Vocab. BDPM

Base de données publique des médicaments

BDPM is a public source for French marketed drugs.

Sources

The vocabulary is retrieved from the download page

Overall Structure of vocabulary meets the criteria described here.

Transformation

The procedures for transforming Concepts from the source to the OMOP Standard Vocabularies can be found on the OHDSI GitHub.

All the drug concepts have only relationship_id = 'Maps to' relating to RxNorm Extension or RxNorm concepts.

RxNorm and RxNorm Extension concepts have all the usual relationships (between Ingredient and Drug, Brand Name and Branded Drug and other) and drug_strength information.

1. We use active substance as Ingredient The CIS_COMPO_bdpm table (containing drug and Ingredient dosages) contains both precise ingredient dosage (acting ingredient and base or salt it exists with) and dosage of active ingredient if such ambiguity is possible. We put in OMOP tables only active substance dosage.

2. Brand Names Take from Drug_descr everything written by capital letter and use it as Brand Name

3. Forms There are drug form and route of administration defined in source tables. So we used a combination of drug form and route of administration as Dose Form, translated that to English and fixed some inaccuracies occur in the source table

4. Unique drug identifier/drug_code CIP7 used in CIS_CIP_bdpm table (packaging info) is used as unique drug identifier/drug_code; But some Homeopathic drugs don't have packaging info and don't have a CIP7 code that is unique identifier, so we don't put it into our tables, and "VACCIN RABIQUE INACTIVE MERIEUX", drug_code = '60253264' also doesn't have packaging info but anyway we put it to all our tables using drug_code as concept_code

5. concept_synonym table

• concept_synonym table contains original names and English translations,
• concept table contains only English translations of concepts

6. packaging / ingredient combination as a way of ds_stage creation

/ concept table with translations ...

61546829 solution 2487 TARTRATE DE NORADRÉNALINE 2 mg 1 ml de solution à diluer pour perfusion SA 1 61546829 solution 9745 NORADRÉNALINE 1 mg 1 ml de solution à diluer pour perfusion FT 1

keep only those ingredients that are standard, so in drug_strength we'll have only standard ingredient and it's dosage

61546829 solution 9745 NORADRÉNALINE 1 mg 1 ml de solution à diluer pour perfusion FT 1

7. non-drugs

identified by the rules defined here for example OLICLINOMEL N7-1000 E, émulsion pour perfusion is a parenteral nutrition that is a non-drug

8. Brand Names

We create mappings for Brands, mostly we find direct equivalents like BREVIBLOC maps to 19021087 Brevibloc

BREVOXYL maps to 19056868 Brevoxyl

BRICANYL maps to 19021117 Bricanyl

BRIDION maps to 35604510 Bridion

also make relationships if there is a little difference

• SERC maps to 19052958 Serc-8
• DALACINE maps to 19054051 Dalacin T
• ESTRADERM TTS maps to 19100516 Estraderm TTS 25
• ORALAIR maps to 45776959 Oralair 100
• STRIVERDI RESPIMAT maps to 45775118 Striverdi
• NERISONE C maps to 19053642 Nerisone

9. Homeopathic Drugs having CIP7 but not relationships and drug_strength exist only in drug_concept_stage.

10. Dosage recalculation rules: -take maximal dosage if interval