v1.1.1

• Updated COAST and COASTSS to return estimated effect sizes and standard errors from the allelic series burden test.
• Added the ability to run COAST and COASTSS, as well as the component tests, with an arbitrary number of discrete annotation categories.

v1.0.2

Streamlined and simplified the summary statistic-based allelic series baseline and sum tests, removing the need for meta-analysis or estimating the cross category correlation.

v1.0.1

The major change in this release is provision of a new function COASTSS for performing the coding-variant allelic series test (COAST) starting from summary statistics. Instructions for running COASTSS are provided in the README, and details of the implementation will be discussed in a forthcoming manuscript. The minimal inputs for running COASTSS are an annotation vector and the corresponding single-variant summary statistics (effect sizes and standard errors), although providing an LD matrix and the per-variant MAF is recommended. Additional changes in this version include:

Addition of a function CalcSumstats for generating summary statistics given annotations, covariates, genotypes, and the phenotype. Alternately, the output of DGP may be provided.
Addition of functions ASBTSS and ASKATSS for performing the allelic series burden and SKAT tests from summary statistics.

v0.6.0

Version 0.6.0

• Replaced the CountAlleles function with a similar (but faster) Counts function that returns counts the total number of alleles, variants, and carriers by variant class.
• Updated the formatting of the results output by the main COAST function.