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Update background.md
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KianBV authored Oct 8, 2024
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Expand Up @@ -73,7 +73,7 @@ To make this a self-sustaining evolution system, a few more adjustments are need

<figure markdown>
![Figure_pace](https://idec-teams.github.io/2024_Evolution_Suisse/img/PACE_related_schematics/onlypace.png)
<figcaption> Figure 4: A schematic representation of the Phage-Assisted Continuous Evolution (PACE) system. Once a phage infects the cell (1), its genome (SP) enters it and the biomolecule that is being evolved is expressed (2). Through a genetic circuit on AP that links the biomolecule activity to _gIII_ expression, the protein pIII, required for phage propagation is expressed (3). In parallel, the phage genome is being replicated (4), with mutations occuring at a higher pace due to the presence of MP. Finally, the newly generated phage genome, structural proteins and pIII assemble into new phage particles. The resulting phages then go on to infect new cells. Should the variant be inactive, pIII is not produced, resulting in non-infectious phages from that cell. New cells are continuously pumped into the lagoon, while old cells and phages are pumped out.
<figcaption> Figure 4: A schematic representation of the Phage-Assisted Continuous Evolution (PACE) system. Once a phage infects the cell (1), its genome (SP) enters it and the biomolecule that is being evolved is expressed (2). Through a genetic circuit on AP that links the biomolecule activity to gIII expression, the protein pIII, required for phage propagation is expressed (3). In parallel, the phage genome is being replicated (4), with mutations occuring at a higher pace due to the presence of MP. Finally, the newly generated phage genome, structural proteins and pIII assemble into new phage particles. The resulting phages then go on to infect new cells. Should the variant be inactive, pIII is not produced, resulting in non-infectious phages from that cell. New cells are continuously pumped into the lagoon, while old cells and phages are pumped out.
</figcaption>
</figure>

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