diff --git a/.github/workflows/unit-tests.yml b/.github/workflows/unit-tests.yml
index 8bd77bf8..5c596301 100644
--- a/.github/workflows/unit-tests.yml
+++ b/.github/workflows/unit-tests.yml
@@ -4,7 +4,7 @@ on: [push, pull_request]
 
 jobs:
   build:
-    runs-on: ubuntu-18.04
+    runs-on: ubuntu-latest
 
     defaults:
       run:
diff --git a/CHANGELOG.md b/CHANGELOG.md
index 12de5c9b..7e861505 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -18,6 +18,35 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 
 ### Changed
 
+## [4.6.0]
+
+### Added
+
+#### Recipes
+ - samtools 1.16.1
+ - bcftools 1.16
+ - htslib 1.16
+
+#### Features
+
+### Removed
+
+#### Recipes
+ - irods 4.2.10
+
+### Changed
+ - Github Actions: Move from ubuntu-18.04 to ubuntu-latest
+
+#### Recipes
+ - Build config with compiler version and cflags and increment build number:
+   - avrocpp 1.8.2, 1.9.0
+   - boost 1.73.0
+ - Remove irods 4.2.10 from build config:
+   - baton 3.1.0, 3.2.0, 3.3.0, 4.0.0
+   - htslib-plugins 201712
+ - Update release url:
+   - libarchive
+
 ## [4.5.0]
 
 ### Added
diff --git a/recipes/avrocpp/1.8.2/conda_build_config.yaml b/recipes/avrocpp/1.8.2/conda_build_config.yaml
new file mode 100644
index 00000000..cdeaa7ff
--- /dev/null
+++ b/recipes/avrocpp/1.8.2/conda_build_config.yaml
@@ -0,0 +1,16 @@
+c_compiler_version:
+  - 9.3
+
+cxx_compiler_version:
+  - 9.3
+
+CFLAGS: >-
+  -O2
+  -fPIC
+  -ffunction-sections
+  -fno-plt
+  -fstack-protector-strong
+  -ftree-vectorize
+  -march=x86-64
+  -mtune=generic
+  -pipe
diff --git a/recipes/avrocpp/1.8.2/meta.yaml b/recipes/avrocpp/1.8.2/meta.yaml
index 19c650e3..5081c9cc 100644
--- a/recipes/avrocpp/1.8.2/meta.yaml
+++ b/recipes/avrocpp/1.8.2/meta.yaml
@@ -12,7 +12,7 @@ source:
   sha1: {{ hash }}
 
 build:
-  number: 4
+  number: 5
 
 requirements:
   build:
diff --git a/recipes/avrocpp/1.9.0/conda_build_config.yaml b/recipes/avrocpp/1.9.0/conda_build_config.yaml
new file mode 100644
index 00000000..cdeaa7ff
--- /dev/null
+++ b/recipes/avrocpp/1.9.0/conda_build_config.yaml
@@ -0,0 +1,16 @@
+c_compiler_version:
+  - 9.3
+
+cxx_compiler_version:
+  - 9.3
+
+CFLAGS: >-
+  -O2
+  -fPIC
+  -ffunction-sections
+  -fno-plt
+  -fstack-protector-strong
+  -ftree-vectorize
+  -march=x86-64
+  -mtune=generic
+  -pipe
diff --git a/recipes/avrocpp/1.9.0/meta.yaml b/recipes/avrocpp/1.9.0/meta.yaml
index 02f15ded..351e7d05 100644
--- a/recipes/avrocpp/1.9.0/meta.yaml
+++ b/recipes/avrocpp/1.9.0/meta.yaml
@@ -12,7 +12,7 @@ source:
   sha1: {{ hash }}
 
 build:
-  number: 4
+  number: 5
 
 requirements:
   build:
diff --git a/recipes/baton/3.1.0/conda_build_config.yaml b/recipes/baton/3.1.0/conda_build_config.yaml
index 3d793f8e..edb823be 100644
--- a/recipes/baton/3.1.0/conda_build_config.yaml
+++ b/recipes/baton/3.1.0/conda_build_config.yaml
@@ -1,4 +1,3 @@
 
 irods:
   - 4.2.7
-  - 4.2.10
diff --git a/recipes/baton/3.2.0/conda_build_config.yaml b/recipes/baton/3.2.0/conda_build_config.yaml
index a7ffa5b0..e250be7b 100644
--- a/recipes/baton/3.2.0/conda_build_config.yaml
+++ b/recipes/baton/3.2.0/conda_build_config.yaml
@@ -1,5 +1,4 @@
 
 irods:
   - 4.2.7
-  - 4.2.10
   - 4.2.11
diff --git a/recipes/baton/3.3.0/conda_build_config.yaml b/recipes/baton/3.3.0/conda_build_config.yaml
index a7ffa5b0..e250be7b 100644
--- a/recipes/baton/3.3.0/conda_build_config.yaml
+++ b/recipes/baton/3.3.0/conda_build_config.yaml
@@ -1,5 +1,4 @@
 
 irods:
   - 4.2.7
-  - 4.2.10
   - 4.2.11
diff --git a/recipes/baton/4.0.0/conda_build_config.yaml b/recipes/baton/4.0.0/conda_build_config.yaml
index a7ffa5b0..e250be7b 100644
--- a/recipes/baton/4.0.0/conda_build_config.yaml
+++ b/recipes/baton/4.0.0/conda_build_config.yaml
@@ -1,5 +1,4 @@
 
