From 29c8ddb8139b742148b0fe364a9f987ec1a16039 Mon Sep 17 00:00:00 2001 From: "Andre F. Rendeiro" Date: Sat, 16 Nov 2024 09:08:10 +0100 Subject: [PATCH] update --- content.yaml | 11 ++++++++--- 1 file changed, 8 insertions(+), 3 deletions(-) diff --git a/content.yaml b/content.yaml index d44101a..cda94ec 100644 --- a/content.yaml +++ b/content.yaml @@ -27,11 +27,16 @@ news: 2024-11-16: title: "Our manuscript on the prediction of biological age from histopathological insights is now online!" description: | +

Our study reveals focuses on the structural changes human tissues undergo during aging and how they reflect its physiological state. - By analyzing over 25,000 histopathological images across various tissues from nearly 1,000 individuals, we developed "tissue clocks" that can estimate biological age based on tissue morphological characteristics. - We found that aging manifests differently in various organs, some showing accelerated changes early in life - and conversely, some individuals show markedly more accceleated aging than others, sometimes in a organ-specific manner. +

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+ By analyzing over 25,000 histopathological images across various tissues from nearly 1,000 individuals, we developed 'tissue clocks' that can estimate biological age based on tissue morphological characteristics. + We found that aging manifests differently in various organs, some showing accelerated changes early in life. Conversely, some individuals show markedly more accceleated aging than others, sometimes in a organ-specific manner. Leveraging these tissue-specific and highly physiological readouts of aging, we demonstrate how we can derive the a proxy for tissue-specific, morphologically driven biological age from blood samples and validate them in diseased samples. - This study highlights the intricate relationship between tissue health, biological aging and could revolutionize the way we assess and understand the biological processes leading to aging-related diseases. +

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This study highlights the intricate relationship between tissue health and biological aging, and could revolutionize the way we assess and understand the biological processes leading to aging-related diseases.

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Read the full work here: https://doi.org/10.1101/2024.11.14.618081

img: 2024-11-16-Tissue-clocks.jpg 2024-11-13: title: "Ernesto presented a poster at the 2024 Frontiers in Single Cell Genomics, Awaji, Japan"