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<title>WikiPathways Academy</title> | ||
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<body> | ||
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<header id="banner"> | ||
<div class="inner"> | ||
<h1>WikiPathways Academy</h1> | ||
<h2>Organized training challenges for new WikiPathways authors</h2> | ||
<a href="../../path.html" class="button"><small>Return to</small>Overview</a> | ||
</div> | ||
</header> | ||
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<h1> | ||
<a id="intro" class="anchor" href="#intro" aria-hidden="true"> | ||
<span aria-hidden="true" class="octicon octicon-link"> | ||
Signaling Pathway - Glycolysis | ||
</span> | ||
</a> | ||
</h1> | ||
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<h2>Background</h2> | ||
<p></p> | ||
<h2>Your Mission</h2> | ||
<p>Draw the part of the pathway outlined in red below:</p> | ||
<img src="40001_2024_1708_Fig2_HTML-glycolysis.jpg" width="500px"> | ||
<ul> | ||
<!--<li>Download the starter pathway here: <a href="https://academy.wikipathways.org/data/fig-met-1-fourth-start.gpml">fig-met-1-fourth-start.gpml</a>.</li> | ||
<li>Launch PathVisio and open the dowloaded file or your draft pathway file via <b>File > Open</b>.</li>--> | ||
<li>Add a metabolite node for "Glucose-6-phosphate".</li> | ||
<li>Connect the glucose node to Glucose-6-phosphate with a <b>mim-conversion</b> interaction.</li> | ||
<li>Add an anchor to the interaction and connect the enzyme (GCK) and inhiibitor (GCKR) with <b>mim-catalysis</b> and <b>mim-inhibition</b> interactions, respectively.</li> | ||
<li>Connect Glucose-6-phosphate with Pyruvate using a <b>mim-conversion</b> interaction.</li> | ||
<li>Update the text label for the node with ChEBI ID 57288 (Actyl-CoA) node to "Acetyl-CoA". Repeat for the node with ChEBI ID 57384 (Malonyl-CoA), updating the label to "Malonyl-CoA".</li> | ||
<li>Connect Pyruvate with Acetyl-CoA using a <b>mim-conversion</b> interaction.</li> | ||
<li>Update the text label for the node with ChEBI ID 26607 (SFA) node to "SFA". Repeat for the node with ChEBI ID 25413 (MUFA), updating the label to "MUFA".</li> | ||
<li>Group the ACACA and ACACB nodes.</li> | ||
<li>Complete the remaining steps in the smae way, adding <b>mim-conversion</b> interactions and enzymes.</li> | ||
<li>Save your work as a GPML file under <b>File > Save As</b>.</li> | ||
<li>Drag-and-drop the GPML file below to check if it is correct.</li> | ||
</ul> | ||
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