 irods:
   - 4.2.7
-  - 4.2.10
   - 4.2.11
diff --git a/recipes/bcftools/1.16/build.sh b/recipes/bcftools/1.16/build.sh
new file mode 100644
index 00000000..69c68710
--- /dev/null
+++ b/recipes/bcftools/1.16/build.sh
@@ -0,0 +1,11 @@
+#!/bin/sh
+
+set -ex
+
+n="$CPU_COUNT"
+
+./configure --prefix="$PREFIX" --with-htslib="$PREFIX" \
+  CPPFLAGS="-I$PREFIX/include" LDFLAGS="-L$PREFIX/lib"
+
+make -j "$n" 
+make install prefix="$PREFIX"
diff --git a/recipes/bcftools/1.16/meta.yaml b/recipes/bcftools/1.16/meta.yaml
new file mode 100644
index 00000000..37253185
--- /dev/null
+++ b/recipes/bcftools/1.16/meta.yaml
@@ -0,0 +1,36 @@
+{% set version = "1.16" %} # reset build to zero on changing
+{% set upstream_version = "1.16" %}
+{% set htslib_version = "1.16" %}  # Bump build version on change
+{% set sha256 = "90bf647c9ad79e10a243b8058c873de057fd7012e250d5ae6574839787a2ecd6" %}
+
+package:
+  name: bcftools
+  version: "{{ version }}"
+
+about:
+  home: https://github.com/samtools/bcftools
+  license: MIT
+  summary: VCF commands and BCF calling.
+
+build:
+  number: 0
+
+source:
+  url: https://github.com/samtools/bcftools/releases/download/{{ upstream_version }}/bcftools-{{ upstream_version }}.tar.bz2
+  fn: bcftools-{{ upstream_version }}.tar.bz2
+  sha256: {{ sha256 }}
+
+requirements:
+  build:
+    - {{ compiler("c") }}
+    - make
+  host:
+    - libhts-dev =={{ htslib_version }}
+    - libz-dev
+  run:
+    - libhts =={{ htslib_version }}
+    - libz
+
+test:
+  commands:
+    - bcftools --help
diff --git a/recipes/boost/1.73.0/conda_build_config.yaml b/recipes/boost/1.73.0/conda_build_config.yaml
index 1ad4b2d8..26a95472 100644
--- a/recipes/boost/1.73.0/conda_build_config.yaml
+++ b/recipes/boost/1.73.0/conda_build_config.yaml
@@ -1,3 +1,9 @@
+c_compiler_version:
+  - 9.3
+
+cxx_compiler_version:
+  - 9.3
+
 CFLAGS: >-
   -O2
   -fPIC
diff --git a/recipes/boost/1.73.0/meta.yaml b/recipes/boost/1.73.0/meta.yaml
index 0b334f06..f30a09a4 100644
--- a/recipes/boost/1.73.0/meta.yaml
+++ b/recipes/boost/1.73.0/meta.yaml
@@ -12,7 +12,7 @@ about:
   summary: "Free peer-reviewed portable C++ source libraries."
 
 build:
-  number: 2
+  number: 3
 
 source:
   url: https://boostorg.jfrog.io/artifactory/main/release/{{ version }}/source/boost_{{ alt_version }}.tar.bz2
diff --git a/recipes/htslib-plugins/201712/conda_build_config.yaml b/recipes/htslib-plugins/201712/conda_build_config.yaml
index a7ffa5b0..e250be7b 100644
--- a/recipes/htslib-plugins/201712/conda_build_config.yaml
+++ b/recipes/htslib-plugins/201712/conda_build_config.yaml
@@ -1,5 +1,4 @@
 
