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Release v2.1.6 #71

Merged
merged 21 commits into from
Nov 27, 2024
Merged

Release v2.1.6 #71

merged 21 commits into from
Nov 27, 2024

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ManuelTgn
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@ManuelTgn ManuelTgn commented Nov 27, 2024

Description

This PR introduces version 2.1.6 of CRISPRme, which includes the following updates and improvements:

Key Features and Changes

🚀 New Features

  • Feature 1: Support for GNOMAD v4.1 VCFs (joint VCFs included)
  • Feature 2: Introduce complete-test function for testing CRISPRme

🐛 Bug Fixes

  • Fix 1: Corrected the handling of indels in off-target reporting to eliminate false positives, ensuring that only valid off-targets created by indels are accurately identified and reported.

  • Fix 2: Addressed alternative alignments report bug, ensuring that all possible alignments for each off-target are accurately listed in the alternative alignments file.

  • Fix 3: Fixed the visualization of the Personal Card tab in CRISPRme's GUI and website for enhanced usability and clarity.

  • Fix 4: Resolved a memory overflow issue occurring during the merging of contiguous targets, ensuring efficient performance and stability.

🛠 Enhancements

  • Upgraded Version available on DockerHub

Upgrade Instructions

To upgrade to version 2.1.6, follow these steps:

  1. mamba create -n crisprme
  2. mamba activate crisprme
  3. mamba install crisprme=2.1.6

Documentation

  • Updated the README.md to reflect the latest changes.
  • Added detailed documentation for complete-search, complete-test, targets-integration, gnomAD-converter, web-interface, generate-personal-card functions in README.md.

Checklist

  • Code reviewed and approved.
  • Tests written and passing.
  • Documentation updated.

Linked Issues

Closes #67, #62, #64 related to this release.

@ManuelTgn ManuelTgn added bug Something isn't working documentation Improvements or additions to documentation enhancement New feature or request labels Nov 27, 2024
@ManuelTgn ManuelTgn added this to the v2.1.6 milestone Nov 27, 2024
@ManuelTgn ManuelTgn self-assigned this Nov 27, 2024
@ManuelTgn ManuelTgn merged commit 58c0961 into main Nov 27, 2024
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@ManuelTgn ManuelTgn deleted the v216 branch November 27, 2024 16:33
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False indel-derived offtargets
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