diff --git a/ornaseq.obo b/ornaseq.obo index 5c9178f..58197b3 100644 --- a/ornaseq.obo +++ b/ornaseq.obo @@ -1,8 +1,5 @@ format-version: 1.2 -data-version: releases/2018-06-04 remark: The following ontology is provided by Stephen A Fisher and Junhyong Kim to annotate next-generation sequencing experiments performed on RNA. -import: http://purl.obolibrary.org/obo/ornaseq/properties_import.owl -import: http://purl.obolibrary.org/obo/ornaseq/terms_import.owl ontology: ornaseq property_value: http://purl.org/dc/elements/1.1/contributor "Junhyong Kim" xsd:string property_value: http://purl.org/dc/elements/1.1/contributor "Stephen A Fisher" xsd:string @@ -11,564 +8,1287 @@ property_value: http://purl.org/dc/elements/1.1/title "Ontology for RNA sequenci owl-axioms: Prefix(owl:=)\nPrefix(rdf:=)\nPrefix(xml:=)\nPrefix(xsd:=)\nPrefix(rdfs:=)\n\n\nOntology(\nDeclaration(Class())\nDeclaration(Class())\n############################\n# Classes\n############################\n\n# Class: (entity)\n\nSubClassOf( owl:Thing)\n\n# Class: (Conceptual Entity)\n\nSubClassOf( owl:Thing)\n\n\n) [Term] -id: BFO:0000002 ! continuant +id: BFO:0000001 +name: entity +property_value: IAO:0000116 "BFO 2 Reference: In all areas of empirical inquiry we encounter general terms of two sorts. First are general terms which refer to universals or types:animaltuberculosissurgical procedurediseaseSecond, are general terms used to refer to groups of entities which instantiate a given universal but do not correspond to the extension of any subuniversal of that universal because there is nothing intrinsic to the entities in question by virtue of which they – and only they – are counted as belonging to the given group. Examples are: animal purchased by the Emperortuberculosis diagnosed on a Wednesdaysurgical procedure performed on a patient from Stockholmperson identified as candidate for clinical trial #2056-555person who is signatory of Form 656-PPVpainting by Leonardo da VinciSuch terms, which represent what are called ‘specializations’ in [81" xsd:string +property_value: IAO:0000116 "Entity doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example Werner Ceusters 'portions of reality' include 4 sorts, entities (as BFO construes them), universals, configurations, and relations. It is an open question as to whether entities as construed in BFO will at some point also include these other portions of reality. See, for example, 'How to track absolutely everything' at http://www.referent-tracking.com/_RTU/papers/CeustersICbookRevised.pdf" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/bfo.owl + +[Term] +id: BFO:0000002 +name: continuant is_a: BFO:0000001 ! entity +property_value: IAO:0000116 "BFO 2 Reference: Continuant entities are entities which can be sliced to yield parts only along the spatial dimension, yielding for example the parts of your table which we call its legs, its top, its nails. ‘My desk stretches from the window to the door. It has spatial parts, and can be sliced (in space) in two. With respect to time, however, a thing is a continuant.’ [60, p. 240" xsd:string +property_value: IAO:0000116 "Continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example, in an expansion involving bringing in some of Ceuster's other portions of reality, questions are raised as to whether universals are continuants" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/bfo.owl [Term] -id: BFO:0000003 ! occurrent +id: BFO:0000003 +name: occurrent is_a: BFO:0000001 ! entity +property_value: IAO:0000116 "BFO 2 Reference: every occurrent that is not a temporal or spatiotemporal region is s-dependent on some independent continuant that is not a spatial region" xsd:string +property_value: IAO:0000116 "BFO 2 Reference: s-dependence obtains between every process and its participants in the sense that, as a matter of necessity, this process could not have existed unless these or those participants existed also. A process may have a succession of participants at different phases of its unfolding. Thus there may be different players on the field at different times during the course of a football game; but the process which is the entire game s-depends_on all of these players nonetheless. Some temporal parts of this process will s-depend_on on only some of the players." xsd:string +property_value: IAO:0000116 "Occurrent doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the sum of a process and the process boundary of another process." xsd:string +property_value: IAO:0000116 "Simons uses different terminology for relations of occurrents to regions: Denote the spatio-temporal location of a given occurrent e by 'spn[e]' and call this region its span. We may say an occurrent is at its span, in any larger region, and covers any smaller region. Now suppose we have fixed a frame of reference so that we can speak not merely of spatio-temporal but also of spatial regions (places) and temporal regions (times). The spread of an occurrent, (relative to a frame of reference) is the space it exactly occupies, and its spell is likewise the time it exactly occupies. We write 'spr[e]' and `spl[e]' respectively for the spread and spell of e, omitting mention of the frame." xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/bfo.owl [Term] -id: BFO:0000004 ! independent continuant +id: BFO:0000004 +name: independent continuant +def: "b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])" [] is_a: BFO:0000002 ! continuant +property_value: IAO:0000412 http://purl.obolibrary.org/obo/bfo.owl [Term] -id: BFO:0000015 ! process +id: BFO:0000015 +name: process +def: "p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003])" [] is_a: BFO:0000003 ! occurrent +property_value: IAO:0000116 "BFO 2 Reference: The realm of occurrents is less pervasively marked by the presence of natural units than is the case in the realm of independent continuants. Thus there is here no counterpart of ‘object’. In BFO 1.0 ‘process’ served as such a counterpart. In BFO 2.0 ‘process’ is, rather, the occurrent counterpart of ‘material entity’. Those natural – as contrasted with engineered, which here means: deliberately executed – units which do exist in the realm of occurrents are typically either parasitic on the existence of natural units on the continuant side, or they are fiat in nature. Thus we can count lives; we can count football games; we can count chemical reactions performed in experiments or in chemical manufacturing. We cannot count the processes taking place, for instance, in an episode of insect mating behavior.Even where natural units are identifiable, for example cycles in a cyclical process such as the beating of a heart or an organism’s sleep/wake cycle, the processes in question form a sequence with no discontinuities (temporal gaps) of the sort that we find for instance where billiard balls or zebrafish or planets are separated by clear spatial gaps. Lives of organisms are process units, but they too unfold in a continuous series from other, prior processes such as fertilization, and they unfold in turn in continuous series of post-life processes such as post-mortem decay. Clear examples of boundaries of processes are almost always of the fiat sort (midnight, a time of death as declared in an operating theater or on a death certificate, the initiation of a state of war)" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/bfo.owl [Term] -id: BFO:0000017 ! realizable entity +id: BFO:0000017 +name: realizable entity is_a: BFO:0000020 ! specifically dependent continuant +property_value: IAO:0000412 http://purl.obolibrary.org/obo/bfo.owl [Term] -id: BFO:0000020 ! specifically dependent continuant +id: BFO:0000020 +name: specifically dependent continuant +def: "b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])" [] is_a: BFO:0000002 ! continuant +property_value: IAO:0000116 "Specifically dependent continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. We're not sure what else will develop here, but for example there are questions such as what are promises, obligation, etc." xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/bfo.owl [Term] -id: BFO:0000023 ! role +id: BFO:0000023 +name: role is_a: BFO:0000017 ! realizable entity +property_value: IAO:0000116 "BFO 2 Reference: One major family of examples of non-rigid universals involves roles, and ontologies developed for corresponding administrative purposes may consist entirely of representatives of entities of this sort. Thus ‘professor’, defined as follows,b instance_of professor at t =Def. there is some c, c instance_of professor role & c inheres_in b at t.denotes a non-rigid universal and so also do ‘nurse’, ‘student’, ‘colonel’, ‘taxpayer’, and so forth. (These terms are all, in the jargon of philosophy, phase sortals.) By using role terms in definitions, we can create a BFO conformant treatment of such entities drawing on the fact that, while an instance of professor may be simultaneously an instance of trade union member, no instance of the type professor role is also (at any time) an instance of the type trade union member role (any more than any instance of the type color is at any time an instance of the type length).If an ontology of employment positions should be defined in terms of roles following the above pattern, this enables the ontology to do justice to the fact that individuals instantiate the corresponding universals – professor, sergeant, nurse – only during certain phases in their lives." xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/bfo.owl [Term] -id: BFO:0000031 ! generically dependent continuant +id: BFO:0000031 +name: generically dependent continuant +def: "b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001])" [] is_a: BFO:0000002 ! continuant +property_value: IAO:0000412 http://purl.obolibrary.org/obo/bfo.owl [Term] -id: BFO:0000040 ! material entity +id: BFO:0000040 +name: material entity is_a: BFO:0000004 ! independent continuant +property_value: IAO:0000116 "BFO 2 Reference: Material entities (continuants) can preserve their identity even while gaining and losing material parts. Continuants are contrasted with occurrents, which unfold themselves in successive temporal parts or phases [60" xsd:string +property_value: IAO:0000116 "BFO 2 Reference: Object, Fiat Object Part and Object Aggregate are not intended to be exhaustive of Material Entity. Users are invited to propose new subcategories of Material Entity." xsd:string +property_value: IAO:0000116 "BFO 2 Reference: ‘Matter’ is intended to encompass both mass and energy (we will address the ontological treatment of portions of energy in a later version of BFO). A portion of matter is anything that includes elementary particles among its proper or improper parts: quarks and leptons, including electrons, as the smallest particles thus far discovered; baryons (including protons and neutrons) at a higher level of granularity; atoms and molecules at still higher levels, forming the cells, organs, organisms and other material entities studied by biologists, the portions of rock studied by geologists, the fossils studied by paleontologists, and so on.Material entities are three-dimensional entities (entities extended in three spatial dimensions), as contrasted with the processes in which they participate, which are four-dimensional entities (entities extended also along the dimension of time).According to the FMA, material entities may have immaterial entities as parts – including the entities identified below as sites; for example the interior (or ‘lumen’) of your small intestine is a part of your body. BFO 2.0 embodies a decision to follow the FMA here." xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/bfo.owl [Term] -id: CHEBI:16991 ! deoxyribonucleic acid +id: CHEBI:16991 +name: deoxyribonucleic acid +def: "High molecular weight, linear polymers, composed of nucleotides containing deoxyribose and linked by phosphodiester bonds; DNA contain the genetic information of organisms." [] is_a: CHEBI:23367 ! molecular entity +property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] -id: CHEBI:23367 ! molecular entity +id: CHEBI:23367 +name: molecular entity +def: "Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity." [] is_a: BFO:0000040 ! material entity +property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] -id: CL:0000000 ! cell +id: CL:0000000 +name: cell +def: "A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane." [] is_a: BFO:0000040 ! material entity +property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl.owl [Term] -id: CL:0000127 ! astrocyte +id: CL:0000127 +name: astrocyte +def: "A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from 'star' cells) are irregularly shaped with many long processes, including those with 'end feet' which form the glial (limiting) membrane and directly and indirectly contribute to the blood-brain barrier. They regulate the extracellular ionic and chemical environment, and 'reactive astrocytes' (along with microglia) respond to injury." [] is_a: CL:0000000 ! cell +property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl.owl [Term] -id: CL:0000449 ! brown fat cell +id: CL:0000449 +name: brown fat cell +def: "A cell from the thermogenic form of adipose tissue found in many species, particularly in newborns and hibernating mammals, but also in lesser amounts in adults of other mammals including humans. Brown fat is capable of rapid liberation of energy and seems to be important in the maintenance of body temperature immediately after birth and upon waking from hibernation." [] is_a: CL:0000000 ! cell +property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl.owl [Term] -id: CL:0000540 ! neuron +id: CL:0000540 +name: neuron +def: "The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [] is_a: CL:0000000 ! cell +property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl.owl [Term] -id: CL:0000746 ! cardiac muscle cell +id: CL:0000746 +name: cardiac muscle cell +def: "Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei." [] is_a: CL:0000000 ! cell +property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl.owl [Term] -id: CL:2000029 ! central nervous system neuron +id: CL:2000029 +name: central nervous system neuron +def: "Any neuron that is part of a central nervous system." [] is_a: CL:0000540 ! neuron +property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl.owl [Term] id: EFO:0000683 +name: replicate +def: "A role played by a a biological sample in the context of an experiment where the intent is that biological or technical variation is measured." [] is_a: BFO:0000023 ! role +property_value: IAO:0000117 "James Malone" xsd:string +property_value: IAO:0000412 http://www.ebi.ac.uk/efo/efo.owl [Term] id: EFO:0004155 +name: FASTQ format +def: "FASTQ format is a text-based format for storing both a biological sequence (usually nucleotide sequence) and its corresponding quality scores." [] is_a: IAO:0000098 ! data format specification +property_value: IAO:0000412 http://www.ebi.ac.uk/efo/efo.owl [Term] id: EFO:0004157 +name: BAM format +def: "BAM is the compressed binary version of the Sequence Alignment/Map (SAM) format" [] is_a: IAO:0000098 ! data format specification +property_value: IAO:0000412 http://www.ebi.ac.uk/efo/efo.owl [Term] id: EFO:0004420 +name: genome +def: "A genome is the full genetic content of an organism, contained in either DNA or RNA (such as for viruses)." [] is_a: BFO:0000040 ! material entity +property_value: IAO:0000117 "James Malone" xsd:string +property_value: IAO:0000412 http://www.ebi.ac.uk/efo/efo.owl [Term] id: EFO:0004421 +name: transcriptome +def: "The transcriptome is the set of all RNA molecules, including mRNA, rRNA, tRNA, and other non-coding RNA produced in one or a population of cells." [] is_a: BFO:0000040 ! material entity +property_value: IAO:0000412 http://www.ebi.ac.uk/efo/efo.owl [Term] id: EFO:0005630 +name: CEL data file format +def: "CEL data file format describes the format used in a CEL file for storing the results of the intensity calculations on the pixel values of a DAT file. This includes an intensity value, standard deviation of the intensity, the number of pixels used to calculate the intensity value, a flag to indicate an outlier as calculated by the algorithm and a user defined flag indicating the feature should be excluded from future analysis. The file stores the previously stated data for each feature on the probe array." [] is_a: IAO:0000098 ! data format specification +property_value: IAO:0000117 "James Malone" xsd:string +property_value: IAO:0000412 http://www.ebi.ac.uk/efo/efo.owl [Term] -id: GENEPIO:0000069 ! sequencing run date +id: GENEPIO:0000069 +name: sequencing run date +def: "date the sequencing run was performed" [] is_a: IAO:0000027 ! data item +property_value: IAO:0000119 "GROUP: IRIDA Ontology (Emma)" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/genepio.owl [Term] -id: GENEPIO:0000081 ! sequencing kit +id: GENEPIO:0000081 +name: sequencing kit +def: "Pre-filled, ready-to-use reagent cartridges. Used to produce improved chemistry, cluster density and read length as well as improve quality (Q) scores. Reagent components are encoded to interact with the sequencing system to validate compatibility with user-defined applications." [] is_a: OBI:0000047 ! processed material +property_value: IAO:0000119 "GROUP: IRIDA Ontology (Emma)" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/genepio.owl [Term] -id: GENEPIO:0000085 ! library preparation kit +id: GENEPIO:0000085 +name: library preparation kit +def: "Packaged kits (containing adapters, indexes, enzymes, buffers etc), tailored for specific sequencing workflows, which allow the simplified preparation of sequencing-ready libraries for small genomes, amplicons, and plasmids." [] is_a: OBI:0000047 ! processed material +property_value: IAO:0000119 "GROUP: IRIDA Ontology (Emma) and http://applications.illumina.com/applications/sequencing/ngs-library-prep.html" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/genepio.owl [Term] -id: GENEPIO:0001170 ! organism datum +id: GENEPIO:0001170 +name: organism datum is_a: IAO:0000109 ! measurement datum +property_value: IAO:0000412 http://purl.obolibrary.org/obo/genepio.owl [Term] -id: GO:0005575 ! cellular_component +id: GO:0005575 +name: cellular_component +def: "A location, relative to cellular compartments and structures, occupied by a macromolecular machine when it carries out a molecular function. There are two ways in which the gene ontology describes locations of gene products: (1) relative to cellular structures (e.g., cytoplasmic side of plasma membrane) or compartments (e.g., mitochondrion), and (2) the stable macromolecular complexes of which they are parts (e.g., the ribosome)." [] is_a: BFO:0000040 ! material entity +property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] -id: GO:0005739 ! mitochondrion +id: GO:0005739 +name: mitochondrion +def: "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [] is_a: GO:0044464 ! cell part +property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] -id: GO:0030425 ! dendrite +id: GO:0030425 +name: dendrite +def: "A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [] is_a: GO:0044464 ! cell part +property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] -id: GO:0044297 ! cell body +id: GO:0044297 +name: cell body +def: "The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections." [] is_a: GO:0044464 ! cell part +property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] -id: GO:0044464 ! cell part +id: GO:0044464 +name: cell part +def: "Any constituent part of a cell, the basic structural and functional unit of all organisms." [] is_a: GO:0005575 ! cellular_component +property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] -id: IAO:0000010 ! software +id: IAO:0000010 +name: software +def: "Software is a plan specification composed of a series of instructions that can be \ninterpreted by or directly executed by a processing unit." [] is_a: IAO:0000104 ! plan specification - -[Term] -id: IAO:0000017 ! model number +property_value: IAO:0000116 "see sourceforge tracker discussion at http://sourceforge.net/tracker/index.php?func=detail&aid=1958818&group_id=177891&atid=886178" xsd:string +property_value: IAO:0000117 "PERSON: Alan Ruttenberg" xsd:string +property_value: IAO:0000117 "PERSON: Bjoern Peters" xsd:string +property_value: IAO:0000117 "PERSON: Chris Stoeckert" xsd:string +property_value: IAO:0000117 "PERSON: Melanie Courtot" xsd:string +property_value: IAO:0000119 "GROUP: OBI" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/iao.owl +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl + +[Term] +id: IAO:0000017 +name: model number +def: "A model number is an information content entity specifically borne by catalogs, design specifications, advertising materials, inventory systems and similar that is about manufactured objects of the same class. The model number is an alternative term for the class. The manufactered objects may or may not also bear the model number. Model numbers can be encoded in a variety of other information objects, such as bar codes, numerals, or patterns of dots." [] is_a: IAO:0000028 ! symbol +property_value: IAO:0000116 "manufactered items may have more than one model number, sometimes by rebranding, or because companies are sold and the products issued new model numbers" xsd:string +property_value: IAO:0000117 "Person: Alan Ruttenberg" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/iao.owl [Term] -id: IAO:0000027 ! data item +id: IAO:0000027 +name: data item +def: "a data item is an information content entity that is intended to be a truthful statement about something (modulo, e.g., measurement precision or other systematic errors) and is constructed/acquired by a method which reliably tends to produce (approximately) truthful statements." [] is_a: IAO:0000030 ! information content entity - -[Term] -id: IAO:0000028 ! symbol +property_value: IAO:0000116 "2/2/2009 Alan and Bjoern discussing FACS run output data. This is a data item because it is about the cell population. Each element records an event and is typically further composed a set of measurment data items that record the fluorescent intensity stimulated by one of the lasers." xsd:string +property_value: IAO:0000116 "2009-03-16: data item deliberatly ambiguous: we merged data set and datum to be one entity, not knowing how to define singular versus plural. So data item is more general than datum." xsd:string +property_value: IAO:0000116 "2009-03-16: removed datum as alternative term as datum specifically refers to singular form, and is thus not an exact synonym." xsd:string +property_value: IAO:0000116 "2014-03-31: See discussion at http://odontomachus.wordpress.com/2014/03/30/aboutness-objects-propositions/" xsd:string +property_value: IAO:0000116 "JAR: datum -- well, this will be very tricky to define, but maybe some \ninformation-like stuff that might be put into a computer and that is \nmeant, by someone, to denote and/or to be interpreted by some \nprocess... I would include lists, tables, sentences... I think I might \ndefer to Barry, or to Brian Cantwell Smith\n\nJAR: A data item is an approximately justified approximately true approximate belief" xsd:string +property_value: IAO:0000117 "PERSON: Alan Ruttenberg" xsd:string +property_value: IAO:0000117 "PERSON: Chris Stoeckert" xsd:string +property_value: IAO:0000117 "PERSON: Jonathan Rees" xsd:string +property_value: IAO:0000118 "data" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/iao.owl + +[Term] +id: IAO:0000028 +name: symbol +def: "An information content entity that is a mark(s) or character(s) used as a conventional representation of another entity." [] is_a: IAO:0000030 ! information content entity +property_value: IAO:0000116 "20091104, MC: this needs work and will most probably change" xsd:string +property_value: IAO:0000116 "2014-03-31: We would like to have a deeper analysis of 'mark' and 'sign' in the future (see https://github.com/information-artifact-ontology/IAO/issues/154)." xsd:string +property_value: IAO:0000117 "PERSON: James A. Overton" xsd:string +property_value: IAO:0000117 "PERSON: Jonathan Rees" xsd:string +property_value: IAO:0000119 "based on Oxford English Dictionary" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/iao.owl [Term] -id: IAO:0000030 ! information content entity +id: IAO:0000030 +name: information content entity +def: "A generically dependent continuant that is about some thing." [] is_a: BFO:0000031 ! generically dependent continuant +property_value: IAO:0000116 "2014-03-10: The use of \"thing\" is intended to be general enough to include universals and configurations (see https://groups.google.com/d/msg/information-ontology/GBxvYZCk1oc/-L6B5fSBBTQJ)." xsd:string +property_value: IAO:0000116 "information_content_entity 'is_encoded_in' some digital_entity in obi before split (040907). information_content_entity 'is_encoded_in' some physical_document in obi before split (040907).\n\nPrevious. An information content entity is a non-realizable information entity that 'is encoded in' some digital or physical entity." xsd:string +property_value: IAO:0000117 "PERSON: Chris Stoeckert" xsd:string +property_value: IAO:0000119 "OBI_0000142" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/iao.owl +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: IAO:0000032 ! scalar measurement datum +id: IAO:0000032 +name: scalar measurement datum +def: "a scalar measurement datum is a measurement datum that is composed of two parts, numerals and a unit label." [] is_a: IAO:0000109 ! measurement datum +property_value: IAO:0000116 "2009-03-16: we decided to keep datum singular in scalar measurement datum, as in\nthis case we explicitly refer to the singular form" xsd:string +property_value: IAO:0000116 "Would write this as: has_part some 'measurement unit label' and has_part some numeral and has_part exactly 2, except for the fact that this won't let us take advantage of OWL reasoning over the numbers. Instead use has measurment value property to represent the same. Use has measurement unit label (subproperty of has_part) so we can easily say that there is only one of them." xsd:string +property_value: IAO:0000117 "PERSON: Alan Ruttenberg" xsd:string +property_value: IAO:0000117 "PERSON: Melanie Courtot" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/iao.owl [Term] -id: IAO:0000033 ! directive information entity +id: IAO:0000033 +name: directive information entity +def: "An information content entity whose concretizations indicate to their bearer how to realize them in a process." [] is_a: IAO:0000027 ! data item - -[Term] -id: IAO:0000064 ! algorithm +property_value: IAO:0000116 "2009-03-16: provenance: a term realizable information entity was proposed for OBI (OBI_0000337) , edited by the PlanAndPlannedProcess branch. Original definition was \"is the specification of a process that can be concretized and realized by an actor\" with alternative term \"instruction\".It has been subsequently moved to IAO where the objective for which the original term was defined was satisfied with the definitionof this, different, term." xsd:string +property_value: IAO:0000116 "2013-05-30 Alan Ruttenberg: What differentiates a directive information entity from an information concretization is that it can have concretizations that are either qualities or realizable entities. The concretizations that are realizable entities are created when an individual chooses to take up the direction, i.e. has the intention to (try to) realize it." xsd:string +property_value: IAO:0000116 "8/6/2009 Alan Ruttenberg: Changed label from \"information entity about a realizable\" after discussions at ICBO" xsd:string +property_value: IAO:0000116 "Werner pushed back on calling it realizable information entity as it isn't realizable. However this name isn't right either. An example would be a recipe. The realizable entity would be a plan, but the information entity isn't about the plan, it, once concretized, *is* the plan. -Alan" xsd:string +property_value: IAO:0000117 "PERSON: Alan Ruttenberg" xsd:string +property_value: IAO:0000117 "PERSON: Bjoern Peters" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/iao.owl + +[Term] +id: IAO:0000064 +name: algorithm +def: "A plan specification which describes the inputs and output of mathematical functions as well as workflow of execution for achieving an predefined objective. Algorithms are realized usually by means of implementation as computer programs for execution by automata." [] is_a: IAO:0000104 ! plan specification +property_value: IAO:0000117 "Philippe Rocca-Serra" xsd:string +property_value: IAO:0000117 "PlanAndPlannedProcess Branch" xsd:string +property_value: IAO:0000119 "adapted from discussion on OBI list (Matthew Pocock, Christian Cocos, Alan Ruttenberg)" xsd:string +property_value: IAO:0000119 "OBI_0000270" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/iao.owl [Term] -id: IAO:0000098 ! data format specification +id: IAO:0000098 +name: data format specification +def: "A data format specification is the information content borne by the document published defining the specification.\nExample: The ISO document specifying what encompasses an XML document; The instructions in a XSD file" [] is_a: IAO:0000033 ! directive information entity +property_value: IAO:0000116 "2009-03-16: provenance: term imported from OBI_0000187, which had original definition \"A data format specification is a plan which organizes\ninformation. Example: The ISO document specifying what encompasses an\nXML document; The instructions in a XSD file\"" xsd:string +property_value: IAO:0000117 "PERSON: Alan Ruttenberg" xsd:string +property_value: IAO:0000117 "PlanAndPlannedProcess Branch" xsd:string +property_value: IAO:0000119 "OBI branch derived" xsd:string +property_value: IAO:0000119 "OBI_0000187" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/iao.owl [Term] -id: IAO:0000104 ! plan specification +id: IAO:0000104 +name: plan specification +def: "A directive information entity with action specifications and objective specifications as parts that, when concretized, is realized in a process in which the bearer tries to achieve the objectives by taking the actions specified." [] is_a: IAO:0000033 ! directive information entity - -[Term] -id: IAO:0000109 ! measurement datum +property_value: IAO:0000116 "2009-03-16: provenance: a term a plan was proposed for OBI (OBI_0000344) , edited by the PlanAndPlannedProcess branch. Original definition was \" a plan is a specification of a process that is realized by an actor to achieve the objective specified as part of the plan\". It has been subsequently moved to IAO where the objective for which the original term was defined was satisfied with the definitionof this, different, term." xsd:string +property_value: IAO:0000116 "2014-03-31: A plan specification can have other parts, such as conditional specifications." xsd:string +property_value: IAO:0000116 "Alternative previous definition: a plan is a set of instructions that specify how an objective should be achieved" xsd:string +property_value: IAO:0000117 "Alan Ruttenberg" xsd:string +property_value: IAO:0000119 "OBI Plan and Planned Process branch" xsd:string +property_value: IAO:0000119 "OBI_0000344" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/iao.owl +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl + +[Term] +id: IAO:0000109 +name: measurement datum +def: "A measurement datum is an information content entity that is a recording of the output of a measurement such as produced by a device." [] is_a: IAO:0000027 ! data item +property_value: IAO:0000116 "2/2/2009 is_specified_output of some assay?" xsd:string +property_value: IAO:0000117 "person:Chris Stoeckert" xsd:string +property_value: IAO:0000119 group:OBI xsd:string +property_value: IAO:0000119 "OBI_0000305" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/iao.owl [Term] -id: IAO:0000416 ! time measurement datum +id: IAO:0000416 +name: time measurement datum +def: "A scalar measurement datum that is the result of measuring a temporal interval" [] is_a: IAO:0000032 ! scalar measurement datum +property_value: IAO:0000116 "2009/09/28 Alan Ruttenberg. Fucoidan-use-case" xsd:string +property_value: IAO:0000117 "Person:Alan Ruttenberg" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/iao.owl [Term] -id: IAO:0000577 ! centrally registered identifier symbol +id: IAO:0000577 +name: centrally registered identifier symbol +def: "A symbol that is part of a CRID and that is sufficient to look up a record from the CRID's registry." [] is_a: IAO:0000028 ! symbol - -[Term] -id: IAO:0000594 ! software application +property_value: IAO:0000117 "PERSON: Alan Ruttenberg" xsd:string +property_value: IAO:0000117 "PERSON: Bill Hogan" xsd:string +property_value: IAO:0000117 "PERSON: Bjoern Peters" xsd:string +property_value: IAO:0000117 "PERSON: Melanie Courtot" xsd:string +property_value: IAO:0000118 "CRID symbol" xsd:string +property_value: IAO:0000119 "Original proposal from Bjoern, discussions at IAO calls" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/iao.owl + +[Term] +id: IAO:0000594 +name: software application +def: "A software application is software that can be directly executed by some processing unit." [] is_a: IAO:0000010 ! software +property_value: IAO:0000117 "PERSON: Melanie Courtot" xsd:string +property_value: IAO:0000117 "PERSON: Michel Dumontier" xsd:string +property_value: IAO:0000119 https://github.com/information-artifact-ontology/IAO/issues/80 xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/iao.owl +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: NCBITaxon:9606 ! Homo sapiens +id: NCBITaxon:9606 +name: Homo sapiens is_a: OBI:0100026 ! organism +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncbitaxon.owl [Term] -id: NCBITaxon:taxonomic_rank ! taxonomic rank +id: NCBITaxon:taxonomic_rank +name: taxonomic rank is_a: IAO:0000109 ! measurement datum +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncbitaxon.owl [Term] -id: NCIT:C19498 ! Document +id: NCIT:C19498 +name: Document +def: "A physical object, or electronic counterpart, that is characterized by containing writing which is meant to be human-readable." [] is_a: NCIT:C25198 ! Record +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncit.owl [Term] -id: NCIT:C25198 ! Record +id: NCIT:C20181 +name: Conceptual Entity +def: "An organizational header for concepts representing mostly abstract entities." [] +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncit.owl + +[Term] +id: NCIT:C25198 +name: Record +def: "Anything (e.g., a document) providing permanent evidence of or information about past events." [] is_a: NCIT:C20181 ! Conceptual Entity +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncit.owl [Term] -id: NCIT:C25364 ! Identifier +id: NCIT:C25364 +name: Identifier +def: "One or more characters used to identify, name, or characterize the nature, properties, or contents of a thing." [] is_a: NCIT:C19498 ! Document +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncit.owl [Term] -id: NCIT:C25402 ! Accession Number +id: NCIT:C25402 +name: Accession Number +def: "A control number unique to an object. It is used to identify the object among other objects in a collection." [] is_a: NCIT:C70663 ! Unique Identifier +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncit.owl [Term] -id: NCIT:C70663 ! Unique Identifier +id: NCIT:C70663 +name: Unique Identifier +def: "A set of characters used as a code that is unique in the context or the system for which it is created. It serves as a means of identification and reference (often instead of a name) for an entity, person, thing, function, procedure, activity, variable, or body of data." [] is_a: NCIT:C25364 ! Identifier +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncit.owl [Term] -id: OBI:0000011 ! planned process +id: OBI:0000011 +name: planned process +def: "A processual entity that realizes a plan which is the concretization of a plan specification." [] is_a: BFO:0000015 ! process +property_value: IAO:0000116 "'Plan' includes a future direction sense. That can be problematic if plans are changed during their execution. There are however implicit contingencies for protocols that an agent has in his mind that can be considered part of the plan, even if the agent didn't have them in mind before. Therefore, a planned process can diverge from what the agent would have said the plan was before executing it, by adjusting to problems encountered during execution (e.g. choosing another reagent with equivalent properties, if the originally planned one has run out.)" xsd:string +property_value: IAO:0000116 "We are only considering successfully completed planned processes. A plan may be modified, and details added during execution. For a given planned process, the associated realized plan specification is the one encompassing all changes made during execution. This means that all processes in which an agent acts towards achieving some \nobjectives is a planned process." xsd:string +property_value: IAO:0000117 "Bjoern Peters" xsd:string +property_value: IAO:0000119 "branch derived" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0000018 ! material supplier role +id: OBI:0000018 +name: material supplier role +def: "a role realized through the process of supplying materials such as animal subjects, reagents or other materials used in an investigation." [] is_a: OBI:0000947 ! service provider role +property_value: IAO:0000116 "Supplier role is a special kind of service, e.g. biobank" xsd:string +property_value: IAO:0000117 "PERSON:Jennifer Fostel" xsd:string +property_value: IAO:0000118 "material provider role" xsd:string +property_value: IAO:0000118 "supplier" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0000025 ! reference substance role +id: OBI:0000025 +name: reference substance role +def: "a role inhering in a material entity that is realized when characteristics or responses elicited by the substance are used for comparison or reference." [] is_a: BFO:0000023 ! role +property_value: IAO:0000117 "Person:Jennifer Fostel" xsd:string +property_value: IAO:0000118 "reference substance" xsd:string +property_value: IAO:0000119 "OBI" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0000047 ! processed material +id: OBI:0000047 +name: processed material +def: "Is a material entity that is created or changed during material processing." [] is_a: BFO:0000040 ! material entity +property_value: IAO:0000117 "PERSON: Alan Ruttenberg" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0000070 ! assay +id: OBI:0000070 +name: assay +def: "A planned process with the objective to produce information about the material entity that is the evaluant, by physically examining it or its proxies." [] is_a: OBI:0000011 ! planned process +property_value: IAO:0000116 "12/3/12: BP: the reference to the 'physical examination' is included to point out that a prediction is not an assay, as that does not require physical examiniation. " xsd:string +property_value: IAO:0000117 "PlanAndPlannedProcess Branch" xsd:string +property_value: IAO:0000118 "measuring" xsd:string +property_value: IAO:0000118 "scientific observation" xsd:string +property_value: IAO:0000119 "OBI branch derived" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0000091 ! detector reagent role +id: OBI:0000091 +name: detector reagent role +def: "a role which inheres in a molecular entity and is realized by the process of recording or registering a stimulus." [] is_a: BFO:0000023 ! role +property_value: IAO:0000116 "19feb2009. not clear we need this term. originally if came from microarrays -- the probes on the array are termed detectors in some instances" xsd:string +property_value: IAO:0000119 "One that detects, especially a mechanical, electrical, or chemical device that automatically identifies and records or registers a stimulus, such as an environmental change in pressure or temperature, an electric signal, or radiation from a radioactive material. http://www.answers.com/topic/detector 19feb2009" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0000094 ! material processing +id: OBI:0000094 +name: material processing +def: "A planned process which results in physical changes in a specified input material" [] is_a: OBI:0000011 ! planned process - -[Term] -id: OBI:0000097 ! participant under investigation role +property_value: IAO:0000117 "PERSON: Bjoern Peters" xsd:string +property_value: IAO:0000117 "PERSON: Frank Gibson" xsd:string +property_value: IAO:0000117 "PERSON: Jennifer Fostel" xsd:string +property_value: IAO:0000117 "PERSON: Melanie Courtot" xsd:string +property_value: IAO:0000117 "PERSON: Philippe Rocca Serra" xsd:string +property_value: IAO:0000118 "material transformation" xsd:string +property_value: IAO:0000119 "OBI branch derived" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl + +[Term] +id: OBI:0000097 +name: participant under investigation role +def: "A role that is realized through the execution of a study design in which the bearer of the role participates and in which data about that bearer is collected." [] is_a: BFO:0000023 ! role +property_value: IAO:0000116 "A participant can realize both \"specimen role\" and \"participant under investigation role\" at the same time. However \"participant under investigation role\" is distinct from \"specimen role\", since a specimen could somehow be involved in an investigation without being the thing that is under investigation." xsd:string +property_value: IAO:0000117 "GROUP: Role Branch" xsd:string +property_value: IAO:0000119 "OBI" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0000102 ! responsible party role +id: OBI:0000102 +name: responsible party role +def: "a study personnel role played by a party who is accountable for the execution of a study component and can make decisions about the conduct of the study" [] is_a: OBI:0000202 ! investigation agent role +property_value: IAO:0000117 "Person: Jennifer Fostel" xsd:string +property_value: IAO:0000118 "responsible party" xsd:string +property_value: IAO:0000119 "OBI" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0000103 ! principal investigator role +id: OBI:0000103 +name: principal investigator role +def: "a responsible party role played by a person responsible for the overall conduct of a study" [] is_a: OBI:0000102 ! responsible party role +property_value: IAO:0000117 "Person: Jennifer Fostel" xsd:string +property_value: IAO:0000118 "principal investigator" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0000116 ! worker role +id: OBI:0000116 +name: worker role +def: "a personnel role played by a party who executes a component of the study plan; this can occur before, during, after or outside the study timeline" [] is_a: OBI:0000202 ! investigation agent role +property_value: IAO:0000116 "\"executes the study plan\" includes the suppliers and manufacturers of reagents and other materials used in the study" xsd:string +property_value: IAO:0000117 "Person:Jennifer Fostel" xsd:string +property_value: IAO:0000118 "worker" xsd:string +property_value: IAO:0000119 "OBI" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0000181 ! population +id: OBI:0000181 +name: population +def: "a population is a collection of individuals from the same taxonomic class living, counted or sampled at a particular site or in a particular area" [] is_a: BFO:0000040 ! material entity +property_value: IAO:0000116 "1/28/2013, BP, on the call it was raised that we may want to switch to an external ontology for all populatin terms: \nhttp://code.google.com/p/popcomm-ontology/" xsd:string +property_value: IAO:0000117 "PERSON: Philippe Rocca-Serra" xsd:string +property_value: IAO:0000119 "adapted from Oxford English Dictionnary" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0000198 ! biological replicate role +id: OBI:0000198 +name: biological replicate role +def: "a reference participant role realized by equivalent treatment of participants" [] is_a: OBI:0000220 ! reference subject role +property_value: IAO:0000117 "Person:Jennifer Fostel" xsd:string +property_value: IAO:0000118 "biological replicate" xsd:string +property_value: IAO:0000119 "OBI" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0000202 ! investigation agent role +id: OBI:0000202 +name: investigation agent role +def: "A role borne by an entity and that is realized in a process that is part of an investigation in which an objective is achieved. These processes include, among others: planning, overseeing, funding, reviewing." [] is_a: BFO:0000023 ! role +property_value: IAO:0000116 "Implementing a study means carrying out or performing the study and providing reagents or other materials used in the study and other tasks without which the study would not happen." xsd:string +property_value: IAO:0000116 "Philly2013: Historically, this role would have been borne only by humans or organizations. However, we now also want to enable representing investigations run by robot scientists such as ADAM (King et al, Science, 2009)" xsd:string +property_value: IAO:0000117 "GROUP: Role Branch" xsd:string +property_value: IAO:0000118 "investigator" xsd:string +property_value: IAO:0000119 "OBI" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0000220 ! reference subject role +id: OBI:0000220 +name: reference subject role +def: "a reference subject role which inheres in an organism or entity of organismal origin so that the characteristics or responses of the participant playing the reference participant role are used for comparison or reference" [] is_a: OBI:0000097 ! participant under investigation role +property_value: IAO:0000117 "Jennifer Fostel" xsd:string +property_value: IAO:0000118 "reference participant" xsd:string +property_value: IAO:0000119 "OBI" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0000245 ! organization +id: OBI:0000245 +name: organization +def: "An entity that can bear roles, has members, and has a set of organization rules. Members of organizations are either organizations themselves or individual people. Members can bear specific organization member roles that are determined in the organization rules. The organization rules also determine how decisions are made on behalf of the organization by the organization members." [] is_a: BFO:0000040 ! material entity - -[Term] -id: OBI:0000249 ! technical replicate role +property_value: IAO:0000116 "BP: The definition summarizes long email discussions on the OBI developer, roles, biomaterial and denrie branches. It leaves open if an organization is a material entity or a dependent continuant, as no consensus was reached on that. The current placement as material is therefore temporary, in order to move forward with development. Here is the entire email summary, on which the definition is based:\n\n1) there are organization_member_roles (president, treasurer, branch\neditor), with individual persons as bearers\n\n2) there are organization_roles (employer, owner, vendor, patent holder)\n\n3) an organization has a charter / rules / bylaws, which specify what roles\nthere are, how they should be realized, and how to modify the\ncharter/rules/bylaws themselves.\n\nIt is debatable what the organization itself is (some kind of dependent\ncontinuant or an aggregate of people). This also determines who/what the\nbearer of organization_roles' are. My personal favorite is still to define\norganization as a kind of 'legal entity', but thinking it through leads to\nall kinds of questions that are clearly outside the scope of OBI.\n\nInterestingly enough, it does not seem to matter much where we place\norganization itself, as long as we can subclass it (University, Corporation,\nGovernment Agency, Hospital), instantiate it (Affymetrix, NCBI, NIH, ISO,\nW3C, University of Oklahoma), and have it play roles.\n\nThis leads to my proposal: We define organization through the statements 1 -\n3 above, but without an 'is a' statement for now. We can leave it in its\ncurrent place in the is_a hierarchy (material entity) or move it up to\n'continuant'. We leave further clarifications to BFO, and close this issue\nfor now." xsd:string +property_value: IAO:0000117 "PERSON: Alan Ruttenberg" xsd:string +property_value: IAO:0000117 "PERSON: Bjoern Peters" xsd:string +property_value: IAO:0000117 "PERSON: Philippe Rocca-Serra" xsd:string +property_value: IAO:0000117 "PERSON: Susanna Sansone" xsd:string +property_value: IAO:0000119 "GROUP: OBI" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl + +[Term] +id: OBI:0000249 +name: technical replicate role +def: "technical replicate role is realized when two portions from one evaluant are used in replicate runs of an assay" [] is_a: OBI:0000220 ! reference subject role +property_value: IAO:0000117 "Person: Jennifer Fostel" xsd:string +property_value: IAO:0000118 "technical replicate" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0000272 ! protocol +id: OBI:0000272 +name: protocol +def: "A plan specification which has sufficient level of detail and quantitative information to communicate it between investigation agents, so that different investigation agents will reliably be able to independently reproduce the process." [] is_a: IAO:0000104 ! plan specification +property_value: IAO:0000117 "PlanAndPlannedProcess Branch" xsd:string +property_value: IAO:0000119 "OBI branch derived + wikipedia (http://en.wikipedia.org/wiki/Protocol_%28natural_sciences%29)" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0000415 ! polymerase chain reaction +id: OBI:0000415 +name: polymerase chain reaction +def: "PCR is the process in which a DNA polymerase is used to amplify a piece of DNA by in vitro enzymatic replication. As PCR progresses, the DNA thus generated is itself used as a template for replication. This sets in motion a chain reaction in which the DNA template is exponentially amplified." [] is_a: OBI:0600058 ! enzymatic amplification +property_value: IAO:0000117 "OBI Plan" xsd:string +property_value: IAO:0000118 "PCR" xsd:string +property_value: IAO:0000119 "adapted from wikipedai" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0000626 ! DNA sequencing +id: OBI:0000626 +name: DNA sequencing +def: "DNA sequencing is a sequencing process which uses deoxyribonucleic acid as input and results in a the creation of DNA sequence information artifact using a DNA sequencer instrument." [] is_a: OBI:0600047 ! sequencing assay +property_value: IAO:0000117 "Philippe Rocca-Serra" xsd:string +property_value: IAO:0000119 "OBI Branch derived" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0000659 ! specimen collection process +id: OBI:0000659 +name: specimen collection process +def: "A planned process with the objective of collecting a specimen." [] is_a: OBI:0000011 ! planned process - -[Term] -id: OBI:0000711 ! library preparation +property_value: IAO:0000116 "label changed to 'specimen collection process' on 10/27/2014, details see tracker:\nhttp://sourceforge.net/p/obi/obi-terms/716/" xsd:string +property_value: IAO:0000116 "Note: definition is in specimen creation objective which is defined as an objective to obtain and store a material entity for potential use as an input during an investigation." xsd:string +property_value: IAO:0000116 "Philly2013: A specimen collection can have as part a material entity acquisition, such as ordering from a bank. The distinction is that specimen collection necessarily involves the creation of a specimen role. However ordering cell lines cells from ATCC for use in an investigation is NOT a specimen collection, because the cell lines already have a specimen role." xsd:string +property_value: IAO:0000116 "Philly2013: The specimen_role for the specimen is created during the specimen collection process." xsd:string +property_value: IAO:0000117 "Bjoern Peters" xsd:string +property_value: IAO:0000118 "specimen collection" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl + +[Term] +id: OBI:0000711 +name: library preparation +def: "is a process which results in the creation of a library from fragments of DNA using cloning vectors or oligonucleotides with the role of adaptors." [] is_a: OBI:0000094 ! material processing +property_value: IAO:0000117 "Philippe Rocca-Serra" xsd:string +property_value: IAO:0000118 "library construction" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0000722 ! paired-end library +id: OBI:0000722 +name: paired-end library +def: "is a collection of short paired tags from the two ends of DNA fragments are extracted and covalently linked as ditag constructs" [] is_a: OBI:0000047 ! processed material +property_value: IAO:0000117 "Philippe Rocca-Serra" xsd:string +property_value: IAO:0000118 "mate-paired library" xsd:string +property_value: IAO:0000118 "paired-end tag (PET) library" xsd:string +property_value: IAO:0000119 "adapted from information provided by Solid web site" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0000832 ! measurement device +id: OBI:0000832 +name: measurement device +def: "A device in which a measure function inheres." [] is_a: OBI:0000968 ! device +property_value: IAO:0000117 "GROUP:OBI Philly workshop" xsd:string +property_value: IAO:0000119 "OBI" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0000835 ! manufacturer +id: OBI:0000835 +name: manufacturer +def: "A person or organization that has a manufacturer role" [] is_a: BFO:0000040 ! material entity +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0000932 ! material separation device +id: OBI:0000932 +name: material separation device +def: "A device with a separation function realized in a planed process" [] is_a: OBI:0000968 ! device +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0000947 ! service provider role +id: OBI:0000947 +name: service provider role +def: "is a role which inheres in a person or organization and is realized in in a planned process which provides access to training, materials or execution of protocols for an organization or person" [] is_a: BFO:0000023 ! role +property_value: IAO:0000117 "PERSON:Helen Parkinson" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0000968 ! device +id: OBI:0000968 +name: device +def: "A material entity that is designed to perform a function in a scientific investigation, but is not a reagent." [] is_a: OBI:0000047 ! processed material +property_value: IAO:0000116 "2012-12-17 JAO: In common lab usage, there is a distinction made between devices and reagents that is difficult to model. Therefore we have chosen to specifically exclude reagents from the definition of \"device\", and are enumerating the types of roles that a reagent can perform.\n\n2013-6-5 MHB: The following clarifications are outcomes of the May 2013 Philly Workshop. Reagents are distinguished from devices that also participate in scientific techniques by the fact that reagents are chemical or biological in nature and necessarily participate in some chemical interaction or reaction during the realization of their experimental role. By contrast, devices do not participate in such chemical reactions/interactions. Note that there are cases where devices use reagent components during their operation, where the reagent-device distinction is less clear. For example:\n\n(1) An HPLC machine is considered a device, but has a column that holds a stationary phase resin as an operational component. This resin qualifies as a device if it participates purely in size exclusion, but bears a reagent role that is realized in the running of a column if it interacts electrostatically or chemically with the evaluant. The container the resin is in (“the column”) considered alone is a device. So the entire column as well as the entire HPLC machine are devices that have a reagent as an operating part.\n\n(2) A pH meter is a device, but its electrode component bears a reagent role in virtue of its interacting directly with the evaluant in execution of an assay.