MGA
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MGA acts as a transcriptional repressor and interacts with MYC, a well-known oncogene. Mutations in MGA have been described in DLBCL.[@jalladesExomeSequencingIdentifies2017] One study suggested MGA mutations were more common in DLBCLs in patients of African ancestry.[@reddyGeneticFunctionalDrivers2017] The mutation pattern in MGA is consistent with a role as a tumour suppressor gene.
| Entity | Tier | Description |
|---|---|---|
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2 | relevance in MZL not firmly established[@jalladesExomeSequencingIdentifies2017] |
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1 | high-confidence DLBCL gene[@reddyGeneticFunctionalDrivers2017] |
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