Our study reveals focuses on the structural changes human tissues undergo during aging and how they reflect its physiological state. - By analyzing over 25,000 histopathological images across various tissues from nearly 1,000 individuals, we developed "tissue clocks" that can estimate biological age based on tissue morphological characteristics. - We found that aging manifests differently in various organs, some showing accelerated changes early in life - and conversely, some individuals show markedly more accceleated aging than others, sometimes in a organ-specific manner. +
++ By analyzing over 25,000 histopathological images across various tissues from nearly 1,000 individuals, we developed 'tissue clocks' that can estimate biological age based on tissue morphological characteristics. + We found that aging manifests differently in various organs, some showing accelerated changes early in life. Conversely, some individuals show markedly more accceleated aging than others, sometimes in a organ-specific manner. Leveraging these tissue-specific and highly physiological readouts of aging, we demonstrate how we can derive the a proxy for tissue-specific, morphologically driven biological age from blood samples and validate them in diseased samples. - This study highlights the intricate relationship between tissue health, biological aging and could revolutionize the way we assess and understand the biological processes leading to aging-related diseases. +
+This study highlights the intricate relationship between tissue health and biological aging, and could revolutionize the way we assess and understand the biological processes leading to aging-related diseases.
+Read the full work here: https://doi.org/10.1101/2024.11.14.618081
img: 2024-11-16-Tissue-clocks.jpg 2024-11-13: title: "Ernesto presented a poster at the 2024 Frontiers in Single Cell Genomics, Awaji, Japan"