\n\n(3) A gel running box is a device that has a metallic lead as a component that participates in a chemical reaction with the running buffer when a charge is passed through it. This metallic lead is considered to have a reagent role as a component of this device realized in the running of a gel.\n\nIn the examples above, a reagent is an operational component of a device, but the device itself does not realize a reagent role (as bearing a reagent role is not transitive across the part_of relation). In this way, the asserted disjointness between a reagent and device holds, as both roles are never realized in the same bearer during execution of an assay. " xsd:string +property_value: IAO:0000117 "PERSON: Helen Parkinson" xsd:string +property_value: IAO:0000118 "instrument" xsd:string +property_value: IAO:0000119 "OBI development call 2012-12-17." xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0000973 ! sequence data +id: OBI:0000973 +name: sequence data +def: "A measurement datum that representing the primary structure of a macromolecule(it's sequence) sometimes associated with an indicator of confidence of that measurement.\n" [] is_a: IAO:0000109 ! measurement datum +property_value: IAO:0000117 "Person:Chris Stoeckert" xsd:string +property_value: IAO:0000119 "GROUP: OBI" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0001140 ! spike-in quality control role +id: OBI:0001140 +name: spike-in quality control role +def: "a reference substance role that is borne by a material entity with a known amount which is mixed into the evaluant of assays for quality control or data normalization purposes" [] is_a: OBI:0000025 ! reference substance role +property_value: IAO:0000117 "PERSON: Chris Stoeckert, Jie Zheng, Bjoern Peter" xsd:string +property_value: IAO:0000119 "MO_937 spike_quality_control" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0001167 ! age measurement datum +id: OBI:0001167 +name: age measurement datum +def: "A time measurement datum that is the result of measurement of age of an organism" [] is_a: IAO:0000416 ! time measurement datum +property_value: IAO:0000116 "note that we are currently defining subtypes of age measurement datum that specify when the age is relative to, e.g. planting, as we don't have adequate temporal predicates yet.\nlife of bearer doesn't imply organism\nthis assay measures time not developmental stage. we recognize that development can take different time periods under different conditions such as media / temperature\nage as a quality is dubious; we plan to revisit\nstages in development are currently handled with controlled vocabulary, such as 2-somite stage " xsd:string +property_value: IAO:0000117 "PERSON: Alan Ruttenberg, Chris Stoeckert, Jie Zheng" xsd:string +property_value: IAO:0000119 "MO_178 Age" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0001169 ! age since birth measurement datum +id: OBI:0001169 +name: age since birth measurement datum +def: "An age measurement datum that is the result of the measurement of the age of an organism since birth, the process of emergence and separation of offspring from the mother." [] is_a: OBI:0001167 ! age measurement datum +property_value: IAO:0000117 "PERSON:Chris Stoeckert, Jie Zheng" xsd:string +property_value: IAO:0000119 "MO_710 birth" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0001185 ! selectively maintained organism +id: OBI:0001185 +name: selectively maintained organism +def: "An organism that is bred to have some uniform behavioral, morphological, physiological, or genetic characteristics with similarly bred organisms" [] is_a: OBI:0100026 ! organism +property_value: IAO:0000117 "Bjoern Peters, Helen Parkinson, Philippe Rocca-Serra, Jie Zheng, Chris Stoeckert " xsd:string +property_value: IAO:0000118 "cultivar" xsd:string +property_value: IAO:0000118 "ecotype" xsd:string +property_value: IAO:0000118 "strain" xsd:string +property_value: IAO:0000119 "MO_9 StrainOrLine, MO_71 Ecotype, MO_124 Cultivar" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0001271 ! RNA-seq assay +id: OBI:0001271 +name: RNA-seq assay +def: "An assay in which sequencing technology (e.g. Solexa/454) is used to generate RNA sequence, analyse the transcibed regions of the genome, and or to quantitate transcript abundance" [] is_a: OBI:0600047 ! sequencing assay +property_value: IAO:0000117 "PERSON: James Malone" xsd:string +property_value: IAO:0000118 "transcription profiling by high throughput sequencing" xsd:string +property_value: IAO:0000119 "EFO_0002770 transcription profiling by high throughput sequencing" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0001468 ! cell specimen +id: OBI:0001468 +name: cell specimen +def: "A specimen primarily composed of a cell or cells collected from a multicellular organism or a cell culture." [] is_a: OBI:0100051 ! specimen +property_value: IAO:0000116 "Discussed on obi call Jan 23, 2017. To improve cell specimen that include single cell specimen. Details see tracker: https://sourceforge.net/p/obi/obi-terms/828/" xsd:string +property_value: IAO:0000117 "PERSON: Chris Stoeckert, Jie Zheng, Alexander Diehl" xsd:string +property_value: IAO:0000119 "MO_612 cell" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0001494 ! linear amplification +id: OBI:0001494 +name: linear amplification +def: "An enzymatic amplification which amplifies nucleic acid sequence by making many copies off the same template." [] is_a: OBI:0600058 ! enzymatic amplification +property_value: IAO:0000117 "PERSON: Chris Stoeckert, Jie Zheng" xsd:string +property_value: IAO:0000119 "MO_997 linear_amplification" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0001616 ! specimen identifier +id: OBI:0001616 +name: specimen identifier +def: "A CRID symbol denotes a specimen and used to distinguish one specimen from another in an investigation." [] is_a: IAO:0000028 ! symbol +property_value: IAO:0000117 "Person: Chris Stoeckert, Jie Zheng" xsd:string +property_value: IAO:0000118 "specimen ID" xsd:string +property_value: IAO:0000119 "NIAID GSCID-BRC metadata working group" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0001850 ! transcript analysis by paired-end tag sequencing +id: OBI:0001850 +name: transcript analysis by paired-end tag sequencing +def: "An assay that incorporates Paired-End Tags and sequencing technology to determine transcripts, gene structures, and gene expressions." [] is_a: OBI:0600047 ! sequencing assay +property_value: IAO:0000117 "Person: Venkat Malladi, Chris Stoeckert, Jie Zheng" xsd:string +property_value: IAO:0000118 "RNA-PET" xsd:string +property_value: IAO:0000118 "RNA-PET assay" xsd:string +property_value: IAO:0000119 "Ruan, et al. Genome wide full-length transcript analysis using 5' and 3' paired-end-tag next generation sequencing (RNA-PET). Methods Mol Biol. 2012;809:535-62. [PMID:22113299]" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0001852 ! paired-end library preparation +id: OBI:0001852 +name: paired-end library preparation +def: "A library preparation that results in the creation of a library of the 5' and 3' ends of DNA or cDNA fragments using adaptors and endonucleases. The preparation may or may not include cloning process. " [] is_a: OBI:0000711 ! library preparation +property_value: IAO:0000117 "Person: Venkat Malladi, Jie Zheng" xsd:string +property_value: IAO:0000119 "Venkat Malladi, Jie Zheng" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0001891 ! sequencing facility organization +id: OBI:0001891 +name: sequencing facility organization +def: "An organization that provides sequence determination service" [] is_a: OBI:0000245 ! organization +property_value: IAO:0000117 "PERSON: Chris Stoeckert, Jie Zheng" xsd:string +property_value: IAO:0000119 "NIAID GSCID-BRC metadata working group" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0001895 ! specimen collector +id: OBI:0001895 +name: specimen collector +def: "A person who collects the specimen" [] is_a: NCBITaxon:9606 ! Homo sapiens +property_value: IAO:0000117 "PERSON: Chris Stoeckert, Jie Zheng" xsd:string +property_value: IAO:0000119 "NIAID GSCID-BRC metadata working group" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0001933 ! value specification +id: OBI:0001933 +name: value specification +def: "An information content entity that specifies a value within a classification scheme or on a quantitative scale." [] is_a: IAO:0000030 ! information content entity +property_value: IAO:0000116 "This term is currently a descendant of 'information content entity', which requires that it 'is about' something. A value specification of '20g' for a measurement data item of the mass of a particular mouse 'is about' the mass of that mouse. However there are cases where a value specification is not clearly about any particular. In the future we may change 'value specification' to remove the 'is about' requirement." xsd:string +property_value: IAO:0000117 "PERSON:Bjoern Peters" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0001959 ! sequencing library multiplexing +id: OBI:0001959 +name: sequencing library multiplexing +def: "a planned process which consists in running a set of samples as a pool in one single instrument run of data acquisition process while retaining the ability to associate individual results to each of the individual input samples thanks to the use of a multiplex identifier, introduced during the ligation step of the individual library preparation and specific to a given sample." [] is_a: OBI:0000094 ! material processing +property_value: IAO:0000117 "PERSON:Philippe Rocca-Serra" xsd:string +property_value: IAO:0000119 "OBI" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0001967 ! multiplexing sequence identifier +id: OBI:0001967 +name: multiplexing sequence identifier +def: "A multiplexing sequence identifier is a nucleic acid sequence which is used in a ligation step of library preparation process to allow pooling of samples while maintaining ability to identify individual source material and creation of a multiplexed library" [] is_a: CHEBI:16991 ! deoxyribonucleic acid +property_value: IAO:0000117 "PERSON:Philippe Rocca-Serra" xsd:string +property_value: IAO:0000119 "OBI" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0002127 ! single cell specimen +id: OBI:0002127 +name: single cell specimen +def: "A cell specimen that contains only one cell." [] is_a: OBI:0001468 ! cell specimen +property_value: IAO:0000116 "Requested by Sirarat Sarntivijai (EBI). Details see tracker: https://sourceforge.net/p/obi/obi-terms/828/" xsd:string +property_value: IAO:0000117 "PERSON: Jie Zheng, Alexander Diehl" xsd:string +property_value: IAO:0000119 "PERSON: Jie Zheng, Alexander Diehl" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0002461 ! BCL format +id: OBI:0002461 +name: BCL format +def: "A data format specification that is a binary file containing base calling data. These files are created by sequencing machines during the act of sequencing, and contain data about each of the nucleotide clusters on a sequencing flow cell." [] is_a: IAO:0000098 ! data format specification +property_value: IAO:0000117 "Stephen A. Fisher, Junhyong Kim, Dan Berrios" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0002462 ! ERCC RNA spike-in +id: OBI:0002462 +name: ERCC RNA spike-in +def: "A processed material developed by the External RNA Controls Consortium (ERCC) that consists of 92 transcripts, derived and traceable from NIST-certified DNA plasmids." [] is_a: OBI:0000047 ! processed material +property_value: IAO:0000117 "Stephen A. Fisher, Junhyong Kim, Dan Berrios" xsd:string +property_value: IAO:0000119 https://www.thermofisher.com/order/catalog/product/4456740 xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0002463 ! SIRV RNA spike-in +id: OBI:0002463 +name: SIRV RNA spike-in +def: "A processed material that consists of transcript isoforms of 7 spike-in RNA variant (SIRV) genes and possibly the 92 External RNA Controls Consortium (ERCC) RNA spike-in genes." [] is_a: OBI:0000047 ! processed material +property_value: IAO:0000117 "Stephen A. Fisher, Junhyong Kim, Dan Berrios" xsd:string +property_value: IAO:0000119 https://www.lexogen.com/sirvs/design/ xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0002464 ! SRS identifier +id: OBI:0002464 +name: SRS identifier +def: "An accession number that applies to a database record for an individual sample object in an NCBI Sequence Read Archive (SRA) submission. These records are imported from the NCBI BioSample database." [] is_a: NCIT:C25402 ! Accession Number +property_value: IAO:0000117 "Stephen Fisher, Dan Berrios" xsd:string +property_value: IAO:0000118 "SRA sample accession number" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0002465 ! age since culture seeding measurement datum +id: OBI:0002465 +name: age since culture seeding measurement datum +def: "An age measurement datum that is the result of the measurement of the age of a cell since cultured (the process of seeding cells onto a culture dish)." [] is_a: OBI:0001167 ! age measurement datum +property_value: IAO:0000117 "Stephen A. Fisher, Junhyong Kim, Dan Berrios" xsd:string +property_value: IAO:0000118 "age of culture" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0002466 ! alignment counting algorithm +id: OBI:0002466 +name: alignment counting algorithm +def: "An algorithm used to assign aligned sequence reads, resulting from a reference genome transcriptome alignment algorithm, to sequence features (e.g. genes or transcripts)." [] is_a: IAO:0000064 ! algorithm +property_value: IAO:0000117 "Stephen A. Fisher, Junhyong Kim, Dan Berrios" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0002467 ! alignment counting application +id: OBI:0002467 +name: alignment counting application +def: "A software application that implements an alignment counting algorithm, used to count the overlap of aligned sequencing reads with genes." [] is_a: IAO:0000594 ! software application +property_value: IAO:0000117 "Stephen A. Fisher, Junhyong Kim, Dan Berrios" xsd:string +property_value: IAO:0000119 doi:10.1093/bioinformatics/btu638 xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0002468 ! base calling algorithm +id: OBI:0002468 +name: base calling algorithm +def: "An algorithm that assigns nucleotides to temporal or spatial peaks generated by a detector, such as peaks of light intensities generated by a DNA sequencer" [] is_a: IAO:0000064 ! algorithm +property_value: IAO:0000117 "Stephen A. Fisher, Junhyong Kim, Dan Berrios" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0002469 ! base calling application +id: OBI:0002469 +name: base calling application +def: "A base-calling application that implments a base-calling algorithm to convert BCL (binary base call) files, (e.g., those generated by Illumina sequencing systems) to standard FASTQ file formats for downstream analysis." [] is_a: IAO:0000594 ! software application +property_value: IAO:0000117 "Stephen A. Fisher, Junhyong Kim, Dan Berrios" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0002470 ! bcl2fastq software application +id: OBI:0002470 +name: bcl2fastq software application +def: "A base calling application that implments a base calling algorithm to convert BCL (binary base call) files generated by Illumina sequencing systems to standard FASTQ file formats for downstream analysis." [] is_a: OBI:0002469 ! base calling application +property_value: IAO:0000117 "Stephen A. Fisher, Junhyong Kim, Dan Berrios" xsd:string +property_value: IAO:0000119 https://support.illumina.com/sequencing/sequencing_software/bcl2fastq-conversion-software.html xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0002471 ! date process started +id: OBI:0002471 +name: date process started +def: "A data item that is the date when a process was initiated." [] is_a: IAO:0000027 ! data item +property_value: IAO:0000117 "Chris Stoeckert, Daniel Berrios, Stephen A. Fisher" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0002472 ! dbGaP study identifier +id: OBI:0002472 +name: dbGaP study identifier +def: "A central registered identifier symbol that denotes a specific study in dbGaP." [] is_a: IAO:0000577 ! centrally registered identifier symbol +property_value: IAO:0000117 "Stephen A. Fisher, Junhyong Kim, Dan Berrios" xsd:string +property_value: IAO:0000118 "dbGaP accession number" xsd:string +property_value: IAO:0000119 doi:10.1038/ng1007-1181 xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0002473 ! material amplification role +id: OBI:0002473 +name: material amplification role +def: "A worker role played by the person who runs the enzymatic amplifying process." [] is_a: OBI:0000116 ! worker role +property_value: IAO:0000117 "Stephen A. Fisher, Junhyong Kim, Dan Berrios" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0002474 ! material sequencing library preparation role +id: OBI:0002474 +name: material sequencing library preparation role +def: "A worker role played by the person who performs the library preparation process to generate a sequencing library for a sample to be sequenced." [] is_a: OBI:0000116 ! worker role +property_value: IAO:0000117 "Stephen A. Fisher, Junhyong Kim, Dan Berrios" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0002475 ! number of PCR cycles during library construction +id: OBI:0002475 +name: number of PCR cycles during library construction +def: "A data item that is the number of PCR cycles used during the construction of a sequencing library." [] is_a: IAO:0000027 ! data item +property_value: IAO:0000117 "Stephen A. Fisher, Junhyong Kim, Dan Berrios" xsd:string +property_value: IAO:0000118 "library construction PCR cycles" xsd:string +property_value: IAO:0000119 https://en.wikipedia.org/wiki/Polymerase_chain_reaction xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0002476 ! number of rounds of amplification +id: OBI:0002476 +name: number of rounds of amplification +def: "A data item that is the number of times an amplification reaction happened." [] is_a: IAO:0000027 ! data item +property_value: IAO:0000117 "Stephen A. Fisher, Junhyong Kim, Dan Berrios" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0002477 ! reference genome role +id: OBI:0002477 +name: reference genome role +def: "A reference substance role that is played by a reference genome when used during sequence alignment." [] is_a: OBI:0000025 ! reference substance role +property_value: IAO:0000117 "Stephen A. Fisher, Junhyong Kim, Dan Berrios" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0002478 ! reference genome-transcriptome alignment algorithm +id: OBI:0002478 +name: reference genome-transcriptome alignment algorithm +def: "An algorithm that attempts to align a nucleic acid sequence to a reference genome and transcriptome." [] is_a: IAO:0000064 ! algorithm +property_value: IAO:0000117 "Stephen A. Fisher, Junhyong Kim, Dan Berrios" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0002479 ! sequence read length measurement datum +id: OBI:0002479 +name: sequence read length measurement datum +def: "A measurement datum that is the result of the measurement of the number of bases in a DNA or RNA sequence." [] is_a: IAO:0000109 ! measurement datum +property_value: IAO:0000117 "Stephen A. Fisher, Junhyong Kim, Dan Berrios" xsd:string +property_value: IAO:0000118 "read length, read length measurement datum" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0002480 ! sequencing library input quantity measurement datum +id: OBI:0002480 +name: sequencing library input quantity measurement datum +def: "A scalar measurement datum that indicates the amount of sequencing library used as input for a sequencer." [] is_a: IAO:0000032 ! scalar measurement datum +property_value: IAO:0000117 "Stephen A. Fisher, Junhyong Kim" xsd:string +property_value: IAO:0000118 "library input amount" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0002481 ! single-end library +id: OBI:0002481 +name: single-end library +def: "A cDNA library that is a collection of short tags from only one end of DNA fragments." [] is_a: OBI:0000047 ! processed material +property_value: IAO:0000117 "Stephen A. Fisher, Junhyong Kim, Dan Berrios" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0002482 ! specimen harvest quantity +id: OBI:0002482 +name: specimen harvest quantity +def: "A scalar measurement datum that indicates the amount of specimen collected." [] is_a: IAO:0000032 ! scalar measurement datum +property_value: IAO:0000117 "Stephen A. Fisher, Junhyong Kim, Dan Berrios" xsd:string +property_value: IAO:0000118 "harvest quantity" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0002483 ! spike-in dilution factor +id: OBI:0002483 +name: spike-in dilution factor +def: "A data item that indicates the dilution of spike-in added to a specimen." [] is_a: IAO:0000027 ! data item +property_value: IAO:0000117 "Stephen A. Fisher, Junhyong Kim, Dan Berrios" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0002484 ! star algorithm +id: OBI:0002484 +name: star algorithm +def: "A reference genome transcriptome alignment algorithm that is a standalone RNA-seq alignment algorithm that uses uncompressed suffix arrays and a mapping algorithm similar to those used in large-scale genome alignment tools to align RNA-seq reads to a genomic reference." [] is_a: OBI:0002478 ! reference genome-transcriptome alignment algorithm +property_value: IAO:0000119 https://www.ncbi.nlm.nih.gov/pubmed/23104886 xsd:string +property_value: IAO:0000119 "Stephen A. Fisher, Junhyong Kim, Dan Berrios" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0002485 ! transcript analysis by single-end sequencing +id: OBI:0002485 +name: transcript analysis by single-end sequencing +def: "A sequencing assay that incorporates single-end reads and sequencing technology to determine transcripts, gene structures, and gene expressions." [] is_a: OBI:0600047 ! sequencing assay +property_value: IAO:0000117 "Stephen A. Fisher, Junhyong Kim, Dan Berrios" xsd:string +property_value: IAO:0000119 https://www.illumina.com/science/technology/next-generation-sequencing/paired-end-vs-single-read-sequencing.html xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0002486 ! verse algorithm +id: OBI:0002486 +name: verse algorithm +def: "An alignment counting algorithm that assigns gene features to genomic alignments using a hierarchical assignment scheme, which allows simultaneous quantification of multiple feature types or annotation levels without repeatedly assigning reads." [] is_a: OBI:0002466 ! alignment counting algorithm +property_value: IAO:0000117 "Stephen A. Fisher, Junhyong Kim" xsd:string +property_value: IAO:0000119 "http://kim.bio.upenn.edu/software/verse.shtml or http://biorxiv.org/content/early/2016/05/14/053306" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0002487 ! microraft +id: OBI:0002487 +name: microraft +def: "A material separation device also commerically known as Isoraft, that is used to isolate single cells." [] is_a: OBI:0000932 ! material separation device +property_value: IAO:0000117 "Stephen A. Fisher, Junhyong Kim, Dan Berrios" xsd:string +property_value: IAO:0000119 https://en.wikipedia.org/wiki/Microrafts xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0002488 ! pipette +id: OBI:0002488 +name: pipette +def: "A device that is a laboratory tool commonly used in chemistry, biology and medicine to transport a measured volume of liquid, often as a media dispenser." [] is_a: OBI:0000968 ! device +property_value: IAO:0000117 "Stephen A. Fisher, Junhyong Kim, Dan Berrios" xsd:string +property_value: IAO:0000119 https://en.wikipedia.org/wiki/Pipette xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0100026 ! organism +id: OBI:0100026 +name: organism +def: "A material entity that is an individual living system, such as animal, plant, bacteria or virus, that is capable of replicating or reproducing, growth and maintenance in the right environment. An organism may be unicellular or made up, like humans, of many billions of cells divided into specialized tissues and organs." [] is_a: BFO:0000040 ! material entity +property_value: IAO:0000116 "10/21/09: This is a placeholder term, that should ideally be imported from the NCBI taxonomy, but the high level hierarchy there does not suit our needs (includes plasmids and 'other organisms')" xsd:string +property_value: IAO:0000116 "13-02-2009:\nOBI doesn't take position as to when an organism starts or ends being an organism - e.g. sperm, foetus.\nThis issue is outside the scope of OBI." xsd:string +property_value: IAO:0000117 "GROUP: OBI Biomaterial Branch" xsd:string +property_value: IAO:0000119 "WEB: http://en.wikipedia.org/wiki/Organism" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0100051 ! specimen +id: OBI:0100051 +name: specimen +def: "A material entity that has the specimen role." [] is_a: BFO:0000040 ! material entity +property_value: IAO:0000116 "Note: definition is in specimen creation objective which is defined as an objective to obtain and store a material entity for potential use as an input during an investigation." xsd:string +property_value: IAO:0000117 "PERSON: James Malone" xsd:string +property_value: IAO:0000117 "PERSON: Philippe Rocca-Serra" xsd:string +property_value: IAO:0000119 "GROUP: OBI Biomaterial Branch" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0400099 ! flow cytometer sorter +id: OBI:0400099 +name: flow cytometer sorter +def: "A flow_cytometer_sorter is a flow_cytometer that analyzes and separates or sorts particles passing through (based on properties measured during analysis) to collect cells of interest." [] is_a: OBI:0000932 ! material separation device +property_value: IAO:0000117 "John Quinn" xsd:string +property_value: IAO:0000117 "Melanie Courtot" xsd:string +property_value: IAO:0000119 http://www.flocyte.com/FRTP/Resources/flow_cytometry_glossary.htm xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0400103 ! DNA sequencer +id: OBI:0400103 +name: DNA sequencer +def: "A DNA sequencer is an instrument that determines the order of deoxynucleotides in deoxyribonucleic acid sequences." [] is_a: OBI:0000832 ! measurement device +property_value: IAO:0000117 "Trish Whetzel" xsd:string +property_value: IAO:0000119 "MO" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0600047 ! sequencing assay +id: OBI:0600047 +name: sequencing assay +def: "the use of a chemical or biochemical means to infer the sequence of a biomaterial" [] is_a: OBI:0000070 ! assay +property_value: IAO:0000116 "has_output should be sequence of input; we don't have sequence well defined yet" xsd:string +property_value: IAO:0000117 "PlanAndPlannedProcess Branch" xsd:string +property_value: IAO:0000119 "OBI branch derived" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBI:0600058 ! enzymatic amplification +id: OBI:0600058 +name: enzymatic amplification +def: "the use of enzymes to increase the number of molecules of a biomaterial" [] is_a: OBI:0000094 ! material processing +property_value: IAO:0000117 "PERSON:Kevin Clancy" xsd:string +property_value: IAO:0000119 "OBI branch derived" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl [Term] -id: OBIws:0000015 ! pairwise sequence alignment algorithm +id: OBIws:0000015 +name: pairwise sequence alignment algorithm +def: "An algorithm that attempts to align two molecular sequences (nucleic acid or protein sequences)." [] is_a: IAO:0000064 ! algorithm +property_value: IAO:0000116 "Ready for OBI-WS : v1.0" xsd:string +property_value: IAO:0000117 "WS Annotations Group, UGA" xsd:string +property_value: IAO:0000119 "WS Annotations Group, UGA" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi/webService.owl [Term] -id: OBIws:0000088 ! BLAST algorithm +id: OBIws:0000088 +name: BLAST algorithm +def: "BLAST (Basic Local Alignment Search Tool), a pairwise sequence alignment algorithm is a heuristic search algorithm for comparing primary biological sequence information, such as the amino-acid or nucleotides sequences with a database of sequences, and identify sequences that resemble the query sequence above a certain threshold." [] is_a: OBIws:0000015 ! pairwise sequence alignment algorithm +property_value: IAO:0000116 "Ready for OBI-WS : v1.0" xsd:string +property_value: IAO:0000117 "ITPPR" xsd:string +property_value: IAO:0000119 "Wikipedia: BLAST" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi/webService.owl [Term] -id: OBIws:0000106 ! sequence data format specification +id: OBIws:0000106 +name: sequence data format specification +def: "A data format specification for molecular sequence feature information." [] is_a: IAO:0000098 ! data format specification +property_value: IAO:0000116 "Ready for OBI-WS : v1.0" xsd:string +property_value: IAO:0000117 "ITPPR" xsd:string +property_value: IAO:0000118 "sequence data format" xsd:string +property_value: IAO:0000119 "EDAM" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi/webService.owl [Term] -id: OBIws:0000140 ! BLASTn +id: OBIws:0000140 +name: BLASTn +def: "A BLAST algorithm that searches/aligns a nucleotide query sequence against a nucleotide database at a nucleotide level." [] is_a: OBIws:0000088 ! BLAST algorithm [Term] -id: OBIws:0000192 ! RNA sequence data +id: OBIws:0000192 +name: RNA sequence data +def: "A sequence data that is about the primary structure of RNA." [] is_a: OBI:0000973 ! sequence data +property_value: IAO:0000117 "ITPPR" xsd:string +property_value: IAO:0000119 "ITPPR" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi/webService.owl [Term] -id: OGMS:0000090 ! treatment +id: OGMS:0000090 +name: treatment +def: "A processual entity whose completion is hypothesized (by a healthcare provider) to alleviate the signs and symptoms associated with a disorder" [] is_a: OBI:0000011 ! planned process +property_value: IAO:0000117 "Albert Goldfain" xsd:string +property_value: IAO:0000119 http://code.google.com/p/ogms/issues/detail?id=35 xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ogms.owl [Term] -id: OMIABIS:0000100 ! study principle investigator or responsible +id: OMIABIS:0000100 +name: study principle investigator or responsible +def: "The principle investigtor or responsible person for a study or a sample collection." [] is_a: NCBITaxon:9606 ! Homo sapiens +property_value: IAO:0000412 http://purl.obolibrary.org/obo/omiabis.owl [Term] -id: OMIABIS:0001039 ! date of specimen collection +id: OMIABIS:0001039 +name: date of specimen collection +def: "A data item that indicates the time when the collection of a specimen occurred." [] is_a: IAO:0000027 ! data item +property_value: IAO:0000117 "Alice Nzinga" xsd:string +property_value: IAO:0000117 "Mathias Brochhausen" xsd:string +property_value: IAO:0000118 "date of specimen preparation" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/omiabis.owl [Term] id: ORNASEQ:0000001 @@ -724,18 +1444,83 @@ property_value: IAO:0000117 "PERSON: Stephen A. Fisher" xsd:string property_value: IAO:0000119 http://kim.bio.upenn.edu/software/verse.shtml xsd:string [Term] -id: SO:0001505 ! reference_genome -is_a: EFO:0004420 +id: SO:0001505 +name: reference_genome +def: "A collection of sequences (often chromosomes) taken as the standard for a given organism and genome assembly." [] +is_a: EFO:0004420 ! genome +property_value: IAO:0000412 http://purl.obolibrary.org/obo/so.owl [Term] -id: TAXRANK:0000000 ! taxonomic_rank +id: TAXRANK:0000000 +name: taxonomic_rank +def: "A level of depth of a taxon in a taxonomic hierarchy." [] is_a: GENEPIO:0001170 ! organism datum +property_value: IAO:0000412 http://purl.obolibrary.org/obo/taxrank.owl [Term] -id: TAXRANK:0000006 ! species +id: TAXRANK:0000006 +name: species is_a: TAXRANK:0000000 ! taxonomic_rank +property_value: IAO:0000412 http://purl.obolibrary.org/obo/taxrank.owl [Term] -id: UBERON:0000465 ! material anatomical entity +id: UBERON:0000465 +name: material anatomical entity +def: "Anatomical entity that has mass." [] is_a: BFO:0000040 ! material entity +property_value: IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl + +[Typedef] +id: BFO:0000050 +name: part of +def: "a core relation that holds between a part and its whole" [] +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ro.owl +is_transitive: true +is_a: RO:0002131 ! overlaps + +[Typedef] +id: OBI:0000312 +name: is_specified_output_of +def: "A relation between a planned process and a continuant participating in that process. The presence of the continuant at the end of the process is explicitly specified in the objective specification which the process realizes the concretization of." [] +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl +is_a: RO:0000056 ! participates in + +[Typedef] +id: RO:0000053 +name: bearer of +def: "a relation between an independent continuant (the bearer) and a specifically dependent continuant (the dependent), in which the dependent specifically depends on the bearer for its existence" [] +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ro.owl + +[Typedef] +id: RO:0000056 +name: participates in +def: "a relation between a continuant and a process, in which the continuant is somehow involved in the process" [] +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ro.owl + +[Typedef] +id: RO:0000087 +name: has role +def: "a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence" [] +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ro.owl +is_a: RO:0000053 ! bearer of + +[Typedef] +id: RO:0002131 +name: overlaps +def: "x overlaps y if and only if there exists some z such that x has part z and z part of y" [] +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ro.owl +is_a: RO:0002323 ! mereotopologically related to + +[Typedef] +id: RO:0002223 +name: starts +def: "inverse of starts with" [] +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ro.owl +is_a: BFO:0000050 ! part of + +[Typedef] +id: RO:0002323 +name: mereotopologically related to +def: "A mereological relationship or a topological relationship" [] +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ro.owl diff --git a/ornaseq.owl b/ornaseq.owl index 89cdefd..6d97370 100644 --- a/ornaseq.owl +++ b/ornaseq.owl @@ -1,22 +1,19 @@ + xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#"> - - - - - Stephen A Fisher - The following ontology is provided by Stephen A Fisher and Junhyong Kim to annotate next-generation sequencing experiments performed on RNA. Junhyong Kim + Stephen A Fisher + Ontology for RNA sequencing (ORNASEQ) + The following ontology is provided by Stephen A Fisher and Junhyong Kim to annotate next-generation sequencing experiments performed on RNA. @@ -32,12 +29,218 @@ + + + + English language definitions of what NCI means by the concept. These are limited to 1024 characters. They may also include information about the definition's source and attribution in a form that can easily be interpreted by software. + The official OBI definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions. + The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions. + 2012-04-05: +Barry Smith + +The official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible. + +Can you fix to something like: + +A statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property. + +Alan Ruttenberg + +Your proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria. + +On the specifics of the proposed definition: + +We don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition. + +Personally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable. + +We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with. + PERSON:Daniel Schober + GROUP:OBI:<http://purl.obolibrary.org/obo/obi> + definition + definition + textual definition + + + + + + + + An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology. + PERSON:Daniel Schober + GROUP:OBI:<http://purl.obfoundry.org/obo/obi> + editor note + editor note + + + + + + + + Name of editor entering the term in the file. The term editor is a point of contact for information regarding the term. The term editor may be, but is not always, the author of the definition, which may have been worked upon by several people + 20110707, MC: label update to term editor and definition modified accordingly. See http://code.google.com/p/information-artifact-ontology/issues/detail?id=115. + 20110707, MC: label update to term editor and definition modified accordingly. See https://github.com/information-artifact-ontology/IAO/issues/115. + PERSON:Daniel Schober + GROUP:OBI:<http://purl.obolibrary.org/obo/obi> + definition editor + definition editor + term editor + term editor + + + + + + + + An alternative name for a class or property which means the same thing as the preferred name (semantically equivalent) + PERSON:Daniel Schober + GROUP:OBI:<http://purl.obolibrary.org/obo/obi> + alternative term + + + + + + + + formal citation, e.g. identifier in external database to indicate / attribute source(s) for the definition. Free text indicate / attribute source(s) for the definition. EXAMPLE: Author Name, URI, MeSH Term C04, PUBMED ID, Wiki uri on 31.01.2007 + PERSON:Daniel Schober + Discussion on obo-discuss mailing-list, see http://bit.ly/hgm99w + GROUP:OBI:<http://purl.obolibrary.org/obo/obi> + definition source + definition source + + + + + + + + imported from + + + + + + + + + + + + + + label + + + + + + + + + + + + + + + a core relation that holds between a part and its whole + + part of + + + + + + + + + A relation between a planned process and a continuant participating in that process. The presence of the continuant at the end of the process is explicitly specified in the objective specification which the process realizes the concretization of. + + is_specified_output_of + + + + + + + + a relation between an independent continuant (the bearer) and a specifically dependent continuant (the dependent), in which the dependent specifically depends on the bearer for its existence + + bearer of + + + + + + + + a relation between a continuant and a process, in which the continuant is somehow involved in the process + + participates in + + + + + + + + + a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence + + has role + + + + + + + + + x overlaps y if and only if there exists some z such that x has part z and z part of y + + overlaps + + + + + + + + + inverse of starts with + + starts + + + + + + + + A mereological relationship or a topological relationship + + mereotopologically related to + + + + - + - + BFO 2 Reference: In all areas of empirical inquiry we encounter general terms of two sorts. First are general terms which refer to universals or types:animaltuberculosissurgical procedurediseaseSecond, are general terms used to refer to groups of entities which instantiate a given universal but do not correspond to the extension of any subuniversal of that universal because there is nothing intrinsic to the entities in question by virtue of which they – and only they – are counted as belonging to the given group. Examples are: animal purchased by the Emperortuberculosis diagnosed on a Wednesdaysurgical procedure performed on a patient from Stockholmperson identified as candidate for clinical trial #2056-555person who is signatory of Form 656-PPVpainting by Leonardo da VinciSuch terms, which represent what are called ‘specializations’ in [81 + Entity doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example Werner Ceusters 'portions of reality' include 4 sorts, entities (as BFO construes them), universals, configurations, and relations. It is an open question as to whether entities as construed in BFO will at some point also include these other portions of reality. See, for example, 'How to track absolutely everything' at http://www.referent-tracking.com/_RTU/papers/CeustersICbookRevised.pdf + + entity + - + - + BFO 2 Reference: Continuant entities are entities which can be sliced to yield parts only along the spatial dimension, yielding for example the parts of your table which we call its legs, its top, its nails. ‘My desk stretches from the window to the door. It has spatial parts, and can be sliced (in space) in two. With respect to time, however, a thing is a continuant.’ [60, p. 240 + Continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example, in an expansion involving bringing in some of Ceuster's other portions of reality, questions are raised as to whether universals are continuants + + continuant + - + - + BFO 2 Reference: every occurrent that is not a temporal or spatiotemporal region is s-dependent on some independent continuant that is not a spatial region + BFO 2 Reference: s-dependence obtains between every process and its participants in the sense that, as a matter of necessity, this process could not have existed unless these or those participants existed also. A process may have a succession of participants at different phases of its unfolding. Thus there may be different players on the field at different times during the course of a football game; but the process which is the entire game s-depends_on all of these players nonetheless. Some temporal parts of this process will s-depend_on on only some of the players. + Occurrent doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the sum of a process and the process boundary of another process. + Simons uses different terminology for relations of occurrents to regions: Denote the spatio-temporal location of a given occurrent e by 'spn[e]' and call this region its span. We may say an occurrent is at its span, in any larger region, and covers any smaller region. Now suppose we have fixed a frame of reference so that we can speak not merely of spatio-temporal but also of spatial regions (places) and temporal regions (times). The spread of an occurrent, (relative to a frame of reference) is the space it exactly occupies, and its spell is likewise the time it exactly occupies. We write 'spr[e]' and `spl[e]' respectively for the spread and spell of e, omitting mention of the frame. + + occurrent + - + - + b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002]) + + independent continuant + - + - + p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003]) + BFO 2 Reference: The realm of occurrents is less pervasively marked by the presence of natural units than is the case in the realm of independent continuants. Thus there is here no counterpart of ‘object’. In BFO 1.0 ‘process’ served as such a counterpart. In BFO 2.0 ‘process’ is, rather, the occurrent counterpart of ‘material entity’. Those natural – as contrasted with engineered, which here means: deliberately executed – units which do exist in the realm of occurrents are typically either parasitic on the existence of natural units on the continuant side, or they are fiat in nature. Thus we can count lives; we can count football games; we can count chemical reactions performed in experiments or in chemical manufacturing. We cannot count the processes taking place, for instance, in an episode of insect mating behavior.Even where natural units are identifiable, for example cycles in a cyclical process such as the beating of a heart or an organism’s sleep/wake cycle, the processes in question form a sequence with no discontinuities (temporal gaps) of the sort that we find for instance where billiard balls or zebrafish or planets are separated by clear spatial gaps. Lives of organisms are process units, but they too unfold in a continuous series from other, prior processes such as fertilization, and they unfold in turn in continuous series of post-life processes such as post-mortem decay. Clear examples of boundaries of processes are almost always of the fiat sort (midnight, a time of death as declared in an operating theater or on a death certificate, the initiation of a state of war) + + process + - + - + + realizable entity + - + - + b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003]) + Specifically dependent continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. We're not sure what else will develop here, but for example there are questions such as what are promises, obligation, etc. + + specifically dependent continuant + - + - + BFO 2 Reference: One major family of examples of non-rigid universals involves roles, and ontologies developed for corresponding administrative purposes may consist entirely of representatives of entities of this sort. Thus ‘professor’, defined as follows,b instance_of professor at t =Def. there is some c, c instance_of professor role & c inheres_in b at t.denotes a non-rigid universal and so also do ‘nurse’, ‘student’, ‘colonel’, ‘taxpayer’, and so forth. (These terms are all, in the jargon of philosophy, phase sortals.) By using role terms in definitions, we can create a BFO conformant treatment of such entities drawing on the fact that, while an instance of professor may be simultaneously an instance of trade union member, no instance of the type professor role is also (at any time) an instance of the type trade union member role (any more than any instance of the type color is at any time an instance of the type length).If an ontology of employment positions should be defined in terms of roles following the above pattern, this enables the ontology to do justice to the fact that individuals instantiate the corresponding universals – professor, sergeant, nurse – only during certain phases in their lives. + + role + - + - + b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001]) + + generically dependent continuant + - + - + BFO 2 Reference: Material entities (continuants) can preserve their identity even while gaining and losing material parts. Continuants are contrasted with occurrents, which unfold themselves in successive temporal parts or phases [60 + BFO 2 Reference: Object, Fiat Object Part and Object Aggregate are not intended to be exhaustive of Material Entity. Users are invited to propose new subcategories of Material Entity. + BFO 2 Reference: ‘Matter’ is intended to encompass both mass and energy (we will address the ontological treatment of portions of energy in a later version of BFO). A portion of matter is anything that includes elementary particles among its proper or improper parts: quarks and leptons, including electrons, as the smallest particles thus far discovered; baryons (including protons and neutrons) at a higher level of granularity; atoms and molecules at still higher levels, forming the cells, organs, organisms and other material entities studied by biologists, the portions of rock studied by geologists, the fossils studied by paleontologists, and so on.Material entities are three-dimensional entities (entities extended in three spatial dimensions), as contrasted with the processes in which they participate, which are four-dimensional entities (entities extended also along the dimension of time).According to the FMA, material entities may have immaterial entities as parts – including the entities identified below as sites; for example the interior (or ‘lumen’) of your small intestine is a part of your body. BFO 2.0 embodies a decision to follow the FMA here. + + material entity + - + - + High molecular weight, linear polymers, composed of nucleotides containing deoxyribose and linked by phosphodiester bonds; DNA contain the genetic information of organisms. + + deoxyribonucleic acid + - + - + Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity. + + molecular entity + - + - + A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane. + + cell + - + - + A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from 'star' cells) are irregularly shaped with many long processes, including those with 'end feet' which form the glial (limiting) membrane and directly and indirectly contribute to the blood-brain barrier. They regulate the extracellular ionic and chemical environment, and 'reactive astrocytes' (along with microglia) respond to injury. + + astrocyte + - + - + A cell from the thermogenic form of adipose tissue found in many species, particularly in newborns and hibernating mammals, but also in lesser amounts in adults of other mammals including humans. Brown fat is capable of rapid liberation of energy and seems to be important in the maintenance of body temperature immediately after birth and upon waking from hibernation. + + brown fat cell + - + - + The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. + + neuron + - + - + Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei. + + cardiac muscle cell + - + - + Any neuron that is part of a central nervous system. + + central nervous system neuron + - + - + date the sequencing run was performed + GROUP: IRIDA Ontology (Emma) + + sequencing run date + - + - + Pre-filled, ready-to-use reagent cartridges. Used to produce improved chemistry, cluster density and read length as well as improve quality (Q) scores. Reagent components are encoded to interact with the sequencing system to validate compatibility with user-defined applications. + GROUP: IRIDA Ontology (Emma) + + sequencing kit + - + - + Packaged kits (containing adapters, indexes, enzymes, buffers etc), tailored for specific sequencing workflows, which allow the simplified preparation of sequencing-ready libraries for small genomes, amplicons, and plasmids. + GROUP: IRIDA Ontology (Emma) and http://applications.illumina.com/applications/sequencing/ngs-library-prep.html + + library preparation kit + - + - + + organism datum + - + - + A location, relative to cellular compartments and structures, occupied by a macromolecular machine when it carries out a molecular function. There are two ways in which the gene ontology describes locations of gene products: (1) relative to cellular structures (e.g., cytoplasmic side of plasma membrane) or compartments (e.g., mitochondrion), and (2) the stable macromolecular complexes of which they are parts (e.g., the ribosome). + + cellular_component + - + - + A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. + + mitochondrion + - + - + A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. + + dendrite + - + - + The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections. + + cell body + - + - + Any constituent part of a cell, the basic structural and functional unit of all organisms. + + cell part + - + - + Software is a plan specification composed of a series of instructions that can be +interpreted by or directly executed by a processing unit. + see sourceforge tracker discussion at http://sourceforge.net/tracker/index.php?func=detail&aid=1958818&group_id=177891&atid=886178 + PERSON: Alan Ruttenberg + PERSON: Bjoern Peters + PERSON: Chris Stoeckert + PERSON: Melanie Courtot + GROUP: OBI + + + software + - + - + A model number is an information content entity specifically borne by catalogs, design specifications, advertising materials, inventory systems and similar that is about manufactured objects of the same class. The model number is an alternative term for the class. The manufactered objects may or may not also bear the model number. Model numbers can be encoded in a variety of other information objects, such as bar codes, numerals, or patterns of dots. + manufactered items may have more than one model number, sometimes by rebranding, or because companies are sold and the products issued new model numbers + Person: Alan Ruttenberg + + model number + - + - + a data item is an information content entity that is intended to be a truthful statement about something (modulo, e.g., measurement precision or other systematic errors) and is constructed/acquired by a method which reliably tends to produce (approximately) truthful statements. + 2/2/2009 Alan and Bjoern discussing FACS run output data. This is a data item because it is about the cell population. Each element records an event and is typically further composed a set of measurment data items that record the fluorescent intensity stimulated by one of the lasers. + 2009-03-16: data item deliberatly ambiguous: we merged data set and datum to be one entity, not knowing how to define singular versus plural. So data item is more general than datum. + 2009-03-16: removed datum as alternative term as datum specifically refers to singular form, and is thus not an exact synonym. + 2014-03-31: See discussion at http://odontomachus.wordpress.com/2014/03/30/aboutness-objects-propositions/ + JAR: datum -- well, this will be very tricky to define, but maybe some +information-like stuff that might be put into a computer and that is +meant, by someone, to denote and/or to be interpreted by some +process... I would include lists, tables, sentences... I think I might +defer to Barry, or to Brian Cantwell Smith + +JAR: A data item is an approximately justified approximately true approximate belief + PERSON: Alan Ruttenberg + PERSON: Chris Stoeckert + PERSON: Jonathan Rees + data + + data item + - + - + An information content entity that is a mark(s) or character(s) used as a conventional representation of another entity. + 20091104, MC: this needs work and will most probably change + 2014-03-31: We would like to have a deeper analysis of 'mark' and 'sign' in the future (see https://github.com/information-artifact-ontology/IAO/issues/154). + PERSON: James A. Overton + PERSON: Jonathan Rees + based on Oxford English Dictionary + + symbol + - + - + A generically dependent continuant that is about some thing. + 2014-03-10: The use of "thing" is intended to be general enough to include universals and configurations (see https://groups.google.com/d/msg/information-ontology/GBxvYZCk1oc/-L6B5fSBBTQJ). + information_content_entity 'is_encoded_in' some digital_entity in obi before split (040907). information_content_entity 'is_encoded_in' some physical_document in obi before split (040907). + +Previous. An information content entity is a non-realizable information entity that 'is encoded in' some digital or physical entity. + PERSON: Chris Stoeckert + OBI_0000142 + + + information content entity + - + - + a scalar measurement datum is a measurement datum that is composed of two parts, numerals and a unit label. + 2009-03-16: we decided to keep datum singular in scalar measurement datum, as in +this case we explicitly refer to the singular form + Would write this as: has_part some 'measurement unit label' and has_part some numeral and has_part exactly 2, except for the fact that this won't let us take advantage of OWL reasoning over the numbers. Instead use has measurment value property to represent the same. Use has measurement unit label (subproperty of has_part) so we can easily say that there is only one of them. + PERSON: Alan Ruttenberg + PERSON: Melanie Courtot + + scalar measurement datum + - + - + An information content entity whose concretizations indicate to their bearer how to realize them in a process. + 2009-03-16: provenance: a term realizable information entity was proposed for OBI (OBI_0000337) , edited by the PlanAndPlannedProcess branch. Original definition was "is the specification of a process that can be concretized and realized by an actor" with alternative term "instruction".It has been subsequently moved to IAO where the objective for which the original term was defined was satisfied with the definitionof this, different, term. + 2013-05-30 Alan Ruttenberg: What differentiates a directive information entity from an information concretization is that it can have concretizations that are either qualities or realizable entities. The concretizations that are realizable entities are created when an individual chooses to take up the direction, i.e. has the intention to (try to) realize it. + 8/6/2009 Alan Ruttenberg: Changed label from "information entity about a realizable" after discussions at ICBO + Werner pushed back on calling it realizable information entity as it isn't realizable. However this name isn't right either. An example would be a recipe. The realizable entity would be a plan, but the information entity isn't about the plan, it, once concretized, *is* the plan. -Alan + PERSON: