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Large genome reassembly based on Hi-C data. Continuation of GRAAL Software from Marie-Nelly et al., Nature Communications, 2014 (High-quality genome assembly using chromosomal contact data), and Marie-Nelly 2013, PhD thesis (https://www.theses.fr/2013PA066714)

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instaGRAAL

Large genome reassembly based on Hi-C data (continuation and partial rewrite of GRAAL)

This work is under continuous development/improvement - see GRAAL for information about the basic principles of GRAAL and on how to deploy it.

How to use

Until more detailed documentation is added, run the following to see options:

python main_single_proc.py -h 

Unlike GRAAL, this is meant to be run from the command line.

Polishing

Lingering artifacts found in output genomes can be corrected by editing the info_frags.txt file, either by hand or with a script. Look at options by running the following:

python parse_info_frags.py -h 

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Large genome reassembly based on Hi-C data. Continuation of GRAAL Software from Marie-Nelly et al., Nature Communications, 2014 (High-quality genome assembly using chromosomal contact data), and Marie-Nelly 2013, PhD thesis (https://www.theses.fr/2013PA066714)

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  • Python 65.3%
  • Cuda 34.7%