Trait-specific sample sizes?

[harryyiheyang]

Hi there,
When I used the mvsusie_rss(), a universal sample size was required for all traits. However, this rarely happens in practice, e.g., the following numbers are the sample sizes of GWAS summary data:
BMI DBP HDL LDL SBP SMK T2D TG
747649.9 969641.0 1232760.0 1222125.6 946218.1 801386.2 747649.9 1242643.5
Is it available to allow trait-specific sample sizes?
Thank you very much
Yihe

[gaow]

@zouyuxin do we take a vector of sample sizes ordered same way as the phenotypes?

[stephens999]

It's strongly advised to use the same individuals for all traits, using imputation where necessary to achieve this. When you use different individuals the results may be unreliable.

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[harryyiheyang]

Hi @stephens999 and @gaow
I appreciate your clarification!
Yihe