 irods:
   - 4.2.7
-  - 4.2.10
   - 4.2.11
diff --git a/recipes/htslib/1.16/build.sh b/recipes/htslib/1.16/build.sh
new file mode 100755
index 00000000..bffda6b4
--- /dev/null
+++ b/recipes/htslib/1.16/build.sh
@@ -0,0 +1,24 @@
+#!/bin/sh
+
+set -ex
+
+n="$CPU_COUNT"
+
+pushd htslib
+
+autoheader
+autoconf
+
+./configure \
+    --prefix="$PREFIX" \
+    --with-libdeflate \
+    --enable-libcurl \
+    --enable-s3 \
+    --enable-gcs \
+    --enable-plugins \
+    CC="$GCC" CPPFLAGS="-I$PREFIX/include" LDFLAGS="-L$PREFIX/lib"
+
+make -j "$n" AR="$AR"
+make install prefix="$PREFIX"
+popd
+
diff --git a/recipes/htslib/1.16/meta.yaml b/recipes/htslib/1.16/meta.yaml
new file mode 100644
index 00000000..bcde2777
--- /dev/null
+++ b/recipes/htslib/1.16/meta.yaml
@@ -0,0 +1,120 @@
+{% set version = "1.16" %} # reset build to zero on changing
+{% set htslib_rev = "4e61c128238f3e7cbb3b1f4e9c0fdb4880aa9a10" %}
+
+package:
+  name: htslib-pkg
+  version: "{{ version }}"
+
+about:
+  home: https://github.com/samtools/htslib
+  license: MIT
+  summary: C library for high-throughput sequencing data formats.
+
+build:
+  number: 0
+
+source:
+  - git_url: https://github.com/samtools/htslib.git
+    git_rev: {{ htslib_rev }}
+    folder: htslib
+
+requirements:
+  build:
+    - {{ compiler("c") }}
+    - autoconf
+    - automake
+    - make
+    - perl
+  host:
+    - libbz2-dev
+    - libcurl-dev
+    - libdeflate-dev
+    - liblzma-dev
+    - libssl-dev
+    - libz-dev
+  run:
+    - libbz2
+    - libcurl
+    - libdeflate
+    - liblzma
+    - libssl
+    - libz
+
+outputs:
+  - name: htslib
+    version: {{ version }}
+    requirements:
+      build:
+        - {{ compiler("c") }}
+        - autoconf
+        - automake
+        - make
+        - perl
+      host:
+        - libbz2-dev
+        - libcurl-dev
+        - libdeflate-dev
+        - liblzma-dev
+        - libssl-dev
+        - libz-dev
+      run:
+        - {{ pin_subpackage("libhts", exact=True) }}
+        - libbz2
+        - libcurl
+        - libdeflate
+        - liblzma
+        - libssl
+        - libz
+    files:
+      - bin/bgzip
+      - bin/htsfile
+      - bin/tabix
+      - share/man/man1/htsfile.1
+      - share/man/man1/tabix.1
+
+  - name: libhts
+    version: {{ version }}
+    requirements:
+      build:
+        - {{ compiler("c") }}
+        - autoconf
+        - automake
+        - make
+        - perl
+      host:
+        - libbz2-dev
+        - libcurl-dev
+        - libdeflate-dev
+        - liblzma-dev
+        - libssl-dev
+        - libz-dev
+      run:
+        - libbz2
+        - libcurl
+        - libdeflate
+        - liblzma
+        - libssl
+        - libz
+    files:
+      - libexec/htslib
+      - lib/libhts.so*
+    test:
+      commands:
+        - test -h ${PREFIX}/lib/libhts.so
+        - test -f ${PREFIX}/libexec/htslib/hfile_libcurl.so
+
+  - name: libhts-dev
+    version: {{ version }}
+    requirements:
+      run:
+        - {{ pin_subpackage("libhts", exact=True) }}
+    files:
+      - include/htslib
+      - lib/libhts.a
+      - share/man/man5/faidx.5
+      - share/man/man5/sam.5
+      - share/man/man5/vcf.5
+    test:
+      commands:
+        - test -f ${PREFIX}/lib/libhts.a
+        - test -f ${PREFIX}/include/htslib/sam.h
diff --git a/recipes/irods/4.2.10/build.sh b/recipes/irods/4.2.10/build.sh
deleted file mode 100644
index 4b8d218f..00000000
--- a/recipes/irods/4.2.10/build.sh
+++ /dev/null
@@ -1,83 +0,0 @@
-#!/bin/bash
-
-set -ex
-
-running_in_docker() {
-    if [ -f /.dockerenv ]; then
-        return 0
-    else
-        return 1
-    fi
-}
-
-export TERM=dumb
-
-if running_in_docker ; then
-    echo "Running in Docker ... "
-fi
-
-pushd irods
-git submodule init && git submodule update
-popd
-
-[ -d build_irods ] || mkdir build_irods
-pushd build_irods
-cmake \
-    -D CMAKE_INSTALL_PREFIX=${PREFIX} \
-    -D CMAKE_INSTALL_LIBDIR=${PREFIX}/lib \
-    -D IRODS_EXTERNALS_FULLPATH_CLANG=${BUILD_PREFIX} \
-    -D IRODS_EXTERNALS_FULLPATH_CLANG_RUNTIME=${PREFIX} \
-    -D IRODS_EXTERNALS_FULLPATH_ARCHIVE=${PREFIX} \
-    -D IRODS_EXTERNALS_FULLPATH_AVRO=${PREFIX} \
-    -D IRODS_EXTERNALS_FULLPATH_BOOST=${PREFIX} \
-    -D IRODS_EXTERNALS_FULLPATH_CATCH2=${PREFIX} \
-    -D IRODS_EXTERNALS_FULLPATH_CPPZMQ=${PREFIX} \
