Add variant region condition for dups ending in UTR (#716)

src/hgvs/utils/altseqbuilder.py

@@ -183,6 +183,11 @@ def _get_variant_region(self):
             and self._var_c.posedit.pos.end.datum == Datum.CDS_END
         ):
             result = self.T_UTR
+        elif (
+            self._var_c.posedit.edit.type in ["dup", "ins"]
+            and self._var_c.posedit.pos.end.datum == Datum.CDS_END
+        ):
+            result = self.T_UTR
         elif self._var_c.posedit.pos.start.base < 0 and self._var_c.posedit.pos.end.base < 0:
             result = self.F_UTR
         elif (

tests/test_hgvs_variantmapper.py

@@ -116,6 +116,18 @@ def test_map_of_c_out_of_reference_bound(self):
         with pytest.raises(HGVSError, match="coordinate is out of bounds"):
             self.vm.c_to_p(var_c)
 
+    def test_map_of_ins_three_prime_utr(self):
+        hgvs_c = "NM_004985.4:c.567_*1insCCC"
+        var_c = self.hp.parse_hgvs_variant(hgvs_c)
+        var_p = self.vm.c_to_p(var_c)
+        self.assertEqual(str(var_p), "NP_004976.2:p.?")
+
+    def test_map_of_dup_three_prime_utr(self):
+        hgvs_c = "NM_153223.3:c.2959_*1dup"
+        var_c = self.hp.parse_hgvs_variant(hgvs_c)
+        var_p = self.vm.c_to_p(var_c)
+        self.assertEqual(str(var_p), "NP_694955.2:p.?")
+
 
 if __name__ == "__main__":
     unittest.main()

tests/test_hgvs_variantmapper_cp_sanity.py

@@ -157,11 +157,21 @@ def test_five_prime_utr(self):
         hgvsp_expected = "MOCK:p.?"
         self._run_conversion(hgvsc, hgvsp_expected)
 
-    def test_three_prime_utr(self):
+    def test_sub_three_prime_utr(self):
         hgvsc = "NM_999999.1:c.*3G>A"
         hgvsp_expected = "MOCK:p.?"
         self._run_conversion(hgvsc, hgvsp_expected)
 
+    def test_ins_three_prime_utr(self):
+        hgvsc = "NM_999999.1:c.39_*1insA"
+        hgvsp_expected = "MOCK:p.?"
+        self._run_conversion(hgvsc, hgvsp_expected)
+
+    def test_dup_three_prime_utr(self):
+        hgvsc = "NM_999999.1:c.12_*1dup"
+        hgvsp_expected = "MOCK:p.?"
+        self._run_conversion(hgvsc, hgvsp_expected)
+
     def test_deletion_into_three_prime_utr_frameshift(self):
         hgvsc = "NM_999999.1:c.27_*3del"
         hgvsp_expected = "MOCK:p.(Lys9XaafsTer?)"