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feat: PureCN implementation #453

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merged 6 commits into from
Oct 11, 2023
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ericblanc20
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@ericblanc20 ericblanc20 commented Oct 11, 2023

Attempted to implement purity & ploidy, but restricted to PureCN implementation of CNV calling & segmentation

Remaining tasks

  • PureCN ploidy & purity in complex_biomarkers step (with TMB & mutational signatures)
  • Complete sequenza purity & ploidy CNV calling and segmentation
  • Add sequenza purity & ploidy to the complex_biomarkers step
  • Add scarHRD to the complex_biomarkersstep and remove thehomologous_recombination_deficiency` step
  • Add GATK4 CNV calling
  • Unify CNV segmentation output (no more bed file, use DNAcopy format)

@ericblanc20 ericblanc20 linked an issue Oct 11, 2023 that may be closed by this pull request
@ericblanc20 ericblanc20 requested a review from mbenary October 11, 2023 13:49
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Coverage Status

coverage: 85.904% (+0.3%) from 85.642% when pulling 3f89ac7 on 414-defining-tumor-purityploidy into 55146c7 on main.

@ericblanc20 ericblanc20 merged commit e394e8c into main Oct 11, 2023
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@ericblanc20 ericblanc20 deleted the 414-defining-tumor-purityploidy branch October 11, 2023 14:14
@tedil tedil mentioned this pull request Jun 28, 2024
This was referenced Dec 9, 2024
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Defining tumor purity/ploidy
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