Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

flu_h1n1pdm_ha_broad: Add samples from early pandemic-era clades #213

Merged
merged 6 commits into from
Jun 25, 2024

Conversation

huddlej
Copy link
Contributor

@huddlej huddlej commented Jun 22, 2024

Add representative samples from early clades to "broad" H1N1pdm HA Nextclade dataset. Improves clade label annotations for older sequences by including clades 1, 2, 3, 4, 6C, 7, and 8 in the dataset.

Before adding these clades, I found the following clade counts for the current H1N1pdm HA data:

image

After adding these clades, I found the following clade counts for the current H1N1pdm HA data:

image

Related to nextstrain/seasonal-flu#172

Add representative samples from early clades to "broad" H1N1pdm HA
Nextclade dataset. Improves clade label annotations for older sequences
by including clades 2, 3, 4, 6C, 7, and 8 in the dataset.

Related to nextstrain/seasonal-flu#172
@huddlej huddlej temporarily deployed to refs/pull/213/merge June 22, 2024 01:00 — with GitHub Actions Inactive
@huddlej huddlej changed the title Add samples from early pandemic-era clades flu_h1n1pdm_ha_broad: Add samples from early pandemic-era clades Jun 22, 2024
Updates the tree for the broad H1N1pdm HA dataset to include the
pandemic-era clade 1 as the MRCA of all other clades.
@huddlej huddlej temporarily deployed to refs/pull/213/merge June 25, 2024 16:40 — with GitHub Actions Inactive
@huddlej
Copy link
Contributor Author

huddlej commented Jun 25, 2024

I tested this new dataset on master.clades.nextstrain.org by randomly sampling ~1000 H1 HA sequences per region and year between 2009 and 2014 (ending up with 901 sequences from augur filter). The resulting annotations look like this in the tree:

image

In comparison, the same sequences in the production broad H1 HA tree look like this:

image

@huddlej huddlej deployed to refs/pull/213/merge June 25, 2024 18:47 — with GitHub Actions Active
@huddlej huddlej merged commit a3daedf into master Jun 25, 2024
@huddlej huddlej deleted the 2024-06-21-update-broad-h1n1pdm-ha branch June 25, 2024 18:49
Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment
Labels
None yet
Projects
None yet
Development

Successfully merging this pull request may close these issues.

2 participants