Alan Ruttenberg + PERSON: Bjoern Peters + + directive information entity + - + - + A plan specification which describes the inputs and output of mathematical functions as well as workflow of execution for achieving an predefined objective. Algorithms are realized usually by means of implementation as computer programs for execution by automata. + Philippe Rocca-Serra + PlanAndPlannedProcess Branch + OBI_0000270 + adapted from discussion on OBI list (Matthew Pocock, Christian Cocos, Alan Ruttenberg) + + algorithm + - + - + A data format specification is the information content borne by the document published defining the specification. +Example: The ISO document specifying what encompasses an XML document; The instructions in a XSD file + 2009-03-16: provenance: term imported from OBI_0000187, which had original definition "A data format specification is a plan which organizes +information. Example: The ISO document specifying what encompasses an +XML document; The instructions in a XSD file" + PERSON: Alan Ruttenberg + PlanAndPlannedProcess Branch + OBI branch derived + OBI_0000187 + + data format specification + - + - + A directive information entity with action specifications and objective specifications as parts that, when concretized, is realized in a process in which the bearer tries to achieve the objectives by taking the actions specified. + 2009-03-16: provenance: a term a plan was proposed for OBI (OBI_0000344) , edited by the PlanAndPlannedProcess branch. Original definition was " a plan is a specification of a process that is realized by an actor to achieve the objective specified as part of the plan". It has been subsequently moved to IAO where the objective for which the original term was defined was satisfied with the definitionof this, different, term. + 2014-03-31: A plan specification can have other parts, such as conditional specifications. + Alternative previous definition: a plan is a set of instructions that specify how an objective should be achieved + Alan Ruttenberg + OBI Plan and Planned Process branch + OBI_0000344 + + + plan specification + - + - + A measurement datum is an information content entity that is a recording of the output of a measurement such as produced by a device. + 2/2/2009 is_specified_output of some assay? + person:Chris Stoeckert + OBI_0000305 + group:OBI + + measurement datum + - + - + A scalar measurement datum that is the result of measuring a temporal interval + 2009/09/28 Alan Ruttenberg. Fucoidan-use-case + Person:Alan Ruttenberg + + time measurement datum + - + - + A symbol that is part of a CRID and that is sufficient to look up a record from the CRID's registry. + PERSON: Alan Ruttenberg + PERSON: Bill Hogan + PERSON: Bjoern Peters + PERSON: Melanie Courtot + CRID symbol + Original proposal from Bjoern, discussions at IAO calls + + centrally registered identifier symbol + - + - + A software application is software that can be directly executed by some processing unit. + PERSON: Melanie Courtot + PERSON: Michel Dumontier + https://github.com/information-artifact-ontology/IAO/issues/80 + + + software application + - + - + + Homo sapiens + - + - + A physical object, or electronic counterpart, that is characterized by containing writing which is meant to be human-readable. + + Document + - + - + An organizational header for concepts representing mostly abstract entities. + + Conceptual Entity + - + - + Anything (e.g., a document) providing permanent evidence of or information about past events. + + Record + - + - + One or more characters used to identify, name, or characterize the nature, properties, or contents of a thing. + + Identifier + - + - + A control number unique to an object. It is used to identify the object among other objects in a collection. + + Accession Number + - + - + A set of characters used as a code that is unique in the context or the system for which it is created. It serves as a means of identification and reference (often instead of a name) for an entity, person, thing, function, procedure, activity, variable, or body of data. + + Unique Identifier + - + - + A processual entity that realizes a plan which is the concretization of a plan specification. + 'Plan' includes a future direction sense. That can be problematic if plans are changed during their execution. There are however implicit contingencies for protocols that an agent has in his mind that can be considered part of the plan, even if the agent didn't have them in mind before. Therefore, a planned process can diverge from what the agent would have said the plan was before executing it, by adjusting to problems encountered during execution (e.g. choosing another reagent with equivalent properties, if the originally planned one has run out.) + We are only considering successfully completed planned processes. A plan may be modified, and details added during execution. For a given planned process, the associated realized plan specification is the one encompassing all changes made during execution. This means that all processes in which an agent acts towards achieving some +objectives is a planned process. + Bjoern Peters + branch derived + + planned process + - + - + a role realized through the process of supplying materials such as animal subjects, reagents or other materials used in an investigation. + Supplier role is a special kind of service, e.g. biobank + PERSON:Jennifer Fostel + material provider role + supplier + + material supplier role + - + - + a role inhering in a material entity that is realized when characteristics or responses elicited by the substance are used for comparison or reference. + Person:Jennifer Fostel + reference substance + OBI + + reference substance role + - + - + Is a material entity that is created or changed during material processing. + PERSON: Alan Ruttenberg + + processed material + - + - + A planned process with the objective to produce information about the material entity that is the evaluant, by physically examining it or its proxies. + 12/3/12: BP: the reference to the 'physical examination' is included to point out that a prediction is not an assay, as that does not require physical examiniation. + PlanAndPlannedProcess Branch + measuring + scientific observation + OBI branch derived + + assay + - + - + a role which inheres in a molecular entity and is realized by the process of recording or registering a stimulus. + 19feb2009. not clear we need this term. originally if came from microarrays -- the probes on the array are termed detectors in some instances + One that detects, especially a mechanical, electrical, or chemical device that automatically identifies and records or registers a stimulus, such as an environmental change in pressure or temperature, an electric signal, or radiation from a radioactive material. http://www.answers.com/topic/detector 19feb2009 + + detector reagent role + - + - + A planned process which results in physical changes in a specified input material + PERSON: Bjoern Peters + PERSON: Frank Gibson + PERSON: Jennifer Fostel + PERSON: Melanie Courtot + PERSON: Philippe Rocca Serra + material transformation + OBI branch derived + + material processing + - + - + A role that is realized through the execution of a study design in which the bearer of the role participates and in which data about that bearer is collected. + A participant can realize both "specimen role" and "participant under investigation role" at the same time. However "participant under investigation role" is distinct from "specimen role", since a specimen could somehow be involved in an investigation without being the thing that is under investigation. + GROUP: Role Branch + OBI + + participant under investigation role + - + - + a study personnel role played by a party who is accountable for the execution of a study component and can make decisions about the conduct of the study + Person: Jennifer Fostel + responsible party + OBI + + responsible party role + - + - + a responsible party role played by a person responsible for the overall conduct of a study + Person: Jennifer Fostel + principal investigator + + principal investigator role + - + - + a personnel role played by a party who executes a component of the study plan; this can occur before, during, after or outside the study timeline + "executes the study plan" includes the suppliers and manufacturers of reagents and other materials used in the study + Person:Jennifer Fostel + worker + OBI + + worker role + - + - + a population is a collection of individuals from the same taxonomic class living, counted or sampled at a particular site or in a particular area + 1/28/2013, BP, on the call it was raised that we may want to switch to an external ontology for all populatin terms: +http://code.google.com/p/popcomm-ontology/ + PERSON: Philippe Rocca-Serra + adapted from Oxford English Dictionnary + + population + - + - + a reference participant role realized by equivalent treatment of participants + Person:Jennifer Fostel + biological replicate + OBI + + biological replicate role + - + - + A role borne by an entity and that is realized in a process that is part of an investigation in which an objective is achieved. These processes include, among others: planning, overseeing, funding, reviewing. + Implementing a study means carrying out or performing the study and providing reagents or other materials used in the study and other tasks without which the study would not happen. + Philly2013: Historically, this role would have been borne only by humans or organizations. However, we now also want to enable representing investigations run by robot scientists such as ADAM (King et al, Science, 2009) + GROUP: Role Branch + investigator + OBI + + investigation agent role + - + - + a reference subject role which inheres in an organism or entity of organismal origin so that the characteristics or responses of the participant playing the reference participant role are used for comparison or reference + Jennifer Fostel + reference participant + OBI + + reference subject role + - + - + An entity that can bear roles, has members, and has a set of organization rules. Members of organizations are either organizations themselves or individual people. Members can bear specific organization member roles that are determined in the organization rules. The organization rules also determine how decisions are made on behalf of the organization by the organization members. + BP: The definition summarizes long email discussions on the OBI developer, roles, biomaterial and denrie branches. It leaves open if an organization is a material entity or a dependent continuant, as no consensus was reached on that. The current placement as material is therefore temporary, in order to move forward with development. Here is the entire email summary, on which the definition is based: + +1) there are organization_member_roles (president, treasurer, branch +editor), with individual persons as bearers + +2) there are organization_roles (employer, owner, vendor, patent holder) + +3) an organization has a charter / rules / bylaws, which specify what roles +there are, how they should be realized, and how to modify the +charter/rules/bylaws themselves. + +It is debatable what the organization itself is (some kind of dependent +continuant or an aggregate of people). This also determines who/what the +bearer of organization_roles' are. My personal favorite is still to define +organization as a kind of 'legal entity', but thinking it through leads to +all kinds of questions that are clearly outside the scope of OBI. + +Interestingly enough, it does not seem to matter much where we place +organization itself, as long as we can subclass it (University, Corporation, +Government Agency, Hospital), instantiate it (Affymetrix, NCBI, NIH, ISO, +W3C, University of Oklahoma), and have it play roles. + +This leads to my proposal: We define organization through the statements 1 - +3 above, but without an 'is a' statement for now. We can leave it in its +current place in the is_a hierarchy (material entity) or move it up to +'continuant'. We leave further clarifications to BFO, and close this issue +for now. + PERSON: Alan Ruttenberg + PERSON: Bjoern Peters + PERSON: Philippe Rocca-Serra + PERSON: Susanna Sansone + GROUP: OBI + + organization + - + - + technical replicate role is realized when two portions from one evaluant are used in replicate runs of an assay + Person: Jennifer Fostel + technical replicate + + technical replicate role + - + - + A plan specification which has sufficient level of detail and quantitative information to communicate it between investigation agents, so that different investigation agents will reliably be able to independently reproduce the process. + PlanAndPlannedProcess Branch + OBI branch derived + wikipedia (http://en.wikipedia.org/wiki/Protocol_%28natural_sciences%29) + + protocol + - + - + PCR is the process in which a DNA polymerase is used to amplify a piece of DNA by in vitro enzymatic replication. As PCR progresses, the DNA thus generated is itself used as a template for replication. This sets in motion a chain reaction in which the DNA template is exponentially amplified. + OBI Plan + PCR + adapted from wikipedai + + polymerase chain reaction + - + - + DNA sequencing is a sequencing process which uses deoxyribonucleic acid as input and results in a the creation of DNA sequence information artifact using a DNA sequencer instrument. + Philippe Rocca-Serra + OBI Branch derived + + DNA sequencing + - + - + A planned process with the objective of collecting a specimen. + Note: definition is in specimen creation objective which is defined as an objective to obtain and store a material entity for potential use as an input during an investigation. + Philly2013: A specimen collection can have as part a material entity acquisition, such as ordering from a bank. The distinction is that specimen collection necessarily involves the creation of a specimen role. However ordering cell lines cells from ATCC for use in an investigation is NOT a specimen collection, because the cell lines already have a specimen role. + Philly2013: The specimen_role for the specimen is created during the specimen collection process. + label changed to 'specimen collection process' on 10/27/2014, details see tracker: +http://sourceforge.net/p/obi/obi-terms/716/ + Bjoern Peters + specimen collection + + specimen collection process + - + - + is a process which results in the creation of a library from fragments of DNA using cloning vectors or oligonucleotides with the role of adaptors. + Philippe Rocca-Serra + library construction + + library preparation + - + - + is a collection of short paired tags from the two ends of DNA fragments are extracted and covalently linked as ditag constructs + Philippe Rocca-Serra + mate-paired library + paired-end tag (PET) library + adapted from information provided by Solid web site + + paired-end library + - + - + A device in which a measure function inheres. + GROUP:OBI Philly workshop + OBI + + measurement device + - + - + A person or organization that has a manufacturer role + + manufacturer + - + - + A device with a separation function realized in a planed process + + material separation device + - + - + is a role which inheres in a person or organization and is realized in in a planned process which provides access to training, materials or execution of protocols for an organization or person + PERSON:Helen Parkinson + + service provider role + - + - + A material entity that is designed to perform a function in a scientific investigation, but is not a reagent. + 2012-12-17 JAO: In common lab usage, there is a distinction made between devices and reagents that is difficult to model. Therefore we have chosen to specifically exclude reagents from the definition of "device", and are enumerating the types of roles that a reagent can perform. + +2013-6-5 MHB: The following clarifications are outcomes of the May 2013 Philly Workshop. Reagents are distinguished from devices that also participate in scientific techniques by the fact that reagents are chemical or biological in nature and necessarily participate in some chemical interaction or reaction during the realization of their experimental role. By contrast, devices do not participate in such chemical reactions/interactions. Note that there are cases where devices use reagent components during their operation, where the reagent-device distinction is less clear. For example: + +(1) An HPLC machine is considered a device, but has a column that holds a stationary phase resin as an operational component. This resin qualifies as a device if it participates purely in size exclusion, but bears a reagent role that is realized in the running of a column if it interacts electrostatically or chemically with the evaluant. The container the resin is in (“the column”) considered alone is a device. So the entire column as well as the entire HPLC machine are devices that have a reagent as an operating part. + +(2) A pH meter is a device, but its electrode component bears a reagent role in virtue of its interacting directly with the evaluant in execution of an assay. + +(3) A gel running box is a device that has a metallic lead as a component that participates in a chemical reaction with the running buffer when a charge is passed through it. This metallic lead is considered to have a reagent role as a component of this device realized in the running of a gel. + +In the examples above, a reagent is an operational component of a device, but the device itself does not realize a reagent role (as bearing a reagent role is not transitive across the part_of relation). In this way, the asserted disjointness between a reagent and device holds, as both roles are never realized in the same bearer during execution of an assay. + PERSON: Helen Parkinson + instrument + OBI development call 2012-12-17. + + device + - + - + A measurement datum that representing the primary structure of a macromolecule(it's sequence) sometimes associated with an indicator of confidence of that measurement. + + Person:Chris Stoeckert + GROUP: OBI + + sequence data + - + - + a reference substance role that is borne by a material entity with a known amount which is mixed into the evaluant of assays for quality control or data normalization purposes + PERSON: Chris Stoeckert, Jie Zheng, Bjoern Peter + MO_937 spike_quality_control + + spike-in quality control role + - + - + A time measurement datum that is the result of measurement of age of an organism + note that we are currently defining subtypes of age measurement datum that specify when the age is