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Merge pull request #1116 from ScilifelabDataCentre/develop
Deployment to production
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cff-version: 1.2.0 | ||
message: "If you use this software, please cite it as below." | ||
cff-version: 1.2.1 | ||
message: "If you use or reuse this software, please cite it using the following metadata." | ||
authors: | ||
- family-names: "Hughes" | ||
given-names: "Liane" | ||
orcid: 0000-0002-4784-5436 | ||
- family-names: "Stark" | ||
given-names: "Katarina Öjefors" | ||
orcid: 0000-0001-7970-7778 | ||
- family-names: "Kochari" | ||
given-names: "Arnold" | ||
orcid: 0000-0003-1373-5121 | ||
- family-names: "Panneerselvam" | ||
given-names: "Senthilkumar" | ||
- family-names: "Ewels" | ||
given-names: "Phil" | ||
- family-names: "Ostberg" | ||
orcid: 0000-0003-4101-2502 | ||
- family-names: "Östberg" | ||
given-names: "Linus" | ||
- family-names: "Kraulis" | ||
given-names: "Per" | ||
- family-names: "Rung" | ||
given-names: "Johan" | ||
orcid: 0000-0003-0560-974X | ||
- family-names: "Lorenz" | ||
given-names: "Jan" | ||
- family-names: "Asklof" | ||
given-names: "Anna" | ||
- family-names: "Kallberg" | ||
given-names: "Yvonne" | ||
orcid: 0000-0002-3977-9600 | ||
- family-names: "Islam" | ||
given-names: "Kazi Jahurul" | ||
- family-names: "Ouyang" | ||
given-names: "Wei" | ||
- family-names: "Kronander" | ||
given-names: "Elin" | ||
- family-names: "Tewatia" | ||
given-names: "Parul" | ||
- family-names: "Englund" | ||
given-names: "Markus" | ||
- family-names: "Hammaren" | ||
given-names: "Rickard" | ||
- family-names: "Xu" | ||
given-names: "Hao" | ||
orcid: 0000-0002-3096-1318 | ||
- family-names: "Rung" | ||
given-names: "Johan" | ||
orcid: 0000-0001-5875-8429 | ||
title: "Swedish Pathogens Portal" | ||
url: "https://github.com/ScilifelabDataCentre/pathogens-portal" |
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FROM klakegg/hugo:0.104.3-ubuntu-onbuild AS build | ||
# Use alpine Linux, download desired version of HUGO and build html files | ||
FROM alpine:3.19.1 AS build | ||
RUN apk add --no-cache wget=1.21.4-r0 | ||
ARG HUGO_VERSION="0.123.7" | ||
RUN wget --quiet "https://github.com/gohugoio/hugo/releases/download/v${HUGO_VERSION}/hugo_${HUGO_VERSION}_Linux-64bit.tar.gz" && \ | ||
tar xzf hugo_${HUGO_VERSION}_Linux-64bit.tar.gz && \ | ||
rm -r hugo_${HUGO_VERSION}_Linux-64bit.tar.gz && \ | ||
mv hugo /usr/bin && \ | ||
chmod 755 /usr/bin/hugo | ||
WORKDIR /src | ||
COPY ./ /src | ||
RUN mkdir /target && \ | ||
hugo -d /target | ||
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# Serve the generated html using nginx | ||
FROM nginxinc/nginx-unprivileged:alpine | ||
RUN sed -i '3 a\ absolute_redirect off;' /etc/nginx/conf.d/default.conf | ||
RUN sed -i 's/#error_page 404/error_page 404/' /etc/nginx/conf.d/default.conf | ||
RUN sed -i '3 a\ absolute_redirect off;' /etc/nginx/conf.d/default.conf && \ | ||
sed -i 's/#error_page 404/error_page 404/' /etc/nginx/conf.d/default.conf | ||
COPY --from=build /target /usr/share/nginx/html | ||
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EXPOSE 8080 |
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**Contact:** <[email protected]> and <[email protected]> | ||
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**Download the data:** [Respiratory virus gene copy numbers normalised per PMMoV gene copy number.CSV file](https://raw.githubusercontent.com/ScilifelabDataCentre/pathogens-portal/develop/static/ww_data_temp/SLU_wastewater_data.csv). Data are available for Influenza A from week 42 of 2022 and for Influenza B from week 12 of 2023; updated weekly. | ||
**Download the data:** [Respiratory virus gene copy numbers normalised per PMMoV gene copy number.CSV file](https://blobserver.dc.scilifelab.se/blob/SLU_wastewater_data.csv). Data are available for Influenza A from week 42 of 2022 and for Influenza B from week 12 of 2023; updated weekly. | ||
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**How to cite the dataset:** | ||
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--- | ||
title: "(Micro)bioterrorism: leveraging genomic data to improve anthrax surveillance" | ||
date: 2024-04-05 | ||
summary: A perspective on Bacillus anthracis, a pathogen known as a biological threat, and how WGS data and surveillance can help researchers respond to cases and threats. | ||
banner: /editorials/topic_infectious_disease.jpg | ||
banner_caption: "Splenic tissue from a monkey with inhalation anthrax, showing a red blood cell (red) and rod-shaped bacilli (yellow). (Credit: Arthur Friedlander)" | ||
tags: | ||
[ | ||
pathogens, | ||
Bacillus anthracis, | ||
WGS data, | ||
Whole genome sequencing, | ||
preparedness, | ||
health threat, | ||
Infectious disease, | ||
] | ||
editorials_topics: [Infectious diseases] | ||
editorials_authors: [Laura Carroll] | ||
images: [/editorials/topic_infectious_disease.jpg] | ||
--- | ||
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### What is anthrax? | ||
