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Update queries and query parsing to work with new variant coordinate schema #149

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merged 3 commits into from
Oct 8, 2024
Merged

Update queries and query parsing to work with new variant coordinate schema #149

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Update queries and query parsing to work with new variant coordinate …
susannasiebert Oct 4, 2024
157444d
Update version
susannasiebert Oct 8, 2024
b39a829
Document CACHE_TIMEOUT_DAYS env variable
susannasiebert Oct 8, 2024
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54 changes: 20 additions & 34 deletions civicpy/civic.py
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Original file line number Diff line number Diff line change
Expand Up @@ -1241,24 +1241,20 @@ def _postprocess_response_element(e, element):
if e['__typename'] != 'GeneVariant':
raise Exception("Variant type {} not supported yet".format(e['__typename']))
e['entrez_id'] = e['gene']['featureInstance']['entrezId']
build = e['referenceBuild']
build = e['coordinates']['referenceBuild']
if build == 'GRCH37':
build = 'GRCh37'
elif build == 'GRCH38':
build = 'GRCh38'
e['coordinates'] = {
'ensembl_version': e['ensemblVersion'],
'ensembl_version': e['coordinates']['ensemblVersion'],
'reference_build': build,
'reference_bases': e['referenceBases'],
'variant_bases': e['variantBases'],
'representative_transcript': None if e['primaryCoordinates'] is None else e['primaryCoordinates']['representativeTranscript'],
'chromosome': None if e['primaryCoordinates'] is None else e['primaryCoordinates']['chromosome'],
'start': None if e['primaryCoordinates'] is None else e['primaryCoordinates']['start'],
'stop': None if e['primaryCoordinates'] is None else e['primaryCoordinates']['stop'],
'representative_transcript2': None if e['secondaryCoordinates'] is None else e['secondaryCoordinates']['representativeTranscript'],
'chromosome2': None if e['secondaryCoordinates'] is None else e['secondaryCoordinates']['chromosome'],
'start2': None if e['secondaryCoordinates'] is None else e['secondaryCoordinates']['start'],
'stop2': None if e['secondaryCoordinates'] is None else e['secondaryCoordinates']['stop'],
'reference_bases': e['coordinates']['referenceBases'],
'variant_bases': e['coordinates']['variantBases'],
'representative_transcript': e['coordinates']['representativeTranscript'],
'chromosome': e['coordinates']['chromosome'],
'start': e['coordinates']['start'],
'stop': e['coordinates']['stop'],
}
elif element == 'variant_group':
e['variant_ids'] = [v['id'] for v in e['variants']['nodes']]
Expand Down Expand Up @@ -1535,22 +1531,17 @@ def _construct_get_variant_payload():
allele_registry_id: alleleRegistryId
clinvar_entries: clinvarIds
hgvs_expressions: hgvsDescriptions
variantBases
referenceBases
referenceBuild
primaryCoordinates {
chromosome
representativeTranscript
start
stop
}
secondaryCoordinates {
coordinates {
referenceBuild
ensemblVersion
chromosome
representativeTranscript
start
stop
referenceBases
variantBases
coordinateType
}
ensemblVersion
}
gene: feature {
id
Expand Down Expand Up @@ -1591,22 +1582,17 @@ def _construct_get_all_variants_payload():
allele_registry_id: alleleRegistryId
clinvar_entries: clinvarIds
hgvs_expressions: hgvsDescriptions
variantBases
referenceBases
referenceBuild
primaryCoordinates {
coordinates {
referenceBuild
ensemblVersion
chromosome
representativeTranscript
start
stop
referenceBases
variantBases
coordinateType
}
secondaryCoordinates {
chromosome
representativeTranscript
start
stop
}
ensemblVersion
}
gene: feature {
id
Expand Down
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