diff --git a/docs/installation.rst b/docs/installation.rst
index 2aac08699d5..f1fec6dfbd1 100644
--- a/docs/installation.rst
+++ b/docs/installation.rst
@@ -156,7 +156,7 @@ Many of Pillow's features require external libraries:
 
 * **libtiff** provides compressed TIFF functionality
 
-  * Pillow has been tested with libtiff versions **3.x** and **4.0-4.5.1**
+  * Pillow has been tested with libtiff versions **3.x** and **4.0-4.6.0**
 
 * **libfreetype** provides type related services
 
diff --git a/wheels/config.sh b/wheels/config.sh
index b6f89bf72e2..2943b0c4b88 100644
--- a/wheels/config.sh
+++ b/wheels/config.sh
@@ -10,7 +10,7 @@ LIBPNG_VERSION=1.6.40
 JPEGTURBO_VERSION=3.0.0
 OPENJPEG_VERSION=2.5.0
 XZ_VERSION=5.4.4
-TIFF_VERSION=4.5.1
+TIFF_VERSION=4.6.0
 LCMS2_VERSION=2.15
 if [[ -n "$IS_MACOS" ]]; then
     GIFLIB_VERSION=5.1.4
diff --git a/winbuild/build_prepare.py b/winbuild/build_prepare.py
index 357c684d03f..4f745465ca7 100644
--- a/winbuild/build_prepare.py
+++ b/winbuild/build_prepare.py
@@ -184,9 +184,9 @@ def cmd_msbuild(
         "libs": [r"output\release-static\{architecture}\lib\*.lib"],
     },
     "libtiff": {
-        "url": "https://download.osgeo.org/libtiff/tiff-4.5.1.tar.gz",
-        "filename": "tiff-4.5.1.tar.gz",
-        "dir": "tiff-4.5.1",
+        "url": "https://download.osgeo.org/libtiff/tiff-4.6.0.tar.gz",
+        "filename": "tiff-4.6.0.tar.gz",
+        "dir": "tiff-4.6.0",
         "license": "LICENSE.md",
         "patch": {
             r"libtiff\tif_lzma.c": {