ST subclone manuscript

Overview

This is the repo for the manuscript "Spatial clonal evolution and clone-specific microenvironment interactions within three-dimensional tumor structures"

Repo structure

• Figure 1. Spatial microregions across cancers
• Figure 2. Focal clonal evolution in microregions
• Figure 3. Genetic changes drive tumour disparities & Cellular pathway at tumour core and edge
• Figure 4. Clonal-specific Tumor-TME interaction
• Figure 5 & 6. 3D tumour structure and TME interactions

Data Access instruction

Data file for each data type can be access using ID listed in the file "Data_access/Sample_ID_Lookup_table_v1.xlsx" Please see the readme in the .xlsx file and under the folder for more instructions