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@bigbio

BigBio Stack

Provide big data solutions Bioinformatics

Welcome to bigbio 👋

bigbio is an open-source organization dedicated to advancing bioinformatics and computational proteomics and multiomics research. We develop scalable tools, workflows, and libraries to support complex experimental designs in proteomics, genomics and multiomics. Our mission is to empower researchers with accessible, efficient, and cutting-edge solutions for data analysis and integration.

🌟 Key Projects

🔬 Proteomics and Quantitative Analysis

  • quantms: A comprehensive workflow for proteomics experiments supporting DDA-LFQ, DDA-Isobaric, and DIA-LFQ quantification.
  • quantms.io: A proteomics quantification format extending mzTab for large-scale datasets.
  • ibaqpy: A package for absolute quantification based on the quantms.io format.
  • quantms.org: Code for quantms.org, a resource for reanalysis and public proteomics data.

🧪 Multiomics and Metadata Tools

⚡ Workflow Utilities

  • pmultiqc: A QC report library based on the MultiQC framework.
  • spectrafuse: An incremental clustering pipeline for quantms data.
  • quantms-utils: Helper scripts and classes for the quantms workflow.
  • quantms-rescoring: Helper functions and scripts for quantms and ms2rescore.

🤝 Contributions

We welcome contributions from the community! Whether it's bug fixes, feature suggestions, or documentation improvements, every contribution helps drive bioinformatics research forward.

🔗 Stay Connected

Join us on this journey to revolutionize data analysis in proteomics and beyond!

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  1. proteomics-sample-metadata proteomics-sample-metadata Public

    The Proteomics sample metadata: Standard for experimental design annotation in proteomics datasets

    80 107

  2. quantms quantms Public

    Quantitative mass spectrometry workflow. Currently supports proteomics experiments with complex experimental designs for DDA-LFQ, DDA-Isobaric and DIA-LFQ quantification.

    Nextflow 34 39

Repositories

Showing 10 of 48 repositories
  • .github Public
    bigbio/.github’s past year of commit activity
    0 MIT 0 0 0 Updated Jan 31, 2025
  • ibaqpy Public

    Absolute quantification package based on quantms.io

    bigbio/ibaqpy’s past year of commit activity
    Python 12 MIT 10 2 0 Updated Jan 31, 2025
  • multiomics-configs Public

    Set of config files for species, taxonomies, etc

    bigbio/multiomics-configs’s past year of commit activity
    Shell 3 2 79 (1 issue needs help) 5 Updated Jan 31, 2025
  • diann-docker Public

    DIANN docker container based on the linux version from DIANN

    bigbio/diann-docker’s past year of commit activity
    Dockerfile 0 Apache-2.0 1 0 0 Updated Jan 30, 2025
  • quantms Public

    Quantitative mass spectrometry workflow. Currently supports proteomics experiments with complex experimental designs for DDA-LFQ, DDA-Isobaric and DIA-LFQ quantification.

    bigbio/quantms’s past year of commit activity
    Nextflow 34 MIT 39 72 (3 issues need help) 1 Updated Jan 23, 2025
  • sdrf-pipelines Public

    A repository to convert SDRF proteomics files into pipelines config files

    bigbio/sdrf-pipelines’s past year of commit activity
    Python 16 Apache-2.0 23 26 (5 issues need help) 1 Updated Jan 21, 2025
  • sdrf-cellline-metadata-db Public

    SDRF Cell Line Metadata Database

    bigbio/sdrf-cellline-metadata-db’s past year of commit activity
    Python 0 Apache-2.0 0 0 0 Updated Jan 20, 2025
  • quantms.io Public

    The proteomics quantification format, extending mzTab for large scale datasets.

    bigbio/quantms.io’s past year of commit activity
    Python 7 4 18 (1 issue needs help) 0 Updated Jan 15, 2025
  • quantms-rescoring Public

    quantms and ms2rescore helper functions and scripts

    bigbio/quantms-rescoring’s past year of commit activity
    Python 0 Apache-2.0 1 0 0 Updated Jan 13, 2025
  • quantms.org Public

    Web page storing all the datasets renalyzed with quantms

    bigbio/quantms.org’s past year of commit activity
    Vue 0 MIT 4 0 0 Updated Jan 13, 2025