA/flake8
-    rev: 6.1.0
-    hooks:
-      - id: flake8
-        additional_dependencies:
-          [flake8-2020, flake8-errmsg, flake8-implicit-str-concat, flake8-logging]
-
   - repo: https://github.com/pre-commit/pygrep-hooks
     rev: v1.10.0
     hooks:
-      - id: python-check-blanket-noqa
       - id: rst-backticks
 
   - repo: https://github.com/pre-commit/pre-commit-hooks
diff --git a/MANIFEST.in b/MANIFEST.in
index 9401ebbbf37..af25dfd2db5 100644
--- a/MANIFEST.in
+++ b/MANIFEST.in
@@ -5,6 +5,7 @@ include *.md
 include *.py
 include *.rst
 include *.sh
+include *.toml
 include *.txt
 include *.yaml
 include .flake8
diff --git a/Makefile b/Makefile
index 57d756b47e3..b7f07e24d07 100644
--- a/Makefile
+++ b/Makefile
@@ -49,7 +49,7 @@ help:
 	@echo "  install            make and install"
 	@echo "  install-coverage   make and install with C coverage"
 	@echo "  lint               run the lint checks"
-	@echo "  lint-fix           run Black and isort to (mostly) fix lint issues"
+	@echo "  lint-fix           run Ruff to (mostly) fix lint issues"
 	@echo "  release-test       run code and package tests before release"
 	@echo "  test               run tests on installed Pillow"
 
@@ -118,6 +118,6 @@ lint:
 .PHONY: lint-fix
 lint-fix:
 	python3 -c "import black" > /dev/null 2>&1 || python3 -m pip install black
-	python3 -c "import isort" > /dev/null 2>&1 || python3 -m pip install isort
 	python3 -m black --target-version py38 .
-	python3 -m isort .
+	python3 -c "import ruff" > /dev/null 2>&1 || python3 -m pip install ruff
+	python3 -m ruff --fix .
diff --git a/pyproject.toml b/pyproject.toml
index 6f6ed6e9336..59d8da44e4c 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -77,8 +77,34 @@ package-dir = {"" = "src"}
 [tool.setuptools.dynamic]
 version = {attr = "PIL.__version__"}
 
-[tool.isort]
-profile = "black"
+[tool.ruff]
+target-version = "py38"
+line-length = 88
+select = [
+  "E", # pycodestyle errors
+  "EM", # flake8-errmsg
+  "F", # pyflakes errors
+  "I", # isort
+  "ISC", # flake8-implicit-str-concat
+  "PGH", # pygrep-hooks
+  "RUF100", # unused noqa (yesqa)
+  "UP", # pyupgrade
+  "W", # pycodestyle warnings
+  "YTT", # flake8-2020
+  # "LOG", # TODO: enable flake8-logging when it's not in preview anymore
+]
+extend-ignore = [
+  "E203", # Whitespace before ':'
+  "E221", # Multiple spaces before operator
+  "E226", # Missing whitespace around arithmetic operator
+  "E241", # Multiple spaces after ','
+]
+
+[tool.ruff.per-file-ignores]
+"Tests/*.py" = ["I001"]
+
+[tool.ruff.isort]
+known-first-party = ["PIL"]
 
 [tool.pytest.ini_options]
 addopts = "-ra --color=yes"