diff --git a/drf_spectacular/plumbing.py b/drf_spectacular/plumbing.py
index 1b14d380..85b61e96 100644
--- a/drf_spectacular/plumbing.py
+++ b/drf_spectacular/plumbing.py
@@ -37,6 +37,7 @@
 from rest_framework.fields import empty
 from rest_framework.settings import api_settings
 from rest_framework.test import APIRequestFactory
+from rest_framework.utils.encoders import JSONEncoder
 from rest_framework.utils.mediatypes import _MediaType
 from rest_framework.utils.serializer_helpers import ReturnDict, ReturnList
 from uritemplate import URITemplate
@@ -839,7 +840,7 @@ def load_enum_name_overrides():
 
 
 def list_hash(lst):
-    return hashlib.sha256(json.dumps(list(lst), sort_keys=True).encode()).hexdigest()
+    return hashlib.sha256(json.dumps(list(lst), sort_keys=True, cls=JSONEncoder).encode()).hexdigest()
 
 
 def anchor_pattern(pattern: str) -> str:
diff --git a/tests/test_postprocessing.py b/tests/test_postprocessing.py
index 3ef0c3fc..3fcf61e4 100644
--- a/tests/test_postprocessing.py
+++ b/tests/test_postprocessing.py
@@ -314,3 +314,29 @@ def get(self, request):
         'items': {'$ref': '#/components/schemas/QualityLevelsEnum'},
         'readOnly': True
     }
+
+
+def test_uuid_choices(no_warnings):
+
+    import uuid
+
+    class XSerializer(serializers.Serializer):
+        foo = serializers.ChoiceField(
+            choices=[
+                (uuid.UUID('93d7527f-de3c-4a76-9cc2-5578675630d4'), 'baz'),
+                (uuid.UUID('47a4b873-409e-4e43-81d5-fafc3faeb849'), 'bar')
+            ]
+        )
+
+    class XAPIView(APIView):
+        @extend_schema(responses=XSerializer)
+        def get(self, request):
+            pass  # pragma: no cover
+
+    schema = generate_schema('x', view=XAPIView)
+
+    assert 'FooEnum' in schema['components']['schemas']
+    assert schema['components']['schemas']['FooEnum']['enum'] == [
+        uuid.UUID('93d7527f-de3c-4a76-9cc2-5578675630d4'),
+        uuid.UUID('47a4b873-409e-4e43-81d5-fafc3faeb849')
+    ]