-    -D IRODS_EXTERNALS_FULLPATH_FMT=${PREFIX} \
-    -D IRODS_EXTERNALS_FULLPATH_JANSSON=${PREFIX} \
-    -D IRODS_EXTERNALS_FULLPATH_JSON=${PREFIX} \
-    -D IRODS_EXTERNALS_FULLPATH_NANODBC=${PREFIX} \
-    -D IRODS_EXTERNALS_FULLPATH_ZMQ=${PREFIX} \
-    -D IRODS_LINUX_DISTRIBUTION_NAME='ubuntu' \
-    -D IRODS_LINUX_DISTRIBUTION_VERSION_MAJOR='18' \
-    -D IRODS_LINUX_DISTRIBUTION_VERSION_CODENAME='bionic' \
-    -D CMAKE_C_FLAGS="-I${PREFIX}/include" \
-    -D CMAKE_CXX_FLAGS='-Wno-deprecated-declarations' \
-    -D CMAKE_LD_FLAGS='-Wno-deprecated-declarations' \
-    -D CMAKE_EXE_LINKER_FLAGS="-Wl,-rpath-link,${PREFIX}/lib -fuse-ld=${LD}" \
-    -D CMAKE_SHARED_LINKER_FLAGS="-Wl,-allow-multiple-definition" \
-    -D CMAKE_C_COMPILER="${BUILD_PREFIX}/bin/clang" \
-    -D CMAKE_CXX_COMPILER="${BUILD_PREFIX}/bin/clang++" \
-    -D BUILD_UNIT_TESTS=OFF \
-    -D CMAKE_AR=${AR} \
-    -D CMAKE_LINKER=${LD} \
-    -D CPP=${CPP} \
-    ../irods
-make VERBOSE=1 -j "$CPU_COUNT" package
-make VERBOSE=1 install
-popd
-
-[ -d build_icommands ] || mkdir build_icommands
-pushd build_icommands
-cmake \
-    -D CMAKE_INSTALL_PREFIX=${PREFIX} \
-    -D CMAKE_INSTALL_LIBDIR=${PREFIX}/lib \
-    -D IRODS_EXTERNALS_FULLPATH_CLANG=${BUILD_PREFIX} \
-    -D IRODS_EXTERNALS_FULLPATH_CLANG_RUNTIME=${PREFIX} \
-    -D IRODS_LINUX_DISTRIBUTION_NAME='ubuntu' \
-    -D IRODS_LINUX_DISTRIBUTION_VERSION_MAJOR='18' \
-    -D IRODS_LINUX_DISTRIBUTION_VERSION_CODENAME='bionic' \
-    -D IRODS_DIR="${PREFIX}/lib/irods/cmake" \
-    -D CMAKE_C_FLAGS="-I${PREFIX}/include" \
-    -D CMAKE_CXX_FLAGS='-Wno-deprecated-declarations' \
-    -D CMAKE_LD_FLAGS='-Wno-deprecated-declarations' \
-    -D CMAKE_EXE_LINKER_FLAGS="-Wl,-rpath-link,${PREFIX}/lib -fuse-ld=${LD}" \
-    -D CMAKE_C_COMPILER="${BUILD_PREFIX}/bin/clang" \
-    -D CMAKE_CXX_COMPILER="${BUILD_PREFIX}/bin/clang++" \
-    -D CMAKE_AR=${AR} \
-    -D CMAKE_LINKER=${LD} \
-    -D CPP=${CPP} \
-    ../irods_client_icommands
-
-make VERBOSE=1 -j "$CPU_COUNT" package
-make install
-popd
diff --git a/recipes/irods/4.2.10/icommands-cmakelists.patch b/recipes/irods/4.2.10/icommands-cmakelists.patch
deleted file mode 100644
index 30efb012..00000000
--- a/recipes/irods/4.2.10/icommands-cmakelists.patch
+++ /dev/null
@@ -1,39 +0,0 @@
-diff --git CMakeLists.txt CMakeLists.txt
-index 984ecd8..8e973fb 100644
---- CMakeLists.txt
-+++ CMakeLists.txt
-@@ -5,7 +5,7 @@ set(IRODS_PACKAGE_PREFIX "${PACKAGE_PREFIX_DIR}")
- 
- include(RequireOutOfSourceBuild)
- 
--set(CMAKE_CXX_COMPILER ${IRODS_EXTERNALS_FULLPATH_CLANG}/bin/clang++)
-+# set(CMAKE_CXX_COMPILER ${IRODS_EXTERNALS_FULLPATH_CLANG}/bin/clang++)
- set(CMAKE_CXX_STANDARD 17)
- # export-dynamic so stacktrace entries from executables have function names
- set(CMAKE_EXE_LINKER_FLAGS_INIT "-rdynamic -Wl,--export-dynamic -Wl,--enable-new-dtags -Wl,--as-needed -Wl,-z,defs")
-@@ -15,6 +15,10 @@ project(icommands
-   VERSION "${IRODS_VERSION}"
-   LANGUAGES CXX)
- 
-+include(GNUInstallDirs)
-+include_directories(AFTER ${CMAKE_INSTALL_PREFIX}/include)
-+include_directories(${IRODS_EXTERNALS_FULLPATH_JSON}/include/nlohmann)
-+
- set(CMAKE_SKIP_BUILD_RPATH OFF)
- set(CMAKE_SKIP_INSTALL_RPATH OFF)
- set(CMAKE_SKIP_RPATH OFF)
-@@ -22,8 +26,6 @@ set(CMAKE_INSTALL_RPATH_USE_LINK_PATH ON)
- set(CMAKE_BUILD_WITH_INSTALL_RPATH OFF)
- set(CMAKE_BUILD_RPATH_USE_ORIGIN ON)
- 
--include(UseLibCXX)
--
- set(CMAKE_EXPORT_COMPILE_COMMANDS TRUE)
- 
- include(${IRODS_TARGETS_PATH})
-@@ -462,3 +464,5 @@ if (NOT CPACK_GENERATOR)
- endif()
- 
- include(CPack)
-+
-+install(TARGETS ${IRODS_CLIENT_ICOMMANDS_EXECUTABLES} DESTINATION ${CMAKE_INSTALL_BINDIR})
diff --git a/recipes/irods/4.2.10/irods-cmakelists.patch b/recipes/irods/4.2.10/irods-cmakelists.patch
deleted file mode 100644
index 9c9e2eab..00000000
--- a/recipes/irods/4.2.10/irods-cmakelists.patch
+++ /dev/null
@@ -1,87 +0,0 @@
-diff --git CMakeLists.txt CMakeLists.txt
-index a51beff1a..5999df394 100644
---- CMakeLists.txt
-+++ CMakeLists.txt
-@@ -30,36 +30,12 @@ macro(IRODS_MACRO_CHECK_DEPENDENCY_SET_FULLPATH_ADD_TO_IRODS_PACKAGE_DEPENDENCIE
-   list(APPEND IRODS_PACKAGE_DEPENDENCIES_LIST irods-externals-${DEPENDENCY_SUBDIRECTORY})
- endmacro()
- 
--IRODS_MACRO_CHECK_DEPENDENCY_SET_FULLPATH(CLANG clang6.0-0)
