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bebatut authored Sep 6, 2023
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---
layout: tutorial_slides
logo: "shared/images/BioNT_Logo.png"
logo: "/shared/images/BioNT_Logo.png"
title: "Bioinformatics Data Types and Databases"
video: true
questions:
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### Definition of a biological database/resources

- The [NAR Database Issue](www.oxfordjournals.org/nar/database/c/) collects publications of established databases in the field
- The [NAR Database Issue](https://www.oxfordjournals.org/nar/database/c/) collects publications of established databases in the field
- Collection of data (and metadata) in the related format
- structured
- searchable (indexed)
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Expand Up @@ -51,7 +51,7 @@ Human opsins are found in the cells of your retina. Opsins catch light and begin

# Searching Human Opsins

To seach Human Opsins, we will start by checking the [NCBI Genome Data Viewer](www.ncbi.nlm.nih.gov/genome/gdv). The NCBI Genome Data Viewer (GDV) ({% cite rangwala2021accessing %}) is a genome browser supporting the exploration and analysis of annotated eukaryotic genome assemblies. The GDV browser displays biological information mapped to a genome, including gene annotation, variation data, BLAST alignments, and experimental study data from the NCBI GEO and dbGaP databases. GDV release notes describe new features relating to this browser.
To seach Human Opsins, we will start by checking the [NCBI Genome Data Viewer](https://www.ncbi.nlm.nih.gov/genome/gdv). The NCBI Genome Data Viewer (GDV) ({% cite rangwala2021accessing %}) is a genome browser supporting the exploration and analysis of annotated eukaryotic genome assemblies. The GDV browser displays biological information mapped to a genome, including gene annotation, variation data, BLAST alignments, and experimental study data from the NCBI GEO and dbGaP databases. GDV release notes describe new features relating to this browser.

> <hands-on-title>Open NCBI Genome Data Viewer</hands-on-title>
>
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![Screenshot of the UniProt entry page header](./images/UniProt.png "UniProt page")
This is a long page with a lot of information, we designed an [entire tutorial]({% link topics/data-sciences/tutorials/online-resources-protein/tutorial.md %}) to go through it.
This is a long page with a lot of information, we designed an [entire tutorial]({% link topics/data-science/tutorials/online-resources-protein/tutorial.md %}) to go through it.
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Expand Up @@ -44,11 +44,11 @@ When doing a biological data analysis, we might end up with some interesting pro
The aim of this tutorial is to familiarize ourselves with that, using Human opsins as an example.

> <comment-title></comment-title>
> This tutorial is a bit atypical: we will not work in Galaxy but mostly outside of it, in the [UniProt](uniprot.org) database pages.
> This tutorial is a bit atypical: we will not work in Galaxy but mostly outside of it, in the [UniProt](https://uniprot.org) database pages.
{: .comment}

> <comment-title></comment-title>
> This tutorial designed to be the continuation of the tutorial ["One gene across file formats"]({% link topics/data.science/tutorials/online-resources-gene/tutorial.md %}), but it can also be consulted as a stand-alone module.
> This tutorial designed to be the continuation of the tutorial ["One gene across file formats"]({% link topics/data-science/tutorials/online-resources-gene/tutorial.md %}), but it can also be consulted as a stand-alone module.
{: .comment}

Opsins are found in the cells of your retina. They catch light and begin the sequence of signals that result in vision, and that is the reason why, when compromised, they are associated to color-blindness and other visual impairments.
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These 410 results give us the feeling that we need to be more specific (although - spoiler - our actual target is among the first hits).

To be specific enough, we suggest to use an unique identifier. From the [previous tutorial]({% link topics/data.science/tutorials/online-resources-gene/tutorial.md %}) we know the gene name of the protein that we are looking for, `OPN1LW`.
To be specific enough, we suggest to use an unique identifier. From the [previous tutorial]({% link topics/data-science/tutorials/online-resources-gene/tutorial.md %}) we know the gene name of the protein that we are looking for, `OPN1LW`.

> <hands-on-title>Search for OPN1LW on UniProtKB</hands-on-title>
>
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