diff --git a/vcpkg/ports/py-pyqt6/portfile.cmake b/vcpkg/ports/py-pyqt6/portfile.cmake
new file mode 100644
index 0000000000000..dd4e2a34e5cb0
--- /dev/null
+++ b/vcpkg/ports/py-pyqt6/portfile.cmake
@@ -0,0 +1,66 @@
+set(VCPKG_POLICY_EMPTY_INCLUDE_FOLDER enabled)
+set(VCPKG_BUILD_TYPE release)
+
+vcpkg_download_distfile(
+    ARCHIVE
+    URLS            https://riverbankcomputing.com/pypi/packages/PyQt6/PyQt6-6.8.0.dev2411221125.tar.gz
+    FILENAME        pyqt6.tar.gz
+    SHA512          f52fe48969a8b86651f6a3bf6156a91c57e42e4192bd184dfe6b7ac8a4728509b4610c2da8fb88039ff2880b02c6dbb455d1ed12fb65b7cd65ddb8ca7fb6a476
+)
+
+vcpkg_extract_source_archive_ex(
+  OUT_SOURCE_PATH SOURCE_PATH
+  ARCHIVE ${ARCHIVE}
+)
+
+# https://www.riverbankcomputing.com/static/Docs/PyQt6/installation.html
+set(SIPBUILD_ARGS
+  "--confirm-license"
+  "--qmake" "${CURRENT_INSTALLED_DIR}/tools/Qt6/bin/qmake${VCPKG_HOST_EXECUTABLE_SUFFIX}"
+  "--api-dir" "${CURRENT_PACKAGES_DIR}/share/Qt6/qsci/api/python"
+  "--verbose"
+  "--qt-shared"
+  "--no-make"
+  "--disable" "QtDesigner"
+  "--pep484-pyi"
+  "--build-dir" "${CURRENT_BUILDTREES_DIR}/${TARGET_TRIPLET}-rel"
+  "--target-dir" "${PYTHON3_SITEPACKAGES}"
+)
+
+if(VCPKG_TARGET_IS_OSX)
+    if(DEFINED VCPKG_OSX_DEPLOYMENT_TARGET)
+        vcpkg_list(APPEND SIPBUILD_ARGS "--qmake-setting" "QMAKE_MACOSX_DEPLOYMENT_TARGET=${VCPKG_OSX_DEPLOYMENT_TARGET}")
+    else()
+        # https://doc.qt.io/qt-6/macos.html
+        vcpkg_list(APPEND SIPBUILD_ARGS "--qmake-setting" "QMAKE_MACOSX_DEPLOYMENT_TARGET=10.15")
+    endif()
+    vcpkg_list(APPEND SIPBUILD_ARGS "--no-dbus-python")
+endif()
+
+
+vcpkg_backup_env_variables(VARS PATH)
+
+vcpkg_add_to_path(PREPEND "${CURRENT_HOST_INSTALLED_DIR}/tools/python3/Scripts/" "${CURRENT_HOST_INSTALLED_DIR}/tools/Qt6/bin/" "${CURRENT_HOST_INSTALLED_DIR}/bin")
+
+message(STATUS "Running sipbuild...")
+vcpkg_execute_required_process(
+    COMMAND "${PYTHON3}" "-m" "sipbuild.tools.build" ${SIPBUILD_ARGS}
+    WORKING_DIRECTORY "${SOURCE_PATH}"
+    LOGNAME "sipbuild-${TARGET_TRIPLET}"
+)
+message(STATUS "Running sipbuild...finished.")
+
+# inventory.txt is consumed by the distinfo tool which is run during make and should be run against the package directory
+file(TO_NATIVE_PATH "${CURRENT_INSTALLED_DIR}" NATIVE_INSTALLED_DIR)
+vcpkg_replace_string("${CURRENT_BUILDTREES_DIR}/${TARGET_TRIPLET}-rel/inventory.txt"
+            "${CURRENT_INSTALLED_DIR}"
+            "${CURRENT_PACKAGES_DIR}")
+            vcpkg_replace_string("${CURRENT_BUILDTREES_DIR}/${TARGET_TRIPLET}-rel/inventory.txt"
+            "${NATIVE_INSTALLED_DIR}"
+            "${CURRENT_PACKAGES_DIR}")
+
+vcpkg_qmake_build(BUILD_LOGNAME "install" TARGETS "install")
+
+vcpkg_restore_env_variables(VARS PATH)
+
+vcpkg_python_test_import(MODULE "PyQt6.QtCore")
diff --git a/vcpkg/ports/py-pyqt6/vcpkg.json b/vcpkg/ports/py-pyqt6/vcpkg.json
new file mode 100644
index 0000000000000..d74a6b9bdd00f
--- /dev/null
+++ b/vcpkg/ports/py-pyqt6/vcpkg.json
@@ -0,0 +1,31 @@
+{
+  "name": "py-pyqt6",
+  "version": "6.8.0",
+  "description": "Python bindings for the Qt cross platform application toolkit",
+  "homepage": "https://www.riverbankcomputing.com/software/pyqt/",
+  "dependencies": [
+    "py-packaging",
+    "py-ply",
+    "py-pyqt-builder",
+    "py-pyqt6-sip",
+    "python3",
+    {
+      "name": "qtactiveqt",
+      "platform": "windows"
+    },
+    "qtbase",
+    "qtmultimedia",
+    "qtsensors",
+    "qtsvg",
+    "qtwebchannel",
+    "qtwebsockets",
+    {
+      "name": "vcpkg-python-scripts",
+      "host": true
+    },
+    {
+      "name": "vcpkg-qmake",
+      "host": true
+    }
+  ]
+}