diff --git a/packages/compiler-core/__tests__/transforms/__snapshots__/vFor.spec.ts.snap b/packages/compiler-core/__tests__/transforms/__snapshots__/vFor.spec.ts.snap
index 3da778eb675..225861919da 100644
--- a/packages/compiler-core/__tests__/transforms/__snapshots__/vFor.spec.ts.snap
+++ b/packages/compiler-core/__tests__/transforms/__snapshots__/vFor.spec.ts.snap
@@ -135,6 +135,26 @@ return function render(_ctx, _cache) {
 }"
 `;
 
+exports[`compiler: v-for > codegen > template w/ v-for + custom directive should not be STABLE_FRAGMENT 1`] = `
+"const _Vue = Vue
+
+return function render(_ctx, _cache) {
+  with (_ctx) {
+    const { renderList: _renderList, Fragment: _Fragment, openBlock: _openBlock, createElementBlock: _createElementBlock, resolveDirective: _resolveDirective, withDirectives: _withDirectives, createCommentVNode: _createCommentVNode } = _Vue
+
+    const _directive_focus = _resolveDirective("focus")
+
+    return show
+      ? (_openBlock(true), _createElementBlock(_Fragment, { key: 0 }, _renderList(arr, (i) => {
+          return _withDirectives((_openBlock(), _createElementBlock("h1", { key: i })), [
+            [_directive_focus]
+          ])
+        }), 128 /* KEYED_FRAGMENT */))
+      : _createCommentVNode("v-if", true)
+  }
+}"
+`;
+
 exports[`compiler: v-for > codegen > v-for on <slot/> 1`] = `
 "const _Vue = Vue
 
diff --git a/packages/compiler-core/__tests__/transforms/vFor.spec.ts b/packages/compiler-core/__tests__/transforms/vFor.spec.ts
index fead2476ac5..8ad5fba9999 100644
--- a/packages/compiler-core/__tests__/transforms/vFor.spec.ts
+++ b/packages/compiler-core/__tests__/transforms/vFor.spec.ts
@@ -1073,5 +1073,12 @@ describe('compiler: v-for', () => {
         },
       })
     })
+
+    test('template w/ v-for + custom directive should not be STABLE_FRAGMENT', () => {
+      const { root } = parseWithForTransform(
+        '<template v-if="show"><h1 v-for="i in arr" :key="i" v-focus></h1></template>',
+      )
+      expect(generate(root).code).toMatchSnapshot()
+    })
   })
 })
diff --git a/packages/compiler-core/src/transforms/vFor.ts b/packages/compiler-core/src/transforms/vFor.ts
index 0dca0ba9ab4..ec32ef41438 100644
--- a/packages/compiler-core/src/transforms/vFor.ts
+++ b/packages/compiler-core/src/transforms/vFor.ts
@@ -105,10 +105,16 @@ export const transformFor: NodeTransform = createStructuralDirectiveTransform(
           )
         }
       }
-
+      const maybeRuntimeDir = findDir(
+        node,
+        /^(?!if$|else$|else-if$|bind$|for$|memo$|on$|once$|slot$|model$).*$/,
+        true,
+      )
       const isStableFragment =
         forNode.source.type === NodeTypes.SIMPLE_EXPRESSION &&
-        forNode.source.constType > ConstantTypes.NOT_CONSTANT
+        forNode.source.constType > ConstantTypes.NOT_CONSTANT &&
+        !maybeRuntimeDir
+
       const fragmentFlag = isStableFragment
         ? PatchFlags.STABLE_FRAGMENT
         : keyProp
diff --git a/packages/vue/__tests__/index.spec.ts b/packages/vue/__tests__/index.spec.ts
index 0c969f15981..ee54042ad51 100644
--- a/packages/vue/__tests__/index.spec.ts
+++ b/packages/vue/__tests__/index.spec.ts
@@ -276,6 +276,38 @@ describe('compiler + runtime integration', () => {
     expect(container.innerHTML).toBe(`<div>false<div>true</div></div>`)
   })
 
+  it('should trigger custom directive unmounted hook with v-for', async () => {
+    const mounted = vi.fn()
+    const unmounted = vi.fn()
+    const visible = ref(true)
+    const App = {
+      directives: {
+        foo: {
+          mounted,
+          unmounted,
+        },
+      },
+      setup() {
+        const arr = [1, 2, 3]
+        return {
+          arr,
+          visible,
+        }
+      },
+      template: `<template v-if="visible">
+        <h1 v-for="i in arr" :key="i" v-foo></h1>
+      </template>`,
+    }
+
+    const container = document.createElement('div')
+    createApp(App).mount(container)
+    await nextTick()
+    expect(mounted).toHaveBeenCalledTimes(3)
+    visible.value = false
+    await nextTick()
+    expect(unmounted).toHaveBeenCalledTimes(3)
+  })
+
   test('v-for + v-once', async () => {
     const list = reactive([1])
     const App = {