Description

CpelTdm is a julia package designed to perform DNA methylation differential analysis. The package is based on a recently published method [1], and has several advantages when compared to traditional DNA methylation differential analysis packages. CpelTdm not only detects mean methylation level differences between groups, but it can also detect significant differences in methylation entropy as well as in the probability distribution of methylation (see [1] for technical details).

Testing

CpelTdm is tested against Julia 1.3.0 on the latest versions of Linux, macOS and Windows.

Getting Started

Prerequisites

• julia v1.3.0
• git.

Installing

CpelTdm and dependencies can be installed via the following command in julia's REPL:

(v1.3) pkg> add https://github.com/jordiabante/CpelTdm.jl.git

Updating

CpelTdm and dependencies can be updated via the following command in julia's REPL:

(v1.3) pkg> update CpelTdm

Running the tests

In order to test the package to ensure that it has been properly installed, run the following command in a julia session:

(v1.3) pkg> test CpelTdm

If the package has been properly installed, then all tests will be successful.

Authors

• Jordi Abante

License

This project is licensed under the MIT License - see the LICENSE.md file for details.

References

[1] Abante, J., Goutsias, J., CpelTdm.jl: a Julia package for targeted differential DNA methylation analysis, bioArxiv (2020), 343020.