diff --git a/drivers/mbox/Kconfig.nrf_vevif_event b/drivers/mbox/Kconfig.nrf_vevif_event
index c9d634dac828c0..94a9658d9a9ee0 100644
--- a/drivers/mbox/Kconfig.nrf_vevif_event
+++ b/drivers/mbox/Kconfig.nrf_vevif_event
@@ -14,3 +14,7 @@ config MBOX_NRF_VEVIF_EVENT_TX
 	default y
 	help
 	  Mailbox driver for transmitting events from VPR to a remote core
+
+config MBOX_NRF_VEVIF_EVENT_USE_54L_ERRATA_16
+	bool "Apply errata 16 for nRF54L series"
+	default y if SOC_SERIES_NRF54LX
diff --git a/drivers/mbox/mbox_nrf_vevif_event_rx.c b/drivers/mbox/mbox_nrf_vevif_event_rx.c
index 4b2760fe5a98c0..f2fc96599f8066 100644
--- a/drivers/mbox/mbox_nrf_vevif_event_rx.c
+++ b/drivers/mbox/mbox_nrf_vevif_event_rx.c
@@ -13,6 +13,12 @@
 #define EVENTS_IDX_MIN NRF_VPR_EVENTS_TRIGGERED_MIN
 #define EVENTS_IDX_MAX NRF_VPR_EVENTS_TRIGGERED_MAX
 
+#if defined(CONFIG_MBOX_NRF_VEVIF_EVENT_USE_54L_ERRATA_16)
+#define VEVIF_54L_EVENT_IDX 20
+BUILD_ASSERT(DT_INST_PROP(0, nordic_events) == 1);
+BUILD_ASSERT(DT_INST_PROP(0, nordic_events_mask) & BIT(VEVIF_54L_EVENT_IDX));
+#endif
+
 /* callbacks */
 struct mbox_vevif_event_rx_cbs {
 	mbox_callback_t cb[EVENTS_IDX_MAX - EVENTS_IDX_MIN + 1U];
@@ -27,24 +33,34 @@ struct mbox_vevif_event_rx_conf {
 	void (*irq_connect)(void);
 };
 
+static void trigger_callback(const struct device *dev, struct mbox_vevif_event_rx_cbs *cbs,
+			     uint8_t id)
+{
+	uint8_t idx = id - EVENTS_IDX_MIN;
+
+	if ((cbs->enabled_mask & BIT(id)) && (cbs->cb[idx] != NULL)) {
+		cbs->cb[idx](dev, id, cbs->user_data[idx], NULL);
+	}
+}
+
 static void vevif_event_rx_isr(const void *device)
 {
 	const struct device *dev = (struct device *)device;
-	const struct mbox_vevif_event_rx_conf *config = dev->config;
 	struct mbox_vevif_event_rx_cbs *cbs = dev->data;
 
+#if !defined(CONFIG_MBOX_NRF_VEVIF_EVENT_USE_54L_ERRATA_16)
+	const struct mbox_vevif_event_rx_conf *config = dev->config;
+
 	for (uint8_t id = EVENTS_IDX_MIN; id < EVENTS_IDX_MAX + 1U; id++) {
 		nrf_vpr_event_t event = nrfy_vpr_triggered_event_get(id);
-
 		if (nrfy_vpr_event_check(config->vpr, event)) {
 			nrfy_vpr_event_clear(config->vpr, event);
-			uint8_t idx = id - EVENTS_IDX_MIN;
-
-			if ((cbs->enabled_mask & BIT(id)) && (cbs->cb[idx] != NULL)) {
-				cbs->cb[idx](dev, id, cbs->user_data[idx], NULL);
-			}
+			trigger_callback(dev, cbs, id);
 		}
 	}
+#else
+	trigger_callback(dev, cbs, VEVIF_54L_EVENT_IDX);
+#endif
 }
 
 static inline bool vevif_event_rx_event_is_valid(uint32_t events_mask, uint32_t id)
diff --git a/drivers/mbox/mbox_nrf_vevif_event_tx.c b/drivers/mbox/mbox_nrf_vevif_event_tx.c
index b0869185da7e09..f7703c8d3b8064 100644
--- a/drivers/mbox/mbox_nrf_vevif_event_tx.c
+++ b/drivers/mbox/mbox_nrf_vevif_event_tx.c
@@ -39,6 +39,13 @@ static int vevif_event_tx_send(const struct device *dev, uint32_t id, const stru
 
 	nrf_vpr_csr_vevif_events_trigger(BIT(id));
 
+#if defined(CONFIG_MBOX_NRF_VEVIF_EVENT_USE_54L_ERRATA_16)
+	while (!nrf_vpr_csr_vevif_events_get()) {
+		;
+	}
+	nrf_vpr_csr_vevif_events_set(0);
+#endif
+
 	return 0;
 }