--IRODS_MACRO_CHECK_DEPENDENCY_SET_FULLPATH(CPPZMQ cppzmq4.2.3-0)
--IRODS_MACRO_CHECK_DEPENDENCY_SET_FULLPATH_ADD_TO_IRODS_PACKAGE_DEPENDENCIES_LIST(ARCHIVE libarchive3.3.2-1)
--IRODS_MACRO_CHECK_DEPENDENCY_SET_FULLPATH_ADD_TO_IRODS_PACKAGE_DEPENDENCIES_LIST(AVRO avro1.9.0-0)
--IRODS_MACRO_CHECK_DEPENDENCY_SET_FULLPATH_ADD_TO_IRODS_PACKAGE_DEPENDENCIES_LIST(BOOST boost1.67.0-0)
--IRODS_MACRO_CHECK_DEPENDENCY_SET_FULLPATH_ADD_TO_IRODS_PACKAGE_DEPENDENCIES_LIST(CLANG_RUNTIME clang-runtime6.0-0)
--IRODS_MACRO_CHECK_DEPENDENCY_SET_FULLPATH_ADD_TO_IRODS_PACKAGE_DEPENDENCIES_LIST(ZMQ zeromq4-14.1.6-0)
--IRODS_MACRO_CHECK_DEPENDENCY_SET_FULLPATH_ADD_TO_IRODS_PACKAGE_DEPENDENCIES_LIST(JSON json3.7.3-0)
--IRODS_MACRO_CHECK_DEPENDENCY_SET_FULLPATH_ADD_TO_IRODS_PACKAGE_DEPENDENCIES_LIST(CATCH2 catch22.3.0-0)
--IRODS_MACRO_CHECK_DEPENDENCY_SET_FULLPATH_ADD_TO_IRODS_PACKAGE_DEPENDENCIES_LIST(NANODBC nanodbc2.13.0-1)
--IRODS_MACRO_CHECK_DEPENDENCY_SET_FULLPATH_ADD_TO_IRODS_PACKAGE_DEPENDENCIES_LIST(FMT fmt6.1.2-1)
--
- string(REPLACE ";" ", " IRODS_PACKAGE_DEPENDENCIES_STRING "${IRODS_PACKAGE_DEPENDENCIES_LIST}")
- 
--if (NOT CLANG_STATIC_ANALYZER)
--  set(CLANG_STATIC_ANALYZER OFF CACHE BOOL "Choose whether to run Clang Static Analyzer." FORCE)
--  message(STATUS "Setting CLANG_STATIC_ANALYZER to 'OFF'.")
--  set(CMAKE_C_COMPILER ${IRODS_EXTERNALS_FULLPATH_CLANG}/bin/clang)
--  set(CMAKE_CXX_COMPILER ${IRODS_EXTERNALS_FULLPATH_CLANG}/bin/clang++)
--else()
--  set(CLANG_STATIC_ANALYZER ON CACHE BOOL "Choose whether to run Clang Static Analyzer." FORCE)
--  message(STATUS "Setting CLANG_STATIC_ANALYZER to 'ON'.")
--  set(CMAKE_C_COMPILER ${IRODS_EXTERNALS_FULLPATH_CLANG}/bin/ccc-analyzer)
--  set(CMAKE_CXX_COMPILER ${IRODS_EXTERNALS_FULLPATH_CLANG}/bin/c++-analyzer)
--endif()
--
- set(CMAKE_CXX_STANDARD 17)
- set(IRODS_CXX_STANDARD "${CMAKE_CXX_STANDARD}")
- # export-dynamic so stacktrace entries from executables have function names
--set(CMAKE_EXE_LINKER_FLAGS_INIT "-Wl,--export-dynamic -Wl,--enable-new-dtags -Wl,--as-needed -Wl,-z,defs")
-+set(CMAKE_EXE_LINKER_FLAGS_INIT "-Wl,--export-dynamic -Wl,--enable-new-dtags -Wl,--as-needed -Wl,-z,defs  -Wl,-rpath-link,${CMAKE_INSTALL_PREFIX}")
- set(CMAKE_MODULE_LINKER_FLAGS_INIT "-Wl,--enable-new-dtags -Wl,--as-needed -Wl,-z,defs")
- set(CMAKE_SHARED_LINKER_FLAGS_INIT "-Wl,--enable-new-dtags -Wl,--as-needed -Wl,-z,defs")
- set(CMAKE_EXE_LINKER_FLAGS_RELEASE_INIT "-Wl,--gc-sections -Wl,-z,combreloc")
-@@ -75,8 +51,8 @@ project(irods
-   VERSION ${IRODS_VERSION}
-   LANGUAGES C CXX)
- 
--include(UseLibCXX)
--
-+include(GNUInstallDirs)
-+include_directories(AFTER ${CMAKE_INSTALL_PREFIX}/include)
- set(CMAKE_EXPORT_COMPILE_COMMANDS TRUE)
- 
- include(${CMAKE_SOURCE_DIR}/cmake/InstallDirs.cmake)
-@@ -85,13 +61,13 @@ set(CMAKE_SKIP_BUILD_RPATH FALSE)
- set(CMAKE_SKIP_INSTALL_RPATH FALSE)
- set(CMAKE_SKIP_RPATH FALSE)
- set(CMAKE_INSTALL_RPATH_USE_LINK_PATH TRUE)
-+# set(CMAKE_INSTALL_RPATH ${CMAKE_INSTALL_PREFIX}/lib) ???
- add_compile_options(-Wall -Wextra -Werror -Wno-unused-function -Wno-unused-parameter)
- 
- if (IRODS_DISABLE_COMPILER_OPTIMIZATIONS)
-     add_compile_options(-O0)
- endif()
- 
--
- if (CMAKE_CXX_COMPILER_ID STREQUAL "Clang" AND CMAKE_CXX_COMPILER_VERSION VERSION_GREATER 9)
-   # Do not error on definition of implicit copy constructor for classes with a
-   # user-declared copy assignment operator.
-@@ -102,7 +78,11 @@ if (CMAKE_CXX_COMPILER_ID STREQUAL "Clang" AND CMAKE_CXX_COMPILER_VERSION VERSIO
-   add_compile_options(-Wno-error=tautological-overlap-compare)
- endif()
- 
--include_directories(${IRODS_EXTERNALS_FULLPATH_JSON}/include)
-+set(IRODS_HOME_DIRECTORY ${CMAKE_INSTALL_LOCALSTATEDIR}/lib/irods)
-+set(IRODS_PLUGINS_DIRECTORY ${CMAKE_INSTALL_LIBDIR}/irods/plugins)
-+
-+include_directories(${IRODS_EXTERNALS_FULLPATH_JSON}/include/nlohmann)
-+include_directories(AFTER ${CMAKE_INSTALL_PREFIX}/include)
- 
- set(CMAKE_THREAD_PREFER_PTHREAD TRUE)
- set(THREADS_PREFER_PTHREAD_FLAG TRUE)
-@@ -1638,3 +1618,5 @@ foreach(DATABASE_PLUGIN postgres oracle mysql)
- endforeach()
- 
- include(CPack)
-+
-+install(TARGETS irods_client DESTINATION ${CMAKE_INSTALL_LIBDIR})
diff --git a/recipes/irods/4.2.10/irods-lib-core-irods-load-plugin-path-truncation-bug.patch b/recipes/irods/4.2.10/irods-lib-core-irods-load-plugin-path-truncation-bug.patch