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Anthrax is a serious, life-threatening infectious disease, which is caused by a rod-shaped bacterium called *Bacillus anthracis* ([CDC, 2024a](https://www.cdc.gov/anthrax/basics/index.html)). | ||
_B. anthracis_ is arguably most well-known for its previous use as a biological weapon and bioterrorism agent ([CDC, 2024b](https://www.cdc.gov/anthrax/bioterrorism/threat.html); [Wagar, 2015](https://journals.asm.org/doi/10.1128/cmr.00033-15)). | ||
However, in some parts of the world, _B. anthracis_ naturally resides in soil, where it can form highly resilient spores capable of withstanding harsh environmental conditions ([CDC, 2024a](https://www.cdc.gov/anthrax/basics/index.html); [Mock and Fouet, 2001](https://www.annualreviews.org/doi/10.1146/annurev.micro.55.1.647)). | ||
Wild and domestic animals (livestock that graze, in particular; e.g., cattle, goats, sheep) can become infected by ingesting or inhaling _B. anthracis_ spores present in soil, water, and other natural environments ([CDC, 2024a](https://www.cdc.gov/anthrax/basics/index.html); [FDA, 2024](https://www.fda.gov/vaccines-blood-biologics/vaccines/anthrax)). | ||
Anthrax cases among humans can occur when _B. anthracis_ spores enter the body (e.g., by inhaling or ingesting spores, or when spores come in contact with a cut or lesion), as such, people who interact with infected animals or animal products have an increased risk of exposure ([CDC, 2024a](https://www.cdc.gov/anthrax/basics/index.html); [CDC, 2024c](https://www.cdc.gov/anthrax/transmission/index.html); [FDA, 2024](https://www.fda.gov/vaccines-blood-biologics/vaccines/anthrax)). | ||
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### Bacillus anthracis: the original anthrax-causing pathogen | ||
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For over a century, _B. anthracis_ has been known to be a causative agent of anthrax. | ||
In 1876, scientist Robert Koch demonstrated that _B. anthracis_, when injected into animals, caused disease ([CDC 2024d](https://www.cdc.gov/anthrax/basics/anthrax-history.html); [Blevins and Bronze, 2010](https://www.sciencedirect.com/science/article/pii/S1201971210023143); [Koch, 1876](https://edoc.rki.de/handle/176904/5139)). | ||
Not only did his studies provide insight into _B. anthracis_ biology, but they were the first to link a specific bacterium to a specific disease ([Blevins and Bronze, 2010](https://www.sciencedirect.com/science/article/pii/S1201971210023143)). | ||
Further, Koch's work with *B. anthracis* led to the publication of what are now famously known as Koch's Postulates, which serve as formal criteria for establishing a causal relationship between a microbe and a disease ([CDC 2024d](https://www.cdc.gov/anthrax/basics/anthrax-history.html)). | ||
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Since Koch's discoveries in the late 1800s, research into _B. anthracis_ biology and pathogenesis has led to numerous breakthroughs in anthrax prevention and treatment ([CDC 2024d](https://www.cdc.gov/anthrax/basics/anthrax-history.html)). | ||
Several anthrax vaccines have been developed for both humans and animals, and improvements in anthrax treatment (e.g., antibiotics, anthrax antitoxins) have led to better patient outcomes ([CDC 2024d](https://www.cdc.gov/anthrax/basics/anthrax-history.html); [Person, et al., 2022](https://academic.oup.com/cid/article/75/Supplement_3/S392/6762174)). | ||
However, these breakthroughs are often overshadowed by the use of _B. anthracis_ as a bioweapon, with the first documented case occurring during World War I ([CDC 2024d](https://www.cdc.gov/anthrax/basics/anthrax-history.html)). | ||
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### "Bacillus cereus" biovar Anthracis: a new type of anthrax | ||
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Over 100 years after Koch linked _B. anthracis_ to anthrax, researchers at the U.S. | ||
Centers for Disease Control and Prevention (CDC) discovered a novel pathogen capable of causing anthrax-like illness ([Hoffmaster, et al., 2004](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC420414/)). | ||
Later termed "_Bacillus cereus_" biovar Anthracis ([Antonation, et al., 2016](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015827/); [Carroll, et al., 2020](https://journals.asm.org/doi/full/10.1128/mbio.00034-20); [Klee, et al., 2006](https://journals.asm.org/doi/full/10.1128/jb.00303-06)), this novel pathogen resembled a completely different species, "_Bacillus cereus_", but was able to cause anthrax-like disease like *B. anthracis* ([Hoffmaster, et al., 2004](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC420414/); [Klee, et al., 2006](https://journals.asm.org/doi/full/10.1128/jb.00303-06)). | ||
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Since its discovery in 2004, "_B. cereus_" biovar Anthracis has been responsible for several other cases of severe, anthrax-like illness among humans and animals, several of which resulted in fatalities ([Baldwin, 2020](https://www.frontiersin.org/articles/10.3389/fmicb.2020.01731/full)). | ||
