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Merge remote-tracking branch 'origin/master' into release-v0.8
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MarkBicknellONT committed Oct 3, 2024
2 parents 05d8c70 + 3140aea commit 1be0040
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15 changes: 15 additions & 0 deletions CHANGELOG.md
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All notable changes to Dorado will be documented in this file.

# [0.8.1] (3 Oct 2024)

This release of Dorado includes fixes and improvements to the Dorado 0.8.1 release, including corrected configuration for DNA v5 SUP-compatible 5mC_5hmC and 5mCG_5hmCG models, improved cDNA poly(A) tail estimation for data from MinION flow cells, reduced basecaller startup time on supported GPUs, and more.

* f74d8917ba3472e07ae4d00bb2e3a745048c8c84 - Corrected bug causing [email protected]_5mC_5hmC@v2 to call CpG contexts only and [email protected]_5mCG_5hmCG@v2 to call all contexts
* eb4649442bbe1ef84eb72fd62e30586c9a45c10d - Improve cDNA poly(A) tail estimation for MinION flow cells
* 762e88689b31099081a7fcd39b959ddc4c7eb2e1 - Cache batch sizes to significantly reduce basecaller startup time on supported GPUs
* 22269a8eed928ed04fbf7731ff99fe4454f87493 - Prevent "Trim interval <range> is invalid for sequence" error when performing trimming
* f156ae6237fa4602d759dc6ee05b1b367e77c09c - Prevent write permission error for model download folder when file write is not required
* fcb9d53ab168f42cdd02cfa740158a0ce0b5cc84 - Include run name in output files from `dorado demux` even if input files are FASTQ
* a4c96490a4409d961ce59b642478ff453d217776 - BED file handling: only split columns on tabs, not spaces; load files with spaces in region names
* e62cbc851a087d778fbde24ebe0ae85b96d28a9e - Allow comment lines in the middle of the BED file
* f15c0b38286dccda86e3244e535e69e30edb60cd - Fix compilation in AppleClang 16


# [0.8.0] (16 Sept 2024)

This release of Dorado adds v5.1 RNA models with new `inosine_m6A` and `m5C` RNA modified base models, updates existing modified base models, improves the speed of v5 SUP basecalling models on A100/H100 GPUs, and enhances the flexibility and stability of `dorado correct`. It also introduces per-barcode configuration for poly(A) estimation with interrupted tails, adds new `--output-dir` and `--bed-file` arguments to Dorado basecalling commands, and includes a variety of other improvements for stability and usability.
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8 changes: 4 additions & 4 deletions README.md
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First, download the relevant installer for your platform:

- [dorado-0.8.0-linux-x64](https://cdn.oxfordnanoportal.com/software/analysis/dorado-0.8.0-linux-x64.tar.gz)
- [dorado-0.8.0-linux-arm64](https://cdn.oxfordnanoportal.com/software/analysis/dorado-0.8.0-linux-arm64.tar.gz)
- [dorado-0.8.0-osx-arm64](https://cdn.oxfordnanoportal.com/software/analysis/dorado-0.8.0-osx-arm64.zip)
- [dorado-0.8.0-win64](https://cdn.oxfordnanoportal.com/software/analysis/dorado-0.8.0-win64.zip)
- [dorado-0.8.1-linux-x64](https://cdn.oxfordnanoportal.com/software/analysis/dorado-0.8.1-linux-x64.tar.gz)
- [dorado-0.8.1-linux-arm64](https://cdn.oxfordnanoportal.com/software/analysis/dorado-0.8.1-linux-arm64.tar.gz)
- [dorado-0.8.1-osx-arm64](https://cdn.oxfordnanoportal.com/software/analysis/dorado-0.8.1-osx-arm64.zip)
- [dorado-0.8.1-win64](https://cdn.oxfordnanoportal.com/software/analysis/dorado-0.8.1-win64.zip)

Once the relevant `.tar.gz` or `.zip` archive is downloaded, extract the archive to your desired location.

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