deleted file mode 100644
index 3fe938d8..00000000
--- a/recipes/irods/4.2.10/irods-lib-core-irods-load-plugin-path-truncation-bug.patch
+++ /dev/null
@@ -1,32 +0,0 @@
-diff --git lib/core/include/irods_load_plugin.hpp lib/core/include/irods_load_plugin.hpp
-index 04acc1111..433ee5738 100644
---- lib/core/include/irods_load_plugin.hpp
-+++ lib/core/include/irods_load_plugin.hpp
-@@ -41,7 +41,6 @@ namespace irods
-             if ( strlen( env.irodsPluginHome ) > 0 ) {
-                 plugin_home = env.irodsPluginHome;
-             }
--
-         }
- 
-         if (plugin_home.empty()) {
-@@ -166,9 +165,19 @@ namespace irods
-             return ERROR( PLUGIN_ERROR_MISSING_SHARED_OBJECT, msg );
-         }
- 
-+        // Defensively remove NUL from the constructed so_name
-+        // string. We have observed a NUL appear between the directory
-+        // and file name components of the so_name path when
-+        // distributed as a Conda package.
-+        //
-+        // When c_str() is called on the offending string the result
-+        // is truncated and dlopen() on the truncated path fails.
-+        so_name.erase(remove(so_name.begin(), so_name.end(), '\0'), so_name.end());
-+
-         // =-=-=-=-=-=-=-
-         // try to open the shared object
-         void*  handle  = dlopen( so_name.c_str(), RTLD_LAZY | RTLD_LOCAL );
-+
-         if ( !handle ) {
-             std::stringstream msg;
-             msg << "failed to open shared object file [" << so_name
diff --git a/recipes/irods/4.2.10/irods-plugins-api-data-object-finalize-compile-error.patch b/recipes/irods/4.2.10/irods-plugins-api-data-object-finalize-compile-error.patch
deleted file mode 100644
index 65afa7f2..00000000
--- a/recipes/irods/4.2.10/irods-plugins-api-data-object-finalize-compile-error.patch
+++ /dev/null
@@ -1,13 +0,0 @@
-diff --git plugins/api/src/data_object_finalize.cpp plugins/api/src/data_object_finalize.cpp
-index ea4855387..9d7114cd3 100644
---- plugins/api/src/data_object_finalize.cpp
-+++ plugins/api/src/data_object_finalize.cpp
-@@ -109,7 +109,7 @@ namespace
- 
-     auto column_is_mutable(const std::string_view _c)
-     {
--        using immutable_columns_list_t = std::vector<const std::string_view>;
-+        using immutable_columns_list_t = std::vector<std::string_view>;
-         static const immutable_columns_list_t immutable_columns =
-         {
-             "data_id",
diff --git a/recipes/irods/4.2.10/irods-plugins-database-cmakelists.patch b/recipes/irods/4.2.10/irods-plugins-database-cmakelists.patch
deleted file mode 100644
index e4425903..00000000
--- a/recipes/irods/4.2.10/irods-plugins-database-cmakelists.patch
+++ /dev/null
@@ -1,13 +0,0 @@
-diff --git plugins/database/CMakeLists.txt plugins/database/CMakeLists.txt
-index 86786dd0b..1890a3e4c 100644
---- plugins/database/CMakeLists.txt
-+++ plugins/database/CMakeLists.txt
-@@ -42,7 +42,7 @@ foreach(PLUGIN ${IRODS_DATABASE_PLUGINS})
- 
-   add_custom_command(
-     OUTPUT ${CMAKE_BINARY_DIR}/icatSysTables_${PLUGIN}.sql
--    COMMAND cpp -E -P -D${PLUGIN} ${CMAKE_BINARY_DIR}/plugins/database/src/icatSysTables.sql.pp ${CMAKE_BINARY_DIR}/icatSysTables_${PLUGIN}.sql
-+    COMMAND ${CPP} -E -P -D${PLUGIN} ${CMAKE_BINARY_DIR}/plugins/database/src/icatSysTables.sql.pp ${CMAKE_BINARY_DIR}/icatSysTables_${PLUGIN}.sql
-     MAIN_DEPENDENCY ${CMAKE_BINARY_DIR}/plugins/database/src/icatSysTables.sql.pp
-     )
-   add_custom_target(IRODS_PHONY_TARGET_icatSysTables_${PLUGIN}.sql ALL DEPENDS ${CMAKE_BINARY_DIR}/icatSysTables_${PLUGIN}.sql) # Forces execution of custom_command
diff --git a/recipes/irods/4.2.10/irods-plugins-libunixfilesystem-compile-error.patch b/recipes/irods/4.2.10/irods-plugins-libunixfilesystem-compile-error.patch
deleted file mode 100644
index a5410c22..00000000
--- a/recipes/irods/4.2.10/irods-plugins-libunixfilesystem-compile-error.patch
+++ /dev/null
@@ -1,13 +0,0 @@
-diff --git plugins/resources/unixfilesystem/libunixfilesystem.cpp plugins/resources/unixfilesystem/libunixfilesystem.cpp
-index 190fabe07..59132c0fb 100644
---- plugins/resources/unixfilesystem/libunixfilesystem.cpp
-+++ plugins/resources/unixfilesystem/libunixfilesystem.cpp
-@@ -468,7 +468,7 @@ void warn_if_deprecated_context_string_set(
-             __FUNCTION__);
-     }
- 
