Potential issue on est.nca

[kevin199011]

Hi, I was using the est.nca function and calculating AUClast. I noticed that when the slope of first two concentrations are positive, the area under 0-t1 is not summed in the final AUClast result. I looked into the original code, and found this is due to line 263 and 264：
nconc <- c(C0, nconc) # extrapolation via log-linear regression
ntime <- c(0, ntime)
This is only performed for slope <0 conditions.

Is this exclusion of 0-t1 area when slope > 0 on purpose? Thank you!

Best

Kevin