diff --git a/zio-http/src/main/scala/zio/http/Handler.scala b/zio-http/src/main/scala/zio/http/Handler.scala
index 52bb0ea89..851a8be2a 100644
--- a/zio-http/src/main/scala/zio/http/Handler.scala
+++ b/zio-http/src/main/scala/zio/http/Handler.scala
@@ -367,6 +367,19 @@ sealed trait Handler[-R, +Err, -In, +Out] { self =>
   ): Handler[R1, Err1, In, Out1] =
     self.foldHandler(err => Handler.fromZIO(f(err)), Handler.succeed(_))
 
+  /**
+   * Transforms all failures of the handler effectfully except pure
+   * interruption.
+   */
+  final def mapErrorCauseZIO[R1 <: R, Err1, Out1 >: Out](
+    f: Cause[Err] => ZIO[R1, Err1, Out1],
+  )(implicit trace: Trace): Handler[R1, Err1, In, Out1] =
+    self.foldCauseHandler(
+      err =>
+        if (err.isInterruptedOnly) Handler.failCause(err.asInstanceOf[Cause[Nothing]]) else Handler.fromZIO(f(err)),
+      Handler.succeed(_),
+    )
+
   /**
    * Returns a new handler where the error channel has been merged into the
    * success channel to their common combined type.
diff --git a/zio-http/src/main/scala/zio/http/Route.scala b/zio-http/src/main/scala/zio/http/Route.scala
index 0e0ec8334..c51d6fc20 100644
--- a/zio-http/src/main/scala/zio/http/Route.scala
+++ b/zio-http/src/main/scala/zio/http/Route.scala
@@ -83,6 +83,32 @@ sealed trait Route[-Env, +Err] { self =>
         Handled(rpm.routePattern, handler2, location)
     }
 
+  final def handleErrorCauseZIO(
+    f: Cause[Err] => ZIO[Any, Nothing, Response],
+  )(implicit trace: Trace): Route[Env, Nothing] =
+    self match {
+      case Provided(route, env)                     => Provided(route.handleErrorCauseZIO(f), env)
+      case Augmented(route, aspect)                 => Augmented(route.handleErrorCauseZIO(f), aspect)
+      case Handled(routePattern, handler, location) => Handled(routePattern, handler, location)
+
+      case Unhandled(rpm, handler, zippable, location) =>
+        val handler2: Handler[Env, Response, Request, Response] = {
+          val paramHandler =
+            Handler.fromFunctionZIO[(rpm.Context, Request)] { case (ctx, request) =>
+              rpm.routePattern.decode(request.method, request.path) match {
+                case Left(error)  => ZIO.dieMessage(error)
+                case Right(value) =>
+                  val params = rpm.zippable.zip(value, ctx)
+
+                  handler(zippable.zip(params, request))
+              }
+            }
+          rpm.aspect.applyHandlerContext(paramHandler.mapErrorCauseZIO(f))
+        }
+
+        Handled(rpm.routePattern, handler2, location)
+    }
+
   /**
    * Determines if the route is defined for the specified request.
    */
diff --git a/zio-http/src/main/scala/zio/http/Routes.scala b/zio-http/src/main/scala/zio/http/Routes.scala
index bc8845d1d..3fb19c578 100644
--- a/zio-http/src/main/scala/zio/http/Routes.scala
+++ b/zio-http/src/main/scala/zio/http/Routes.scala
@@ -76,6 +76,9 @@ final class Routes[-Env, +Err] private (val routes: Chunk[zio.http.Route[Env, Er
   def handleErrorCause(f: Cause[Err] => Response)(implicit trace: Trace): Routes[Env, Nothing] =
     new Routes(routes.map(_.handleErrorCause(f)))
 
+  def handleErrorCauseZIO(f: Cause[Err] => ZIO[Any, Nothing, Response])(implicit trace: Trace): Routes[Env, Nothing] =
+    new Routes(routes.map(_.handleErrorCauseZIO(f)))
+
   /**
    * Returns new routes that have each been provided the specified environment,
    * thus eliminating their requirement for any specific environment.
diff --git a/zio-http/src/test/scala/zio/http/RouteSpec.scala b/zio-http/src/test/scala/zio/http/RouteSpec.scala
index 8555051a5..13b4baf74 100644
--- a/zio-http/src/test/scala/zio/http/RouteSpec.scala
+++ b/zio-http/src/test/scala/zio/http/RouteSpec.scala
@@ -16,8 +16,6 @@
 
 package zio.http
 
-import scala.collection.Seq
-
 import zio._
 import zio.test._
 
@@ -64,5 +62,21 @@ object RouteSpec extends ZIOHttpSpec {
         } yield assertTrue(cnt == 2)
       },
     ),
+    suite("error handle")(
+      test("handleErrorCauseZIO should execute a ZIO effect") {
+        val route = Method.GET / "endpoint" -> handler { (req: Request) => ZIO.fail(new Exception("hmm...")) }
+        for {
+          p <- zio.Promise.make[Exception, String]
+
+          errorHandled = route
+            .handleErrorCauseZIO(c => p.failCause(c).as(Response.internalServerError))
+
+          request = Request.get(URL.decode("/endpoint").toOption.get)
+          response <- errorHandled.toHttpApp.runZIO(request)
+          result   <- p.await.catchAllCause(c => ZIO.succeed(c.prettyPrint))
+
+        } yield assertTrue(extractStatus(response) == Status.InternalServerError, result.contains("hmm..."))
+      },
+    ),
   )
 }