BTG2
BTG2 is one of a number of genes affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus.
| Entity | Tier | Description |
|---|---|---|
| BL | 2-a | aSHM target; Although recurrent, the relevance of mutations in BL is tenuous |
| DLBCL | 1-a | aSHM target and high-confidence DLBCL gene |
| FL | 1-a | aSHM target and high-confidence FL gene |
| Entity | source | frequency (%) |
|---|---|---|
| BL | GAMBL genomes+capture | 4.85 |
| BL | Thomas cohort | 4.20 |
| BL | Panea cohort | 9.90 |
| DLBCL | GAMBL genomes | 13.38 |
| DLBCL | Schmitz cohort | 17.23 |
| DLBCL | Reddy cohort | 9.21 |
| DLBCL | Chapuy cohort | 5.98 |
| FL | GAMBL genomes | 4.39 |
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | Yes | No | 6.152 | 42.280 |
| DLBCL | Yes | Yes | 3.562 | 10.265 |
| FL | Yes | No | 6.073 | 0.000 |
| chr_name | hg19_start | hg19_end | region | regulatory_comment |
|---|---|---|---|---|
| chr1 | 203274698 | 203275778 | intron | active_promoter |
Note
First described in BL in 2019 by Panea RI. First described in DLBCL in 2011 by Morin RD. First described in FL in 2011 by Morin RD
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
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