Deleted H3.6 and H3.8

intbio · Dec 5, 2024 · 9239b85 · 9239b85
1 parent c87a212
commit 9239b85
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Showing 3 changed files with 971 additions and 55 deletions.
diff --git a/CURATED_SET/classification.json b/CURATED_SET/classification.json
@@ -271,9 +271,7 @@
             "H3.5_(Hominidae)": {
                 "H3.5_(Homo_sapiens)": "null"
             },
-            "H3.6_(Homo_sapiens)": "null",
             "H3.7_(Homo_sapiens)": "null",
-            "H3.8_(Homo_sapiens)": "null",
             "H3.B_(Giardia?)": "null",
             "H3.P_(Moneuplotes?)": "null",
             "H3.V_(Trypanosomatidae)": "null"
@@ -4892,31 +4890,6 @@
             "alternate_names": [],
             "publications": []
         },
-        "H3.6_(Homo_sapiens)": {
-            "level": "variant_group",
-            "description": {
-                "summary": "H3.6_(Homo_sapiens) is a human histone variant, similar to histone variant H3.3 in amino acid sequence, encoded by the H3F3AP6 gene. Expression levels of H3F3AP6 are extremely low, as compared to H3F3B gene (encodes histone H3.3) [taguchi_crystal_2017]. H3.6 nucleosomes are substantially unstable due to the Val62 residue, which weakens interactions with H4 [taguchi_crystal_2017].",
-                "taxonomy": "null",
-                "genes": "null",
-                "evolution": "null",
-                "expression": "null",
-                "knock-out": "null",
-                "function": "null",
-                "sequence": "null",
-                "localization": "null",
-                "deposition": "null",
-                "structure": "H3.6 nucleosomes are substantially unstable due to the Val62 residue, which weakens interactions with H4 [taguchi_crystal_2017].",
-                "interactions": "null",
-                "disease": "null",
-                "caveats": "null"
-            },
-            "taxonomic_span": "null",
-            "taxonomic_span_id": "null",
-            "alternate_names": [],
-            "publications": [
-                "taguchi_crystal_2017"
-            ]
-        },
         "H3.7_(Homo_sapiens)": {
             "level": "variant_group",
             "description": {
@@ -4942,31 +4915,6 @@
                 "taguchi_crystal_2017"
             ]
         },
-        "H3.8_(Homo_sapiens)": {
-            "level": "variant_group",
-            "description": {
-                "summary": "H3.8_(Homo_sapiens) is a human histone variant, similar to histone variant H3.3 in amino acid sequence, encoded by the H3F3AP5 gene. Expression levels of H3F3AP5 are extremely low, as compared to H3F3B gene (encodes histone H3.3) [taguchi_crystal_2017]. H3.8 nucleosomes are extremely unstable [taguchi_crystal_2017].",
-                "taxonomy": "null",
-                "genes": "null",
-                "evolution": "null",
-                "expression": "null",
-                "knock-out": "null",
-                "function": "null",
-                "sequence": "null",
-                "localization": "null",
-                "deposition": "null",
-                "structure": "H3.8 nucleosomes are extremely unstable [taguchi_crystal_2017].",
-                "interactions": "null",
-                "disease": "null",
-                "caveats": "null"
-            },
-            "taxonomic_span": "null",
-            "taxonomic_span_id": "null",
-            "alternate_names": [],
-            "publications": [
-                "taguchi_crystal_2017"
-            ]
-        },
         "H3.B_(Giardia?)": {
             "level": "variant_group",
             "description": {