Notably, using whole-genome sequencing (WGS), scientists have revealed that "_B. cereus_" biovar Anthracis strains are incredibly diverse, indicating that different strains--and even species--have acquired the ability to cause anthrax; as a result, novel approaches must be developed to prepare for the emergence of novel anthrax-causing pathogens ([Carroll, et al., 2022](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9413466/)). | ||
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### Combating anthrax with genomic data | ||
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Due to their severity and bioterrorism potential, anthrax-causing *B. anthracis* and "_B. cereus_" biovar Anthracis represent severe global public health threats. | ||
To prepare for potential emergencies, scientists are taking proactive, data-driven approaches. | ||
Specifically, laboratories around the world are routinely using WGS to query the genomes of anthrax-causing bacteria. | ||
This WGS data is deposited in public databases (e.g. [the National Center for Biotechnology Information (NCBI) databases](https://www.ncbi.nlm.nih.gov/)), often alongside metadata conveying when, where, and how the anthrax-causing strain was isolated ([Ramnath, et al., 2023](https://www.biorxiv.org/content/10.1101/2023.12.20.572685v1.full)). | ||
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WGS data and metadata derived from anthrax-causing pathogens have tremendous potential to be utilised within the realms of public health and emergency preparedness. | ||
Specifically, WGS-based pathogen surveillance tools are allowing scientists to monitor pathogens in close to real-time ([Gardy and Loman, 2018](https://www.nature.com/articles/nrg.2017.88)). | ||
This (meta)data can be used to identify and resolve outbreaks sooner, leading to better public health outcomes and lower burdens of illness ([Gardy and Loman, 2018](https://www.nature.com/articles/nrg.2017.88); [Ramnath, et al., 2023](https://www.biorxiv.org/content/10.1101/2023.12.20.572685v1.full)). | ||
We envision that similar methods can be used for anthrax-causing pathogens. | ||
For example, routine WGS of bacilli can allow public health officials to rapidly identify novel, emerging anthrax-causing pathogens, facilitating faster response times and minimising the number of human illness cases ([Ramnath, et al., 2023](https://www.biorxiv.org/content/10.1101/2023.12.20.572685v1.full)). | ||
Overall, whether the culprit is _B. anthracis_, "_B. cereus_" biovar Anthracis, or a yet-unknown anthrax-causing pathogen, WGS has the potential to help public health officials and clinicians prepare for and respond to illness cases, outbreaks, and bioterrorism attacks. | ||
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#### Cite this editorial | ||
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Carroll, L. (2024). Editorial- (Micro)bioterrorism: leveraging genomic data to improve anthrax surveillance. Online resource. DOI: [10.17044/scilifelab.25547476](https://doi.org/10.17044/scilifelab.25547476). |
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--- | ||
title: "New Editorial about leveraging genomic data to improve anthrax surveillance" | ||
date: 2024-04-05 | ||
summary: A perspective on Bacillus anthracis, a pathogen known as a biological threat, and how WGS data and surveillance can help researchers respond to cases and threats. | ||
banner: /editorials/topic_infectious_disease.jpg | ||
banner_caption: "Splenic tissue from a monkey with inhalation anthrax, showing a red blood cell (red) and rod-shaped bacilli (yellow). (Credit: Arthur Friedlander)" | ||
--- | ||
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We have published a new editorial in our [Editorials section](/editorials/). | ||
Our editorials are short, opinion-style pieces reflecting the ‘current thinking’ on a topic related to infectious disease and pandemic preparedness. | ||
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This latest editorial, entitled [“Micro(bioterrorism) leveraging genomic data to improve anthrax surveillance”](/editorials/microbioterrorism) discusses _Bacillus anthracis_; a pathogen known as the cause of the life-threatening disease anthrax, and a known biological threat. _Bacillus anthracis_ does, however, also naturally occur in soil and can infect lifestock such as cattle, goat, and sheep. The focus of this Editorial is a discussion on how researchers are using surveillance and whole-genome sequencing (WGS) data to proactively study such pathogens. | ||
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The editorial was written by Laura Carroll, a DDLS fellow at Umeå University, who is part of the Swedish Pathogens Portal's [editorial committee](/about/editorial_committee/). | ||
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If you are interested in writing an editorial for the portal, please [contact the portal team](/contact/). | ||
We will contact you as soon as possible to discuss your suggestion. |
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