UPDATE #3

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Process completed with exit code 1.

unable to access index for repository https://cloud.r-project.org/bin/macosx/big-sur-arm64/contrib/4.1:

unable to access index for repository https://cran.rstudio.com/bin/macosx/big-sur-arm64/contrib/4.1:

pkg-config 0.29.2_3 is already installed and up-to-date. To reinstall 0.29.2_3, run: brew reinstall pkg-config

qpdf 11.9.1 is already installed and up-to-date. To reinstall 11.9.1, run: brew reinstall qpdf

ghostscript 10.03.1 is already installed and up-to-date. To reinstall 10.03.1, run: brew reinstall ghostscript

macOS's Gatekeeper has been disabled for this Cask