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amahurkar edited this page Apr 17, 2020
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3 revisions
Within-species
Find the profile with the specific single-cell dataset
Select a consensus cell type (e.g. chandelier cells, ChC) and identify marker genes for that cell type across species. (How are marker genes identified?)
Intersect lists of marker genes across species and identify conserved (need to define what conserved means) and species-specific markers (Need a little more clarification here)
What next?
Cross-species
Select a consensus type in all species and calculate differential expression
Sort DE genes by fold-change
Export list of DE genes for GO analysis or gene annotation