--    const std::vector<const std::string> deprecated_keys{HIGH_WATER_MARK, REQUIRED_FREE_INODES_FOR_CREATE};
-+    const std::vector<std::string> deprecated_keys{HIGH_WATER_MARK, REQUIRED_FREE_INODES_FOR_CREATE};
- 
-     for (const auto& k : deprecated_keys) {
-         std::string holder{};
diff --git a/recipes/irods/4.2.10/meta.yaml b/recipes/irods/4.2.10/meta.yaml
deleted file mode 100644
index a43c7fa4..00000000
--- a/recipes/irods/4.2.10/meta.yaml
+++ /dev/null
@@ -1,160 +0,0 @@
-{% set version = "4.2.10" %}
-{% set clang_version = "8.0.1" %}
-
-package:
-  name: irods
-  version: "{{ version }}"
-
-about:
-  home: https://irods.org
-  license: BSD
-  summary: "Open Source Data Management Software."
-
-build:
-  number: 1
-
-source:
-  - git_url: https://github.com/irods/irods.git
-    git_rev: "{{ version }}"
-    folder: irods
-    patches:
-      - irods-cmakelists.patch
-      - irods-lib-core-irods-load-plugin-path-truncation-bug.patch
-      - irods-plugins-api-data-object-finalize-compile-error.patch
-      - irods-plugins-database-cmakelists.patch
-      - irods-plugins-libunixfilesystem-compile-error.patch
-  - git_url: https://github.com/irods/irods_client_icommands.git
-    git_rev: "{{ version }}"
-    folder: irods_client_icommands
-    patches:
-      - icommands-cmakelists.patch
-
-requirements:
-  build:
-    - cmake >=3.7.0
-    - {{ compiler('c') }}
-    - {{ compiler('cxx') }}
-    - clang =={{ clang_version }}
-    - clangxx =={{ clang_version }}
-    - make
-    - help2man
-  host:
-    - avrocpp-dev >=1.9
-    - catch2
-    - cppzmq
-    - fmt <8.0
-    - json
-    - krb5-dev
-    - libarchive-dev
-    - libboost-dev
-    - libjansson-dev
-    - libpam-dev
-    - libssl-dev
-    - nanodbc
-    - unixodbc
-    - zeromq
-
-outputs:
-  - name: irods-runtime
-    version: {{ version }}
-    requirements:
-      run:
-        - fmt <8.0
-        - libarchive
-        - libavrocpp >=1.9
-        - libboost
-        - libjansson
-        - libkrb5
-        - libpam
-        - libssl
-        - zeromq
-    files:
-      - lib/irods/plugins
-      - lib/libirods_client.so*
-      - lib/libirods_common.so*
-      - lib/libirods_plugin_dependencies.so*
-      - lib/libirods_server.so*
-
-  - name: irods-dev
-    version: {{ version }}
-    requirements:
-      run:
-        - {{ pin_subpackage("irods-runtime", exact=True) }}
-    files:
-      - include/irods
-      - lib/irods/externals
-      - lib/libRodsAPIs.a
-      - lib/libirods_client.a
-      - lib/libirods_client_api.a
-      - lib/libirods_client_api_table.a
-      - lib/libirods_client_core.a
-      - lib/libirods_client_plugins.a
-      - lib/libirods_server.a
-      - share/irods
-
-  - name: irods-icommands
-    version: {{ version }}
-    requirements:
-      run:
-        - {{ pin_subpackage("irods-runtime", exact=True) }}
-        - fmt <8.0
-        - libarchive
-        - libavrocpp >=1.9
-        - libboost
-        - libjansson
-        - libkrb5
-        - libpam
-        - libssl
-        - zeromq
-    files:
-      - bin/iadmin
-      - bin/ibun
-      - bin/ichksum
-      - bin/ichmod
-      - bin/icp
-      - bin/idbug
-      - bin/ienv
-      - bin/ierror
-      - bin/iexecmd
-      - bin/iexit
-      - bin/ifsck
-      - bin/iget
-      - bin/igroupadmin
-      - bin/ihelp
-      - bin/iinit
-      - bin/ils
-      - bin/ilsresc
-      - bin/imcoll
-      - bin/imeta
-      - bin/imiscsvrinfo
-      - bin/imkdir
-      - bin/imv
-      - bin/ipasswd
-      - bin/iphybun
-      - bin/iphymv
-      - bin/ips
-      - bin/iput
-      - bin/ipwd
-      - bin/iqdel
-      - bin/iqmod
-      - bin/iqmod
-      - bin/iqstat
-      - bin/iquest
-      - bin/iquota
-      - bin/irepl
-      - bin/irm
-      - bin/irmtrash
-      - bin/irsync
-      - bin/irule
-      - bin/iscan
-      - bin/isysmeta
-      - bin/iticket
-      - bin/itrim
-      - bin/iuserinfo
-      - bin/ixmsg
-      - bin/izonereport
-      - share/man
-
-    test:
-      commands:
-        - ienv
diff --git a/recipes/libarchive/3.5.1/meta.yaml b/recipes/libarchive/3.5.1/meta.yaml
index 63ad9c62..143c7330 100644
--- a/recipes/libarchive/3.5.1/meta.yaml
+++ b/recipes/libarchive/3.5.1/meta.yaml
@@ -11,7 +11,7 @@ about:
   summary: "Multi-format archive and compression library"
 
