diff --git a/src/Autocomplete/CHANGELOG.md b/src/Autocomplete/CHANGELOG.md
index d7384fee5f9..2498c7b9bfb 100644
--- a/src/Autocomplete/CHANGELOG.md
+++ b/src/Autocomplete/CHANGELOG.md
@@ -1,5 +1,9 @@
 # CHANGELOG
 
+## 2.23.0
+
+-   Reset TomSelect when updating url attribute #1505
+
 ## 2.22.0
 
 -   Take `labelField` TomSelect option into account #2382
diff --git a/src/Autocomplete/assets/dist/controller.d.ts b/src/Autocomplete/assets/dist/controller.d.ts
index 59938a721c6..d5cc6b3e272 100644
--- a/src/Autocomplete/assets/dist/controller.d.ts
+++ b/src/Autocomplete/assets/dist/controller.d.ts
@@ -40,6 +40,7 @@ export default class extends Controller {
     connect(): void;
     initializeTomSelect(): void;
     disconnect(): void;
+    urlValueChanged(): void;
     private getMaxOptions;
     get selectElement(): HTMLSelectElement | null;
     get formElement(): HTMLInputElement | HTMLSelectElement;
diff --git a/src/Autocomplete/assets/dist/controller.js b/src/Autocomplete/assets/dist/controller.js
index fb04294a331..e021770d8b5 100644
--- a/src/Autocomplete/assets/dist/controller.js
+++ b/src/Autocomplete/assets/dist/controller.js
@@ -91,6 +91,9 @@ class default_1 extends Controller {
             }
         }
     }
+    urlValueChanged() {
+        this.resetTomSelect();
+    }
     getMaxOptions() {
         return this.selectElement ? this.selectElement.options.length : 50;
     }
@@ -131,7 +134,6 @@ class default_1 extends Controller {
             this.element.innerHTML = currentHtml;
             this.initializeTomSelect();
             this.tomSelect.setValue(currentValue);
-            this.startMutationObserver();
         }
     }
     changeTomSelectDisabledState(isDisabled) {
diff --git a/src/Autocomplete/assets/src/controller.ts b/src/Autocomplete/assets/src/controller.ts
index 38b324fcb68..6b68283b51d 100644
--- a/src/Autocomplete/assets/src/controller.ts
+++ b/src/Autocomplete/assets/src/controller.ts
@@ -128,6 +128,10 @@ export default class extends Controller {
         }
     }
 
+    urlValueChanged() {
+        this.resetTomSelect();
+    }
+
     #getCommonConfig(): Partial<TomSettings> {
         const plugins: TPluginHash = {};
 
@@ -391,8 +395,6 @@ export default class extends Controller {
             this.element.innerHTML = currentHtml;
             this.initializeTomSelect();
             this.tomSelect.setValue(currentValue);
-
-            this.startMutationObserver();
         }
     }
 
diff --git a/src/Autocomplete/assets/test/controller.test.ts b/src/Autocomplete/assets/test/controller.test.ts
index e17dc6ae8d3..5b72e7fb075 100644
--- a/src/Autocomplete/assets/test/controller.test.ts
+++ b/src/Autocomplete/assets/test/controller.test.ts
@@ -138,6 +138,80 @@ describe('AutocompleteController', () => {
         expect(fetchMock.requests()[1].url).toEqual('/path/to/autocomplete?query=foo');
     });
 
+    it('resets when ajax URL attribute on a select element changes', async () => {
+        const { container, tomSelect } = await startAutocompleteTest(`
+            <label for="the-select">Items</label>
+            <select
+                id="the-select"
+                data-testid="main-element"
+                data-controller="autocomplete"
+                data-autocomplete-url-value="/path/to/autocomplete"
+            ></select>
+        `);
+
+        const selectElement = getByTestId(container, 'main-element') as HTMLSelectElement;
+
+        // initial Ajax request on focus
+        fetchMock.mockResponseOnce(
+            JSON.stringify({
+                results: [
+                    {
+                        value: 3,
+                        text: 'salad',
+                    },
+                ],
+            })
+        );
+
+        fetchMock.mockResponseOnce(
+            JSON.stringify({
+                results: [
+                    {
+                        value: 1,
+                        text: 'pizza',
+                    },
+                    {
+                        value: 2,
+                        text: 'popcorn',
+                    },
+                ],
+            })
+        );
+
+        const controlInput = tomSelect.control_input;
+
+        // wait for the initial Ajax request to finish
+        userEvent.click(controlInput);
+        await waitFor(() => {
+            expect(container.querySelectorAll('.option[data-selectable]')).toHaveLength(1);
+        });
+
+        controlInput.value = 'foo';
+        controlInput.dispatchEvent(new Event('input'));
+
+        await waitFor(() => {
+            expect(container.querySelectorAll('.option[data-selectable]')).toHaveLength(2);
+        });
+
+        expect(selectElement.value).toBe('');
+        tomSelect.addItem('2');
+        expect(selectElement.value).toBe('2');
+
+        selectElement.outerHTML = `
+            <select
+                id="the-select"
+                data-testid="main-element"
+                data-controller="autocomplete"
+                data-autocomplete-url-value="/path/to/autocomplete2"
+            ></select>
+        `;
+
+        // wait for the MutationObserver to flush these changes
+        await shortDelay(10);
+
+        expect(selectElement.value).toBe('');
+    });
+
     it('connect with ajax URL on an input element', async () => {
         const { container, tomSelect } = await startAutocompleteTest(`
             <label for="the-input">Items</label>