relative to, e.g. planting, as we don't have adequate temporal predicates yet. +life of bearer doesn't imply organism +this assay measures time not developmental stage. we recognize that development can take different time periods under different conditions such as media / temperature +age as a quality is dubious; we plan to revisit +stages in development are currently handled with controlled vocabulary, such as 2-somite stage + PERSON: Alan Ruttenberg, Chris Stoeckert, Jie Zheng + MO_178 Age + + age measurement datum + - + - + An age measurement datum that is the result of the measurement of the age of an organism since birth, the process of emergence and separation of offspring from the mother. + PERSON:Chris Stoeckert, Jie Zheng + MO_710 birth + + age since birth measurement datum + - + - + An organism that is bred to have some uniform behavioral, morphological, physiological, or genetic characteristics with similarly bred organisms + Bjoern Peters, Helen Parkinson, Philippe Rocca-Serra, Jie Zheng, Chris Stoeckert + cultivar + ecotype + strain + MO_9 StrainOrLine, MO_71 Ecotype, MO_124 Cultivar + + selectively maintained organism + - + - + An assay in which sequencing technology (e.g. Solexa/454) is used to generate RNA sequence, analyse the transcibed regions of the genome, and or to quantitate transcript abundance + PERSON: James Malone + transcription profiling by high throughput sequencing + EFO_0002770 transcription profiling by high throughput sequencing + + RNA-seq assay + - + - + A specimen primarily composed of a cell or cells collected from a multicellular organism or a cell culture. + Discussed on obi call Jan 23, 2017. To improve cell specimen that include single cell specimen. Details see tracker: https://sourceforge.net/p/obi/obi-terms/828/ + PERSON: Chris Stoeckert, Jie Zheng, Alexander Diehl + MO_612 cell + + cell specimen + - + - + An enzymatic amplification which amplifies nucleic acid sequence by making many copies off the same template. + PERSON: Chris Stoeckert, Jie Zheng + MO_997 linear_amplification + + linear amplification + - + - + A CRID symbol denotes a specimen and used to distinguish one specimen from another in an investigation. + Person: Chris Stoeckert, Jie Zheng + specimen ID + NIAID GSCID-BRC metadata working group + + specimen identifier + - + - + An assay that incorporates Paired-End Tags and sequencing technology to determine transcripts, gene structures, and gene expressions. + Person: Venkat Malladi, Chris Stoeckert, Jie Zheng + RNA-PET + RNA-PET assay + Ruan, et al. Genome wide full-length transcript analysis using 5' and 3' paired-end-tag next generation sequencing (RNA-PET). Methods Mol Biol. 2012;809:535-62. [PMID:22113299] + + transcript analysis by paired-end tag sequencing + - + - + A library preparation that results in the creation of a library of the 5' and 3' ends of DNA or cDNA fragments using adaptors and endonucleases. The preparation may or may not include cloning process. + Person: Venkat Malladi, Jie Zheng + Venkat Malladi, Jie Zheng + + paired-end library preparation + - + - + An organization that provides sequence determination service + PERSON: Chris Stoeckert, Jie Zheng + NIAID GSCID-BRC metadata working group + + sequencing facility organization + - + - + A person who collects the specimen + PERSON: Chris Stoeckert, Jie Zheng + NIAID GSCID-BRC metadata working group + + specimen collector + - + - + An information content entity that specifies a value within a classification scheme or on a quantitative scale. + This term is currently a descendant of 'information content entity', which requires that it 'is about' something. A value specification of '20g' for a measurement data item of the mass of a particular mouse 'is about' the mass of that mouse. However there are cases where a value specification is not clearly about any particular. In the future we may change 'value specification' to remove the 'is about' requirement. + PERSON:Bjoern Peters + + value specification + - + - + a planned process which consists in running a set of samples as a pool in one single instrument run of data acquisition process while retaining the ability to associate individual results to each of the individual input samples thanks to the use of a multiplex identifier, introduced during the ligation step of the individual library preparation and specific to a given sample. + PERSON:Philippe Rocca-Serra + OBI + + sequencing library multiplexing + - + - + A multiplexing sequence identifier is a nucleic acid sequence which is used in a ligation step of library preparation process to allow pooling of samples while maintaining ability to identify individual source material and creation of a multiplexed library + PERSON:Philippe Rocca-Serra + OBI + + multiplexing sequence identifier + - + - + A cell specimen that contains only one cell. + Requested by Sirarat Sarntivijai (EBI). Details see tracker: https://sourceforge.net/p/obi/obi-terms/828/ + PERSON: Jie Zheng, Alexander Diehl + PERSON: Jie Zheng, Alexander Diehl + + single cell specimen + - + - + A data format specification that is a binary file containing base calling data. These files are created by sequencing machines during the act of sequencing, and contain data about each of the nucleotide clusters on a sequencing flow cell. + Stephen A. Fisher, Junhyong Kim, Dan Berrios + + BCL format + - + - + A processed material developed by the External RNA Controls Consortium (ERCC) that consists of 92 transcripts, derived and traceable from NIST-certified DNA plasmids. + Stephen A. Fisher, Junhyong Kim, Dan Berrios + https://www.thermofisher.com/order/catalog/product/4456740 + + ERCC RNA spike-in + - + - + A processed material that consists of transcript isoforms of 7 spike-in RNA variant (SIRV) genes and possibly the 92 External RNA Controls Consortium (ERCC) RNA spike-in genes. + Stephen A. Fisher, Junhyong Kim, Dan Berrios + https://www.lexogen.com/sirvs/design/ + + SIRV RNA spike-in + - + - + An accession number that applies to a database record for an individual sample object in an NCBI Sequence Read Archive (SRA) submission. These records are imported from the NCBI BioSample database. + Stephen Fisher, Dan Berrios + SRA sample accession number + + SRS identifier + - + - + An age measurement datum that is the result of the measurement of the age of a cell since cultured (the process of seeding cells onto a culture dish). + Stephen A. Fisher, Junhyong Kim, Dan Berrios + age of culture + + age since culture seeding measurement datum + - + - + An algorithm used to assign aligned sequence reads, resulting from a reference genome transcriptome alignment algorithm, to sequence features (e.g. genes or transcripts). + Stephen A. Fisher, Junhyong Kim, Dan Berrios + + alignment counting algorithm + - + - + A software application that implements an alignment counting algorithm, used to count the overlap of aligned sequencing reads with genes. + Stephen A. Fisher, Junhyong Kim, Dan Berrios + doi:10.1093/bioinformatics/btu638 + + alignment counting application + - + - + An algorithm that assigns nucleotides to temporal or spatial peaks generated by a detector, such as peaks of light intensities generated by a DNA sequencer + Stephen A. Fisher, Junhyong Kim, Dan Berrios + + base calling algorithm + - + - + A base-calling application that implments a base-calling algorithm to convert BCL (binary base call) files, (e.g., those generated by Illumina sequencing systems) to standard FASTQ file formats for downstream analysis. + Stephen A. Fisher, Junhyong Kim, Dan Berrios + + base calling application + - + - + A base calling application that implments a base calling algorithm to convert BCL (binary base call) files generated by Illumina sequencing systems to standard FASTQ file formats for downstream analysis. + Stephen A. Fisher, Junhyong Kim, Dan Berrios + https://support.illumina.com/sequencing/sequencing_software/bcl2fastq-conversion-software.html + + bcl2fastq software application + - + - + A data item that is the date when a process was initiated. + Chris Stoeckert, Daniel Berrios, Stephen A. Fisher + + date process started + - + - + A central registered identifier symbol that denotes a specific study in dbGaP. + Stephen A. Fisher, Junhyong Kim, Dan Berrios + dbGaP accession number + doi:10.1038/ng1007-1181 + + dbGaP study identifier + - + - + A worker role played by the person who runs the enzymatic amplifying process. + Stephen A. Fisher, Junhyong Kim, Dan Berrios + + material amplification role + - + - + A worker role played by the person who performs the library preparation process to generate a sequencing library for a sample to be sequenced. + Stephen A. Fisher, Junhyong Kim, Dan Berrios + + material sequencing library preparation role + - + - + A data item that is the number of PCR cycles used during the construction of a sequencing library. + Stephen A. Fisher, Junhyong Kim, Dan Berrios + library construction PCR cycles + https://en.wikipedia.org/wiki/Polymerase_chain_reaction + + number of PCR cycles during library construction + - + - + A data item that is the number of times an amplification reaction happened. + Stephen A. Fisher, Junhyong Kim, Dan Berrios + + number of rounds of amplification + - + - + A reference substance role that is played by a reference genome when used during sequence alignment. + Stephen A. Fisher, Junhyong Kim, Dan Berrios + + reference genome role + - + - + An algorithm that attempts to align a nucleic acid sequence to a reference genome and transcriptome. + Stephen A. Fisher, Junhyong Kim, Dan Berrios + + reference genome-transcriptome alignment algorithm + - + - + A measurement datum that is the result of the measurement of the number of bases in a DNA or RNA sequence. + Stephen A. Fisher, Junhyong Kim, Dan Berrios + read length, read length measurement datum + + sequence read length measurement datum + - + - + A scalar measurement datum that indicates the amount of sequencing library used as input for a sequencer. + Stephen A. Fisher, Junhyong Kim + library input amount + + sequencing library input quantity measurement datum + - + - + A cDNA library that is a collection of short tags from only one end of DNA fragments. + Stephen A. Fisher, Junhyong Kim, Dan Berrios + + single-end library + - + - + A scalar measurement datum that indicates the amount of specimen collected. + Stephen A. Fisher, Junhyong Kim, Dan Berrios + harvest quantity + + specimen harvest quantity + - + - + A data item that indicates the dilution of spike-in added to a specimen. + Stephen A. Fisher, Junhyong Kim, Dan Berrios + + spike-in dilution factor + - + - + A reference genome transcriptome alignment algorithm that is a standalone RNA-seq alignment algorithm that uses uncompressed suffix arrays and a mapping algorithm similar to those used in large-scale genome alignment tools to align RNA-seq reads to a genomic reference. + Stephen A. Fisher, Junhyong Kim, Dan Berrios + https://www.ncbi.nlm.nih.gov/pubmed/23104886 + + star algorithm + - + - + A sequencing assay that incorporates single-end reads and sequencing technology to determine transcripts, gene structures, and gene expressions. + Stephen A. Fisher, Junhyong Kim, Dan Berrios + https://www.illumina.com/science/technology/next-generation-sequencing/paired-end-vs-single-read-sequencing.html + + transcript analysis by single-end sequencing + - + - + An alignment counting algorithm that assigns gene features to genomic alignments using a hierarchical assignment scheme, which allows simultaneous quantification of multiple feature types or annotation levels without repeatedly assigning reads. + Stephen A. Fisher, Junhyong Kim + http://kim.bio.upenn.edu/software/verse.shtml or http://biorxiv.org/content/early/2016/05/14/053306 + + verse algorithm + - + - + A material separation device also commerically known as Isoraft, that is used to isolate single cells. + Stephen A. Fisher, Junhyong Kim, Dan Berrios + https://en.wikipedia.org/wiki/Microrafts + + microraft + - + - + A device that is a laboratory tool commonly used in chemistry, biology and medicine to transport a measured volume of liquid, often as a media dispenser. + Stephen A. Fisher, Junhyong Kim, Dan Berrios + https://en.wikipedia.org/wiki/Pipette + + pipette + - + - + A material entity that is an individual living system, such as animal, plant, bacteria or virus, that is capable of replicating or reproducing, growth and maintenance in the right environment. An organism may be unicellular or made up, like humans, of many billions of cells divided into specialized tissues and organs. + 10/21/09: This is a placeholder term, that should ideally be imported from the NCBI taxonomy, but the high level hierarchy there does not suit our needs (includes plasmids and 'other organisms') + 13-02-2009: +OBI doesn't take position as to when an organism starts or ends being an organism - e.g. sperm, foetus. +This issue is outside the scope of OBI. + GROUP: OBI Biomaterial Branch + WEB: http://en.wikipedia.org/wiki/Organism + + organism + - + - + A material entity that has the specimen role. + Note: definition is in specimen creation objective which is defined as an objective to obtain and store a material entity for potential use as an input during an investigation. + PERSON: James Malone + PERSON: Philippe Rocca-Serra + GROUP: OBI Biomaterial Branch + + specimen + - + - + A flow_cytometer_sorter is a flow_cytometer that analyzes and separates or sorts particles passing through (based on properties measured during analysis) to collect cells of interest. + John Quinn + Melanie Courtot + http://www.flocyte.com/FRTP/Resources/flow_cytometry_glossary.htm + + flow cytometer sorter + - + - + A DNA sequencer is an instrument that determines the order of deoxynucleotides in deoxyribonucleic acid sequences. + Trish Whetzel + MO + + DNA sequencer + - + - + the use of a chemical or biochemical means to infer the sequence of a biomaterial + has_output should be sequence of input; we don't have sequence well defined yet + PlanAndPlannedProcess Branch + OBI branch derived + + sequencing assay + - + - + the use of enzymes to increase the number of molecules of a biomaterial + PERSON:Kevin Clancy + OBI branch derived + + enzymatic amplification + - + - + An algorithm that attempts to align two molecular sequences (nucleic acid or protein sequences). + Ready for OBI-WS : v1.0 + WS Annotations Group, UGA + WS Annotations Group, UGA + + pairwise sequence alignment algorithm + - + - + BLAST (Basic Local Alignment Search Tool), a pairwise sequence alignment algorithm is a heuristic search algorithm for comparing primary biological sequence information, such as the amino-acid or nucleotides sequences with a database of sequences, and identify sequences that resemble the query sequence above a certain threshold. + Ready for OBI-WS : v1.0 + ITPPR + Wikipedia: BLAST + + BLAST algorithm + - + - + A data format specification for molecular sequence feature information. + Ready for OBI-WS : v1.0 + ITPPR + sequence data format + EDAM + + sequence data format specification + - + - + - + - + A sequence data that is about the primary structure of RNA. + ITPPR + ITPPR + + RNA sequence data + - + - + A processual entity whose completion is hypothesized (by a healthcare provider) to alleviate the signs and symptoms associated with a disorder + Albert Goldfain + http://code.google.com/p/ogms/issues/detail?id=35 + + treatment + - + - + The principle investigtor or responsible person for a study or a sample collection. + + study principle investigator or responsible + - + - + A data item that indicates the time when the collection of a specimen occurred. + Alice Nzinga + Mathias Brochhausen + date of specimen preparation + + date of specimen collection + @@ -1382,92 +2336,160 @@ - + - + A collection of sequences (often chromosomes) taken as the standard for a given organism and genome assembly. + + reference_genome + - + - + A level of depth of a taxon in a taxonomic hierarchy. + + taxonomic_rank + - + - + + species + - + - + Anatomical entity that has mass. + + material anatomical entity + - + - + + taxonomic rank + - + - + A role played by a a biological sample in the context of an experiment where the intent is that biological or technical variation is measured. + James Malone + + replicate + - + - + FASTQ format is a text-based format for storing both a biological sequence (usually nucleotide sequence) and its corresponding quality scores. + + FASTQ format + - + - + BAM is the compressed binary version of the Sequence Alignment/Map (SAM) format + + BAM format + - + - + A genome is the full genetic content of an organism, contained in either DNA or RNA (such as for viruses). + James Malone + + genome + - + - + The transcriptome is the set of all RNA molecules, including mRNA, rRNA, tRNA, and other non-coding RNA produced in one or a population of cells. + + transcriptome + - + + CEL data file format describes the format used in a CEL file for storing the results of the intensity calculations on the pixel values of a DAT file. This includes an intensity value, standard deviation of the intensity, the number of pixels used to calculate the intensity value, a flag to indicate an outlier as calculated by the algorithm and a user defined flag indicating the feature should be excluded from future analysis. The file stores the previously stated data for each feature on the probe array. + James Malone + + CEL data file format + + + + + + + + + + + + + + + + + + + + + A BLAST algorithm that searches/aligns a nucleotide query sequence against a nucleotide database at a nucleotide level. + BLASTn - + diff --git a/src/ontology/Makefile b/src/ontology/Makefile index a608710..3c81384 100644 --- a/src/ontology/Makefile +++ b/src/ontology/Makefile @@ -34,7 +34,8 @@ prepare_release: all # by default we use Elk to perform a reason-relax-reduce chain # after that we annotate the ontology with the release versionInfo $(ONT).owl: $(SRC) - $(ROBOT) reason -i $< -r ELK relax reduce -r ELK annotate -V $(BASE)/releases/`date +%Y-%m-%d`/$(ONT).owl -o $@ + $(ROBOT) merge --input $(SRC) reason --output $(ONT).owl +# $(ROBOT) reason -i $< -r ELK relax reduce -r ELK annotate -V $(BASE)/releases/`date +%Y-%m-%d`/$(ONT).owl -o $@ $(ONT).obo: $(ONT).owl $(ROBOT) convert -i $< -f obo -o $(ONT).obo.tmp && mv $(ONT).obo.tmp $@ @@ -45,7 +46,7 @@ $(ONT).obo: $(ONT).owl # These live in the imports/ folder # These can be regenerated with make all_imports -IMPORTS = +IMPORTS = properties terms IMPORTS_OWL = $(patsubst %, imports/%_import.owl,$(IMPORTS)) $(patsubst %, imports/%_import.obo,$(IMPORTS)) # Make this target to regenerate ALL