 source:
-  url: https://github.com/libarchive/libarchive/releases/download/{{ version }}/libarchive-{{ version }}.tar.gz
+  url: https://github.com/libarchive/libarchive/releases/download/v{{ version }}/libarchive-{{ version }}.tar.gz
   sha256: {{ sha256 }}
 
 build:
diff --git a/recipes/samtools/1.16.1/build.sh b/recipes/samtools/1.16.1/build.sh
new file mode 100755
index 00000000..ced763db
--- /dev/null
+++ b/recipes/samtools/1.16.1/build.sh
@@ -0,0 +1,16 @@
+#!/bin/sh
+
+set -ex
+
+n="$CPU_COUNT"
+
+autoheader
+autoconf
+
+./configure --prefix="$PREFIX" \
+            --with-htslib=system \
+            --without-curses \
+            CPPFLAGS="-I$PREFIX/include" LDFLAGS="-L$PREFIX/lib"
+        
+make -j "$n" AR="$AR"
+make install prefix="$PREFIX"
diff --git a/recipes/samtools/1.16.1/meta.yaml b/recipes/samtools/1.16.1/meta.yaml
new file mode 100644
index 00000000..6903a8e5
--- /dev/null
+++ b/recipes/samtools/1.16.1/meta.yaml
@@ -0,0 +1,65 @@
+{% set version = "1.16.1" %} # reset build to zero on changing
+{% set htslib_version = "1.16" %}
+
+package:
+  name: samtools-pkg
+  version: "{{ version }}"
+
+about:
+  home: https://github.com/samtools/samtools
+  license: MIT
+  summary: C library for high-throughput sequencing data formats.
+
+build:
+  number: 0
+
+source:
+  git_url: https://github.com/samtools/samtools.git
+  git_rev: 1.16.1
+
+requirements:
+  build:
+    - {{ compiler("c") }}
+    - autoconf
+    - automake
+    - make
+    - perl
+  host:
+    - libhts-dev =={{ htslib_version }}
+    - libz-dev
+  run:
+    - libhts =={{ htslib_version }}
+    - libz
+
+outputs:
+  - name: samtools
+    version: {{ version }}
+    requirements:
+      build:
+        - {{ compiler("c") }}
+        - autoconf
+        - automake
+        - make
+        - perl
+      host:
+        - libhts-dev =={{ htslib_version }}
+        - libz-dev
+      run:
+        - libhts =={{ htslib_version }}
+        - libz
+    files:
+      - bin/ace2sam
+      - bin/maq2sam-*
+      - bin/md5*
+      - bin/plot-ampliconstats
+      - bin/plot-bamstats
+      - bin/samtools
+      - bin/wgsim
+      - bin/*.pl
+      - bin/*.py
+      - share/man/man1/samtools*.1
+      - share/man/man1/wgsim.1
+    test:
+      commands:
+        - echo -e '@HD\tVN:1.0\tSO:unsorted' | samtools view
+        - samtools --help | grep Version:\ {{ version }}\ \(