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Directed evolution is a powerful tool for protein evolution to obtain new functional biomolecules + [1], and contains two + aspects, mutation and selection. Many efficient methods have been developed + to facilitate fast and efficient mutagenesis of proteins[2], while a + suitable and high-throughput + selection strategy is urgently needed to screen for desirable and optimal + phenotypes. +

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A dual selection system was developed to identify allosteric transcription factor (aTF) PobR mutants + responsive to different aromatic compounds. This dual selection system was proved to be efficient, + and can be potentially applied to adjusting the specificity of other aTFs to generate fine-tuned + tools in synthetic biology.

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References

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1. McLure RJ, Radford SE, Brockwell DJ. High-throughput directed + evolution: + a golden era for protein science. Trends in Chemistry. 2022; + 4(5):378-391.doi:10.1016/j.trechm.2022.02.004 +

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2. Morrison MS, Podracky CJ, Liu DR. The developing toolkit of + continuous + directed evolution. Nat Chem Biol. 2020; 16(6):610-619. doi: 10.1038/s41589-020-0532-y.

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