diff --git a/docker/Dockerfile b/docker/Dockerfile
index a02b129..865a7cb 100644
--- a/docker/Dockerfile
+++ b/docker/Dockerfile
@@ -1,7 +1,7 @@
 ARG IRODS_VERSION="4.2.11"
-ARG HTSLIB_VERSION=1.20
-ARG SAMTOOLS_VERSION=1.20
-ARG BCFTOOLS_VERSION=1.20
+ARG HTSLIB_VERSION=1.21
+ARG SAMTOOLS_VERSION=1.21
+ARG BCFTOOLS_VERSION=1.21
 ARG DEFLATE_VERSION=1.20
 
 FROM ubuntu:18.04 AS samtools_build
diff --git a/docker/Makefile b/docker/Makefile
index 0931b64..a8b21fa 100644
--- a/docker/Makefile
+++ b/docker/Makefile
@@ -38,9 +38,9 @@ samtools.$(TAG): Dockerfile
 	--build-arg DOCKER_TAG=$(TAG) \
 	--build-arg IRODS_VERSION=4.2.11 \
 	--build-arg BATON_VERSION=4.2.1 \
-	--build-arg HTSLIB_VERSION=1.20 \
-	--build-arg SAMTOOLS_VERSION=1.20 \
-	--build-arg BCFTOOLS_VERSION=1.20 \
+	--build-arg HTSLIB_VERSION=1.21 \
+	--build-arg SAMTOOLS_VERSION=1.21 \
+	--build-arg BCFTOOLS_VERSION=1.21 \
 	--build-arg DEFLATE_VERSION=1.20 \
 	--label org.opencontainers.image.title=$(image_names) \
 	--label org.opencontainers.image.source=$(git_url) \