Tumour mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade

References

• Mahnoor Mahmood*, Eric Minwei Liu, Amy L. Shergold, Elisabetta Tolla, Jacqueline Tait-Mulder, Alejandro Huerta Uribe, Engy Shokry, Alex L. Young, Sergio Lilla, Minsoo Kim, Tricia Park, Sonia Boscenco, Javier L. Manchon, Crístina Rodríguez-Antona, Rowan C. Walters, Roger J. Springett, James N. Blaza, Louise Mitchell, Karen Blyth, Sara Zanivan, David Sumpton, Edward W. Roberts, Ed Reznik#, Payam A. Gammage# "Tumour mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade" (2023)

Overview

Analysis scripts for Mahmood et al.(2023)

Requirements

• R version 4.1.0 -- "Camp Pontanezen"

Getting started

1. Clone this repo:

git clone https://github.com/reznik-lab/engineered-mtDNA-mutation-in-tumor
cd engineered-mtDNA-mutation-in-tumor

2. Running the scripts in the R folder to generate relevant figures of the study.

Contacts

For any questions, comments and suggestions, please email

• Payam A. Gammage, Payam.Gammage [at] glasgow.ac.uk
• Ed Reznik, reznike [at] mskcc.org
• Mahnoor Mahmood, Mahnoor.Mahmood [at] glasgow.ac.uk
• Eric Minwei Liu, lium2 [at] mskcc.org