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afrendeiro committed Nov 16, 2024
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2024-11-16:
title: "Our manuscript on the prediction of biological age from histopathological insights is now online!"
description: |
<p>
Our study reveals focuses on the structural changes human tissues undergo during aging and how they reflect its physiological state.
By analyzing over 25,000 histopathological images across various tissues from nearly 1,000 individuals, we developed "tissue clocks" that can estimate biological age based on tissue morphological characteristics.
We found that aging manifests differently in various organs, some showing accelerated changes early in life - and conversely, some individuals show markedly more accceleated aging than others, sometimes in a organ-specific manner.
</p>
<p>
By analyzing over 25,000 histopathological images across various tissues from nearly 1,000 individuals, we developed 'tissue clocks' that can estimate biological age based on tissue morphological characteristics.
We found that aging manifests differently in various organs, some showing accelerated changes early in life. Conversely, some individuals show markedly more accceleated aging than others, sometimes in a organ-specific manner.
Leveraging these tissue-specific and highly physiological readouts of aging, we demonstrate how we can derive the a proxy for tissue-specific, morphologically driven biological age from blood samples and validate them in diseased samples.
This study highlights the intricate relationship between tissue health, biological aging and could revolutionize the way we assess and understand the biological processes leading to aging-related diseases.
</p>
<p>This study highlights the intricate relationship between tissue health and biological aging, and could revolutionize the way we assess and understand the biological processes leading to aging-related diseases.</p>
<p><a href='https://doi.org/10.1101/2024.11.16.48333'>Read the full work here: https://doi.org/10.1101/2024.11.14.618081</a></p>
img: 2024-11-16-Tissue-clocks.jpg
2024-11-13:
title: "Ernesto presented a poster at the 2024 Frontiers in Single Cell Genomics, Awaji, Japan"
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