diff --git a/Tests/images/bgr15.dds b/Tests/images/bgr15.dds
new file mode 100644
index 00000000000..ba3bbddcae4
Binary files /dev/null and b/Tests/images/bgr15.dds differ
diff --git a/Tests/images/bgr15.png b/Tests/images/bgr15.png
new file mode 100644
index 00000000000..a15ab5ad256
Binary files /dev/null and b/Tests/images/bgr15.png differ
diff --git a/Tests/test_file_dds.py b/Tests/test_file_dds.py
index bb9af7967b7..7772956aff8 100644
--- a/Tests/test_file_dds.py
+++ b/Tests/test_file_dds.py
@@ -26,6 +26,7 @@
 TEST_FILE_UNCOMPRESSED_L = "Tests/images/uncompressed_l.dds"
 TEST_FILE_UNCOMPRESSED_L_WITH_ALPHA = "Tests/images/uncompressed_la.dds"
 TEST_FILE_UNCOMPRESSED_RGB = "Tests/images/hopper.dds"
+TEST_FILE_UNCOMPRESSED_BGR15 = "Tests/images/bgr15.dds"
 TEST_FILE_UNCOMPRESSED_RGB_WITH_ALPHA = "Tests/images/uncompressed_rgb.dds"
 
 
@@ -211,6 +212,7 @@ def test_unimplemented_dxgi_format():
         ("L", (128, 128), TEST_FILE_UNCOMPRESSED_L),
         ("LA", (128, 128), TEST_FILE_UNCOMPRESSED_L_WITH_ALPHA),
         ("RGB", (128, 128), TEST_FILE_UNCOMPRESSED_RGB),
+        ("RGB", (128, 128), TEST_FILE_UNCOMPRESSED_BGR15),
         ("RGBA", (800, 600), TEST_FILE_UNCOMPRESSED_RGB_WITH_ALPHA),
     ],
 )
diff --git a/src/PIL/DdsImagePlugin.py b/src/PIL/DdsImagePlugin.py
index 54f358c7f9a..af3d883baa2 100644
--- a/src/PIL/DdsImagePlugin.py
+++ b/src/PIL/DdsImagePlugin.py
@@ -137,7 +137,6 @@ def _open(self):
         pfsize, pfflags = struct.unpack("<2I", header.read(8))
         fourcc = header.read(4)
         (bitcount,) = struct.unpack("<I", header.read(4))
-        masks = struct.unpack("<4I", header.read(16))
         if pfflags & DDPF_LUMINANCE:
             # Texture contains uncompressed L or LA data
             if pfflags & DDPF_ALPHAPIXELS:
@@ -148,15 +147,38 @@ def _open(self):
             self.tile = [("raw", (0, 0) + self.size, 0, (self.mode, 0, 1))]
         elif pfflags & DDPF_RGB:
             # Texture contains uncompressed RGB data
-            masks = {mask: ["R", "G", "B", "A"][i] for i, mask in enumerate(masks)}
-            rawmode = ""
-            if pfflags & DDPF_ALPHAPIXELS:
-                rawmode += masks[0xFF000000]
-            else:
+            if not pfflags & DDPF_ALPHAPIXELS:
                 self._mode = "RGB"
-            rawmode += masks[0xFF0000] + masks[0xFF00] + masks[0xFF]
 
-            self.tile = [("raw", (0, 0) + self.size, 0, (rawmode[::-1], 0, 1))]
+            # Each channel is derived using a mask of the pixel values
+            masks = {
+                mask: "RGB"[i]
+                for i, mask in enumerate(struct.unpack("<3I", header.read(12)))
+            }
+            if self.mode == "RGB" and all(
+                mask in (0b0000000000011111, 0b0000001111100000, 0b0111110000000000)
+                for mask in masks
+            ):
+                # Each mask uses 5 bits
+                rawmode = (
+                    masks[0b0000000000011111]
+                    + masks[0b0000001111100000]
+                    + masks[0b0111110000000000]
+                    + ";15"
+                )
+            else:
+                # Try 8 bits for each mask
+                if self.mode == "RGBA":
+                    # The fourth mask, alpha,
+                    # is only valid when the correct flags are present
+                    a_mask = struct.unpack("<I", header.read(4))[0]
+                    masks[a_mask] = "A"
+
+                rawmode = masks[0xFF] + masks[0xFF00] + masks[0xFF0000]
+                if 0xFF000000 in masks:
+                    rawmode += masks[0xFF000000]
+
+            self.tile = [("raw", (0, 0) + self.size, 0, (rawmode, 0, 1))]
         elif pfflags & DDPF_PALETTEINDEXED8:
             self._mode = "P"
             self.palette = ImagePalette.raw("RGBA", self.fp.read(1024))