This is the official repository of the paper "Alzheimer’s disease rewires gene coexpression networks coupling different brain regions" by Sanga Mitra (+), Kailash B P (+), Srivatsan C R, Naga Venkata Saikumar, Philge Philip and Manikandan Narayanan (+ equal contributions).
The code was developed by Kailash B P, Manikandan Narayanan (in consultation with the other co-authors of the paper listed above), and these developers are jointly referred to as the "BIRDS Group, IIT Madras" in the preamble of all code files in this InterTissueDC project.
Copyright 2022 BIRDS Group, IIT Madras
InterTissueDC code is open source: you can redistribute it and/or modify it under the terms of the GNU Lesser General Public License as published by the Free Software Foundation, either version 2.1 or 3 of the License, or (at your option) any later version.
InterTissueDC is distributed in the hope that it will be useful, but WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the GNU Lesser General Public License for more details.
You should have received a copy of the GNU Lesser General Public License along with BioEmbedS. If not, see https://www.gnu.org/licenses/.
See requirements.txt file for the list of dependencies.
Source the script scripts/libaries.R to install, and load all the necessary packages.
Provides step by step instructions on how to run all the pieces of code to generate the results obtained in the study.
Provides step by step instructions on how to run all the pieces of code to generate the plots obtained in the study.
- Data paper: The Mount Sinai cohort of large-scale genomic, transcriptomic and proteomic data in Alzheimer's disease
- Synapse link to data: MSBB synapse
Results generated in this study is made available here.