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- include comments from reviewer
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fbergmann committed Aug 14, 2023
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Expand Up @@ -28,7 +28,7 @@ used to gain a deeper understanding of the system or to answer more applied
questions such as predicting drug targets. `COPASI` is a powerful environment
for creating, editing, simulating and analyzing computational models. It provides
a user-friendly GUI that is easy to use even by people who are not experts in the
field. At the same time its broad range of tasks, makes it attractive for more
field. At the same time, its broad range of tasks makes it attractive for more
advanced computational biologists. By using a scripting language in conjunction with
COPASI, scientists can automate tasks such as parameter estimation, sensitivity analysis,
optimization, and model fitting. They can also create custom scripts to perform complex
Expand Down Expand Up @@ -78,7 +78,7 @@ directly for approximate Bayesian computation (ABC), but through using `BASICO`
pyABC package [@pyABC] it can be done.

As scripting module `BASICO` lends itself for constructing large networks, as is for example
done in the reproducibility study in [@mendes2023reproducibility].
done in the reproducibility study in @mendes2023reproducibility.

Documentation for `BASICO` along with many examples, in the form of Jupyter Notebooks
can be found at [https://basico.readthedocs.io/](https://basico.readthedocs.io/). `BASICO`
Expand Down Expand Up @@ -110,8 +110,8 @@ BioModels Database [@BioModels2015b] or JWS Online [@JWS].
Of course the wrappers for the REST API to JWS Online or the BioModels Database can also be readily used by other Python packages to
obtain the SBML models. This is done for example by SBMLtoODEjax [@sbmltoodejax]

Once a model is loaded all of `COPASI`'s analysis methods can be used. Running simulations are a core feature of COPASI, so we started
We started `BASICO` with implementing time course simulations and steady state analysis.
Once a model is loaded all of `COPASI`'s analysis methods can be used. Running simulations are a core feature of COPASI,
so we started `BASICO` with implementing time course simulations and steady state analysis.

```python

Expand All @@ -126,7 +126,7 @@ optimizations, sensitivity analysis and parameter scans.

Most recently we added the automation of profile likelihood calculations, that for a given
parameter estimation result, automatically generates [profile likelihood plots](https://basico.readthedocs.io/en/latest/notebooks/Profile_likelihood.html).
This is another example, that would have been quite cumbersome to do without basico. Following the
This is another example, that would have been quite cumbersome to do without `BASICO`. Following the
approach of Schaber [@SCHABER2012183] `BASICO` generates parameter scans (running a local optimization
method) for each parameter to be estimated, can run these individual models in parallel, and generate
the likelihood plots from the generated data.
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