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Cannon committed Dec 3, 2024
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"Previous work identified that while six prominent somatic cancer variant knowledgebases were highly disparate in content structure, the actual content within had large degrees of overlap in individual variants, diseases, and drugs as a result of harmonization. Since this original work, we have demonstrated improvements in harmonization of terminology and seek to expand on this analysis by demonstrating overlap at the conceptual level. This includes harmonization of variants, diseases, and therapeutics individually but also together as an evidence level statement."
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"### Table of Contents:\n",
"* [Evidence Statements](#evidence-statements)\n",
" * [Connect to Neo4j Database](#connect-to-the-neo4j-database)\n",
" * [Structure Data Response](#structure-response-data-for-analysis)\n",
" * [Grab Additional Data](#grab-additional-data-connected-to-study-nodes)\n",
" * [Create Evidence Statements](#create-evidence-statements)\n",
" * [Make the Data Graph](#make-the-data-graphs)\n",
"* [Individual Components](#individual-components)\n",
" * [Variant Overlap](#variants)\n",
" * [Therapeutic Overlap](#therapeutics)\n",
" * [Disease Overlap](#diseases)\n",
" * [Uniqueness (Singletons)](#uniqueness-singletons)\n",
" * [Therapeutic/Disease Overlap](#therapeutics-on-disease)\n",
" * [Therapeutic/Variant Overlap](#variants-with-therapeutics)\n",
" * [Variant/Disease Overlap](#variants-in-disease)\n",
" * [Uniqueness (Paired)](#uniqueness-pairs)\n",
"* [Evidence Strength](#evidence-strength)\n",
" * Incomplete\n",
"* [Concordance](#concordance)\n",
" * Incomplete"
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"## Individual Components\n",
"Exhibit overlap in concepts at individual and pairwise component levels. This is important to demonstrate potential overlap and utility for planned aggregation features on the HTML interface."
"Exhibit overlap in concepts at individual and pairwise component levels. This is important to demonstrate potential overlap and utility for planned aggregation features on the HTML interface and to demonstrate uniqueness of concepts obtained from definitive sources."
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